{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T00:47:11Z","timestamp":1792630031676,"version":"4.5.0"},"reference-count":180,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2023,10,27]],"date-time":"2023-10-27T00:00:00Z","timestamp":1698364800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biomolecules"],"abstract":"<jats:p>Oxidative stress is increasingly recognized as a central player in a range of gastrointestinal (GI) disorders, as well as complications stemming from therapeutic interventions. This article presents an overview of the mechanisms of oxidative stress in GI conditions and highlights a link between oxidative insult and disruption to the enteric nervous system (ENS), which controls GI functions. The dysfunction of the ENS is characteristic of a spectrum of disorders, including neurointestinal diseases and conditions such as inflammatory bowel disease (IBD), diabetic gastroparesis, and chemotherapy-induced GI side effects. Neurons in the ENS, while essential for normal gut function, appear particularly vulnerable to oxidative damage. Mechanistically, oxidative stress in enteric neurons can result from intrinsic nitrosative injury, mitochondrial dysfunction, or inflammation-related pathways. Although antioxidant-based therapies have shown limited efficacy, recognizing the multifaceted role of oxidative stress in GI diseases offers a promising avenue for future interventions. This comprehensive review summarizes the literature to date implicating oxidative stress as a critical player in the pathophysiology of GI disorders, with a focus on its role in ENS injury and dysfunction, and highlights opportunities for the development of targeted therapeutics for these diseases.<\/jats:p>","DOI":"10.3390\/biom13111586","type":"journal-article","created":{"date-parts":[[2023,10,27]],"date-time":"2023-10-27T09:42:52Z","timestamp":1698399772000},"page":"1586","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":42,"title":["The Oxidative Stress and Nervous Distress Connection in Gastrointestinal Disorders"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5099-3704","authenticated-orcid":false,"given":"Rhian","family":"Stavely","sequence":"first","affiliation":[{"name":"Department of Pediatric Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3889-1550","authenticated-orcid":false,"given":"Leah C.","family":"Ott","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niloufar","family":"Rashidi","sequence":"additional","affiliation":[{"name":"Institute for Health and Sport, Victoria University, St Albans, VIC 3021, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0430-4012","authenticated-orcid":false,"given":"Samy","family":"Sakkal","sequence":"additional","affiliation":[{"name":"Institute for Health and Sport, Victoria University, St Albans, VIC 3021, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2597-6929","authenticated-orcid":false,"given":"Kulmira","family":"Nurgali","sequence":"additional","affiliation":[{"name":"Institute for Health and Sport, Victoria University, St Albans, VIC 3021, Australia"},{"name":"Department of Medicine Western Health, The University of Melbourne, St Albans, VIC 3021, Australia"},{"name":"Regenerative Medicine and Stem Cell Program, Australian Institute for Musculoskeletal Science (AIMSS), St Albans, VIC 3021, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,10,27]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1349","DOI":"10.1089\/ars.2008.2378","article-title":"Redox signaling across cell membranes","volume":"11","author":"Fisher","year":"2009","journal-title":"Antioxid. Redox Signal."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.biocel.2006.07.001","article-title":"Free radicals and antioxidants in normal physiological functions and human disease","volume":"39","author":"Valko","year":"2007","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1038\/s41573-021-00233-1","article-title":"Targeting oxidative stress in disease: Promise and limitations of antioxidant therapy","volume":"20","author":"Forman","year":"2021","journal-title":"Nat. Rev. Drug Discov."},{"key":"ref_4","first-page":"9","article-title":"Defining ROS in biology and medicine","volume":"1","author":"Li","year":"2016","journal-title":"React. Oxyg. Species"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1271","DOI":"10.1016\/j.freeradbiomed.2011.06.011","article-title":"Oxidases and peroxidases in cardiovascular and lung disease: New concepts in reactive oxygen species signaling","volume":"51","author":"Khoo","year":"2011","journal-title":"Free Radic. Biol. Med."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1159\/000136357","article-title":"Oxidative innate immune defenses by Nox\/Duox family NADPH oxidases","volume":"15","author":"Rada","year":"2008","journal-title":"Contrib. Microbiol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1042","DOI":"10.1111\/j.1600-0854.2012.01358.x","article-title":"Mycobacteria and the intraphagosomal environment: Take it with a pinch of salt(s)!","volume":"13","author":"Soldati","year":"2012","journal-title":"Traffic"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1111\/bph.14459","article-title":"Nitric oxide and its role as a non-adrenergic, non-cholinergic inhibitory neurotransmitter in the gastrointestinal tract","volume":"176","author":"Sanders","year":"2019","journal-title":"Br. J. Pharmacol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1016\/j.redox.2015.01.002","article-title":"Oxidative stress: A concept in redox biology and medicine","volume":"4","author":"Sies","year":"2015","journal-title":"Redox Biol."