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Technology of Zunyi","award":["ZKH-HZ-2021-193"],"award-info":[{"award-number":["ZKH-HZ-2021-193"]}]},{"name":"Project of the Department of Science and Technology of Zunyi","award":["ZYSKRPT-2020-6"],"award-info":[{"award-number":["ZYSKRPT-2020-6"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biomolecules"],"abstract":"<jats:p>MicroRNAs (miRNAs) are a class of small noncoding RNA that can regulate physiological and pathological processes through post-transcriptional regulatory gene expression. As an important member of the miRNAs family, microRNA-7 (miR-7) was first discovered in 2001 to play an important regulatory role in tissue and organ development. Studies have shown that miR-7 participates in various tissue and organ development processes, tumorigenesis, aging, and other processes by regulating different target molecules. Notably, a series of recent studies have determined that miR-7 plays a key regulatory role in the occurrence of inflammation and related diseases. In particular, miR-7 can affect the immune response of the body by influencing T cell activation, macrophage function, dendritic cell (DC) maturation, inflammatory body activation, and other mechanisms, which has important potential application value in the intervention of related diseases. This article reviews the current regulatory role of miR-7 in inflammation and related diseases, including viral infection, autoimmune hepatitis, inflammatory bowel disease, and encephalitis. It expounds on the molecular mechanism by which miR-7 regulates the occurrence of inflammatory diseases. Finally, the existing problems and future development directions of miR-7-based intervention on inflammation and related diseases are discussed to provide new references and help strengthen the understanding of the pathogenesis of inflammation and related diseases, as well as the development of new strategies for clinical intervention.<\/jats:p>","DOI":"10.3390\/biom13081185","type":"journal-article","created":{"date-parts":[[2023,7,31]],"date-time":"2023-07-31T01:26:40Z","timestamp":1690766800000},"page":"1185","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["MicroRNA-7: A New Intervention Target for Inflammation and Related Diseases"],"prefix":"10.3390","volume":"13","author":[{"given":"Chao","family":"Chen","sequence":"first","affiliation":[{"name":"School of Medicine, Guizhou University, Guiyang 550025, China"},{"name":"Department of Immunology, Zunyi Medical University, Zunyi 563000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengmeng","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Immunology, Zunyi Medical University, Zunyi 563000, China"},{"name":"Specifc Key Laboratory of Gene Detection and Treatment of Guizhou Province, Zunyi 563000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xu","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Immunology, Zunyi Medical University, Zunyi 563000, China"},{"name":"Specifc Key Laboratory of Gene Detection and Treatment of Guizhou Province, Zunyi 563000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juanjuan","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Immunology, Zunyi Medical University, Zunyi 563000, China"},{"name":"Specifc Key Laboratory of Gene Detection and Treatment of Guizhou Province, Zunyi 563000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Longqing","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Immunology, Zunyi Medical University, Zunyi 563000, China"},{"name":"Specifc Key Laboratory of Gene Detection and Treatment of Guizhou Province, Zunyi 563000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhixu","family":"He","sequence":"additional","affiliation":[{"name":"Collaborative Innovation Center of Tissue Damage Repair and Regeneration Medicine of Zunyi Medical University, Zunyi 563000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6889-0279","authenticated-orcid":false,"given":"Lin","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Immunology, Zunyi Medical University, Zunyi 563000, China"},{"name":"Specifc Key Laboratory of Gene Detection and Treatment of Guizhou Province, Zunyi 563000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8713-1665","authenticated-orcid":false,"given":"Yan","family":"Zha","sequence":"additional","affiliation":[{"name":"School