{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T16:41:16Z","timestamp":1793032876320,"version":"4.5.0"},"reference-count":81,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2023,8,28]],"date-time":"2023-08-28T00:00:00Z","timestamp":1693180800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003977","name":"Israel Science Foundation","doi-asserted-by":"publisher","award":["2054\/19"],"award-info":[{"award-number":["2054\/19"]}],"id":[{"id":"10.13039\/501100003977","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003977","name":"Israel Science Foundation","doi-asserted-by":"publisher","award":["RA2000000457"],"award-info":[{"award-number":["RA2000000457"]}],"id":[{"id":"10.13039\/501100003977","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013043","name":"Ariel University Research &amp; Development Department","doi-asserted-by":"publisher","award":["2054\/19"],"award-info":[{"award-number":["2054\/19"]}],"id":[{"id":"10.13039\/501100013043","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013043","name":"Ariel University Research &amp; Development Department","doi-asserted-by":"publisher","award":["RA2000000457"],"award-info":[{"award-number":["RA2000000457"]}],"id":[{"id":"10.13039\/501100013043","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biomolecules"],"abstract":"<jats:p>Knee osteoarthritis (KOA) is one of the most common progressive, age-dependent chronic degenerative joint diseases. KOA often develops as a result of a gradual articular cartilage loss caused by its wear and tear. Numerous studies suggest that the degradation of the knee joint involves inflammatory components. This process is also associated with body composition, particularly being overweight and muscle mass loss. The present study aimed to search for novel circulating KOA inflammatory biomarkers, taking into account body composition characteristics. To this aim, we recruited 98 patients diagnosed and radiologically confirmed with KOA and 519 healthy controls from the Arab community in Israel. A panel of soluble molecules, related to inflammatory, metabolic, and musculoskeletal disorders, was measured by ELISA in plasma samples, while several body composition parameters were assessed with bioimpedance analysis. Statistical analysis, including multivariable logistic regression, revealed a number of the factors significantly associated with KOA, independently of age and sex. The most significant independent associations [OR (95% CI)] were fat body mass\/body weight index\u20141.56 (1.20\u20132.02), systemic immune-inflammation index\u20144.03 (2.23\u20137.27), circulating vaspin levels\u20141.39 (1.15\u20131.68), follistatin\/FSTL1 ratio\u20141.32 (1.02\u20131.70), and activin A\/FSTL1 ratio\u20141.33 (1.01\u20131.75). Further clinical studies are warranted to confirm the relevance of these KOA-associated biological factors. Hereafter, they could serve as reliable biomarkers for KOA in the general human population.<\/jats:p>","DOI":"10.3390\/biom13091315","type":"journal-article","created":{"date-parts":[[2023,8,28]],"date-time":"2023-08-28T02:23:25Z","timestamp":1693189405000},"page":"1315","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Pro-Inflammatory Biomarkers Combined with Body Composition Display a Strong Association with Knee Osteoarthritis in a Community-Based Study"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0566-9673","authenticated-orcid":false,"given":"Nader","family":"Tarabeih","sequence":"first","affiliation":[{"name":"Department of Morphological Studies, Adelson School of Medicine, Ariel University, Ariel 40700, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Kalinkovich","sequence":"additional","affiliation":[{"name":"Department of Anatomy and Anthropology, Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv 6905126, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adel","family":"Shalata","sequence":"additional","affiliation":[{"name":"The Simon Winter Institute for Human Genetics, Bnai Zion Medical Center, The Ruth and Bruce Rappaport Faculty of Medicine, Technion, Haifa 