{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T11:02:54Z","timestamp":1761562974017,"version":"build-2065373602"},"reference-count":60,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2023,5,23]],"date-time":"2023-05-23T00:00:00Z","timestamp":1684800000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"the European Structural and Investments Funds for the projects Croatian National Center of Research Excellence in Personalized Healthcare","award":["KK.01.1.1.01.0010","KK.01.2.2.03.0006","KK.01.2.1.02.0321"],"award-info":[{"award-number":["KK.01.1.1.01.0010","KK.01.2.2.03.0006","KK.01.2.1.02.0321"]}]},{"name":"Croatian National Center of Competence in Molecular Diagnostics","award":["KK.01.1.1.01.0010","KK.01.2.2.03.0006","KK.01.2.1.02.0321"],"award-info":[{"award-number":["KK.01.1.1.01.0010","KK.01.2.2.03.0006","KK.01.2.1.02.0321"]}]},{"name":"Development of personalized diagnostic tool for prevention and treatment of cardiometabolic disorders\u2014CardioMetabolic","award":["KK.01.1.1.01.0010","KK.01.2.2.03.0006","KK.01.2.1.02.0321"],"award-info":[{"award-number":["KK.01.1.1.01.0010","KK.01.2.2.03.0006","KK.01.2.1.02.0321"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biomolecules"],"abstract":"<jats:p>Obstructive sleep apnea (OSA) is a prevalent disease associated with increased risk for cardiovascular and metabolic diseases and shortened lifespan. The aim of this study was to explore the possibility of using N-glycome as a biomarker for the severe form of OSA. Seventy subjects who underwent a whole-night polysomnography\/polygraphy and had apnea\u2013hypopnea index (AHI) over 30 were compared to 23 controls (AHI under 5). Plasma samples were used to extract 39 glycan peaks using ultra-high-performance liquid chromatography (UPLC) and 27 IgG peaks using capillary gel electrophoresis (CGE). We also measured glycan age, a molecular proxy for biological aging. Three plasma and one IgG peaks were significant in a multivariate model controlling for the effects of age, sex, and body mass index. These included decreased GP24 (disialylated triantennary glycans as major structure) and GP28 (trigalactosylated, triantennary, disialylated, and trisialylated glycans), and increased GP32 (trisialylated triantennary glycan). Only one IgG glycan peak was significantly increased (P26), which contains biantennary digalactosylated glycans with core fucose. Patients with severe OSA exhibited accelerated biological aging, with a median of 6.9 years more than their chronological age (p &lt; 0.001). Plasma N-glycome can be used as a biomarker for severe OSA.<\/jats:p>","DOI":"10.3390\/biom13060880","type":"journal-article","created":{"date-parts":[[2023,5,23]],"date-time":"2023-05-23T10:51:56Z","timestamp":1684839116000},"page":"880","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Not-So-Sweet Dreams: Plasma and IgG N-Glycome in the Severe Form of the Obstructive Sleep Apnea"],"prefix":"10.3390","volume":"13","author":[{"given":"Doris","family":"Ple\u0107a\u0161","sequence":"first","affiliation":[{"name":"Mediterranean Institute for Life Sciences, 21000 Split, Croatia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nikol","family":"Mraz","sequence":"additional","affiliation":[{"name":"Genos Glycoscience Ltd., 10000 Zagreb, Croatia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne Marie","family":"Patanaude","sequence":"additional","affiliation":[{"name":"Genos Glycoscience Ltd., 10000 Zagreb, Croatia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tea","family":"Pribi\u0107","sequence":"additional","affiliation":[{"name":"Genos Glycoscience Ltd., 10000 Zagreb, Croatia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5464-9716","authenticated-orcid":false,"given":"Ivana","family":"Pavlinac Dodig","sequence":"additional","affiliation":[{"name":"Department for Neuroscience, School of Medicine, Sleep Medicine Center, University of Split, 21000 Split, Croatia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3519-2201","authenticated-orcid":false,"given":"Renata","family":"Pecoti\u0107","sequence":"additional","affiliation":[{"name":"Department for Neuroscience, School of Medicine, Sleep Medicine Center, University of Split, 21000 Split, Croatia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gordan","family":"Lauc","sequence":"additional","affiliation":[{"name":"Genos Glycoscience Ltd., 10000 Zagreb, Croatia"},{"name":"Faculty of Pharmacy and Biochemistry, University of Zagreb, 10000 Zagreb, Croatia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5765-1862","authenticated-orcid":false,"given":"Ozren","family":"Pola\u0161ek","sequence":"additional","affiliation":[{"name":"Department of Public Health, School of Medicine, University of Split, 21000 Split, Croatia"},{"name":"Department of General Courses, Algebra University, 10000 Zagreb, Croatia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zoran","family":"\u0110oga\u0161","sequence":"additional","affiliation":[{"name":"Department for Neuroscience, School of Medicine, Sleep Medicine Center, University of Split, 21000 Split, Croatia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,5,23]]},"reference":[{"key":"ref_1","unstructured":"Varki, A., Cummings, R.D., Esko, J.D., Freeze, H.H., Stanley, P., Bertozzi, C.R., Hart, G.W., and Etzler, M.E. 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