of Medicine, Guizhou University, Guiyang 550025, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,7,28]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1038\/nrrheum.2017.37","article-title":"Metabolic regulation of inflammation","volume":"13","author":"Gaber","year":"2017","journal-title":"Nat. Rev. Rheumatol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1016\/j.immuni.2021.01.018","article-title":"Autophagy in inflammation, infection, and immunometabolism","volume":"54","author":"Deretic","year":"2021","journal-title":"Immunity"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.cell.2007.12.024","article-title":"Getting to the root of miRNA-mediated gene silencing","volume":"132","author":"Eulalio","year":"2008","journal-title":"Cell"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1016\/j.cell.2013.04.003","article-title":"The long and short of microRNA","volume":"153","author":"Yates","year":"2013","journal-title":"Cell"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1038\/s41579-018-0064-6","article-title":"Molecular mechanisms of viral oncogenesis in humans","volume":"16","author":"Krump","year":"2018","journal-title":"Nat. Rev. Microbiol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1038\/s41467-017-00972-z","article-title":"An NF-\u03baB-microRNA regulatory network tunes macrophage inflammatory responses","volume":"8","author":"Mann","year":"2017","journal-title":"Nat. Commun."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"630","DOI":"10.2174\/1566524022666220525150259","article-title":"MicroRNAs and their Implications in CD4+ T-cells, Oligodendrocytes and Dendritic Cells in Multiple Sclerosis Pathogenesis","volume":"23","author":"Safari","year":"2023","journal-title":"Curr. Mol. Med."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1126\/science.1064921","article-title":"Identification of novel genes coding for small expressed RNAs","volume":"294","author":"Rauhut","year":"2001","journal-title":"Science"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1186\/s12935-015-0259-0","article-title":"MicroRNA-7: A promising new target in cancer therapy","volume":"15","author":"Zhao","year":"2015","journal-title":"Cancer Cell Int."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.biocel.2015.11.001","article-title":"MicroRNA-7: A miRNA with expanding roles in development and disease","volume":"69","author":"Horsham","year":"2015","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Morales-Mart\u00ednez, M., and Vega, M.I. (2022). Role of MicroRNA-7 (MiR-7) in Cancer Physiopathology. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23169091"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.omtn.2018.08.012","article-title":"miR-7 Suppresses Tumor Progression by Directly Targeting MAP3K9 in Pancreatic Cancer","volume":"13","author":"Xia","year":"2018","journal-title":"Mol. Ther. Nucleic Acids"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1007\/s12253-009-9162-0","article-title":"TLR9 signaling promotes tumor progression of human lung cancer cell in vivo","volume":"15","author":"Ren","year":"2009","journal-title":"Pathol. Oncol. Res. POR"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1091\/mbc.e12-07-0519","article-title":"MicroRNA-7-regulated TLR9 signaling-enhanced growth and metastatic potential of human lung cancer cells by altering the phosphoinositide-3-kinase, regulatory subunit 3\/Akt pathway","volume":"24","author":"Xu","year":"2013","journal-title":"Mol. Biol. Cell"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1186\/1475-2867-13-90","article-title":"TLR9 signaling repressed tumor suppressor miR-7 expression through up-regulation of HuR in human lung cancer cells","volume":"13","author":"Li","year":"2013","journal-title":"Cancer Cell Int."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.omtn.2016.12.005","article-title":"Targeted Expression of miR-7 Operated by TTF-1 Promoter Inhibited the Growth of Human Lung Cancer through the NDUFA4 Pathway","volume":"6","author":"Lei","year":"2017","journal-title":"Mol. Ther. Nucleic Acids"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1038\/nchembio.2569","article-title":"Structural and evolutionary insights into ribosomal RNA methylation","volume":"14","author":"Sergiev","year":"2018","journal-title":"Nat. Chem. Biol."