},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Sies, H. (2021). Oxidative eustress: On constant alert for redox homeostasis. Redox Biol., 41.","DOI":"10.1016\/j.redox.2021.101867"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1016\/j.tips.2017.04.005","article-title":"Targeting Free Radicals in Oxidative Stress-Related Human Diseases","volume":"38","author":"Poprac","year":"2017","journal-title":"Trends Pharmacol. Sci."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s10059-011-1021-7","article-title":"Bioactive lipoxygenase metabolites stimulation of NADPH oxidases and reactive oxygen species","volume":"32","author":"Cho","year":"2011","journal-title":"Mol. Cells"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1016\/j.redox.2015.09.005","article-title":"Reactive oxygen species and mitochondria: A nexus of cellular homeostasis","volume":"6","author":"Alvarez","year":"2015","journal-title":"Redox Biol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1040","DOI":"10.1038\/cdd.2009.49","article-title":"Superoxide is the major reactive oxygen species regulating autophagy","volume":"16","author":"Chen","year":"2009","journal-title":"Cell Death Differ."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1080\/15321819.2019.1583109","article-title":"Peroxynitrite: Cellular pathology and implications in autoimmunity","volume":"40","author":"Ahmad","year":"2019","journal-title":"J. Immunoass. Immunochem."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"2776","DOI":"10.1089\/ars.2013.5602","article-title":"Roles of DUOX-mediated hydrogen peroxide in metabolism, host defense, and signaling","volume":"20","author":"Corvilain","year":"2014","journal-title":"Antioxid. Redox Signal."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1016\/0378-4274(95)03532-X","article-title":"Toxicity of iron and hydrogen peroxide: The Fenton reaction","volume":"82","author":"Winterbourn","year":"1995","journal-title":"Toxicol. Lett."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1016\/j.jnutbio.2005.05.013","article-title":"Novel mechanisms of natural antioxidant compounds in biological systems: Involvement of glutathione and glutathione-related enzymes","volume":"16","author":"Masella","year":"2005","journal-title":"J. Nutr. Biochem."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"2055","DOI":"10.1053\/j.gastro.2008.09.003","article-title":"Heme oxygenase-1 protects interstitial cells of Cajal from oxidative stress and reverses diabetic gastroparesis","volume":"135","author":"Choi","year":"2008","journal-title":"Gastroenterology"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"2399","DOI":"10.1053\/j.gastro.2010.02.014","article-title":"CD206-positive M2 macrophages that express heme oxygenase-1 protect against diabetic gastroparesis in mice","volume":"138","author":"Choi","year":"2010","journal-title":"Gastroenterology"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"L1029","DOI":"10.1152\/ajplung.2000.279.6.L1029","article-title":"Heme oxygenase: Colors of defense against cellular stress","volume":"279","author":"Otterbein","year":"2000","journal-title":"Am. J. Physiol. Lung Cell. Mol. Physiol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/S0891-5849(99)00223-3","article-title":"The heme synthesis and degradation pathways: Role in oxidant sensitivity. Heme oxygenase has both pro- and antioxidant properties","volume":"28","author":"Ryter","year":"2000","journal-title":"Free Radic. Biol. Med."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"2697","DOI":"10.3748\/wjg.v11.i18.2697","article-title":"Free radicals and antioxidant systems in reflux esophagitis and Barrett\u2019s esophagus","volume":"11","author":"Piazuelo","year":"2005","journal-title":"World J. Gastroenterol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"20368","DOI":"10.1074\/jbc.M603353200","article-title":"cAMP-response element-binding protein mediates acid-induced NADPH oxidase NOX5-S expression in Barrett esophageal adenocarcinoma cells","volume":"281","author":"Fu","year":"2006","journal-title":"J. Biol. Chem."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1007\/s10353-015-0372-2","article-title":"The effect of ozone treatment on experimental colon anastomosis in rats","volume":"48","author":"Ersoz","year":"2016","journal-title":"Eur. Surg."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1179\/135100007X239261","article-title":"Colonic healing after portal ischemia and reperfusion: An experimental study with oxidative stress biomarkers","volume":"12","author":"Riger","year":"2007","journal-title":"Redox Rep."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"9968642","DOI":"10.1155\/2021\/9968642","article-title":"Oxidative Stress Level as a Predictor of Anastomotic Leakage after Rectal Surgery","volume":"2021","author":"Luo","year":"2021","journal-title":"Mediat. Inflamm."