32000, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Orabi","family":"Higla","sequence":"additional","affiliation":[{"name":"Orthopedics Clinic, Clalit, Migdal HaMeah, Tel-Aviv 6203854, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory","family":"Livshits","sequence":"additional","affiliation":[{"name":"Department of Anatomy and Anthropology, Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv 6905126, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,8,28]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1001\/jama.2020.22171","article-title":"Diagnosis and Treatment of Hip and Knee Osteoarthritis: A Review","volume":"325","author":"Katz","year":"2021","journal-title":"JAMA"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1016\/j.joca.2021.10.003","article-title":"Osteoarthritis year in review 2021: Epidemiology & therapy","volume":"30","author":"Quicke","year":"2022","journal-title":"Osteoarthr. Cartil."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1016\/j.autrev.2018.06.002","article-title":"Osteoarthritis and its management\u2014Epidemiology, nutritional aspects and environmental factors","volume":"17","author":"Bortoluzzi","year":"2018","journal-title":"Autoimmun. Rev."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"234","DOI":"10.2174\/157339710793205684","article-title":"Outlines of the biochemistry of osteoarthritis","volume":"6","author":"Livshits","year":"2010","journal-title":"Curr. Rheumatol. Rev."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/j.mcna.2019.10.007","article-title":"Osteoarthritis: Pathology, Diagnosis, and Treatment Options","volume":"104","author":"Abramoff","year":"2020","journal-title":"Med. Clin. N. Am."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1186\/s13075-019-1969-9","article-title":"Prognostic factors for progression of osteoarthritis of the hip: A systematic review","volume":"21","author":"Teirlinck","year":"2019","journal-title":"Arthritis Res. Ther."},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Couldrick, J.M., Woodward, A.P., Silva, M.D.C., Lynch, J.T., Perriman, D.M., Barton, C.J., and Scarvell, J.M. (2023). Evidence for key individual characteristics associated with outcomes following combined first-line interventions for knee osteoarthritis: A systematic review. PLoS ONE, 18.","DOI":"10.1371\/journal.pone.0284249"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.maturitas.2015.04.004","article-title":"Biomarkers for osteoarthritis: Can they be used for risk assessment? A systematic review","volume":"82","author":"Runhaar","year":"2015","journal-title":"Maturitas"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"170","DOI":"10.2174\/1573397113666170427125918","article-title":"Synovial Fluid and Serum Concentrations of Inflammatory Markers in Rheumatoid Arthritis, Psoriatic Arthritis and Osteoarthitis: A Systematic Review","volume":"13","author":"Altobelli","year":"2017","journal-title":"Curr. Rheumatol. Rev."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"501","DOI":"10.2147\/CIA.S242288","article-title":"Soluble Biomarkers of Osteoporosis and Osteoarthritis, from Pathway Mapping to Clinical Trials: An Update","volume":"15","author":"Nagy","year":"2020","journal-title":"Clin. Interv. Aging"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1511S","DOI":"10.1177\/1947603520941239","article-title":"Clinically Relevant Molecular Biomarkers for Use in Human Knee Osteoarthritis: A Systematic Review","volume":"13","author":"Convill","year":"2021","journal-title":"Cartilage"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1136\/postgradmedj-2013-203726rep","article-title":"Republished: Value of biomarkers in osteoarthritis: Current status and perspectives","volume":"90","author":"Lotz","year":"2014","journal-title":"Postgrad. Med. J."