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Neutrophils have a broad spectrum of functions, including phagocytosis of microorganisms, the release of pro-inflammatory cytokines and chemokines, oxidative burst, and the formation of neutrophil extracellular traps. Traditionally, neutrophils were thought to be most important for acute inflammatory responses, with a short half-life and a more static response to infections and injury. However, this view has changed in recent years showing neutrophil heterogeneity and dynamics, indicating a much more regulated and flexible response. Here we will discuss the role of neutrophils in aging and neurological disorders; specifically, we focus on recent data indicating the impact of neutrophils in chronic inflammatory processes and their contribution to neurological diseases. Lastly, we aim to conclude that reactive neutrophils directly contribute to increased vascular inflammation and age-related diseases.<\/jats:p>","DOI":"10.3390\/biom13050743","type":"journal-article","created":{"date-parts":[[2023,4,26]],"date-time":"2023-04-26T02:30:52Z","timestamp":1682476252000},"page":"743","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["A Brief Overview of Neutrophils in Neurological Diseases"],"prefix":"10.3390","volume":"13","author":[{"given":"Supriya","family":"Chakraborty","sequence":"first","affiliation":[{"name":"Department of Biology, University of Miami, Coral Gables, FL 33146, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zeynab","family":"Tabrizi","sequence":"additional","affiliation":[{"name":"Department of Biology, University of Miami, Coral Gables, FL 33146, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nairuti Nikhil","family":"Bhatt","sequence":"additional","affiliation":[{"name":"Department of Biology, University of Miami, Coral Gables, FL 33146, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sofia Andrea","family":"Franciosa","sequence":"additional","affiliation":[{"name":"Department of Biology, University of Miami, Coral Gables, FL 33146, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9414-6590","authenticated-orcid":false,"given":"Oliver","family":"Bracko","sequence":"additional","affiliation":[{"name":"Department of Biology, University of Miami, Coral Gables, FL 33146, USA"},{"name":"Department of Neurology, University of Miami-Miller School of Medicine, Miami, FL 33136, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,4,25]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1172\/JCI108517","article-title":"Neutrophil kinetics in man","volume":"58","author":"Dancey","year":"1976","journal-title":"J. Clin. Investig."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1182\/blood-2010-01-259028","article-title":"In vivo labeling with 2H2O reveals a human neutrophil lifespan of 5.4 days","volume":"116","author":"Pillay","year":"2010","journal-title":"Blood"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1016\/j.it.2019.04.013","article-title":"The Neutrophil Life Cycle","volume":"40","author":"Hidalgo","year":"2019","journal-title":"Trends Immunol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3233\/BIR-2011-0579","article-title":"Biomechanics of leukocyte rolling","volume":"48","author":"Sundd","year":"2011","journal-title":"Biorheology"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1080\/10739680500466376","article-title":"Induction of LFA-1-Dependent Neutrophil Rolling on ICAM-1 by Engagement of E-Selectin","volume":"13","author":"Chesnutt","year":"2006","journal-title":"Microcirculation"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1038\/nri.2016.49","article-title":"Neutrophil migration in infection and wound repair: Going forward in reverse","volume":"16","author":"Rosowski","year":"2016","journal-title":"Nat. Rev. Immunol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"2149","DOI":"10.1182\/blood-2018-12-844605","article-title":"Neutrophil transendothelial migration: Updates and new perspectives","volume":"133","author":"Filippi","year":"2019","journal-title":"Blood"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"113","DOI":"10.3389\/fphys.2018.00113","article-title":"Neutrophil: A Cell with Many Roles in Inflammation or Several Cell Types?","volume":"9","author":"Rosales","year":"2018","journal-title":"Front. Physiol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"448","DOI":"10.3389\/fimmu.2014.00448","article-title":"Granule Protein Processing and Regulated Secretion in Neutrophils","volume":"5","author":"Sheshachalam","year":"2014","journal-title":"Front. Immunol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1038\/nri.2017.105","article-title":"Neutrophil extracellular traps in immunity and disease","volume":"18","author":"Papayannopoulos","year":"2018","journal-title":"Nat. Rev. Immunol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1007\/978-1-61779-527-5_8","article-title":"Measurement of Oxidative Burst in Neutrophils","volume":"844","author":"Chen","year":"2012","journal-title":"Methods Mol. Biol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1172\/JCI113970","article-title":"Macrophage phagocytosis of aging neutrophils in inflammation. Programmed cell death in the neutrophil leads to its recognition by macrophages","volume":"83","author":"Savill","year":"1989","journal-title":"J. Clin. Investig."},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"(2006). Lacy, Mechanisms of Degranulation in Neutrophils. Allergy Asthma Clin. Immunol., 2, 98\u2013108.","DOI":"10.1186\/1710-1492-2-3-98"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1038\/nm.3913","article-title":"Neutrophils promote Alzheimer\u2019s disease-like pathology and cognitive decline via LFA-1 integrin","volume":"21","author":"Zenaro","year":"2015","journal-title":"Nat. Med."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1016\/j.trci.2018.06.014","article-title":"Inflammation as a central mechanism in Alzheimer\u2019s disease","volume":"4","author":"Kinney","year":"2018","journal-title":"Alzheimers Dement."},{"key":"ref_16","first-page":"73","article-title":"X.