{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,3]],"date-time":"2026-03-03T20:31:24Z","timestamp":1772569884469,"version":"3.50.1"},"reference-count":88,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2023,6,10]],"date-time":"2023-06-10T00:00:00Z","timestamp":1686355200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biomolecules"],"abstract":"<jats:p>Background: Invasive dental treatment in patients exposed to antiresorptive and antiangiogenic drugs can cause medication-related osteonecrosis of the jaw (MRONJ). Currently, the exact pathogenesis of this disease is unclear. Methods: In March 2022, Medline (Ovid), Embase (Ovid), Scopus, and Web of Science were screened to identify eligible in vitro studies investigating the effects of antiresorptive and antiangiogenic compounds on orally derived cells. Results: Fifty-nine articles met the inclusion criteria. Bisphosphonates were used in 57 studies, denosumab in two, and sunitinib and bevacizumab in one. Zoledronate was the most commonly used nitrogen-containing bisphosphonate. The only non-nitrogen-containing bisphosphonate studied was clodronate. The most frequently tested tissues were gingival fibroblasts, oral keratinocytes, and alveolar osteoblasts. These drugs caused a decrease in cell proliferation, viability, and migration. Conclusions: Antiresorptive and antiangiogenic drugs displayed cytotoxic effects in a dose and time-dependent manner. Additional research is required to further elucidate the pathways of MRONJ.<\/jats:p>","DOI":"10.3390\/biom13060973","type":"journal-article","created":{"date-parts":[[2023,6,12]],"date-time":"2023-06-12T03:02:27Z","timestamp":1686538947000},"page":"973","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["In Vitro Cytotoxicity of Antiresorptive and Antiangiogenic Compounds on Oral Tissues Contributing to MRONJ: Systematic Review"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7939-5495","authenticated-orcid":false,"given":"Robert H.","family":"Guirguis","sequence":"first","affiliation":[{"name":"Melbourne Dental School, The University of Melbourne, 720 Swanston Street, Carlton, VIC 3053, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8570-7950","authenticated-orcid":false,"given":"Leonard P.","family":"Tan","sequence":"additional","affiliation":[{"name":"Melbourne Dental School, The University of Melbourne, 720 Swanston Street, Carlton, VIC 3053, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rebecca M.","family":"Hicks","sequence":"additional","affiliation":[{"name":"Melbourne Dental School, The University of Melbourne, 720 Swanston Street, Carlton, VIC 3053, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aniqa","family":"Hasan","sequence":"additional","affiliation":[{"name":"Melbourne Dental School, The University of Melbourne, 720 Swanston Street, Carlton, VIC 3053, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tina D.","family":"Duong","sequence":"additional","affiliation":[{"name":"Melbourne Dental School, The University of Melbourne, 720 Swanston Street, Carlton, VIC 3053, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3274-0949","authenticated-orcid":false,"given":"Xia","family":"Hu","sequence":"additional","affiliation":[{"name":"Melbourne Dental School, The University of Melbourne, 720 Swanston Street, Carlton, VIC 3053, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jordan Y. S.","family":"Hng","sequence":"additional","affiliation":[{"name":"Melbourne Dental School, The University of Melbourne, 720 Swanston Street, Carlton, VIC 3053, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammad H.","family":"Hadi","sequence":"additional","affiliation":[{"name":"Melbourne Dental School, The University of Melbourne, 720 Swanston Street, Carlton, VIC 3053, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Henry C.","family":"Owuama","sequence":"additional","affiliation":[{"name":"Melbourne Dental School, The University of Melbourne, 720 Swanston Street, Carlton, VIC 3053, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tamara","family":"Matthyssen","sequence":"additional","affiliation":[{"name":"Melbourne Dental School, The University of Melbourne, 720 Swanston Street, Carlton, VIC 3053, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7829-4684","authenticated-orcid":false,"given":"Michael","family":"McCullough","sequence":"additional","affiliation":[{"name":"Melbourne Dental School, The University of Melbourne, 720 Swanston Street, Carlton, VIC 3053, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4610-6690","authenticated-orcid":false,"given":"Federica","family":"Canfora","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, Reproductive Sciences and Dentistry, University of Naples Federico II, 80131 Naples, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2170-4723","authenticated-orcid":false,"given":"Rita","family":"Paolini","sequence":"additional","affiliation":[{"name":"Melbourne Dental School, The University of Melbourne, 720 Swanston Street, Carlton, VIC 3053, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4293-2511","authenticated-orcid":false,"given":"Antonio","family":"Celentano","sequence":"additional","affiliation":[{"name":"Melbourne Dental School, The University of Melbourne, 720 Swanston Street, Carlton, VIC 3053, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,6,10]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"97","DOI":"10.4103\/2231-0762.178742","article-title":"Medication-related osteonecrosis of the jaw: Clinical and practical guidelines","volume":"6","author":"Rosella","year":"2016","journal-title":"J. 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