},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Primorac, D., Molnar, V., Rod, E., Jele\u010d, \u017d., \u010cukelj, F., Mati\u0161i\u0107, V., Vrdoljak, T., Hudetz, D., Hajsok, H., and Bori\u0107, I. (2020). Knee Osteoarthritis: A Review of Pathogenesis and State-Of-The-Art Non-Operative Therapeutic Considerations. Genes, 11.","DOI":"10.3390\/genes11080854"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.joca.2012.11.012","article-title":"Osteoarthritis as an inflammatory disease (osteoarthritis is not osteoarthrosis!)","volume":"21","author":"Berenbaum","year":"2013","journal-title":"Osteoarthr. Cartil."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1038\/nrrheum.2016.136","article-title":"Low-grade inflammation as a key mediator of the pathogenesis of osteoarthritis","volume":"12","author":"Robinson","year":"2016","journal-title":"Nat. Rev. Rheumatol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.joca.2017.10.013","article-title":"Hierarchical, imbalanced pro-inflammatory cytokine networks govern the pathogenesis of chronic arthropathies","volume":"26","author":"Livshits","year":"2018","journal-title":"Osteoarthr. Cartil."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1697","DOI":"10.1002\/art.34453","article-title":"Osteoarthritis: A disease of the joint as an organ","volume":"64","author":"Loeser","year":"2012","journal-title":"Arthritis Rheum."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"561459","DOI":"10.1155\/2014\/561459","article-title":"The role of inflammatory and anti-inflammatory cytokines in the pathogenesis of osteoarthritis","volume":"2014","author":"Wojdasiewicz","year":"2014","journal-title":"Mediat. Inflamm."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"e1232","DOI":"10.1002\/ctm2.1232","article-title":"Obesity defined molecular endotypes in the synovium of patients with osteoarthritis provides a rationale for therapeutic targeting of fibroblast subsets","volume":"13","author":"Wijesinghe","year":"2023","journal-title":"Clin. Transl. Med."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1038\/nrrheum.2010.196","article-title":"Role of proinflammatory cytokines in the pathophysiology of osteoarthritis","volume":"7","author":"Kapoor","year":"2011","journal-title":"Nat. Rev. Rheumatol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1177\/1759720X12467868","article-title":"Role of inflammation in the pathogenesis of osteoarthritis: Latest findings and interpretations","volume":"5","author":"Sokolove","year":"2013","journal-title":"Ther. Adv. Musculoskelet. Dis."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1038\/s41584-022-00749-9","article-title":"Synovial inflammation in osteoarthritis progression","volume":"18","author":"Coras","year":"2022","journal-title":"Nat. Rev. Rheumatol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"105444","DOI":"10.1016\/j.jbspin.2022.105444","article-title":"Effect of disease-modifying anti-rheumatic drugs in osteoarthritis: A meta-analysis","volume":"89","author":"Mathieu","year":"2022","journal-title":"Jt. Bone Spine"},{"key":"ref_24","first-page":"91","article-title":"The involvement of follistatin-like protein 1 in osteoarthritis by elevating NF-\u03baB-mediated inflammatory cytokines and enhancing fibroblast like synoviocyte proliferation","volume":"17","author":"Ni","year":"2015","journal-title":"Thromb. Haemost."},{"key":"ref_25","first-page":"R193","article-title":"Follistatin-like protein 1: A serum biochemical marker reflecting the severity of joint damage in patients with osteoarthritis","volume":"13","author":"Wang","year":"2011","journal-title":"Thromb. Haemost."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"a021873","DOI":"10.1101\/cshperspect.a021873","article-title":"TGF-\u03b2 and the TGF-\u03b2 Family: Context-Dependent Roles in Cell and Tissue Physiology","volume":"8","author":"Morikawa","year":"2016","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"43514","DOI":"10.1074\/jbc.M407041200","article-title":"Proteomic Analysis of Articular Cartilage Shows Increased Type II Collagen Synthesis in Osteoarthritis and Expression of Inhibin \u03b2A (Activin A), a Regulatory Molecule for Chondrocytes","volume":"279","author":"Hermansson","year":"2004","journal-title":"J. Biol. Chem."