},{"key":"ref_18","first-page":"506","article-title":"Hypermethylation of Anti-oncogenic MicroRNA 7 is Increased in Emphysema Patients","volume":"56","author":"Galera","year":"2020","journal-title":"Arch. Bronconeumol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"5609","DOI":"10.1158\/0008-5472.CAN-13-1568","article-title":"Circular RNA and miR-7 in cancer","volume":"73","author":"Hansen","year":"2013","journal-title":"Cancer Res."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"2669","DOI":"10.3892\/or.2015.3904","article-title":"The emerging landscape of circular RNA ciRS-7 in cancer","volume":"33","author":"Peng","year":"2015","journal-title":"Oncol. Rep."},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"Zhao, Y., Alexandrov, P.N., Jaber, V., and Lukiw, W.J. (2016). Deficiency in the Ubiquitin Conjugating Enzyme UBE2A in Alzheimer\u2019s Disease (AD) is Linked to Deficits in a Natural Circular miRNA-7 Sponge (circRNA; ciRS-7). Genes, 7.","DOI":"10.3390\/genes7120116"},{"key":"ref_22","first-page":"3173","article-title":"Long non-coding RNA ANRIL down-regulates microRNA-7 to protect human trabecular meshwork cells in an experimental model for glaucoma","volume":"23","author":"Zhao","year":"2019","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"key":"ref_23","first-page":"9004738","article-title":"lncRNA ZFAS1 Positively Facilitates Endothelial Ferroptosis via miR-7-5p\/ACSL4 Axis in Diabetic Retinopathy","volume":"2022","author":"Liu","year":"2022","journal-title":"Oxid. Med. Cell. Longev."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1007\/s13258-021-01084-1","article-title":"LINC00943 knockdown exerts neuroprotective effects in Parkinson\u2019s disease through regulates CXCL12 expression by sponging miR-7-5p","volume":"43","author":"Lian","year":"2021","journal-title":"Genes Genom."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/j.neuroscience.2018.07.019","article-title":"Long Noncoding RNA SNHG1 Promotes Neuroinflammation in Parkinson\u2019s Disease via Regulating miR-7\/NLRP3 Pathway","volume":"388","author":"Cao","year":"2018","journal-title":"Neuroscience"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1111\/acel.12462","article-title":"17\u03b2-estradiol ameliorates age-associated loss of fibroblast function by attenuating IFN-\u03b3\/STAT1-dependent miR-7 upregulation","volume":"15","author":"Midgley","year":"2016","journal-title":"Aging Cell"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1002\/hep.31607","article-title":"C\/EBP\u03b1\/miR-7 Controls CD4+ T-Cell Activation and Function and Orchestrates Experimental Autoimmune Hepatitis in Mice","volume":"74","author":"Zhao","year":"2021","journal-title":"Hepatology"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1016\/j.cell.2018.05.022","article-title":"A Network of Noncoding Regulatory RNAs Acts in the Mammalian Brain","volume":"174","author":"Kleaveland","year":"2018","journal-title":"Cell"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"eabc9359","DOI":"10.1126\/science.abc9359","article-title":"The ZSWIM8 ubiquitin ligase mediates target-directed microRNA degradation","volume":"370","author":"Shi","year":"2020","journal-title":"Science"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"eabc9546","DOI":"10.1126\/science.abc9546","article-title":"A ubiquitin ligase mediates target-directed microRNA decay independently of tailing and trimming","volume":"370","author":"Han","year":"2020","journal-title":"Science"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"8195","DOI":"10.1158\/0008-5472.CAN-08-2103","article-title":"MicroRNA-7, a homeobox D10 target, inhibits p21-activated kinase 1 and regulates its functions","volume":"68","author":"Reddy","year":"2008","journal-title":"Cancer Res."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"5733","DOI":"10.1038\/s41467-022-33367-w","article-title":"MicroRNA-7 regulates melanocortin circuits involved in mammalian energy homeostasis","volume":"13","author":"LaPierre","year":"2022","journal-title":"Nat. Commun."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1101\/gad.199190.112","article-title":"Tissue-specific control of brain-enriched miR-7 biogenesis","volume":"27","author":"Choudhury","year":"2013","journal-title":"Genes Dev."