\u2014Mitosis and Cell Differentiation in the Blood","volume":"62","year":"1944","journal-title":"Proc. R. Soc. Edinburgh. Sect. B Boil."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1084\/jem.134.4.907","article-title":"The development of neutrophilic polymorphonuclear leukocytes in human bone marrow","volume":"134","author":"Bainton","year":"1971","journal-title":"J. Exp. Med."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"211","DOI":"10.3389\/fimmu.2017.00211","article-title":"NETosis in Alzheimer\u2019s Disease","volume":"8","author":"Pietronigro","year":"2017","journal-title":"Front. Immunol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"602963","DOI":"10.3389\/fimmu.2021.602963","article-title":"Neutrophils: Need for Standardized Nomenclature","volume":"12","author":"McKenna","year":"2021","journal-title":"Front. Immunol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1007\/s12016-020-08804-7","article-title":"A Review of Neutrophil Extracellular Traps (NETs) in Disease: Potential Anti-NETs Therapeutics","volume":"61","author":"Mutua","year":"2021","journal-title":"Clin. Rev. Allergy Immunol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1186\/s12974-018-1284-4","article-title":"The role of neutrophil granule proteins in neuroinflammation and Alzheimer\u2019s disease","volume":"15","author":"Stock","year":"2018","journal-title":"J. Neuroinflamm."},{"key":"ref_22","first-page":"79","article-title":"Cell transformation by the superoxide-generating oxidase Mox1","volume":"401","author":"Suh","year":"1999","journal-title":"Nat. Cell Biol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1111\/j.1365-2141.1984.tb06080.x","article-title":"Neutrophils with ring-shaped nuclei in myeloproliferative disease","volume":"58","author":"Langenhuijsen","year":"1984","journal-title":"Br. J. Haematol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"772","DOI":"10.4049\/jimmunol.2200154","article-title":"Single-Cell Analysis Reveals the Range of Transcriptional States of Circulating Human Neutrophils","volume":"209","author":"Wigerblad","year":"2022","journal-title":"J. Immunol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1111\/imr.13123","article-title":"Neutrophil modulation of behavior and cognition in health and disease: The unexplored role of an innate immune cell","volume":"311","author":"Coulibaly","year":"2022","journal-title":"Immunol. Rev."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"1496","DOI":"10.1038\/s41590-020-00813-0","article-title":"A new neutrophil subset promotes CNS neuron survival and axon regeneration","volume":"21","author":"Sas","year":"2020","journal-title":"Nat. Immunol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1016\/j.immuni.2010.11.011","article-title":"Neutrophils, from Marrow to Microbes","volume":"33","author":"Borregaard","year":"2010","journal-title":"Immunity"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1111\/bjh.13798","article-title":"Understanding chronic neutropenia: Life is short","volume":"172","author":"Bartels","year":"2016","journal-title":"Br. J. Haematol."},{"key":"ref_29","doi-asserted-by":"crossref","unstructured":"Shirakawa, K., and Sano, M. (2022). Neutrophils and Neutrophil Extracellular Traps in Cardiovascular Disease: An Overview and Potential Therapeutic Approaches. Biomedicines, 10.","DOI":"10.3390\/biomedicines10081850"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1002\/jcp.1041160211","article-title":"Proliferative effects of purified granulocyte colony-stimulating factor (G-CSF) on normal mouse hemopoietic cells","volume":"116","author":"Metcalf","year":"1983","journal-title":"J. Cell. Physiol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1080\/08977190500055836","article-title":"G-CSF: A key regulator of neutrophil production, but that\u2019s not all!","volume":"23","author":"Roberts","year":"2005","journal-title":"Growth Factors"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"2423","DOI":"10.1172\/JCI41649","article-title":"CXCR2 and CXCR4 antagonistically regulate neutrophil trafficking from murine bone marrow","volume":"120","author":"Eash","year":"2010","journal-title":"J. Clin. Investig."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1073\/pnas.94.2.569","article-title":"Absence of granulocyte colony-stimulating factor signaling and neutrophil development in CCAAT enhancer binding protein \u03b1-deficient mice","volume":"94","author":"Zhang","year":"1997","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"2403","DOI":"10.1101\/gad.12.15.2403","article-title":"PU. 1 induces myeloid lineage commitment in multipotent hematopoietic progenitors","volume":"12","author":"Nerlov","year":"1998","journal-title":"Genes Dev."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1038\/nature01514","article-title":"Disease proteomics","volume":"422","author":"Hanash","year":"2003","journal-title":"Nature"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"57","DOI":"10.4331\/wjbc.v12.i5.57","article-title":"Proteomics: Concepts and applications in human medicine","volume":"12","author":"Alshekaili","year":"2021","journal-title":"World J. Biol. Chem."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1016\/j.jprot.2009.06.013","article-title":"Application of proteomics to neutrophil biology","volume":"73","author":"Luerman","year":"2010","journal-title":"J. Proteom."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"14541","DOI":"10.1021\/bi0352365","article-title":"Generation of the R2 Subunit of Ribonucleotide Reductase by Intein Chemistry: Insertion of 3-Nitrotyrosine at Residue 356 as a Probe of the Radical Initiation Process","volume":"42","author":"Yee","year":"2003","journal-title":"Biochemistry"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"1811","DOI":"10.1016\/j.bbapap.2006.10.003","article-title":"The utility of ETD mass spectrometry in proteomic analysis","volume":"1764","author":"Mikesh","year":"2006","journal-title":"Biochim. Biophys. Acta"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/j.cccn.2005.03.019","article-title":"Functional proteomics","volume":"357","author":"Monti","year":"2005","journal-title":"Clin. Chim. Acta"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"1903","DOI":"10.1038\/s41467-019-09670-4","article-title":"Single-cell trajectories reconstruction, exploration and mapping of omics data with STREAM","volume":"10","author":"Chen","year":"2019","journal-title":"Nat. Commun."