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Initially, CGRP had vasodilatory and nociceptive effects. As research progressed, evidence revealed that the peripheral nervous system is closely associated with bone metabolism, osteogenesis, and bone remodeling. Thus, CGRP is the bridge between the nervous system and the skeletal muscle system. CGRP can promote osteogenesis, inhibit bone resorption, promote vascular growth, and regulate the immune microenvironment. The G protein-coupled pathway is vital for its effects, while MAPK, Hippo, NF-\u03baB, and other pathways have signal crosstalk, affecting cell proliferation and differentiation. The current review provides a detailed description of the bone repair effects of CGRP, subjected to several therapeutic studies, such as drug injection, gene editing, and novel bone repair materials.<\/jats:p>","DOI":"10.3390\/biom13050838","type":"journal-article","created":{"date-parts":[[2023,5,15]],"date-time":"2023-05-15T02:56:57Z","timestamp":1684119417000},"page":"838","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":57,"title":["Research Progress in Calcitonin Gene-Related Peptide and Bone Repair"],"prefix":"10.3390","volume":"13","author":[{"given":"Qichang","family":"Wang","sequence":"first","affiliation":[{"name":"National & Local Joint Engineering Research Center of Orthopaedic Biomaterials, Peking University Shenzhen Hospital, Shenzhen 518036, China"},{"name":"Department of Bone & Joint Surgery, Peking University Shenzhen Hospital, Shenzhen 518036, China"},{"name":"School of Clinical Medicine, Department of Medicine, Shenzhen University, Shenzhen 518061, China"},{"name":"Shenzhen Key Laboratory of Orthopaedic Diseases and Biomaterials Research, Shenzhen 518036, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haotian","family":"Qin","sequence":"additional","affiliation":[{"name":"National & Local Joint Engineering Research Center of Orthopaedic Biomaterials, Peking University Shenzhen Hospital, Shenzhen 518036, China"},{"name":"Department of Bone & Joint Surgery, Peking University Shenzhen Hospital, Shenzhen 518036, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiapeng","family":"Deng","sequence":"additional","affiliation":[{"name":"National & Local Joint Engineering Research Center of Orthopaedic Biomaterials, Peking University Shenzhen Hospital, Shenzhen 518036, China"},{"name":"Department of Bone & Joint Surgery, Peking University Shenzhen Hospital, Shenzhen 518036, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huihui","family":"Xu","sequence":"additional","affiliation":[{"name":"National & Local Joint Engineering Research Center of Orthopaedic Biomaterials, Peking University Shenzhen Hospital, Shenzhen 518036, China"},{"name":"Department of Bone & Joint Surgery, Peking University Shenzhen Hospital, Shenzhen 518036, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Su","family":"Liu","sequence":"additional","affiliation":[{"name":"National & Local Joint Engineering Research Center of Orthopaedic Biomaterials, Peking University Shenzhen Hospital, Shenzhen 518036, China"},{"name":"Department of Bone & Joint Surgery, Peking University Shenzhen Hospital, Shenzhen 518036, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Weng","sequence":"additional","affiliation":[{"name":"National & Local Joint Engineering Research Center of Orthopaedic Biomaterials, Peking University Shenzhen Hospital, Shenzhen 518036, China"},{"name":"Department of Bone & Joint Surgery, Peking University Shenzhen Hospital, Shenzhen 518036, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Zeng","sequence":"additional","affiliation":[{"name":"National & Local Joint Engineering Research Center of Orthopaedic Biomaterials, Peking University Shenzhen Hospital, Shenzhen 518036, China"},{"name":"Department of Bone & Joint Surgery, Peking University Shenzhen Hospital, Shenzhen 518036, China"},{"name":"Shenzhen Key Laboratory of Orthopaedic Diseases and Biomaterials Research, Shenzhen 518036, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,5,15]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.1152\/physrev.00034.2013","article-title":"Calcitonin gene-related peptide: Physiology and pathophysiology","volume":"94","author":"Russell","year":"2014","journal-title":"Physiol. 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