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"9722","DOI":"10.1038\/srep09722","article-title":"Host-virus interaction: The antiviral defense function of small interfering RNAs can be enhanced by host microRNA-7 in vitro","volume":"5","author":"Zhang","year":"2015","journal-title":"Sci. Rep."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1038\/s41598-017-18529-x","article-title":"MicroRNA-7 mediates cross-talk between metabolic signaling pathways in the liver","volume":"8","author":"Singaravelu","year":"2018","journal-title":"Sci. Rep."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1111\/acel.12167","article-title":"MicroRNA-7 inhibition rescues age-associated loss of epidermal growth factor receptor and hyaluronan-dependent differentiation in fibroblasts","volume":"13","author":"Midgley","year":"2014","journal-title":"Aging Cell"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1186\/s12951-021-01137-3","article-title":"Hepatic small extracellular vesicles promote microvascular endothelial hyperpermeability during NAFLD via novel-miRNA-7","volume":"19","author":"Zuo","year":"2021","journal-title":"J. Nanobiotechnol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1016\/j.bbalip.2018.04.009","article-title":"Liver-directed microRNA-7a depletion induces nonalcoholic fatty liver disease by stabilizing YY1-mediated lipogenic pathways in zebrafish","volume":"1863","author":"Lai","year":"2018","journal-title":"Biochim. Biophys. Acta. Mol. Cell Biol. Lipids"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1186\/s13024-016-0094-3","article-title":"MicroRNA-7 targets Nod-like receptor protein 3 inflammasome to modulate neuroinflammation in the pathogenesis of Parkinson\u2019s disease","volume":"11","author":"Zhou","year":"2016","journal-title":"Mol. Neurodegener."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"7057","DOI":"10.1007\/s12035-015-9620-5","article-title":"MicroRNA-7 Enhances Subventricular Zone Neurogenesis by Inhibiting NLRP3\/Caspase-1 Axis in Adult Neural Stem Cells","volume":"53","author":"Fan","year":"2016","journal-title":"Mol. Neurobiol."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"12725","DOI":"10.1523\/JNEUROSCI.0985-14.2014","article-title":"MicroRNA-7 protects against 1-methyl-4-phenylpyridinium-induced cell death by targeting RelA","volume":"34","author":"Choi","year":"2014","journal-title":"J. Neurosci."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"12425","DOI":"10.1074\/jbc.M114.625962","article-title":"MicroRNA-7 Promotes Glycolysis to Protect against 1-Methyl-4-phenylpyridinium-induced Cell Death","volume":"290","author":"Chaudhuri","year":"2015","journal-title":"J. Biol. Chem."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1089\/dna.2015.3097","article-title":"microRNA-7 Protects Against 1-Methyl-4-Phenylpyridinium Iodide-Induced Cell Apoptosis in SH-SY5Y Cells by Directly Targeting Kr\u00fcpple-Like Factor 4","volume":"35","author":"Kong","year":"2016","journal-title":"DNA Cell Biol."},{"key":"ref_44","first-page":"993","article-title":"MicroRNA-7 inhibits neuronal apoptosis in a cellular Parkinson\u2019s disease model by targeting Bax and Sirt2","volume":"8","author":"Li","year":"2016","journal-title":"Am. J. Transl. Res."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"107900","DOI":"10.1016\/j.neuropharm.2019.107900","article-title":"Neuroprotective effect of crocin against rotenone-induced Parkinson\u2019s disease in rats: Interplay between PI3K\/Akt\/mTOR signaling pathway and enhanced expression of miRNA-7 and miRNA-221","volume":"164","author":"Salama","year":"2020","journal-title":"Neuropharmacology"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"13052","DOI":"10.1073\/pnas.0906277106","article-title":"Repression of alpha-synuclein expression and toxicity by microRNA-7","volume":"106","author":"Junn","year":"2009","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1016\/j.chemosphere.2019.05.064","article-title":"Identification of miRNA-7 as a regulator of brain-derived neurotrophic factor\/\u03b1-synuclein axis in atrazine-induced Parkinson\u2019s disease by peripheral blood and brain microRNA profiling","volume":"233","author":"Li","year":"2019","journal-title":"Chemosphere"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"2404","DOI":"10.1016\/j.ymthe.2017.08.017","article-title":"Loss of MicroRNA-7 Regulation Leads to \u03b1-Synuclein Accumulation and Dopaminergic Neuronal Loss In Vivo","volume":"25","author":"McMillan","year":"2017","journal-title":"Mol. Ther. J. Am. Soc. Gene Ther."