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1038\/s41590-020-0736-z","article-title":"Single-cell transcriptome profiling reveals neutrophil heterogeneity in homeostasis and infection","volume":"21","author":"Xie","year":"2020","journal-title":"Nat. Immunol."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"2856","DOI":"10.1038\/s41467-021-22973-9","article-title":"The neutrotime transcriptional signature defines a single continuum of neutrophils across biological compartments","volume":"12","author":"Radtke","year":"2021","journal-title":"Nat. Commun."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"1243259","DOI":"10.1126\/science.1243259","article-title":"Single-Cell Metabolomics: Analytical and Biological Perspectives","volume":"342","author":"Zenobi","year":"2013","journal-title":"Science"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1177\/1753425920951985","article-title":"Metabolomic analysis of spontaneous neutrophil apoptosis reveals the potential involvement of glutathione depletion","volume":"27","author":"Yuyun","year":"2021","journal-title":"Innate Immun."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"932","DOI":"10.1038\/nmeth818","article-title":"Deep tissue two-photon microscopy","volume":"2","author":"Helmchen","year":"2005","journal-title":"Nat. Methods"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1038\/nphoton.2012.336","article-title":"In vivo three-photon microscopy of subcortical structures within an intact mouse brain","volume":"7","author":"Horton","year":"2013","journal-title":"Nat. Photonics"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"18073","DOI":"10.1073\/pnas.1008737107","article-title":"In vivo two-photon imaging reveals monocyte-dependent neutrophil extravasation during pulmonary inflammation","volume":"107","author":"Kreisel","year":"2010","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_49","first-page":"e89761","article-title":"Lung vaso-occlusion in sickle cell disease mediated by arteriolar neutrophil-platelet microemboli","volume":"2","author":"Bennewitz","year":"2017","journal-title":"J. Clin. Investig."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1038\/nmeth.1543","article-title":"Stabilized imaging of immune surveillance in the mouse lung","volume":"8","author":"Looney","year":"2011","journal-title":"Nat. Methods"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"1020","DOI":"10.1182\/blood.2021014552","article-title":"Liver-to-lung microembolic NETs promote gasdermin D\u2013dependent inflammatory lung injury in sickle cell disease","volume":"140","author":"Vats","year":"2022","journal-title":"Blood"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"e80","DOI":"10.1002\/cpcy.80","article-title":"Live Imaging of the Lung","volume":"95","author":"Brzoska","year":"2020","journal-title":"Curr. Protoc. Cytom."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1186\/s42826-022-00126-3","article-title":"Real-time observation of neutrophil extracellular trap formation in the inflamed mouse brain via two-photon intravital imaging","volume":"38","author":"Byun","year":"2022","journal-title":"Lab. Anim. Res."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1189\/jlb.0910538","article-title":"The paradox of the neutrophil\u2019s role in tissue injury","volume":"89","author":"Segel","year":"2011","journal-title":"J. Leukoc. Biol."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1038\/nri3399","article-title":"Neutrophil recruitment and function in health and inflammation","volume":"13","author":"Kolaczkowska","year":"2013","journal-title":"Nat. Rev. Immunol."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1038\/nature08780","article-title":"Circulating mitochondrial DAMPs cause inflammatory responses to injury","volume":"464","author":"Zhang","year":"2010","journal-title":"Nature"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"888","DOI":"10.1038\/jcbfm.2015.45","article-title":"Targeting Neutrophils in Ischemic Stroke: Translational Insights from Experimental Studies","volume":"35","author":"Jickling","year":"2015","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"5140679","DOI":"10.1155\/2017\/5140679","article-title":"Thrombosis, Neuroinflammation, and Poststroke Infection: The Multifaceted Role of Neutrophils in Stroke","volume":"2017","author":"Ruhnau","year":"2017","journal-title":"J. Immunol. Res."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"924","DOI":"10.1111\/imcb.12463","article-title":"Dynamic roles of neutrophils in post-stroke neuroinflammation","volume":"99","author":"Wanrooy","year":"2021","journal-title":"Immunol. Cell Biol."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"108260","DOI":"10.1016\/j.celrep.2020.108260","article-title":"Neutrophils Obstructing Brain Capillaries Are a Major Cause of No-Reflow in Ischemic Stroke","volume":"33","author":"Binder","year":"2020","journal-title":"Cell Rep."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1177\/0271678X20914179","article-title":"Dynamic capillary stalls in reperfused ischemic penumbra contribute to injury: A hyperacute role for neutrophils in persistent traffic jams","volume":"41","author":"Erdener","year":"2021","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1007\/s10072-016-2758-8","article-title":"Comparison of neutrophil\u2013lymphocyte ratio (NLR) in Parkinson\u2019s disease subtypes","volume":"38","author":"Inan","year":"2017","journal-title":"Neurol. Sci."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1038\/ni1001-907","article-title":"Nitric oxide and the immune response","volume":"2","author":"Bogdan","year":"2001","journal-title":"Nat. Immunol."