{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T12:13:58Z","timestamp":1789388038348,"version":"build-2803163510"},"reference-count":146,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2023,9,16]],"date-time":"2023-09-16T00:00:00Z","timestamp":1694822400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Institute of Health","award":["R01NS083378"],"award-info":[{"award-number":["R01NS083378"]}]},{"name":"National Institute of Health","award":["R21NS128756"],"award-info":[{"award-number":["R21NS128756"]}]},{"name":"National Institute of Health","award":["T32GM007267"],"award-info":[{"award-number":["T32GM007267"]}]},{"name":"National Institute of Health","award":["T32GM139787"],"award-info":[{"award-number":["T32GM139787"]}]},{"name":"National Institute of Health","award":["F30AG079497"],"award-info":[{"award-number":["F30AG079497"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biomolecules"],"abstract":"<jats:p>Intracellular endosomal trafficking controls the balance between protein degradation and synthesis, i.e., proteostasis, but also many of the cellular signaling pathways that emanate from activated growth factor receptors after endocytosis. Endosomal trafficking, sorting, and motility are coordinated by the activity of small GTPases, including Rab proteins, whose function as molecular switches direct activity at endosomal membranes through effector proteins. Rab7 is particularly important in the coordination of the degradative functions of the pathway. Rab7 effectors control endosomal maturation and the properties of late endosomal and lysosomal compartments, such as coordination of recycling, motility, and fusion with downstream compartments. The spatiotemporal regulation of endosomal receptor trafficking is particularly challenging in neurons because of their enormous size, their distinct intracellular domains with unique requirements (dendrites vs. axons), and their long lifespans as postmitotic, differentiated cells. In Charcot\u2013Marie\u2013Tooth 2B disease (CMT2B), familial missense mutations in Rab7 cause alterations in GTPase cycling and trafficking, leading to an ulcero-mutilating peripheral neuropathy. The prevailing hypothesis to account for CMT2B pathologies is that CMT2B-associated Rab7 alleles alter endocytic trafficking of the neurotrophin NGF and its receptor TrkA and, thereby, disrupt normal trophic signaling in the peripheral nervous system, but other Rab7-dependent pathways are also impacted. Here, using TrkA as a prototypical endocytic cargo, we review physiologic Rab7 effector interactions and control in neurons. Since neurons are among the largest cells in the body, we place particular emphasis on the temporal and spatial regulation of endosomal sorting and trafficking in neuronal processes. We further discuss the current findings in CMT2B mutant Rab7 models, the impact of mutations on effector interactions or balance, and how this dysregulation may confer disease.<\/jats:p>","DOI":"10.3390\/biom13091399","type":"journal-article","created":{"date-parts":[[2023,9,17]],"date-time":"2023-09-17T06:12:21Z","timestamp":1694931141000},"page":"1399","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["Regulation of Endosomal Trafficking by Rab7 and Its Effectors in Neurons: Clues from Charcot\u2013Marie\u2013Tooth 2B Disease"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8880-6938","authenticated-orcid":false,"given":"Ryan J.","family":"Mulligan","sequence":"first","affiliation":[{"name":"Department of Cell Biology, University of Virginia, Charlottesville, VA 22903, USA"},{"name":"Medical Scientist Training Program, University of Virginia, Charlottesville, VA 22903, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bettina","family":"Winckler","sequence":"additional","affiliation":[{"name":"Department of Cell Biology, University of Virginia, Charlottesville, VA 22903, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,9,16]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1159\/000343487","article-title":"Molecular genetics of charcot-marie-tooth disease: From genes to genomes","volume":"3","author":"Azzedine","year":"2012","journal-title":"Mol. Syndromol."},{"key":"ref_2","first-page":"235","article-title":"The genetics of Charcot-Marie-Tooth disease: Current trends and future implications for diagnosis and management","volume":"8","author":"Hoyle","year":"2015","journal-title":"Appl. Clin. Genet."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1038\/ncpneuro0071","article-title":"Mechanisms of disease: A molecular genetic update on hereditary axonal neuropathies","volume":"2","author":"Vance","year":"2006","journal-title":"Nat. Clin. Pract. Neurol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1093\/brain\/103.2.259","article-title":"The clinical features of hereditary motor and sensory neuropathy types I and II","volume":"103","author":"Harding","year":"1980","journal-title":"Brain"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1111\/j.1469-1809.2007.00412.x","article-title":"Charcot-Marie-Tooth disease: A clinico-genetic confrontation","volume":"72","author":"Barisic","year":"2008","journal-title":"Ann. Hum. Genet."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1358\/dot.2004.40.5.850487","article-title":"Hereditary sensory neuropathies","volume":"40","year":"2004","journal-title":"Drugs Today"},{"key":"ref_7","first-page":"853","article-title":"Assignment of a second Charcot-Marie-Tooth type II locus to chromosome 3q","volume":"57","author":"Kwon","year":"1995","journal-title":"Am. J. Hum. Genet."