},{"key":"ref_28","first-page":"320","article-title":"Correlation of concentrations of activin A with occurrence and severity of knee osteoarthritis","volume":"18","author":"Zou","year":"2018","journal-title":"J. Musculoskelet. Neuronal Interact."},{"key":"ref_29","doi-asserted-by":"crossref","unstructured":"Parfenova, O.K., Kukes, V.G., and Grishin, D.V. (2021). Follistatin-Like Proteins: Structure, Functions and Biomedical Importance. Biomedicines, 9.","DOI":"10.3390\/biomedicines9080999"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"7058","DOI":"10.1073\/pnas.1007293108","article-title":"Follistatin-like 1 (Fstl1) is a bone morphogenetic protein (BMP) 4 signaling antagonist in controlling mouse lung development","volume":"108","author":"Geng","year":"2011","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"2442","DOI":"10.1002\/art.11249","article-title":"Activin A induces cell proliferation of fibroblast-like synoviocytes in rheumatoid arthritis","volume":"48","author":"Ota","year":"2003","journal-title":"Arthritis Rheum."},{"key":"ref_32","first-page":"144","article-title":"The activin-follistatin anti-inflammatory cycle is deregulated in synovial fibroblasts","volume":"21","author":"Diller","year":"2019","journal-title":"Thromb. Haemost."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1002\/acr.22550","article-title":"Do Knee Osteoarthritis and Fat-Free Mass Interact in Their Impact on Health-Related Quality of Life in Men? Results from a Population-Based Cohort","volume":"67","author":"Visser","year":"2015","journal-title":"Arthritis Care Res."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1002\/art.40692","article-title":"Risk of Knee Osteoarthritis with Obesity, Sarcopenic Obesity, and Sarcopenia","volume":"71","author":"Misra","year":"2019","journal-title":"Arthritis Rheumatol."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/j.jbspin.2011.05.015","article-title":"Body mass index and susceptibility to knee osteoarthritis: A systematic review and meta-analysis","volume":"79","author":"Jiang","year":"2012","journal-title":"Jt. Bone Spine"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1136\/ard.2008.089748","article-title":"Incidence of severe knee and hip osteoarthritis in relation to different measures of body mass: A population-based prospective cohort study","volume":"68","author":"Lohmander","year":"2008","journal-title":"Ann. Rheum. Dis."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.joca.2013.12.002","article-title":"The role of fat mass and skeletal muscle mass in knee osteoarthritis is different for men and women: The NEO study","volume":"22","author":"Visser","year":"2014","journal-title":"Osteoarthr. Cartil."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/j.arr.2016.09.008","article-title":"Sarcopenic obesity or obese sarcopenia: A cross talk between age-associated adipose tissue and skeletal muscle inflammation as a main mechanism of the pathogenesis","volume":"35","author":"Kalinkovich","year":"2017","journal-title":"Ageing Res. Rev."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"C375","DOI":"10.1152\/ajpcell.00379.2020","article-title":"Adipose tissue inflammation and metabolic dysfunction in obesity","volume":"320","author":"Kawai","year":"2021","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.1007\/s00264-015-2707-9","article-title":"The role of adipocytokines in the pathogenesis of knee joint osteoarthritis","volume":"39","author":"Richter","year":"2015","journal-title":"Int. Orthop."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"iv10","DOI":"10.1093\/rheumatology\/kex399","article-title":"The role of fat and inflammation in the pathogenesis and management of osteoarthritis","volume":"57","author":"Urban","year":"2018","journal-title":"Rheumatology"},{"key":"ref_42","doi-asserted-by":"crossref","unstructured":"Carri\u00f3n, M., Frommer, K.W., P\u00e9rez-Garc\u00eda, S., M\u00fcller-Ladner, U., Gomariz, R.P., and Neumann, E. (2019). The Adipokine Network in Rheumatic Joint Diseases. Int. J. Mol. Sci., 20.","DOI":"10.3390\/ijms20174091"},{"key":"ref_43","first-page":"176","article-title":"Vaspin in obesity and diabetes: Pathophysiological and clinical significance","volume":"41","year":"2011","journal-title":"Endocrine"},{"key":"ref_44","first-page":"3447","article-title":"Expression of vaspin in the joint and the levels in the serum and synovial fluid of patients with osteoarthritis","volume":"7","author":"Bao","year":"2014","journal-title":"Int. J. Clin. Exp. Med."