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1006\/niox.2000.0288","article-title":"Overexpression of neutrophil neuronal nitric oxide synthase in Parkinson\u2019s disease","volume":"4","author":"Gatto","year":"2000","journal-title":"Nitric Oxide"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"3059","DOI":"10.1007\/s00018-019-03331-x","article-title":"Nitric oxide and peroxynitrite trigger and enhance release of neutrophil extracellular traps","volume":"77","author":"Bystrzycka","year":"2020","journal-title":"Cell. Mol. Life Sci."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1042\/BCJ20170803","article-title":"Interrogating Parkinson\u2019s disease LRRK2 kinase pathway activity by assessing Rab10 phosphorylation in human neutrophils","volume":"475","author":"Fan","year":"2018","journal-title":"Biochem. J."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"2426","DOI":"10.1002\/mds.28685","article-title":"Peripheral Immune Profile and Neutrophil-to-Lymphocyte Ratio in Parkinson\u2019s Disease","volume":"36","author":"Carrillo","year":"2021","journal-title":"Mov. Disord."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1038\/s41579-020-00459-7","article-title":"Characteristics of SARS-CoV-2 and COVID-19","volume":"19","author":"Hu","year":"2021","journal-title":"Nat. Rev. Microbiol."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"864387","DOI":"10.3389\/fimmu.2022.864387","article-title":"Neutrophils in COVID-19: Not Innocent Bystanders","volume":"13","author":"McKenna","year":"2022","journal-title":"Front. Immunol."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"e2128568","DOI":"10.1001\/jamanetworkopen.2021.28568","article-title":"Short-term and Long-term Rates of Postacute Sequelae of SARS-CoV-2 Infection: A Systematic Review","volume":"4","author":"Groff","year":"2021","journal-title":"JAMA Netw. Open"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"eabo5795","DOI":"10.1126\/scitranslmed.abo5795","article-title":"A persistent neutrophil-associated immune signature characterizes post\u2013COVID-19 pulmonary sequelae","volume":"14","author":"George","year":"2022","journal-title":"Sci. Transl. Med."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1038\/s41586-020-2008-3","article-title":"A new coronavirus associated with human respiratory disease in China","volume":"579","author":"Wu","year":"2020","journal-title":"Nature"},{"key":"ref_73","first-page":"e14726","article-title":"SARS-CoV-2 related microvascular damage and symptoms during and after COVID-19: Consequences of capillary transit-time changes, tissue hypoxia and inflammation","volume":"9","year":"2021","journal-title":"Physiol. Rep."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"1609","DOI":"10.1161\/CIRCULATIONAHA.120.050354","article-title":"Severe COVID-19 is a Microvascular Disease","volume":"142","author":"Lowenstein","year":"2020","journal-title":"Circulation"},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"105131","DOI":"10.1016\/j.nbd.2020.105131","article-title":"The SARS-CoV-2 spike protein alters barrier function in 2D static and 3D microfluidic in-vitro models of the human blood-brain barrier","volume":"146","author":"Buzhdygan","year":"2020","journal-title":"Neurobiol. Dis."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"1014","DOI":"10.1016\/j.stemcr.2022.04.012","article-title":"Response to: SARS-CoV-2 and type I interferon signaling in brain endothelial cells: Blurring the lines between friend or foe","volume":"17","author":"Krasemann","year":"2022","journal-title":"Stem Cell Rep."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1093\/brain\/awac272","article-title":"SARS-CoV-2 triggers pericyte-mediated cerebral capillary constriction","volume":"146","author":"Hirunpattarasilp","year":"2023","journal-title":"Brain"},{"key":"ref_78","first-page":"e30603","article-title":"COVID-19 Demonstrates That Inflammation Is a Hyperviscous State","volume":"14","author":"Sloop","year":"2022","journal-title":"Cureus"},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"524369","DOI":"10.3389\/fnagi.2020.524369","article-title":"The Interaction of Aging and Cellular Stress Contributes to Pathogenesis in Mouse and Human Huntington Disease Neurons","volume":"12","author":"Machiela","year":"2020","journal-title":"Front. Aging Neurosci."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.bbi.2014.09.011","article-title":"Plasma inflammatory biomarkers for Huntington\u2019s disease patients and mouse model","volume":"44","author":"Chang","year":"2015","journal-title":"Brain Behav. Immun."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"4737","DOI":"10.1172\/JCI64484","article-title":"Mutant huntingtin impairs immune cell migration in Huntington disease","volume":"122","author":"Kwan","year":"2012","journal-title":"J. Clin. Investig."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1093\/ajcn\/74.3.328","article-title":"Factors correlated with hypermetabolism in patients with amyotrophic lateral sclerosis","volume":"74","author":"Desport","year":"2001","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/S1474-4422(18)30394-6","article-title":"Immune dysregulation in amyotrophic lateral sclerosis: Mechanisms and emerging therapies","volume":"18","author":"Beers","year":"2019","journal-title":"Lancet Neurol."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1186\/s12974-015-0350-4","article-title":"Humoral factors in ALS patients during disease progression","volume":"12","author":"Ehrhart","year":"2015","journal-title":"J. Neuroinflamm."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1111\/j.1468-1331.2011.03623.x","article-title":"Elevated levels of IFN\u03b3 and LIGHT in the spinal cord of patients with sporadic amyotrophic lateral sclerosis","volume":"19","author":"Aebischer","year":"2012","journal-title":"Eur. J. Neurol."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1089\/jir.2005.25.241","article-title":"IL-6 transsignaling: The in vivo consequences","volume":"25","author":"Jones","year":"2005","journal-title":"J. Interferon Cytokine Res."