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1552","DOI":"10.1212\/WNL.55.10.1552","article-title":"Phenotype-genotype correlations in a CMT2B family with refined 3q13-q22 locus","volume":"55","author":"Wagner","year":"2000","journal-title":"Neurology"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1136\/jnnp.62.6.570","article-title":"Mutilating neuropathic ulcerations in a chromosome 3q13-q22 linked Charcot-Marie-Tooth disease type 2B family","volume":"62","author":"Timmerman","year":"1997","journal-title":"J. Neurol. Neurosurg. Psychiatr."},{"key":"ref_10","first-page":"258","article-title":"Misclassification and linkage of hereditary sensory and autonomic neuropathy type 1 as Charcot-Marie-Tooth disease, type 2B","volume":"59","author":"Vance","year":"1996","journal-title":"Am. J. Hum. Genet."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1086\/367847","article-title":"Mutations in the small GTP-ase late endosomal protein RAB7 cause Charcot-Marie-Tooth type 2B neuropathy","volume":"72","author":"Verhoeven","year":"2003","journal-title":"Am. J. Hum. Genet."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1002\/ana.20281","article-title":"A novel RAB7 mutation associated with ulcero-mutilating neuropathy","volume":"56","author":"Houlden","year":"2004","journal-title":"Ann. Neurol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1476","DOI":"10.1212\/01.wnl.0000240068.21499.f5","article-title":"Charcot-Marie-Tooth disease due to a de novo mutation of the RAB7 gene","volume":"67","author":"Meggouh","year":"2006","journal-title":"Neurology"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1016\/j.gene.2013.10.023","article-title":"A novel RAB7 mutation in a Chinese family with Charcot-Marie-Tooth type 2B disease","volume":"534","author":"Wang","year":"2014","journal-title":"Gene"},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Saveri, P., De Luca, M., Nisi, V., Pisciotta, C., Romano, R., Piscosquito, G., Reilly, M.M., Polke, J.M., Cavallaro, T., and Fabrizi, G.M. (2020). Charcot-Marie-Tooth Type 2B: A New Phenotype Associated with a Novel RAB7A Mutation and Inhibited EGFR Degradation. Cells, 9.","DOI":"10.3390\/cells9041028"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1111\/febs.15453","article-title":"Rab family of small GTPases: An updated view on their regulation and functions","volume":"288","author":"Homma","year":"2021","journal-title":"FEBS J."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"11821","DOI":"10.1073\/pnas.0601617103","article-title":"Rabs and their effectors: Achieving specificity in membrane traffic","volume":"103","author":"Grosshans","year":"2006","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"a022616","DOI":"10.1101\/cshperspect.a022616","article-title":"Rab proteins and the compartmentalization of the endosomal system","volume":"6","author":"Zerial","year":"2014","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1038\/s41580-018-0053-7","article-title":"To degrade or not to degrade: Mechanisms and significance of endocytic recycling","volume":"19","author":"Cullen","year":"2018","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.1074\/jbc.M504175200","article-title":"rab7 activity affects epidermal growth factor:epidermal growth factor receptor degradation by regulating endocytic trafficking from the late endosome","volume":"281","author":"Ceresa","year":"2006","journal-title":"J. Biol. Chem."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"10930","DOI":"10.1523\/JNEUROSCI.2029-05.2005","article-title":"The small GTPase Rab7 controls the endosomal trafficking and neuritogenic signaling of the nerve growth factor receptor TrkA","volume":"25","author":"Saxena","year":"2005","journal-title":"J. Neurosci."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1016\/j.cell.2005.06.043","article-title":"Rab conversion as a mechanism of progression from early to late endosomes","volume":"122","author":"Rink","year":"2005","journal-title":"Cell"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/j.cell.2010.03.011","article-title":"Identification of the switch in early-to-late endosome transition","volume":"141","author":"Poteryaev","year":"2010","journal-title":"Cell"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"9364","DOI":"10.1523\/JNEUROSCI.1665-18.2018","article-title":"The endolysosomal system and proteostasis: From development to degeneration","volume":"38","author":"Winckler","year":"2018","journal-title":"J. Neurosci."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"107733","DOI":"10.1016\/j.celrep.2020.107733","article-title":"Rab7-Mediated Endocytosis Establishes Patterning of Wnt Activity through Inactivation of Dkk Antagonism","volume":"31","author":"Kawamura","year":"2020","journal-title":"Cell Rep."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1038\/s42003-022-03632-1","article-title":"Mitochondria dysfunction in Charcot Marie Tooth 2B Peripheral Sensory Neuropathy","volume":"5","author":"Gu","year":"2022","journal-title":"Commun. Biol."