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"2685","DOI":"10.1001\/archinte.161.22.2685","article-title":"Total Cholesterol\/HDL Cholesterol Ratio vs LDL Cholesterol\/HDL Cholesterol Ratio as Indices of Ischemic Heart Disease Risk in Men: The Quebec Cardiovascular Study","volume":"161","author":"Lemieux","year":"2001","journal-title":"Arch. Intern. Med."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.1007\/s10067-010-1429-z","article-title":"The synovial fluid adiponectin-leptin ratio predicts pain with knee osteoarthritis","volume":"29","author":"Gandhi","year":"2010","journal-title":"Clin. Rheumatol."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1123\/japa.2017-0389","article-title":"Improvement in Skeletal Muscle Strength and Plasma Levels of Follistatin and Myostatin Induced by an 8-Week Resistance Training and Epicatechin Supplementation in Sarcopenic Older Adults","volume":"27","author":"Mafi","year":"2019","journal-title":"J. Aging Phys. Act."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"110869","DOI":"10.1016\/j.exger.2020.110869","article-title":"The effects of concurrent training order on body composition and serum concentrations of follistatin, myostatin and GDF11 in sarcopenic elderly men","volume":"133","author":"Bagheri","year":"2020","journal-title":"Exp. Gerontol."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"1163","DOI":"10.1016\/j.joca.2019.04.016","article-title":"The ratio adipsin\/MCP-1 is strongly associated with structural changes and CRP\/MCP-1 with symptoms in obese knee osteoarthritis subjects: Data from the Osteoarthritis Initiative","volume":"27","author":"Tardif","year":"2019","journal-title":"Osteoarthr. Cartil."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"215","DOI":"10.2147\/JPR.S349251","article-title":"Deciphering the Causal Relationships Between Low Back Pain Complications, Metabolic Factors, and Comorbidities","volume":"15","author":"Tarabeih","year":"2022","journal-title":"J. Pain Res."},{"key":"ref_51","unstructured":"(2023, June 21). Risk Factors for the Incidence and Progression of Radiographic Knee Osteoarthritis\u2014PubMed, Available online: https:\/\/pubmed.ncbi.nlm.nih.gov\/10817551\/."},{"key":"ref_52","doi-asserted-by":"crossref","unstructured":"Achamrah, N., Colange, G., Delay, J., Rimbert, A., Folope, V., Petit, A., Grigioni, S., D\u00e9chelotte, P., and Co\u00ebffier, M. (2018). Comparison of body composition assessment by DXA and BIA according to the body mass index: A retrospective study on 3655 measures. PLoS ONE, 13.","DOI":"10.1371\/journal.pone.0200465"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"3548284","DOI":"10.1155\/2019\/3548284","article-title":"Assessment of Body Composition in Health and Disease Using Bioelectrical Impedance Analysis (BIA) and Dual Energy X-Ray Absorptiometry (DXA): A Critical Overview","volume":"2019","author":"Marra","year":"2019","journal-title":"Contrast Media Mol. Imaging"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"54564","DOI":"10.18632\/oncotarget.10515","article-title":"Systemic immune-inflammation index predicts the clinical outcome in patients with metastatic renal cell cancer treated with sunitinib","volume":"7","author":"Lolli","year":"2016","journal-title":"Oncotarget"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1007\/s12016-022-08941-1","article-title":"Inflammaging and Osteoarthritis","volume":"64","author":"Motta","year":"2022","journal-title":"Clin. Rev. Allergy Immunol."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"865370","DOI":"10.3389\/fbioe.2022.865370","article-title":"Adipokine Signaling Pathways in Osteoarthritis","volume":"10","author":"Zhang","year":"2022","journal-title":"Front. Bioeng. Biotechnol."