},{"key":"ref_49","first-page":"5597","article-title":"MiR-7 alleviates secondary inflammatory response of microglia caused by cerebral hemorrhage through inhibiting TLR4 expression","volume":"22","author":"Zhang","year":"2018","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1186\/s12974-016-0527-5","article-title":"Potential role of microRNA-7 in the anti-neuroinflammation effects of nicorandil in astrocytes induced by oxygen-glucose deprivation","volume":"13","author":"Dong","year":"2016","journal-title":"J. Neuroinflammation"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1186\/s12974-020-1710-2","article-title":"MicroRNA-7, synergizes with ROR\u03b1, negatively controls the pathology of brain tissue inflammation","volume":"17","author":"Yue","year":"2020","journal-title":"J. Neuroinflammation"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"1479","DOI":"10.1074\/jbc.M109.057141","article-title":"MicroRNA-7 modulates CD98 expression during intestinal epithelial cell differentiation","volume":"285","author":"Nguyen","year":"2010","journal-title":"J. Biol. Chem."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1093\/ecco-jcc\/jjw023","article-title":"E3 Ubiquitin ligase RNF183 Is a Novel Regulator in Inflammatory Bowel Disease","volume":"10","author":"Yu","year":"2016","journal-title":"J. Crohn\u2019s Colitis"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"1200","DOI":"10.3892\/mmr.2017.6730","article-title":"MicroRNA-7-5p regulates the expression of TFF3 in inflammatory bowel disease","volume":"16","author":"Guo","year":"2017","journal-title":"Mol. Med. Rep."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"1435","DOI":"10.3892\/ijmm.2017.3120","article-title":"MicroRNA-7-5p regulates the proliferation and migration of intestinal epithelial cells by targeting trefoil factor 3 via inhibiting the phosphoinositide 3-kinase\/Akt signalling pathway","volume":"40","author":"Guo","year":"2017","journal-title":"Int. J. Mol. Med."},{"key":"ref_56","doi-asserted-by":"crossref","unstructured":"Zhao, J., Guo, M., Yan, Y., Wang, Y., Zhao, X., Yang, J., Chen, J., Chen, C., Tang, L., and Zeng, W. (2023). The miR-7\/EGFR axis controls the epithelial cell immunomodulation and regeneration and orchestrates the pathology in inflammatory bowel disease. J. Adv. Res.","DOI":"10.1016\/j.jare.2023.04.011"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"958","DOI":"10.1016\/j.bbrc.2019.04.051","article-title":"Exosomes derived from plasma of septic patients inhibit apoptosis of T lymphocytes by down-regulating bad via hsa-miR-7-5p","volume":"513","author":"Deng","year":"2019","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1080\/08916934.2021.2012764","article-title":"CircVMA21 ameliorates lipopolysaccharide (LPS)-induced HK-2 cell injury depending on the regulation of miR-7-5p\/PPARA","volume":"55","author":"Wang","year":"2022","journal-title":"Autoimmunity"},{"key":"ref_59","first-page":"246ra99","article-title":"Defective PTEN regulation contributes to B cell hyperresponsiveness in systemic lupus erythematosus","volume":"6","author":"Wu","year":"2014","journal-title":"Sci. Transl. Transl. Med."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"102440","DOI":"10.1016\/j.jaut.2020.102440","article-title":"Antagonizing miR-7 suppresses B cell hyperresponsiveness and inhibits lupus development","volume":"109","author":"Wang","year":"2020","journal-title":"J. Autoimmun."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/j.intimp.2019.03.037","article-title":"Role of the ciRS-7\/miR-7 axis in the regulation of proliferation, apoptosis and inflammation of chondrocytes induced by IL-1\u03b2","volume":"71","author":"Zhou","year":"2019","journal-title":"Int. Immunopharmacol."