},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"Liu, H., and Wu, C. (2017). Charcot marie tooth 2B peripheral sensory neuropathy: How rab7 mutations impact NGF signaling?. Int. J. Mol. Sci., 18.","DOI":"10.3390\/ijms18020324"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"129","DOI":"10.3389\/fcell.2018.00129","article-title":"This is the end: Regulation of rab7 nucleotide binding in endolysosomal trafficking and autophagy","volume":"6","author":"Stroupe","year":"2018","journal-title":"Front. Cell Dev. Biol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"1654","DOI":"10.1016\/j.cub.2010.08.002","article-title":"The Mon1-Ccz1 complex is the GEF of the late endosomal Rab7 homolog Ypt7","volume":"20","author":"Nordmann","year":"2010","journal-title":"Curr. Biol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1038\/nature08853","article-title":"Identification of two evolutionarily conserved genes regulating processing of engulfed apoptotic cells","volume":"464","author":"Kinchen","year":"2010","journal-title":"Nature"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1042\/BST0371027","article-title":"Rab7 and the CMT2B disease","volume":"37","author":"Cogli","year":"2009","journal-title":"Biochem. Soc. Trans."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1093\/hmg\/ddp567","article-title":"Disease mutations in Rab7 result in unregulated nucleotide exchange and inappropriate activation","volume":"19","author":"McCray","year":"2010","journal-title":"Hum. Mol. Genet."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"1640","DOI":"10.1523\/JNEUROSCI.3677-07.2008","article-title":"Functional characterization of Rab7 mutant proteins associated with Charcot-Marie-Tooth type 2B disease","volume":"28","author":"Spinosa","year":"2008","journal-title":"J. Neurosci."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/j.bbrc.2008.05.060","article-title":"Characterization of the Rab7K157N mutant protein associated with Charcot-Marie-Tooth type 2B","volume":"372","author":"Progida","year":"2008","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"1368","DOI":"10.1042\/BST20120197","article-title":"Molecular basis of Charcot-Marie-Tooth type 2B disease","volume":"40","author":"Bucci","year":"2012","journal-title":"Biochem. Soc. Trans."},{"key":"ref_36","first-page":"167","article-title":"Post-translational modifications: How to modulate Rab7 functions","volume":"11","author":"Modica","year":"2020","journal-title":"Small GTPases"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"10689","DOI":"10.1038\/ncomms10689","article-title":"PTEN modulates EGFR late endocytic trafficking and degradation by dephosphorylating Rab7","volume":"7","author":"Shinde","year":"2016","journal-title":"Nat. Commun."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"2425","DOI":"10.1523\/JNEUROSCI.2569-15.2016","article-title":"Parkin Modulates Endosomal Organization and Function of the Endo-Lysosomal Pathway","volume":"36","author":"Song","year":"2016","journal-title":"J. Neurosci."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"eadh3347","DOI":"10.1126\/sciadv.adh3347","article-title":"Parkin regulates amino acid homeostasis at mitochondria-lysosome (M\/L) contact sites in Parkinson\u2019s disease","volume":"9","author":"Peng","year":"2023","journal-title":"Sci. Adv."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1091\/mbc.11.2.467","article-title":"Rab7: A key to lysosome biogenesis","volume":"11","author":"Bucci","year":"2000","journal-title":"Mol. Biol. Cell"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"4391","DOI":"10.1074\/jbc.272.7.4391","article-title":"Role of the small GTPase Rab7 in the late endocytic pathway","volume":"272","author":"Vitelli","year":"1997","journal-title":"J. Biol. Chem."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"12110","DOI":"10.1074\/jbc.M809277200","article-title":"Rab7 regulates late endocytic trafficking downstream of multivesicular body biogenesis and cargo sequestration","volume":"284","author":"Vanlandingham","year":"2009","journal-title":"J. Biol. Chem."},{"key":"ref_43","doi-asserted-by":"crossref","unstructured":"Guerra, F., and Bucci, C. (2016). Multiple roles of the small gtpase rab7. Cells, 5.","DOI":"10.3390\/cells5030034"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1016\/j.tcb.2018.06.007","article-title":"Rab gtpase function in endosome and lysosome biogenesis","volume":"28","author":"Langemeyer","year":"2018","journal-title":"Trends Cell Biol."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"e202105120","DOI":"10.1083\/jcb.202105120","article-title":"Who\u2019s in control? Principles of Rab GTPase activation in endolysosomal membrane trafficking and beyond","volume":"220","author":"Borchers","year":"2021","journal-title":"J. Cell Biol."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"102537","DOI":"10.1016\/j.conb.2022.102537","article-title":"Dynamics and distribution of endosomes and lysosomes in dendrites","volume":"74","author":"Yap","year":"2022","journal-title":"Curr. Opin. Neurobiol."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"112709","DOI":"10.1016\/j.celrep.2023.112709","article-title":"Organelle mapping in dendrites of human iPSC-derived neurons reveals dynamic functional dendritic Golgi structures","volume":"42","author":"Wang","year":"2023","journal-title":"Cell Rep."