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1517\/14728222.11.5.613","article-title":"The IL-6\/sIL-6R complex as a novel target for therapeutic approaches","volume":"11","author":"Waetzig","year":"2007","journal-title":"Expert Opin. Ther. Targets"},{"key":"ref_88","doi-asserted-by":"crossref","unstructured":"Garbuzova-Davis, S., Ehrhart, J., Sanberg, P.R., and Borlongan, C.V. (2018). Potential Role of Humoral IL-6 Cytokine in Mediating Pro-Inflammatory Endothelial Cell Response in Amyotrophic Lateral Sclerosis. Int. J. Mol. Sci., 19.","DOI":"10.3390\/ijms19020423"},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1007\/s12192-010-0192-z","article-title":"The response of interleukin-6 and soluble interleukin-6 receptor isoforms following intermittent high intensity and continuous moderate intensity cycling","volume":"15","author":"Leggate","year":"2010","journal-title":"Cell Stress Chaperones"},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/0014-5793(93)80507-Q","article-title":"Differential shedding of the two subunits of the interleukin-6 receptor","volume":"332","author":"Dittrich","year":"1993","journal-title":"FEBS Lett."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"e953","DOI":"10.1212\/NXI.0000000000000953","article-title":"Amyotrophic Lateral Sclerosis Survival Associates with Neutrophils in a Sex-specific Manner","volume":"8","author":"Murdock","year":"2021","journal-title":"Neurol. Neuroimmunol. Neuroinflamm."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"e242","DOI":"10.1212\/NXI.0000000000000242","article-title":"Increased ratio of circulating neutrophils to monocytes in amyotrophic lateral sclerosis","volume":"3","author":"Murdock","year":"2016","journal-title":"Neurol. Neuroimmunol. Neuroinflamm."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"875","DOI":"10.4103\/1673-5374.322476","article-title":"Neutrophil-to-lymphocyte ratio in sporadic amyotrophic lateral sclerosis","volume":"17","author":"Shang","year":"2022","journal-title":"Neural Regen. Res."},{"key":"ref_94","doi-asserted-by":"crossref","unstructured":"Leone, M.A., Mandrioli, J., Russo, S., Cucovici, A., Gianferrari, G., Lisnic, V., Muresanu, D.F., Giuliani, F., Copetti, M., and The Pooled Resource Open-Access ALS Clinical Trials Consortium (2022). Neutrophils-to-Lymphocyte Ratio Is Associated with Progression and Overall Survival in Amyotrophic Lateral Sclerosis. Biomedicines, 10.","DOI":"10.3390\/biomedicines10020354"},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"24708","DOI":"10.1038\/srep24708","article-title":"Elastase levels and activity are increased in dystrophic muscle and impair myoblast cell survival, proliferation and differentiation","volume":"6","author":"Arecco","year":"2016","journal-title":"Sci. Rep."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1002\/jlb.65.6.875","article-title":"Regulation of neutrophil Fc\u03b3RIIIb (CD16) surface expression following delayed apoptosis in response to GM-CSF and sodium butyrate","volume":"65","author":"Moulding","year":"1999","journal-title":"J. Leukoc. Biol."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"fcaa013","DOI":"10.1093\/braincomms\/fcaa013","article-title":"Monocytes and neutrophils are associated with clinical features in amyotrophic lateral sclerosis","volume":"2","author":"McGill","year":"2020","journal-title":"Brain Commun."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"1446","DOI":"10.1001\/jamaneurol.2017.2255","article-title":"Correlation of Peripheral Immunity with Rapid Amyotrophic Lateral Sclerosis Progression","volume":"74","author":"Murdock","year":"2017","journal-title":"JAMA Neurol."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.brainres.2011.06.022","article-title":"Detailed characterization of neuro-immune responses following neuropathic injury in mice","volume":"1405","author":"Kim","year":"2011","journal-title":"Brain Res."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1038\/nri.2016.90","article-title":"Sex differences in immune responses","volume":"16","author":"Klein","year":"2016","journal-title":"Nat. Rev. Immunol."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"3265029","DOI":"10.1155\/2022\/3265029","article-title":"Correlation between the Neutrophil-to-Lymphocyte Ratio and Multiple Sclerosis: Recent Understanding and Potential Application Perspectives","volume":"2022","author":"Zhou","year":"2022","journal-title":"Neurol. Res. Int."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"590409","DOI":"10.1155\/2014\/590409","article-title":"Interactions between Neutrophils, Th17 Cells, and Chemokines during the Initiation of Experimental Model of Multiple Sclerosis","volume":"2014","author":"Wojkowska","year":"2014","journal-title":"Mediat. Inflamm."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1096\/fj.09-141978","article-title":"Cellular mechanisms of IL-17-induced blood-brain barrier disruption","volume":"24","author":"Huppert","year":"2010","journal-title":"FASEB J."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1186\/s12974-020-1730-y","article-title":"Neutrophil-selective deletion of Cxcr2 protects against CNS neurodegeneration in a mouse model of multiple sclerosis","volume":"17","author":"Khaw","year":"2020","journal-title":"J. Neuroinflamm."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1038\/nn.2491","article-title":"CXCR2-positive neutrophils are essential for cuprizone-induced demyelination: Relevance to multiple sclerosis","volume":"13","author":"Liu","year":"2010","journal-title":"Nat. Neurosci."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.jneuroim.2011.11.009","article-title":"Neutrophils in multiple sclerosis are characterized by a primed phenotype","volume":"242","author":"Naegele","year":"2012","journal-title":"J. Neuroimmunol."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1177\/1352458515586084","article-title":"Distinct functionality of neutrophils in multiple sclerosis and neuromyelitis optica","volume":"22","author":"Hertwig","year":"2016","journal-title":"Mult. Scler. J."},{"key":"ref_108","doi-asserted-by":"crossref","unstructured":"De Bondt, M., Hellings, N., Opdenakker, G., and Struyf, S. (2020). Neutrophils: Underestimated Players in the Pathogenesis of Multiple Sclerosis (MS). Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21124558"},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.jneuroim.2004.06.008","article-title":"Increased CXCL8 (IL-8) expression in Multiple Sclerosis","volume":"155","author":"Lund","year":"2004","journal-title":"J. Neuroimmunol."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1093\/intimm\/dxq434","article-title":"Neutrophil activation and survival are modulated by interaction with NK cells","volume":"22","author":"Costantini","year":"2010","journal-title":"Int. Immunol."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.jneuroim.2013.05.004","article-title":"Gender differences in circulating levels of neutrophil extracellular traps in serum of multiple sclerosis patients","volume":"261","author":"Tillack","year":"2013","journal-title":"J. Neuroimmunol."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"23969415221126391","DOI":"10.1177\/23969415221126391","article-title":"FOXP2 down expression is associated with executive dysfunctions and electrophysiological abnormalities of brain in Autism spectrum disorder; a neuroimaging genetic study","volume":"7","author":"Haghighatfard","year":"2022","journal-title":"Autism Dev. Lang. Impair."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1016\/j.pnpbp.2018.12.002","article-title":"Oxidative and inflammatory mediators are upregulated in neutrophils of autistic children: Role of IL-17A receptor signaling","volume":"90","author":"Nadeem","year":"2019","journal-title":"Prog. Neuro Psychopharmacol. Biol. Psychiatry"},{"key":"ref_114","doi-asserted-by":"crossref","unstructured":"He, X., Zhou, M., Yang, T., Ren, J.-K., Sun, L., Liu, T.-Y., Sun, J.-B., Ma, P.-J., Liu, H.-T., and Fang, J.-Q. (Res. Sq., 2022). Early postnatal activation of A2ARs alleviates social deficits by attenuating the abnormal infiltration of peripheral neutrophils in the BTBR T + Itpr3 tf\/J mouse model of autism, Res. Sq., preprint.","DOI":"10.21203\/rs.3.rs-2257868\/v1"},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.jneuroim.2015.07.003","article-title":"Increased production of IL-17 in children with autism spectrum disorders and co-morbid asthma","volume":"286","author":"Akintunde","year":"2015","journal-title":"J. Neuroimmunol."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/j.bbr.2019.02.031","article-title":"Nrf2 activator, sulforaphane ameliorates autism-like symptoms through suppression of Th17 related signaling and rectification of oxidant-antioxidant imbalance in periphery and brain of BTBR T+tf\/J mice","volume":"364","author":"Nadeem","year":"2019","journal-title":"Behav. Brain Res."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"108619","DOI":"10.1016\/j.intimp.2022.108619","article-title":"Dysregulated Nrf2 signaling in response to di(2-ethylhexyl) phthalate in neutrophils of children with autism","volume":"106","author":"Nadeem","year":"2022","journal-title":"Int. Immunopharmacol."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1097\/01.mcp.0000144502.50149.e0","article-title":"Chemokines and their receptors in the pathogenesis of allergic asthma: Progress and perspective","volume":"11","author":"Bisset","year":"2005","journal-title":"Curr. Opin. Pulm. Med."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1186\/s12993-015-0056-x","article-title":"The possible link between elevated serum levels of epithelial cell-derived neutrophil-activating peptide-78 (ENA-78\/CXCL5) and autoimmunity in autistic children","volume":"11","author":"Mostafa","year":"2015","journal-title":"Behav. Brain Funct."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1111\/cns.13074","article-title":"Cathepsin B inhibition ameliorates leukocyte-endothelial adhesion in the BTBR mouse model of autism","volume":"25","author":"Wang","year":"2019","journal-title":"CNS Neurosci. Ther."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/S1474-4422(22)00437-9","article-title":"Lessons from Down syndrome and autosomal dominant Alzheimer\u2019s disease","volume":"22","author":"Fortea","year":"2023","journal-title":"Lancet Neurol."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/S1474-4422(22)00408-2","article-title":"Comparison of amyloid burden in individuals with Down syndrome versus autosomal dominant Alzheimer\u2019s disease: A cross-sectional study","volume":"22","author":"Boerwinkle","year":"2023","journal-title":"Lancet Neurol."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1111\/j.1365-2249.2011.04335.x","article-title":"Infections and immunodeficiency in Down syndrome","volume":"164","author":"Ram","year":"2011","journal-title":"Clin. Exp. Immunol."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"154938","DOI":"10.1016\/j.cyto.2019.154938","article-title":"Increased systemic inflammation in children with Down syndrome","volume":"127","author":"Huggard","year":"2020","journal-title":"Cytokine"},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"4068734","DOI":"10.1155\/2019\/4068734","article-title":"Altered Toll-like Receptor Signalling in Children with Down Syndrome","volume":"2019","author":"Huggard","year":"2019","journal-title":"Mediat. Inflamm."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1038\/nm1565","article-title":"Platelet TLR4 activates neutrophil extracellular traps to ensnare bacteria in septic blood","volume":"13","author":"Clark","year":"2007","journal-title":"Nat. Med."},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"170276","DOI":"10.1155\/2012\/170276","article-title":"Neuroinflammation in the aging down syndrome brain; lessons from Alzheimer\u2019s disease","volume":"2012","author":"Wilcock","year":"2012","journal-title":"Curr. Gerontol. Geriatr. Res."},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"3352","DOI":"10.1073\/pnas.94.7.3352","article-title":"HCAR and MCAR: The human and mouse cellular receptors for subgroup C adenoviruses and group B coxsackieviruses","volume":"94","author":"Tomko","year":"1997","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1084\/jem.186.4.517","article-title":"Endothelial-dependent Mechanisms Regulate Leukocyte Transmigration: A Process Involving the Proteasome and Disruption of the Vascular Endothelial\u2013Cadherin Complex at Endothelial Cell-to-Cell Junctions","volume":"186","author":"Allport","year":"1997","journal-title":"J. Exp. Med."