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Sirt3 activation can slow down or prevent mitochondrial dysfunction in response to neurodegenerative disorders, demonstrating a strong neuroprotective impact. The mechanism of Sirt3 in neurodegenerative illnesses has been elucidated over time; it is essential for neuron, astrocyte, and microglial function, and its primary regulatory factors include antiapoptosis, oxidative stress, and the maintenance of metabolic homeostasis. Neurodegenerative disorders, such as Alzheimer\u2019s disease (AD), Parkinson\u2019s disease (PD), Huntington\u2019s disease (HD), amyotrophic lateral sclerosis (ALS), and multiple sclerosis (MS), may benefit from a thorough and in-depth investigation of Sirt3. In this review, we primarily cover Sirt3\u2019s role and its regulation in the nerve cells and the connection between Sirt3 and neurodegenerative disorders.<\/jats:p>","DOI":"10.3390\/biom13050735","type":"journal-article","created":{"date-parts":[[2023,4,25]],"date-time":"2023-04-25T02:06:35Z","timestamp":1682388395000},"page":"735","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["Role of Sirtuin 3 in Degenerative Diseases of the Central Nervous System"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0831-2714","authenticated-orcid":false,"given":"Haofuzi","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Neurosurgery, Xijing Hospital, Fourth Military Medical University, Xi\u2019an 710032, China"},{"name":"Institute of Neurosurgery of People\u2019s Liberation Army of China (PLA), PLA\u2019s Key Laboratory of Critical Care Medicine, Xijing Hospital, Fourth Military Medical University, Xi\u2019an 710032, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuhui","family":"Dai","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Xijing Hospital, Fourth Military Medical University, Xi\u2019an 710032, China"},{"name":"National Translational Science Center for Molecular Medicine and Department of Cell Biology, Fourth Military Medical University, Xi\u2019an 710032, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuefan","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Xijing Hospital, Fourth Military Medical University, Xi\u2019an 710032, China"},{"name":"Department of Biomedical Engineering, Fourth Military Medical University, Xi\u2019an 710032, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jialiang","family":"Wei","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Xijing Hospital, Fourth Military Medical University, Xi\u2019an 710032, China"},{"name":"Department of Health Service, Fourth Military Medical University, Xi\u2019an 710032, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Xijing Hospital, Fourth Military Medical University, Xi\u2019an 710032, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Xijing Hospital, Fourth Military Medical University, Xi\u2019an 710032, China"},{"name":"Institute of Neurosurgery of People\u2019s Liberation Army of China (PLA), PLA\u2019s Key Laboratory of Critical Care Medicine, Xijing Hospital, Fourth Military Medical University, Xi\u2019an 710032, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaofan","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Xijing Hospital, Fourth Military Medical University, Xi\u2019an 710032, China"},{"name":"Institute of Neurosurgery of People\u2019s Liberation Army of China (PLA), PLA\u2019s Key Laboratory of Critical Care Medicine, Xijing Hospital, Fourth Military Medical University, Xi\u2019an 710032, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,4,24]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"2778","DOI":"10.1016\/j.apsb.2022.03.001","article-title":"Mitochondria targeting drugs for neurodegenerative diseases-Design, mechanism and application","volume":"12","author":"Xu","year":"2022","journal-title":"Acta Pharm. 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