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1111\/tra.12701","article-title":"ToolBox: Live Imaging of intracellular organelle transport in induced pluripotent stem cell-derived neurons","volume":"21","author":"Boecker","year":"2020","journal-title":"Traffic"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"3141","DOI":"10.1083\/jcb.201711039","article-title":"Degradation of dendritic cargos requires Rab7-dependent transport to somatic lysosomes","volume":"217","author":"Yap","year":"2018","journal-title":"J. Cell Biol."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/j.ydbio.2022.03.004","article-title":"Spatial regulation of endosomes in growing dendrites","volume":"486","author":"Yap","year":"2022","journal-title":"Dev. Biol."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"4415","DOI":"10.1523\/JNEUROSCI.2530-21.2022","article-title":"Dynein Is Required for Rab7-Dependent Endosome Maturation, Retrograde Dendritic Transport, and Degradation","volume":"42","author":"Yap","year":"2022","journal-title":"J. Neurosci."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1083\/jcb.201412046","article-title":"Axonal autophagosomes recruit dynein for retrograde transport through fusion with late endosomes","volume":"209","author":"Cheng","year":"2015","journal-title":"J. Cell Biol."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"3127","DOI":"10.1083\/jcb.201711083","article-title":"Characterization of LAMP1-labeled nondegradative lysosomal and endocytic compartments in neurons","volume":"217","author":"Cheng","year":"2018","journal-title":"J. Cell Biol."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"109034","DOI":"10.1016\/j.celrep.2021.109034","article-title":"Post-Golgi carriers, not lysosomes, confer lysosomal properties to pre-degradative organelles in normal and dystrophic axons","volume":"35","author":"Lie","year":"2021","journal-title":"Cell Rep."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.devcel.2020.03.011","article-title":"The dynein adaptor RILP controls neuronal autophagosome biogenesis, transport, and clearance","volume":"53","author":"Khobrekar","year":"2020","journal-title":"Dev. Cell"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"7817","DOI":"10.1523\/JNEUROSCI.6412-10.2011","article-title":"Lysosomal proteolysis inhibition selectively disrupts axonal transport of degradative organelles and causes an Alzheimer\u2019s-like axonal dystrophy","volume":"31","author":"Lee","year":"2011","journal-title":"J. Neurosci."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"8524","DOI":"10.1523\/JNEUROSCI.1292-22.2022","article-title":"Retrograde axonal autophagy and endocytic pathways are parallel and separate in neurons","volume":"42","author":"Kulkarni","year":"2022","journal-title":"J. Neurosci."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"e81721","DOI":"10.7554\/eLife.81721","article-title":"Differential axonal trafficking of Neuropeptide Y-, LAMP1-, and RAB7-tagged organelles in vivo","volume":"11","author":"Nassal","year":"2022","journal-title":"eLife"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"1199","DOI":"10.1080\/15548627.2022.2119351","article-title":"HTT (huntingtin) and RAB7 co-migrate retrogradely on a signaling LAMP1-containing late endosome during axonal injury","volume":"19","author":"Krzystek","year":"2023","journal-title":"Autophagy"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"7451","DOI":"10.1523\/JNEUROSCI.4322-12.2013","article-title":"Defective axonal transport of Rab7 GTPase results in dysregulated trophic signaling","volume":"33","author":"Zhang","year":"2013","journal-title":"J. Neurosci."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"108973","DOI":"10.1016\/j.celrep.2021.108973","article-title":"Rab2 drives axonal transport of dense core vesicles and lysosomal organelles","volume":"35","author":"Lund","year":"2021","journal-title":"Cell Rep."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1089\/hum.2013.189","article-title":"Adeno-associated virus serotypes 1, 8, and 9 share conserved mechanisms for anterograde and retrograde axonal transport","volume":"25","author":"Castle","year":"2014","journal-title":"Hum. Gene Ther."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/j.neuron.2006.08.018","article-title":"Rab5 and Rab7 control endocytic sorting along the axonal retrograde transport pathway","volume":"52","author":"Deinhardt","year":"2006","journal-title":"Neuron"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"1306","DOI":"10.1016\/j.cell.2006.12.013","article-title":"Retrograde control of neural circuit formation","volume":"127","author":"Deppmann","year":"2006","journal-title":"Cell"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.conb.2010.07.007","article-title":"Retrograde neural circuit specification by target-derived neurotrophins and growth factors","volume":"21","author":"Wang","year":"2011","journal-title":"Curr. Opin. Neurobiol."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.mcn.2018.03.013","article-title":"Mechanisms of neurotrophin trafficking via Trk receptors","volume":"91","author":"Kuruvilla","year":"2018","journal-title":"Mol. Cell. Neurosci."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.conb.2005.01.010","article-title":"Long-distance retrograde neurotrophic signaling","volume":"15","author":"Howe","year":"2005","journal-title":"Curr. Opin. Neurobiol."