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"1245","DOI":"10.1016\/S0306-4522(98)00058-X","article-title":"Loss of the tight junction proteins occludin and zonula occludens-1 from cerebral vascular endothelium during neutrophil-induced blood\u2013brain barrier breakdown in vivo","volume":"86","author":"Bolton","year":"1998","journal-title":"Neuroscience"},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1002\/em.20511","article-title":"Neutrophil oxidative metabolism in Down syndrome patients with congenital heart defects","volume":"51","author":"Akinci","year":"2010","journal-title":"Environ. Mol. Mutagen."},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/0006-8993(89)91550-3","article-title":"Superoxide dismutase activity in Alzheimer\u2019s disease: Possible mechanism for paired helical filament formation","volume":"476","author":"Zemlan","year":"1989","journal-title":"Brain Res."},{"key":"ref_133","doi-asserted-by":"crossref","unstructured":"Ferrari, M., and Stagi, S. (2021). Oxidative Stress in Down and Williams-Beuren Syndromes: An Overview. Molecules, 26.","DOI":"10.3390\/molecules26113139"},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1002\/ana.25159","article-title":"Neutrophil hyperactivation correlates with Alzheimer\u2019s disease progression","volume":"83","author":"Dong","year":"2018","journal-title":"Ann. Neurol."},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1038\/s41593-018-0329-4","article-title":"Neutrophil adhesion in brain capillaries reduces cortical blood flow and impairs memory function in Alzheimer\u2019s disease mouse models","volume":"22","author":"Bracko","year":"2019","journal-title":"Nat. Neurosci."},{"key":"ref_136","doi-asserted-by":"crossref","unstructured":"Ruiz-Uribe, N.E., Bracko, O., Swallow, M., Omurzakov, A., Dash, S., Uchida, H., Xiang, D., Haft-Javaherian, M., Falkenhain, K., and Lamont, M.E. (2023). Vascular oxidative stress causes neutrophil arrest in brain capillaries, leading to decreased cerebral blood flow and contributing to memory impairment in a mouse model of Alzheimer\u2019s disease. bioRxiv.","DOI":"10.1101\/2023.02.15.528710"},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1038\/s41582-019-0231-z","article-title":"Neuroinflammation in frontotemporal dementia","volume":"15","author":"Bright","year":"2019","journal-title":"Nat. Rev. Neurol."},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1159\/000322228","article-title":"Presence of Reactive Microglia and Neuroinflammatory Mediators in a Case of Frontotemporal Dementia with P301S Mutation","volume":"8","author":"Bellucci","year":"2011","journal-title":"Neurodegener. Dis."},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1038\/jcbfm.2015.164","article-title":"The neuropathology and cerebrovascular mechanisms of dementia","volume":"36","author":"Raz","year":"2016","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1212\/01.WNL.0000052685.09194.39","article-title":"Staging disease severity in pathologically confirmed cases of frontotemporal dementia","volume":"60","author":"Broe","year":"2003","journal-title":"Neurology"},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1007\/s40142-019-0160-6","article-title":"Recent Advances in the Genetics of Frontotemporal Dementia","volume":"7","author":"Sirkis","year":"2019","journal-title":"Curr. Genet. Med. Rep."},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1186\/1742-2094-4-7","article-title":"Progranulin in frontotemporal lobar degeneration and neuroinflammation","volume":"4","author":"Ahmed","year":"2007","journal-title":"J. Neuroinflamm."},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1038\/nm816","article-title":"Progranulin is a mediator of the wound response","volume":"9","author":"He","year":"2003","journal-title":"Nat. Med."},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"1034","DOI":"10.1038\/s41593-022-01124-3","article-title":"Neurovascular dysfunction in GRN-associated frontotemporal dementia identified by single-nucleus RNA sequencing of human cerebral cortex","volume":"25","author":"Gerrits","year":"2022","journal-title":"Nat. Neurosci."},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"32298","DOI":"10.1074\/jbc.R112.399170","article-title":"Progranulin: A proteolytically processed protein at the crossroads of inflammation and neurodegeneration","volume":"287","author":"Cenik","year":"2012","journal-title":"J. Biol. Chem."},{"key":"ref_146","doi-asserted-by":"crossref","unstructured":"Suh, H.-S., Choi, N., Tarassishin, L., and Lee, S.C. (2012). Regulation of Progranulin Expression in Human Microglia and Proteolysis of Progranulin by Matrix Metalloproteinase-12 (MMP-12). PLoS ONE, 7.","DOI":"10.1371\/journal.pone.0035115"},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1016\/j.jns.2017.03.031","article-title":"Role of inflammatory molecules in the Alzheimer\u2019s disease progression and diagnosis","volume":"376","author":"Bagyinszky","year":"2017","journal-title":"J. Neurol. Sci."},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1186\/s12974-020-01750-3","article-title":"A peripheral neutrophil-related inflammatory factor predicts a decline in executive function in mild Alzheimer\u2019s disease","volume":"17","author":"Bawa","year":"2020","journal-title":"J. Neuroinflamm."},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1002\/1873-3468.14549","article-title":"Senile plaques in Alzheimer\u2019s disease arise from A\u03b2-and Cathepsin D-enriched mixtures leaking out during intravascular haemolysis and microaneurysm rupture","volume":"597","author":"Fu","year":"2022","journal-title":"FEBS Lett."