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"20163","DOI":"10.18632\/aging.103731","article-title":"Down-regulated ciRS-7\/up-regulated miR-7 axis aggravated cartilage degradation and autophagy defection by PI3K\/AKT\/mTOR activation mediated by IL-17A in osteoarthritis","volume":"12","author":"Zhou","year":"2020","journal-title":"Aging"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"8622","DOI":"10.1080\/21655979.2021.1988362","article-title":"miR-7\/EGFR\/MEGF9 axis regulates cartilage degradation in osteoarthritis via PI3K\/AKT\/mTOR signaling pathway","volume":"12","author":"Jiang","year":"2021","journal-title":"Bioengineered"},{"key":"ref_64","first-page":"e923868","article-title":"Long Non-Coding RNA (lncRNA) Small Nucleolar RNA Host Gene 15 (SNHG15) Alleviates Osteoarthritis Progression by Regulation of Extracellular Matrix Homeostasis","volume":"26","author":"Chen","year":"2020","journal-title":"Med. Sci. Monit. Int. Med. J. Exp. Clin. Res."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"9674221","DOI":"10.1155\/2022\/9674221","article-title":"SEMA6D, Negatively Regulated by miR-7, Contributes to C28\/I2 chondrocyte\u2019s Catabolic and Anabolic Activities via p38 Signaling Pathway","volume":"2022","author":"Yang","year":"2022","journal-title":"Oxid. Med. Cell. Longev."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"3949","DOI":"10.1038\/onc.2011.558","article-title":"Inflammation-induced repression of tumor suppressor miR-7 in gastric tumor cells","volume":"31","author":"Kong","year":"2012","journal-title":"Oncogene"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"56309","DOI":"10.18632\/oncotarget.10462","article-title":"Nuclear IKK\u03b1 mediates microRNA-7\/-103\/107\/21 inductions to downregulate maspin expression in response to HBx overexpression","volume":"7","author":"Chen","year":"2016","journal-title":"Oncotarget"},{"key":"ref_68","first-page":"682380","article-title":"Hepatitis B Virus-Encoded X Protein Downregulates EGFR Expression via Inducing MicroRNA-7 in Hepatocellular Carcinoma Cells","volume":"2013","author":"Chen","year":"2013","journal-title":"Evid. Based Complement. Altern. Med. Ecam"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"389","DOI":"10.3389\/fimmu.2016.00389","article-title":"MicroRNA-7 Deficiency Ameliorates the Pathologies of Acute Lung Injury through Elevating KLF4","volume":"7","author":"Zhao","year":"2016","journal-title":"Front. Immunol."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"57","DOI":"10.2174\/2211536611666220413100636","article-title":"MicroRNA-7 Regulates Insulin Signaling Pathway by Targeting IRS1, IRS2, and RAF1 Genes in Gestational Diabetes Mellitus","volume":"11","author":"Bhushan","year":"2022","journal-title":"MicroRNA"},{"key":"ref_71","doi-asserted-by":"crossref","unstructured":"Zhou, Y., Chen, L., Du, J., Hu, X., Xie, Y., Wu, J., Lin, X., Yin, N., Sun, M., and Li, H. (2020). MicroRNA-7 Inhibits Rotavirus Replication by Targeting Viral NSP5 In Vivo and In Vitro. Viruses, 12.","DOI":"10.3390\/v12020209"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"1741","DOI":"10.4251\/wjgo.v13.i11.1741","article-title":"Preventive and inhibitive effects of Yiwei Xiaoyu granules on the development and progression of spasmolytic polypeptide-expressing metaplasia lesions","volume":"13","author":"Chen","year":"2021","journal-title":"World J. Gastrointest. Oncol."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"e104","DOI":"10.1097\/QAI.0000000000001191","article-title":"MicroRNA-210, MicroRNA-331, and MicroRNA-7 Are Differentially Regulated in Treated HIV-1-Infected Individuals and Are Associated With Markers of Systemic Inflammation","volume":"74","author":"Ballegaard","year":"2017","journal-title":"J. Acquir. Immune Defic. Syndr."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1111\/imm.13252","article-title":"MicroRNA-7 negatively regulates Toll-like receptor 4 signaling pathway through FAM177A","volume":"162","author":"Chen","year":"2021","journal-title":"Immunology"},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"1379","DOI":"10.1016\/j.jhep.2020.05.053","article-title":"Integrative molecular profiling of autoreactive CD4 T cells in autoimmune hepatitis","volume":"73","author":"Renand","year":"2020","journal-title":"J. Hepatol."},{"key":"ref_76","doi-asserted-by":"crossref","unstructured":"Hern\u00e1ndez, A., Arab, J.P., Reyes, D., Lapitz, A., Moshage, H., Ba\u00f1ales, J.M., and Arrese, M. (2020). Extracellular Vesicles in NAFLD\/ALD: From Pathobiology to Therapy. Cells, 9.","DOI":"10.3390\/cells9040817"},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"143","DOI":"10.2174\/1566523218666180430121323","article-title":"miR-7 Replacement Therapy in Parkinson\u2019s Disease","volume":"18","year":"2018","journal-title":"Curr. Gene Ther."