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"33012","DOI":"10.7554\/eLife.33012","article-title":"Multivesicular bodies mediate long-range retrograde NGF-TrkA signaling","volume":"7","author":"Ye","year":"2018","journal-title":"eLife"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/S0896-6273(03)00397-0","article-title":"NGF signaling in sensory neurons: Evidence that early endosomes carry NGF retrograde signals","volume":"39","author":"Delcroix","year":"2003","journal-title":"Neuron"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"4715","DOI":"10.1038\/s41598-018-23036-8","article-title":"Transcytosis of TrkA leads to diversification of dendritic signaling endosomes","volume":"8","author":"Barford","year":"2018","journal-title":"Sci. Rep."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1002\/dneu.22427","article-title":"The neurotrophin receptor signaling endosome: Where trafficking meets signaling","volume":"77","author":"Barford","year":"2017","journal-title":"Dev. Neurobiol."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.1074\/jbc.M112.417766","article-title":"Rab7 mutants associated with Charcot-Marie-Tooth disease cause delayed growth factor receptor transport and altered endosomal and nuclear signaling","volume":"288","author":"BasuRay","year":"2013","journal-title":"J. Biol. Chem."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1007\/s00018-020-03510-1","article-title":"Alteration of the late endocytic pathway in Charcot-Marie-Tooth type 2B disease","volume":"78","author":"Romano","year":"2021","journal-title":"Cell. Mol. Life Sci."},{"key":"ref_74","doi-asserted-by":"crossref","unstructured":"BasuRay, S., Mukherjee, S., Romero, E., Wilson, M.C., and Wandinger-Ness, A. (2010). Rab7 mutants associated with Charcot-Marie-Tooth disease exhibit enhanced NGF-stimulated signaling. PLoS ONE, 5.","DOI":"10.1371\/journal.pone.0015351"},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1007\/s00401-010-0696-8","article-title":"CMT2B-associated Rab7 mutants inhibit neurite outgrowth","volume":"120","author":"Cogli","year":"2010","journal-title":"Acta Neuropathol."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"3189","DOI":"10.1002\/jnr.22460","article-title":"The mood stabilizer valproic acid improves defective neurite formation caused by Charcot-Marie-Tooth disease-associated mutant Rab7 through the JNK signaling pathway","volume":"88","author":"Yamauchi","year":"2010","journal-title":"J. Neurosci. Res."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"258559","DOI":"10.1242\/jcs.258559","article-title":"Tubular microdomains of Rab7-endosomes retrieve TrkA, a mechanism disrupted in Charcot-Marie-Tooth 2B","volume":"134","author":"Markworth","year":"2021","journal-title":"J. Cell Sci."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1186\/s13064-016-0058-x","article-title":"Charcot-Marie-Tooth 2b associated Rab7 mutations cause axon growth and guidance defects during vertebrate sensory neuron development","volume":"11","author":"Ponomareva","year":"2016","journal-title":"Neural Dev."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.cell.2018.11.030","article-title":"Late Endosomes Act as mRNA Translation Platforms and Sustain Mitochondria in Axons","volume":"176","author":"Cioni","year":"2019","journal-title":"Cell"},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"1680","DOI":"10.1016\/S0960-9822(01)00531-0","article-title":"The Rab7 effector protein RILP controls lysosomal transport by inducing the recruitment of dynein-dynactin motors","volume":"11","author":"Jordens","year":"2001","journal-title":"Curr. Biol."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1093\/emboj\/20.4.683","article-title":"Rab-interacting lysosomal protein (RILP): The Rab7 effector required for transport to lysosomes","volume":"20","author":"Cantalupo","year":"2001","journal-title":"EMBO J."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"104916","DOI":"10.1016\/j.jbc.2023.104916","article-title":"Disruption of Golgi markers by two RILP-directed shRNAs in neurons: A new role for RILP or a neuron-specific off-target phenotype?","volume":"299","author":"Yap","year":"2023","journal-title":"J. Biol. Chem."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"e202010179","DOI":"10.1083\/jcb.202010179","article-title":"Sequential dynein effectors regulate axonal autophagosome motility in a maturation-dependent pathway","volume":"220","author":"Cason","year":"2021","journal-title":"J. Cell Biol."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"e202205135","DOI":"10.1083\/jcb.202205135","article-title":"ER as master regulator of membrane trafficking and organelle function","volume":"221","author":"Wenzel","year":"2022","journal-title":"J. Cell Biol."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"664788","DOI":"10.3389\/fcell.2021.664788","article-title":"Functions of Oxysterol-Binding Proteins at Membrane Contact Sites and Their Control by Phosphoinositide Metabolism","volume":"9","author":"Nakatsu","year":"2021","journal-title":"Front. Cell Dev. Biol."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"5480","DOI":"10.1091\/mbc.e05-03-0189","article-title":"The oxysterol-binding protein homologue ORP1L interacts with Rab7 and alters functional properties of late endocytic compartments","volume":"16","author":"Johansson","year":"2005","journal-title":"Mol. Biol. Cell"},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1083\/jcb.200606077","article-title":"Activation of endosomal dynein motors by stepwise assembly of Rab7-RILP-p150Glued, ORP1L, and the receptor betalll spectrin","volume":"176","author":"Johansson","year":"2007","journal-title":"J. Cell Biol."