},{"key":"ref_28","first-page":"200","article-title":"Regenerative Capacity of the Enteric Nervous System after Ileoileal Anastomoses in a Rat Model","volume":"27","author":"Pfeifle","year":"2017","journal-title":"Eur. J. Pediatr. Surg."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1080\/00015458.2011.11680699","article-title":"Effects of prevention of oxidative and nitro-oxidative stress on experimental rat colon anastomosis using acetylcysteine, Ebselen and 1400w","volume":"111","author":"Poyrazoglu","year":"2011","journal-title":"Acta Chir. Belg."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"3502","DOI":"10.1111\/bph.13646","article-title":"Role of oxidative stress in oxaliplatin-induced enteric neuropathy and colonic dysmotility in mice","volume":"173","author":"McQuade","year":"2016","journal-title":"Br. J. Pharmacol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/j.pathophys.2017.07.002","article-title":"Irinotecan chemotherapy-induced intestinal oxidative stress: Underlying causes of disturbed mucosal water and electrolyte transport","volume":"24","author":"Rtibi","year":"2017","journal-title":"Pathophysiology"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"314","DOI":"10.2152\/jmi.57.314","article-title":"Protective effects of glycoglycerolipids extracted from spinach on 5-fluorouracil induced intestinal mucosal injury","volume":"57","author":"Shiota","year":"2010","journal-title":"J. Med. Investig."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1111\/j.1530-0277.2006.00110.x","article-title":"Chronic ethanol exposure impairs neuronal nitric oxide synthase in the rat intestine","volume":"30","author":"Krecsmarik","year":"2006","journal-title":"Alcohol. Clin. Exp. Res."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1016\/j.jhep.2008.10.028","article-title":"Evidence that chronic alcohol exposure promotes intestinal oxidative stress, intestinal hyperpermeability and endotoxemia prior to development of alcoholic steatohepatitis in rats","volume":"50","author":"Keshavarzian","year":"2009","journal-title":"J. Hepatol."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"G185","DOI":"10.1152\/ajpgi.00354.2012","article-title":"Role for intestinal CYP2E1 in alcohol-induced circadian gene-mediated intestinal hyperpermeability","volume":"305","author":"Forsyth","year":"2013","journal-title":"Am. J. Physiol.-Gastrointest. Liver Physiol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"38899","DOI":"10.1038\/srep38899","article-title":"Calcium Channels and Oxidative Stress Mediate a Synergistic Disruption of Tight Junctions by Ethanol and Acetaldehyde in Caco-2 Cell Monolayers","volume":"6","author":"Samak","year":"2016","journal-title":"Sci. Rep."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1186\/s12957-015-0667-6","article-title":"Immunohistochemical expression of 8-oxo-7,8-dihydro-2\u2032-deoxyguanosine in cytoplasm of tumour and adjacent normal mucosa cells in patients with colorectal cancer","volume":"13","author":"Matosevic","year":"2015","journal-title":"World J. Surg. Oncol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"403","DOI":"10.3748\/wjg.v11.i3.403","article-title":"Lipid peroxidation and antioxidant status in colorectal cancer","volume":"11","author":"Skrzydlewska","year":"2005","journal-title":"World J. Gastroenterol."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"157","DOI":"10.2478\/v10042-010-0029-8","article-title":"Morphological changes in the enteric nervous system caused by carcinoma of the human large intestine","volume":"48","author":"Godlewski","year":"2010","journal-title":"Folia Histochem. Cytobiol."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"6","DOI":"10.5603\/FHC.a2017.0003","article-title":"Ultrastructural characteristics of myenteric plexus in patients with colorectal cancer","volume":"55","author":"Godlewski","year":"2017","journal-title":"Folia Histochem. Cytobiol."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1006\/jsre.2000.5842","article-title":"Role of Stasis and Oxidative Stress in Ileal Pouch Inflammation","volume":"90","author":"Shebani","year":"2000","journal-title":"J. Surg. Res."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1007\/s00795-014-0093-9","article-title":"Reduced neurons in the ileum of proctocolectomized rat models","volume":"48","author":"Zhao","year":"2015","journal-title":"Med. Mol. Morphol."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3164\/jcbn.40.1","article-title":"Oxidative stress and ischemia-reperfusion injury in gastrointestinal tract and antioxidant, protective agents","volume":"40","author":"Sasaki","year":"2007","journal-title":"J. Clin. Biochem. Nutr."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"980","DOI":"10.1111\/j.1365-2982.2011.01780.x","article-title":"The involvement of nitric oxide synthase neurons in enteric neuropathies","volume":"23","author":"Rivera","year":"2011","journal-title":"Neurogastroenterol. Motil."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1007\/s00441-010-1126-x","article-title":"Deleterious effects of intestinal ischemia\/reperfusion injury in the mouse enteric nervous system are associated with protein nitrosylation","volume":"344","author":"Rivera","year":"2011","journal-title":"Cell Tissue Res."