{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T18:30:39Z","timestamp":1793039439645,"version":"4.5.0"},"reference-count":100,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2023,4,21]],"date-time":"2023-04-21T00:00:00Z","timestamp":1682035200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"PRIN-MIUR (Research Projects of Relevant National Interest\u2013Ministry of Education, University and Research)","award":["Prot. 2017NKB2N4"],"award-info":[{"award-number":["Prot. 2017NKB2N4"]}]},{"name":"PRIN-MIUR (Research Projects of Relevant National Interest\u2013Ministry of Education, University and Research)","award":["IG 21558"],"award-info":[{"award-number":["IG 21558"]}]},{"name":"PRIN-MIUR (Research Projects of Relevant National Interest\u2013Ministry of Education, University and Research)","award":["20174TB8KW"],"award-info":[{"award-number":["20174TB8KW"]}]},{"name":"PRIN-MIUR (Research Projects of Relevant National Interest\u2013Ministry of Education, University and Research)","award":["GMR22T102"],"award-info":[{"award-number":["GMR22T102"]}]},{"name":"Fondazione AIRC per la Ricerca sul Cancro","award":["Prot. 2017NKB2N4"],"award-info":[{"award-number":["Prot. 2017NKB2N4"]}]},{"name":"Fondazione AIRC per la Ricerca sul Cancro","award":["IG 21558"],"award-info":[{"award-number":["IG 21558"]}]},{"name":"Fondazione AIRC per la Ricerca sul Cancro","award":["20174TB8KW"],"award-info":[{"award-number":["20174TB8KW"]}]},{"name":"Fondazione AIRC per la Ricerca sul Cancro","award":["GMR22T102"],"award-info":[{"award-number":["GMR22T102"]}]},{"name":"PRIN-MIUR","award":["Prot. 2017NKB2N4"],"award-info":[{"award-number":["Prot. 2017NKB2N4"]}]},{"name":"PRIN-MIUR","award":["IG 21558"],"award-info":[{"award-number":["IG 21558"]}]},{"name":"PRIN-MIUR","award":["20174TB8KW"],"award-info":[{"award-number":["20174TB8KW"]}]},{"name":"PRIN-MIUR","award":["GMR22T102"],"award-info":[{"award-number":["GMR22T102"]}]},{"name":"Fondazione Telethon","award":["Prot. 2017NKB2N4"],"award-info":[{"award-number":["Prot. 2017NKB2N4"]}]},{"name":"Fondazione Telethon","award":["IG 21558"],"award-info":[{"award-number":["IG 21558"]}]},{"name":"Fondazione Telethon","award":["20174TB8KW"],"award-info":[{"award-number":["20174TB8KW"]}]},{"name":"Fondazione Telethon","award":["GMR22T102"],"award-info":[{"award-number":["GMR22T102"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biomolecules"],"abstract":"<jats:p>Given the key role played by ClC-K chloride channels in kidney and inner ear physiology and pathology, they can be considered important targets for drug discovery. Indeed, ClC-Ka and ClC-Kb inhibition would interfere with the urine countercurrent concentration mechanism in Henle\u2019s loop, which is responsible for the reabsorption of water and electrolytes from the collecting duct, producing a diuretic and antihypertensive effect. On the other hand, ClC-K\/barttin channel dysfunctions in Bartter Syndrome with or without deafness will require the pharmacological recovery of channel expression and\/or activity. In these cases, a channel activator or chaperone would be appealing. Starting from a brief description of the physio-pathological role of ClC-K channels in renal function, this review aims to provide an overview of the recent progress in the discovery of ClC-K channel modulators.<\/jats:p>","DOI":"10.3390\/biom13040710","type":"journal-article","created":{"date-parts":[[2023,4,21]],"date-time":"2023-04-21T06:06:18Z","timestamp":1682057178000},"page":"710","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Small Molecules Targeting Kidney ClC-K Chloride Channels: Applications in Rare Tubulopathies and Common Cardiovascular Diseases"],"prefix":"10.3390","volume":"13","author":[{"given":"Maria Antonietta","family":"Coppola","sequence":"first","affiliation":[{"name":"Department of Pharmacy\u2013Drug Sciences, University of Bari \u201cAldo Moro\u201d, 70125 Bari, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8644-8847","authenticated-orcid":false,"given":"Michael","family":"Pusch","sequence":"additional","affiliation":[{"name":"Institute of Biophysics, National Research Council, 16149 Genova, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9140-5350","authenticated-orcid":false,"given":"Paola","family":"Imbrici","sequence":"additional","affiliation":[{"name":"Department of Pharmacy\u2013Drug Sciences, University of Bari \u201cAldo Moro\u201d, 70125 Bari, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonella","family":"Liantonio","sequence":"additional","affiliation":[{"name":"Department of Pharmacy\u2013Drug Sciences, University of Bari \u201cAldo Moro\u201d, 70125 Bari, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,4,21]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"6943","DOI":"10.1073\/pnas.91.15.6943","article-title":"Two highly homologous members of the ClC chloride channel family in both rat and human kidney","volume":"91","author":"Kieferle","year":"1994","journal-title":"Proc. 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