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"1209","DOI":"10.1083\/jcb.200811005","article-title":"Cholesterol sensor ORP1L contacts the ER protein VAP to control Rab7-RILP-p150 Glued and late endosome positioning","volume":"185","author":"Rocha","year":"2009","journal-title":"J. Cell Biol."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"14155","DOI":"10.1074\/jbc.RA118.001854","article-title":"A non-canonical GTPase interaction enables ORP1L-Rab7-RILP complex formation and late endosome positioning","volume":"293","author":"Ma","year":"2018","journal-title":"J. Biol. Chem."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.bbalip.2004.08.009","article-title":"Lipid and cholesterol trafficking in NPC","volume":"1685","author":"Mukherjee","year":"2004","journal-title":"Biochim. Biophys. Acta"},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"23191","DOI":"10.1074\/jbc.M603215200","article-title":"Roles of endogenously synthesized sterols in the endocytic pathway","volume":"281","author":"Sugii","year":"2006","journal-title":"J. Biol. Chem."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"1234","DOI":"10.1038\/s41556-019-0394-2","article-title":"Phagolysosome resolution requires contacts with the endoplasmic reticulum and phosphatidylinositol-4-phosphate signalling","volume":"21","author":"Li","year":"2019","journal-title":"Nat. Cell Biol."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"183341","DOI":"10.1016\/j.bbamem.2020.183341","article-title":"Regulation and function of V-ATPases in physiology and disease","volume":"1862","author":"Collins","year":"2020","journal-title":"Biochim. Biophys. Acta Biomembr."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.ceb.2021.02.006","article-title":"From the inside out: Ion fluxes at the centre of endocytic traffic","volume":"71","author":"Chadwick","year":"2021","journal-title":"Curr. Opin. Cell Biol."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1152\/physrev.00009.2022","article-title":"Determinants, maintenance, and function of organellar pH","volume":"103","author":"Freeman","year":"2023","journal-title":"Physiol. Rev."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"1426","DOI":"10.1248\/bpb.b22-00371","article-title":"V-ATPase a3 Subunit in Secretory Lysosome Trafficking in Osteoclasts","volume":"45","author":"Matsumoto","year":"2022","journal-title":"Biol. Pharm. Bull."},{"key":"ref_97","first-page":"2697","article-title":"RILP regulates vacuolar ATPase through interaction with the V1G1 subunit","volume":"127","author":"Cogli","year":"2014","journal-title":"J. Cell Sci."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1083\/jcb.201507112","article-title":"The position of lysosomes within the cell determines their luminal pH","volume":"212","author":"Johnson","year":"2016","journal-title":"J. Cell Biol."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"3435","DOI":"10.1091\/mbc.e12-06-0445","article-title":"Endosomal acidification by Na+\/H+ exchanger NHE5 regulates TrkA cell-surface targeting and NGF-induced PI3K signaling","volume":"24","author":"Diering","year":"2013","journal-title":"Mol. Biol. Cell"},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.neuron.2013.07.043","article-title":"Christianson syndrome protein NHE6 modulates TrkB endosomal signaling required for neuronal circuit development","volume":"80","author":"Ouyang","year":"2013","journal-title":"Neuron"},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1038\/nrm1050","article-title":"Mannose 6-phosphate receptors: New twists in the tale","volume":"4","author":"Ghosh","year":"2003","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1083\/jcb.200312034","article-title":"Cargo-selective endosomal sorting for retrieval to the Golgi requires retromer","volume":"165","author":"Seaman","year":"2004","journal-title":"J. Cell Biol."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1083\/jcb.200312055","article-title":"Role of the mammalian retromer in sorting of the cation-independent mannose 6-phosphate receptor","volume":"165","author":"Arighi","year":"2004","journal-title":"J. Cell Biol."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1111\/tra.12542","article-title":"Retromer and the cation-independent mannose 6-phosphate receptor-Time for a trial separation?","volume":"19","author":"Seaman","year":"2018","journal-title":"Traffic"},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1016\/j.tcb.2018.06.005","article-title":"Endosomal retrieval of cargo: Retromer is not alone","volume":"28","author":"McNally","year":"2018","journal-title":"Trends Cell Biol."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1083\/jcb.200804048","article-title":"Regulation of retromer recruitment to endosomes by sequential action of Rab5 and Rab7","volume":"183","author":"Rojas","year":"2008","journal-title":"J. Cell Biol."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"2371","DOI":"10.1242\/jcs.048686","article-title":"Membrane recruitment of the cargo-selective retromer subcomplex is catalysed by the small GTPase Rab7 and inhibited by the Rab-GAP TBC1D5","volume":"122","author":"Seaman","year":"2009","journal-title":"J. Cell Sci."