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/j.neulet.2018.05.009","article-title":"MicroRNA-7 facilitates the degradation of alpha-synuclein and its aggregates by promoting autophagy","volume":"678","author":"Choi","year":"2018","journal-title":"Neurosci. Lett."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"2529","DOI":"10.1007\/s13311-021-01130-6","article-title":"MicroRNA-7 Protects Against Neurodegeneration Induced by \u03b1-Synuclein Preformed Fibrils in the Mouse Brain","volume":"18","author":"Zhang","year":"2021","journal-title":"Neurotherapeutics"},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1016\/j.cyto.2009.02.001","article-title":"TNF-alpha gene expression in colorectal mucosa as a predictor of remission after induction therapy with infliximab in ulcerative colitis","volume":"46","author":"Olsen","year":"2009","journal-title":"Cytokine"},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"745647","DOI":"10.1155\/2015\/745647","article-title":"Genetic Factors in Systemic Lupus Erythematosus: Contribution to Disease Phenotype","volume":"2015","author":"Ceccarelli","year":"2015","journal-title":"J. Immunol. Res."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.immuni.2019.06.025","article-title":"Inflammation and Cancer: Triggers, Mechanisms, and Consequences","volume":"51","author":"Greten","year":"2019","journal-title":"Immunity"},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1038\/nri.2017.142","article-title":"NF-\u03baB, inflammation, immunity and cancer: Coming of age","volume":"18","author":"Taniguchi","year":"2018","journal-title":"Nat. Rev. Immunol."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"1329","DOI":"10.3892\/mco.2015.648","article-title":"Promoter mutation of tumor suppressor microRNA-7 is associated with poor prognosis of lung cancer","volume":"3","author":"Zhao","year":"2015","journal-title":"Mol. Clin. Oncol."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1111\/imm.12227","article-title":"Role of miR-155 in the regulation of lymphocyte immune function and disease","volume":"142","author":"Seddiki","year":"2014","journal-title":"Immunology"},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"6542","DOI":"10.4049\/jimmunol.1202496","article-title":"MicroRNA let-7c regulates macrophage polarization","volume":"190","author":"Banerjee","year":"2013","journal-title":"J. Immunol."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1007\/s00018-017-2656-0","article-title":"Evaluation and control of miRNA-like off-target repression for RNA interference","volume":"75","author":"Seok","year":"2018","journal-title":"Cell. Mol. Life Sci. CMLS"},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1002\/ijc.31064","article-title":"CRHR2\/Ucn2 signaling is a novel regulator of miR-7\/YY1\/Fas circuitry contributing to reversal of colorectal cancer cell resistance to Fas-mediated apoptosis","volume":"142","author":"Pothoulakis","year":"2018","journal-title":"Int. J. Cancer"},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1016\/j.omtn.2018.04.003","article-title":"Promoter-Operating Targeted Expression of Gene Therapy in Cancer: Current Stage and Prospect","volume":"11","author":"Chen","year":"2018","journal-title":"Mol. Ther. Nucleic Acids"},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"6687","DOI":"10.18632\/oncotarget.2235","article-title":"Systemic miRNA-7 delivery inhibits tumor angiogenesis and growth in murine xenograft glioblastoma","volume":"5","author":"Babae","year":"2014","journal-title":"Oncotarget"}],"container-title":["Biomolecules"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2218-273X\/13\/8\/1185\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T20:21:58Z","timestamp":1760127718000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2218-273X\/13\/8\/1185"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,7,28]]},"references-count":90,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2023,8]]}},"alternative-id":["biom13081185"],"URL":"https:\/\/doi.org\/10.3390\/biom13081185","relation":{},"ISSN":["2218-273X"],"issn-type":[{"value":"2218-273X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,7,28]]}}}