},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"1286","DOI":"10.1016\/j.neurobiolaging.2014.01.003","article-title":"Migration of neutrophils targeting amyloid plaques in Alzheimer\u2019s disease mouse model","volume":"35","author":"Baik","year":"2014","journal-title":"Neurobiol. Aging"},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1016\/S0197-4580(01)00346-3","article-title":"Neutrophils CD11b and fibroblasts PGE2 are elevated in Alzheimer\u2019s disease","volume":"23","author":"Scali","year":"2002","journal-title":"Neurobiol. Aging"},{"key":"ref_152","doi-asserted-by":"crossref","unstructured":"Smith, C.W., Burns, A.R., and Simon, S.I. (1999). Co-operative signaling between leukocytes and endothelium mediating firm attachment. Vasc. Adhes. Mol. Inflamm., 39\u201364.","DOI":"10.1007\/978-3-0348-8743-4_3"},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1159\/000213837","article-title":"Neuroautoimmunity: Pathogenic Implications for Alzheimer\u2019s Disease","volume":"43","author":"Singh","year":"1997","journal-title":"Gerontology"},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"796","DOI":"10.1002\/cbin.10618","article-title":"Basal neutrophil function in human aging: Implications in endothelial cell adhesion","volume":"40","author":"Cardoso","year":"2016","journal-title":"Cell Biol. Int."},{"key":"ref_155","doi-asserted-by":"crossref","first-page":"1","DOI":"10.7762\/cnr.2018.7.1.1","article-title":"Perspectives in Lipocalin-2: Emerging biomarker for medical diagnosis and prognosis for Alzheimer\u2019s disease","volume":"7","author":"Song","year":"2018","journal-title":"Clin. Nutr. Res."},{"key":"ref_156","doi-asserted-by":"crossref","first-page":"122","DOI":"10.3389\/fncel.2013.00122","article-title":"Lipocalin-2 is involved in emotional behaviors and cognitive function","volume":"7","author":"Ferreira","year":"2013","journal-title":"Front. Cell. Neurosci."},{"key":"ref_157","doi-asserted-by":"crossref","first-page":"1588","DOI":"10.1038\/cdd.2014.68","article-title":"Lipocalin 2 modulates the cellular response to amyloid beta","volume":"21","author":"Mesquita","year":"2014","journal-title":"Cell Death Differ."},{"key":"ref_158","doi-asserted-by":"crossref","unstructured":"Kang, H., Shin, H.J., An, H.S., Jin, Z., Lee, J.Y., Lee, J., Kim, K.E., Jeong, E.A., Choi, K.Y., and McLean, C. (2021). Role of Lipocalin-2 in Amyloid-Beta Oligomer-Induced Mouse Model of Alzheimer\u2019s Disease. Antioxidants, 10.","DOI":"10.3390\/antiox10111657"},{"key":"ref_159","doi-asserted-by":"crossref","first-page":"3346","DOI":"10.1002\/eji.201142351","article-title":"Lipocalin-2 ameliorates granulocyte functionality","volume":"42","author":"Schroll","year":"2012","journal-title":"Eur. J. Immunol."},{"key":"ref_160","first-page":"149","article-title":"Capillary Stalling: A Mechanism of Decreased Cerebral Blood Flow in AD\/ADRD","volume":"2","author":"Crumpler","year":"2021","journal-title":"J. Exp. Neurol."},{"key":"ref_161","doi-asserted-by":"crossref","first-page":"1347","DOI":"10.1073\/pnas.0711568105","article-title":"Nox2-derived radicals contribute to neurovascular and behavioral dysfunction in mice overexpressing the amyloid precursor protein","volume":"105","author":"Park","year":"2008","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_162","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.ibror.2019.07.1721","article-title":"The role of NOX inhibitors in neurodegenerative diseases","volume":"7","author":"Barua","year":"2019","journal-title":"IBRO Rep."},{"key":"ref_163","doi-asserted-by":"crossref","first-page":"3170","DOI":"10.1007\/s00586-016-4509-1","article-title":"Validity and reliability of photographic measures to evaluate waistline asymmetry in idiopathic scoliosis","volume":"25","author":"Matamalas","year":"2016","journal-title":"Eur. Spine J."},{"key":"ref_164","first-page":"2327","article-title":"Aged neutrophils contribute to the first line of defense in the acute inflammatory response","volume":"128","author":"Uhl","year":"2016","journal-title":"Blood J. Am. Soc. Hematol."},{"key":"ref_165","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1111\/bpa.12478","article-title":"Inflammasomes as therapeutic targets for Alzheimer\u2019s disease","volume":"27","author":"White","year":"2017","journal-title":"Brain Pathol."},{"key":"ref_166","doi-asserted-by":"crossref","first-page":"683803","DOI":"10.3389\/fimmu.2021.683803","article-title":"NLRP3 Inflammasome Assembly in Neutrophils Is Supported by PAD4 and Promotes NETosis Under Sterile Conditions","volume":"12","author":"Negro","year":"2021","journal-title":"Front. Immunol."},{"key":"ref_167","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1111\/j.1600-065X.2007.00550.x","article-title":"How human neutrophils kill and degrade microbes: An integrated view","volume":"219","author":"Nauseef","year":"2007","journal-title":"Immunol. Rev."},{"key":"ref_168","first-page":"433","article-title":"Differences in Innate Immune Response between Man and Mouse","volume":"34","author":"Zschaler","year":"2014","journal-title":"Crit. Rev. Immunol."},{"key":"ref_169","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1038\/s41590-020-00857-2","article-title":"Naturalizing mouse models for immunology","volume":"22","author":"Graham","year":"2021","journal-title":"Nat. Immunol."},{"key":"ref_170","doi-asserted-by":"crossref","first-page":"e2121077119","DOI":"10.1073\/pnas.2121077119","article-title":"Human neutrophil development and functionality are enabled in a humanized mouse model","volume":"119","author":"Zheng","year":"2022","journal-title":"Proc. Natl. Acad. Sci. USA"}],"container-title":["Biomolecules"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2218-273X\/13\/5\/743\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T19:23:18Z","timestamp":1760124198000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2218-273X\/13\/5\/743"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,4,25]]},"references-count":170,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2023,5]]}},"alternative-id":["biom13050743"],"URL":"https:\/\/doi.org\/10.3390\/biom13050743","relation":{},"ISSN":["2218-273X"],"issn-type":[{"value":"2218-273X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,4,25]]}}}