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1111\/tra.12237","article-title":"Molecular insights into Rab7-mediated endosomal recruitment of core retromer: Deciphering the role of Vps26 and Vps35","volume":"16","author":"Priya","year":"2015","journal-title":"Traffic"},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"jcs217398","DOI":"10.1242\/jcs.217398","article-title":"Inhibition of TBC1D5 activates Rab7a and can enhance the function of the retromer cargo-selective complex","volume":"131","author":"Seaman","year":"2018","journal-title":"J. Cell Sci."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"235","DOI":"10.15252\/embj.201797128","article-title":"Control of RAB7 activity and localization through the retromer-TBC1D5 complex enables RAB7-dependent mitophagy","volume":"37","author":"Kvainickas","year":"2018","journal-title":"EMBO J."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"1088","DOI":"10.1111\/tra.12309","article-title":"Retromer ensures the degradation of autophagic cargo by maintaining lysosome function in drosophila","volume":"16","author":"Maruzs","year":"2015","journal-title":"Traffic"},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1083\/jcb.201806153","article-title":"Retromer has a selective function in cargo sorting via endosome transport carriers","volume":"218","author":"Cui","year":"2019","journal-title":"J. Cell Biol."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.neuroscience.2019.01.006","article-title":"Contributions of VPS35 mutations to parkinson\u2019s disease","volume":"401","author":"Rahman","year":"2019","journal-title":"Neuroscience"},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1007\/s10571-020-00849-8","article-title":"The role of VPS35 in the pathobiology of parkinson\u2019s disease","volume":"41","author":"Sassone","year":"2021","journal-title":"Cell. Mol. Neurobiol."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"168140","DOI":"10.1016\/j.jmb.2023.168140","article-title":"The Endo-lysosomal System in Parkinson\u2019s Disease: Expanding the Horizon","volume":"435","author":"Muraleedharan","year":"2023","journal-title":"J. Mol. Biol."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"3086","DOI":"10.1038\/s41467-023-38719-8","article-title":"Multi-omic approach characterises the neuroprotective role of retromer in regulating lysosomal health","volume":"14","author":"Daly","year":"2023","journal-title":"Nat. Commun."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"35","DOI":"10.3389\/fcell.2016.00035","article-title":"Membrane tethering complexes in the endosomal system","volume":"4","author":"Spang","year":"2016","journal-title":"Front. Cell Dev. Biol."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"9402","DOI":"10.1073\/pnas.97.17.9402","article-title":"A Ypt\/Rab effector complex containing the Sec1 homolog Vps33p is required for homotypic vacuole fusion","volume":"97","author":"Seals","year":"2000","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1083\/jcb.151.3.551","article-title":"New component of the vacuolar class C-Vps complex couples nucleotide exchange on the Ypt7 GTPase to SNARE-dependent docking and fusion","volume":"151","author":"Wurmser","year":"2000","journal-title":"J. Cell Biol."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"1353","DOI":"10.1091\/mbc.e10-03-0260","article-title":"Subunit organization and Rab interactions of Vps-C protein complexes that control endolysosomal membrane traffic","volume":"22","author":"Plemel","year":"2011","journal-title":"Mol. Biol. Cell"},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"2655","DOI":"10.1091\/mbc.E14-04-0922","article-title":"The HOPS\/class C Vps complex tethers membranes by binding to one Rab GTPase in each apposed membrane","volume":"26","author":"Ho","year":"2015","journal-title":"Mol. Biol. Cell"},{"key":"ref_122","first-page":"1746","article-title":"The small GTPase Arl8b regulates assembly of the mammalian HOPS complex on lysosomes","volume":"128","author":"Khatter","year":"2015","journal-title":"J. Cell Sci."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"111969","DOI":"10.1016\/j.celrep.2022.111969","article-title":"Consecutive functions of small GTPases guide HOPS-mediated tethering of late endosomes and lysosomes","volume":"42","author":"Schleinitz","year":"2023","journal-title":"Cell Rep."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"e102301","DOI":"10.15252\/embj.2019102301","article-title":"SKIP-HOPS recruits TBC1D15 for a Rab7-to-Arl8b identity switch to control late endosome transport","volume":"39","author":"Jongsma","year":"2020","journal-title":"EMBO J."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"1327","DOI":"10.1091\/mbc.e13-08-0447","article-title":"The HOPS complex mediates autophagosome-lysosome fusion through interaction with syntaxin 17","volume":"25","author":"Jiang","year":"2014","journal-title":"Mol. Biol. Cell"},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"1338","DOI":"10.1091\/mbc.e13-08-0449","article-title":"Interaction of the HOPS complex with Syntaxin 17 mediates autophagosome clearance in Drosophila","volume":"25","author":"Pircs","year":"2014","journal-title":"Mol. Biol. Cell"},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"7282","DOI":"10.1038\/srep07282","article-title":"RILP interacts with HOPS complex via VPS41 subunit to regulate endocytic trafficking","volume":"4","author":"Lin","year":"2014","journal-title":"Sci. Rep."