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Lanzhou University Second Hospital","award":["2020QN-02"],"award-info":[{"award-number":["2020QN-02"]}]},{"name":"Cuiying Student Research and Cultivation Project of Lanzhou University Second Hospital","award":["CYXZ2021-20"],"award-info":[{"award-number":["CYXZ2021-20"]}]},{"name":"Cuiying Student Research and Cultivation Project of Lanzhou University Second Hospital","award":["CYXZ2021-21"],"award-info":[{"award-number":["CYXZ2021-21"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biomolecules"],"abstract":"<jats:p>S100A6, also known as calcyclin, is a low-molecular-weight Ca2+-binding protein from the S100 family that contains two EF-hands. S100A6 is expressed in a variety of mammalian cells and tissues. It is also expressed in lung, colorectal, pancreatic, and liver cancers, as well as other cancers such as melanoma. S100A6 has many molecular functions related to cell proliferation, the cell cycle, cell differentiation, and the cytoskeleton. It is not only involved in tumor invasion, proliferation, and migration, but also the pathogenesis of other non-neoplastic diseases. In this review, we focus on the molecular mechanisms and potential therapeutic targets of S100A6 in tumors, nervous system diseases, leukemia, endometriosis, cardiovascular disease, osteoarthritis, and other related diseases.<\/jats:p>","DOI":"10.3390\/biom13071139","type":"journal-article","created":{"date-parts":[[2023,7,18]],"date-time":"2023-07-18T01:31:32Z","timestamp":1689643892000},"page":"1139","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["The Role of S100A6 in Human Diseases: Molecular Mechanisms and Therapeutic Potential"],"prefix":"10.3390","volume":"13","author":[{"given":"Fengguang","family":"Yang","sequence":"first","affiliation":[{"name":"Department of Orthopedics, Lanzhou University Second Hospital, Lanzhou 730030, China"},{"name":"The Second Clinical Medical College, Lanzhou University, Lanzhou 730030, China"},{"name":"Orthopaedics Key Laboratory of Gansu Province, Lanzhou University Second Hospital, Lanzhou 730030, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinglin","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, Lanzhou University Second Hospital, Lanzhou 730030, China"},{"name":"The Second Clinical Medical College, Lanzhou University, Lanzhou 730030, China"},{"name":"Orthopaedics Key Laboratory of Gansu Province, Lanzhou University Second Hospital, Lanzhou 730030, China"},{"name":"School of Petrochemical Engineering, Lanzhou University of Technology, Lanzhou 730050, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daxue","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, Lanzhou University Second Hospital, Lanzhou 730030, China"},{"name":"The Second Clinical Medical College, Lanzhou University, Lanzhou 730030, China"},{"name":"Orthopaedics Key Laboratory of Gansu Province, Lanzhou University Second Hospital, Lanzhou 730030, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhaoheng","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, Lanzhou University Second Hospital, Lanzhou 730030, China"},{"name":"The Second Clinical Medical College, Lanzhou University, Lanzhou 730030, China"},{"name":"Orthopaedics Key Laboratory of Gansu Province, Lanzhou University Second Hospital, Lanzhou 730030, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanhu","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, Lanzhou University Second Hospital, Lanzhou 730030, China"},{"name":"The Second Clinical Medical College, Lanzhou University, Lanzhou 730030, China"},{"name":"Orthopaedics Key Laboratory of Gansu Province, Lanzhou University Second Hospital, Lanzhou 730030, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuegang","family":"He","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, Lanzhou University Second Hospital, Lanzhou 730030, China"},{"name":"The Second Clinical Medical College, Lanzhou University, Lanzhou 730030, China"},{"name":"Orthopaedics Key Laboratory of Gansu Province, Lanzhou University Second Hospital, Lanzhou 730030, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3193-0297","authenticated-orcid":false,"given":"Guangzhi","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, Lanzhou University Second Hospital, Lanzhou 730030, China"},{"name":"The Second Clinical Medical College, Lanzhou University, Lanzhou 730030, China"},{"name":"Orthopaedics Key Laboratory of Gansu Province, Lanzhou University Second Hospital, Lanzhou 730030, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuewen","family":"Kang","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, Lanzhou University Second Hospital, Lanzhou 730030, China"},{"name":"The Second Clinical Medical College, Lanzhou University, Lanzhou 730030, China"},{"name":"Orthopaedics Key Laboratory of Gansu Province, Lanzhou University Second Hospital, Lanzhou 730030, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,7,17]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1016\/j.bbrc.2004.07.096","article-title":"S100 proteins in mouse and man: From evolution to function and pathology (including an update of the nomenclature)","volume":"322","author":"Marenholz","year":"2004","journal-title":"Biochem. 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