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"952953","DOI":"10.3389\/fcvm.2022.952953","article-title":"Association of the systemic immune-inflammation index with all-cause mortality in patients with arteriosclerotic cardiovascular disease","volume":"9","author":"He","year":"2022","journal-title":"Front. Cardiovasc. Med."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"975400","DOI":"10.3389\/fimmu.2022.975400","article-title":"Systemic immune-inflammation index and bone mineral density in postmenopausal women: A cross-sectional study of the national health and nutrition examination survey (NHANES) 2007\u20132018","volume":"13","author":"Tang","year":"2022","journal-title":"Front. Immunol."},{"key":"ref_59","doi-asserted-by":"crossref","unstructured":"Wu, D., Gao, X., Shi, Y., Wang, H., Wang, W., Li, Y., and Zheng, Z. (2022). Association between Handgrip Strength and the Systemic Immune-Inflammation Index: A Nationwide Study, NHANES 2011\u20132014. Int. J. Environ. Res. Public Health, 19.","DOI":"10.3390\/ijerph192013616"},{"key":"ref_60","doi-asserted-by":"crossref","unstructured":"Sugimoto, E., Matsuda, H., Shibata, S., Mizuno, Y., Koyama, A., Li, L., Taira, H., Ito, Y., Awaji, K., and Yamashita, T. (2023). Impact of Pretreatment Systemic Inflammatory Markers on Treatment Persistence with Biologics and Conventional Systemic Therapy: A Retrospective Study of Patients with Psoriasis Vulgaris and Psoriatic Arthritis. J. Clin. Med., 12.","DOI":"10.3390\/jcm12083046"},{"key":"ref_61","first-page":"34","article-title":"The association between systemic immune-inflammation index and rheumatoid arthritis: Evidence from NHANES 1999\u20132018","volume":"25","author":"Liu","year":"2023","journal-title":"Thromb. Haemost."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.biochi.2023.04.008","article-title":"Adipokines in obesity and metabolic-related-diseases","volume":"212","author":"Pestel","year":"2023","journal-title":"Biochimie"},{"key":"ref_63","doi-asserted-by":"crossref","unstructured":"Escot\u00e9, X., G\u00f3mez-Zorita, S., L\u00f3pez-Yoldi, M., Milton-Laskibar, I., Fern\u00e1ndez-Quintela, A., Mart\u00ednez, J.A., Moreno-Aliaga, M.J., and Portillo, M.P. (2017). Role of Omentin, Vaspin, Cardiotrophin-1, TWEAK and NOV\/CCN3 in Obesity and Diabetes Development. Int. J. Mol. Sci., 18.","DOI":"10.3390\/ijms18081770"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"192","DOI":"10.5114\/reum.2022.117839","article-title":"Evaluation of the adipokine profile (adiponectin, resistin, adipsin, vaspin, and leptin) in patients with early rheumatoid arthritis and its correlation with disease activity","volume":"60","author":"Calixto","year":"2022","journal-title":"Rheumatology"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"65","DOI":"10.4149\/BLL_2019_010","article-title":"Vaspin, neutrophil gelatinase-associated lipocalin and apolipoprotein levels in patients with psoriatic arthritis","volume":"120","author":"Colak","year":"2019","journal-title":"Bratisl. Med. J."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"100323","DOI":"10.1016\/j.ocarto.2022.100323","article-title":"The search for systemic biomarkers for monitoring degenerative lumbar spinal disorders","volume":"4","author":"Tarabeih","year":"2022","journal-title":"Osteoarthr. Cartil. Open"},{"key":"ref_67","doi-asserted-by":"crossref","unstructured":"Tarabeih, N., Kalinkovich, A., Shalata, A., and Livshits, G. (2020). Circulating Levels of Visceral Adipose Tissue-Derived Serine Protease Inhibitor (Vaspin) Appear as a Marker of Musculoskeletal Pain Disability. Diagnostics, 10.","DOI":"10.3390\/diagnostics10100797"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"1397","DOI":"10.2119\/molmed.2010.00105","article-title":"Potential Role of Leptin, Adiponectin and Three Novel Adipokines\u2014Visfatin, Chemerin and Vaspin\u2014In Chronic Hepatitis","volume":"17","author":"Kukla","year":"2011","journal-title":"Mol. Med."