},{"key":"ref_128","first-page":"3462","article-title":"Late endosomal transport and tethering are coupled processes controlled by RILP and the cholesterol sensor ORP1L","volume":"126","author":"Fish","year":"2013","journal-title":"J. Cell Sci."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/j.nbd.2014.01.021","article-title":"Human Rab7 mutation mimics features of Charcot-Marie-Tooth neuropathy type 2B in Drosophila","volume":"65","author":"Janssens","year":"2014","journal-title":"Neurobiol. Dis."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1073\/pnas.1316482111","article-title":"A mechanism for retromer endosomal coat complex assembly with cargo","volume":"111","author":"Harrison","year":"2014","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_131","doi-asserted-by":"crossref","unstructured":"Romano, R., Del Fiore, V.S., Saveri, P., Palam\u00e0, I.E., Pisciotta, C., Pareyson, D., Bucci, C., and Guerra, F. (2022). Autophagy and lysosomal functionality in CMT2B fibroblasts carrying the RAB7K126R mutation. Cells, 11.","DOI":"10.3390\/cells11030496"},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1016\/j.cell.2011.07.008","article-title":"Recruitment of actin modifiers to TrkA endosomes governs retrograde NGF signaling and survival","volume":"146","author":"Harrington","year":"2011","journal-title":"Cell"},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"6056","DOI":"10.1523\/JNEUROSCI.16-19-06056.1996","article-title":"Dynamic organization of endocytic pathways in axons of cultured sympathetic neurons","volume":"16","author":"Overly","year":"1996","journal-title":"J. Neurosci."},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.celrep.2019.06.013","article-title":"Neuronal Soma-Derived Degradative Lysosomes Are Continuously Delivered to Distal Axons to Maintain Local Degradation Capacity","volume":"28","author":"Roney","year":"2019","journal-title":"Cell Rep."},{"key":"ref_135","first-page":"930","article-title":"Alterations of autophagy in the peripheral neuropathy Charcot-Marie-Tooth type 2B","volume":"14","author":"Colecchia","year":"2018","journal-title":"Autophagy"},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"158805","DOI":"10.1016\/j.bbalip.2020.158805","article-title":"An altered lipid metabolism characterizes Charcot-Marie-Tooth type 2B peripheral neuropathy","volume":"1865","author":"Giudetti","year":"2020","journal-title":"Biochim. Biophys. Acta Mol. Cell Biol. Lipids"},{"key":"ref_137","doi-asserted-by":"crossref","unstructured":"Kuchitsu, Y., and Fukuda, M. (2018). Revisiting Rab7 functions in mammalian autophagy: Rab7 knockout studies. Cells, 7.","DOI":"10.3390\/cells7110215"},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"e202106046","DOI":"10.1083\/jcb.202106046","article-title":"ER-lysosome lipid transfer protein VPS13C\/PARK23 prevents aberrant mtDNA-dependent STING signaling","volume":"221","author":"Wu","year":"2022","journal-title":"J. Cell Biol."},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"4493","DOI":"10.1038\/s41467-021-24713-5","article-title":"ER-lysosome contacts at a pre-axonal region regulate axonal lysosome availability","volume":"12","author":"Koppers","year":"2021","journal-title":"Nat. Commun."},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"jcs255026","DOI":"10.1242\/jcs.255026","article-title":"PDZD8-mediated lipid transfer at contacts between the ER and late endosomes\/lysosomes is required for neurite outgrowth","volume":"135","author":"Gao","year":"2022","journal-title":"J. Cell Sci."},{"key":"ref_141","doi-asserted-by":"crossref","unstructured":"Kuijpers, M., Nguyen, P.T., and Haucke, V. (2023). The endoplasmic reticulum and its contacts: Emerging roles in axon development, neurotransmission, and degeneration. Neuroscientist, 10738584231162810.","DOI":"10.1177\/10738584231162810"},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"11808","DOI":"10.1038\/ncomms11808","article-title":"Cholesterol and ORP1L-mediated ER contact sites control autophagosome transport and fusion with the endocytic pathway","volume":"7","author":"Wijdeven","year":"2016","journal-title":"Nat. Commun."},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1007\/s00401-012-1063-8","article-title":"Charcot-Marie-Tooth type 2B disease-causing RAB7A mutant proteins show altered interaction with the neuronal intermediate filament peripherin","volume":"125","author":"Cogli","year":"2013","journal-title":"Acta Neuropathol."},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1016\/j.tcb.2019.02.004","article-title":"Regulation and Function of Mitochondria-Lysosome Membrane Contact Sites in Cellular Homeostasis","volume":"29","author":"Wong","year":"2019","journal-title":"Trends Cell Biol."},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1038\/nature25486","article-title":"Mitochondria-lysosome contacts regulate mitochondrial fission via RAB7 GTP hydrolysis","volume":"554","author":"Wong","year":"2018","journal-title":"Nature"},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/j.devcel.2019.05.033","article-title":"Lysosomal Regulation of Inter-mitochondrial Contact Fate and Motility in Charcot-Marie-Tooth Type 2","volume":"50","author":"Wong","year":"2019","journal-title":"Dev. 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