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Hyperuricemia and gout are primarily attributed to genetic factors, along with lifestyle factors like consuming a purine-rich diet, alcohol and\/or fructose intake, and physical activity. While numerous studies have reported various comorbidities linked to hyperuricemia or gout, the range of these associations is extensive. This review article focuses on the relationship between uric acid and thirteen specific domains: transporters, genetic factors, diet, lifestyle, gout, diabetes mellitus, metabolic syndrome, atherosclerosis, hypertension, kidney diseases, cardiovascular diseases, neurological diseases, and malignancies. The present article provides a comprehensive review of recent developments in these areas, compiled by experts from the Young Committee of the Japanese Society of Gout and Uric and Nucleic Acids. The consolidated summary serves to enhance the global comprehension of uric acid-related matters.<\/jats:p>","DOI":"10.3390\/biom13101519","type":"journal-article","created":{"date-parts":[[2023,10,13]],"date-time":"2023-10-13T06:07:26Z","timestamp":1697177246000},"page":"1519","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":70,"title":["Exploring the Multifaceted Nexus of Uric Acid and Health: A Review of Recent Studies on Diverse Diseases"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6601-4347","authenticated-orcid":false,"given":"Masanari","family":"Kuwabara","sequence":"first","affiliation":[{"name":"Department of Cardiology, Toranomon Hospital, 2-2-2-Toranomon, Minato, Tokyo 105-8470, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomoko","family":"Fukuuchi","sequence":"additional","affiliation":[{"name":"Laboratory of Biomedical and Analytical Sciences, Faculty of Pharma-Science, Teikyo University, Itabashi, Tokyo 173-8605, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3142-3343","authenticated-orcid":false,"given":"Yuhei","family":"Aoki","sequence":"additional","affiliation":[{"name":"Department of Cardiorenal and Cerebrovascular Medicine, Faculty of Medicine, Kagawa University, Takamatsu 761-0793, Kagawa, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Einosuke","family":"Mizuta","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Sanin Rosai Hospital, Yonago 683-8605, Tottori, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Motoshi","family":"Ouchi","sequence":"additional","affiliation":[{"name":"Department of Health Promotion in Nursing and Midwifery, Innovative Nursing for Life Course, Graduate School of Nursing, Chiba University, Chiba 260-8672, Chiba, Japan"},{"name":"Department of Pharmacology and 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Cardiovascular Medicine, Saga University, Saga 849-8501, Saga, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nagisa","family":"Morikawa","sequence":"additional","affiliation":[{"name":"Division of Cardio-Vascular Medicine, Department of Internal Medicine, Kurume University School of Medicine, Kurume 830-0011, Fukuoka, Japan"},{"name":"Department of Community Medicine, Kurume University School of Medicine, Kurume 830-0011, Fukuoka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kensuke","family":"Nishimiya","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Tohoku University Hospital, Sendai 980-8574, Miyagi, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8603-2630","authenticated-orcid":false,"given":"Naoyuki","family":"Akashi","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine, Jichi Medical University Saitama Medical Center, Saitama 330-8503, Saitama, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6150-1592","authenticated-orcid":false,"given":"Yoshihiro","family":"Tanaka","sequence":"additional","affiliation":[{"name":"Division of Epidemiology, Graduate School of Public Health, Shizuoka Graduate University of Public Health, Shizuoka 420-0881, Shizuoka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoyuki","family":"Otani","sequence":"additional","affiliation":[{"name":"Cardiovascular Center, Dokkyo Medical University Nikko Medical Center, Nikko 321-1298, Tochigi, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mihoko","family":"Morita","sequence":"additional","affiliation":[{"name":"Department of Hematology and Oncology, University of Fukui Hospital, Eiheiji 910-1193, Fukui, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Miyata","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, The University of Tokyo Hospital, Bunkyo, Tokyo 113-8655, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3868-9320","authenticated-orcid":false,"given":"Tappei","family":"Takada","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, The University of Tokyo Hospital, Bunkyo, Tokyo 113-8655, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Tsutani","sequence":"additional","affiliation":[{"name":"National Hospital Organization Awara Hospital, Awara 910-4272, Fukui, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuhide","family":"Ogino","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Japanese Red Cross Tottori Hospital, Tottori 680-8517, Tottori, 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