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1007\/s13679-018-0318-7","article-title":"Classic and Novel Adipocytokines at the Intersection of Obesity and Cancer: Diagnostic and Therapeutic Strategies","volume":"7","author":"Spyrou","year":"2018","journal-title":"Curr. Obes. Rep."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/S0303-7207(01)00517-2","article-title":"Expression of activin A in inflammatory arthropathies","volume":"180","author":"Gribi","year":"2001","journal-title":"Mol. Cell. Endocrinol."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"106465","DOI":"10.1016\/j.intimp.2020.106465","article-title":"Molecular functions of FSTL1 in the osteoarthritis","volume":"83","author":"Li","year":"2020","journal-title":"Int. Immunopharmacol."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"2339","DOI":"10.1007\/s00018-018-2805-0","article-title":"Follistatin-like 1 in development and human diseases","volume":"75","author":"Mattiotti","year":"2018","journal-title":"Cell. Mol. Life Sci."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"1998","DOI":"10.1210\/me.2010-0127","article-title":"Regulation of Muscle Mass by Follistatin and Activins","volume":"24","author":"Lee","year":"2010","journal-title":"Mol. Endocrinol."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"959271","DOI":"10.1155\/2014\/959271","article-title":"Follistatin Alleviates Synovitis and Articular Cartilage Degeneration Induced by Carrageenan","volume":"2014","author":"Yamada","year":"2014","journal-title":"Int. J. Inflamm."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"eaaz7492","DOI":"10.1126\/sciadv.aaz7492","article-title":"Gene therapy for follistatin mitigates systemic metabolic inflammation and post-traumatic arthritis in high-fat diet\u2013induced obesity","volume":"6","author":"Tang","year":"2020","journal-title":"Sci. Adv."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"2230","DOI":"10.1111\/jcmm.14155","article-title":"Follistatin-like protein 1 (FSTL1) promotes chondrocyte expression of matrix metalloproteinase and inflammatory factors via the NF-\u03baB pathway","volume":"23","author":"Hu","year":"2019","journal-title":"J. Cell. Mol. Med."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"2205161","DOI":"10.1002\/advs.202205161","article-title":"Blockade of Activin Receptor IIB Protects Arthritis Pathogenesis by Non-Amplification of Activin A-ACVR2B-NOX4 Axis Pathway","volume":"10","author":"Jeon","year":"2023","journal-title":"Adv. Sci."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1159\/000506260","article-title":"Activin A Expressed in Rheumatoid Synovial Cells Downregulates TNF\u03b1-Induced CXCL10 Expression and Osteoclastogenesis","volume":"87","author":"Kuranobu","year":"2020","journal-title":"Pathobiology"},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/B978-0-12-385961-7.00013-5","article-title":"The Regulation and Functions of Activin and Follistatin in Inflammation and Immunity","volume":"85","author":"Hedger","year":"2011","journal-title":"Vitam. Horm."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"102314","DOI":"10.1016\/j.jaut.2019.102314","article-title":"Activin-A in the regulation of immunity in health and disease","volume":"104","author":"Morianos","year":"2019","journal-title":"J. Autoimmun."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1016\/j.atherosclerosis.2005.04.011","article-title":"Sex differences in the relation of body composition to markers of inflammation","volume":"184","author":"Thorand","year":"2006","journal-title":"Atherosclerosis"}],"container-title":["Biomolecules"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2218-273X\/13\/9\/1315\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T20:40:36Z","timestamp":1760128836000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2218-273X\/13\/9\/1315"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,8,28]]},"references-count":81,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2023,9]]}},"alternative-id":["biom13091315"],"URL":"https:\/\/doi.org\/10.3390\/biom13091315","relation":{},"ISSN":["2218-273X"],"issn-type":[{"value":"2218-273X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,8,28]]}}}