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.1097\/00042737-199612000-00003","article-title":"Superoxide dismutase activity in duodenal ulcer patients","volume":"8","author":"Klinowski","year":"1996","journal-title":"Eur. J. Gastroenterol. Hepatol."},{"key":"ref_47","first-page":"318","article-title":"Direct cytotoxic effect of oxygen radicals on the gastric mucosa","volume":"106","author":"Stein","year":"1989","journal-title":"Surgery"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.1111\/j.1476-5381.1989.tb12565.x","article-title":"Gastric damage following local intra-arterial administration of reactive oxygen metabolites in the rat","volume":"97","author":"Esplugues","year":"1989","journal-title":"Br. J. Pharmacol."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"G470","DOI":"10.1152\/ajpgi.1991.261.3.G470","article-title":"Role of oxygen-derived free radicals in indomethacin-induced gastric injury","volume":"261","author":"Vaananen","year":"1991","journal-title":"Am. J. Physiol.-Gastrointest. Liver Physiol."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"564457","DOI":"10.3389\/fphar.2020.564457","article-title":"Neurochemistry of Enteric Neurons Following Prolonged Indomethacin Administration in the Porcine Duodenum","volume":"11","author":"Czajkowska","year":"2020","journal-title":"Front. Pharmacol."},{"key":"ref_51","doi-asserted-by":"crossref","unstructured":"Rz\u0105p, D., Czajkowska, M., and Ca\u0142ka, J. (2020). Neurochemical Plasticity of nNOS-, VIP- and CART-Immunoreactive Neurons Following Prolonged Acetylsalicylic Acid Supplementation in the Porcine Jejunum. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21062157"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.exger.2014.01.001","article-title":"Food restriction enhances oxidative status in aging rats with neuroprotective effects on myenteric neuron populations in the proximal colon","volume":"51","author":"Schoffen","year":"2014","journal-title":"Exp. Gerontol."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1111\/j.1474-9726.2006.00214.x","article-title":"Reactive oxygen species, dietary restriction and neurotrophic factors in age-related loss of myenteric neurons","volume":"5","author":"Thrasivoulou","year":"2006","journal-title":"Aging Cell"},{"key":"ref_54","doi-asserted-by":"crossref","unstructured":"Musa, A.E., Shabeeb, D., and Alhilfi, H.S.Q. (2019). Protective effect of melatonin against radiotherapy-induced small intestinal oxidative stress: Biochemical evaluation. Medicina, 55.","DOI":"10.3390\/medicina55060308"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"87","DOI":"10.3390\/gastroent13010010","article-title":"Irradiation Induces Tuft Cell Hyperplasia and Myenteric Neuronal Loss in the Absence of Dietary Fiber in a Mouse Model of Pelvic Radiotherapy","volume":"13","author":"Voss","year":"2022","journal-title":"Gastroenterol. Insights"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"2086","DOI":"10.1210\/me.2009-0056","article-title":"Deficiency of ferritin heavy-chain nuclear import in triple a syndrome implies nuclear oxidative damage as the primary disease mechanism","volume":"23","author":"Storr","year":"2009","journal-title":"Mol. Endocrinol."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"R63","DOI":"10.1530\/JOE-13-0346","article-title":"Oxidative stress and adrenocortical insufficiency","volume":"221","author":"Prasad","year":"2014","journal-title":"J. Endocrinol."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"7397659","DOI":"10.1155\/2018\/7397659","article-title":"Oxidative Stress and Necrotizing Enterocolitis: Pathogenetic Mechanisms, Opportunities for Intervention, and Role of Human Milk","volume":"2018","author":"Aceti","year":"2018","journal-title":"Oxidative Med. Cell. Longev."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"2096","DOI":"10.1016\/j.jpedsurg.2011.06.032","article-title":"Total oxidant status and oxidative stress are increased in infants with necrotizing enterocolitis","volume":"46","author":"Aydemir","year":"2011","journal-title":"J. Pediatr. Surg."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"128","DOI":"10.3109\/14767058.2012.663197","article-title":"May oxidative stress biomarkers in cord blood predict the occurrence of necrotizing enterocolitis in preterm infants?","volume":"25","author":"Perrone","year":"2012","journal-title":"J. Matern. Fetal Neonatal Med."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jss.2009.07.028","article-title":"Mesenteric nitric oxide and superoxide production in experimental necrotizing enterocolitis","volume":"161","author":"Whitehouse","year":"2010","journal-title":"J. Surg. Res."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1186\/scrt387","article-title":"Enteric nervous system abnormalities are present in human necrotizing enterocolitis: Potential neurotransplantation therapy","volume":"4","author":"Zhou","year":"2013","journal-title":"Stem Cell Res. Ther."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1186\/s10020-022-00536-y","article-title":"Stem cell therapy as a promising strategy in necrotizing enterocolitis","volume":"28","author":"Di","year":"2022","journal-title":"Mol. Med."},{"key":"ref_64","doi-asserted-by":"crossref","unstructured":"Silva, K.D.A., Nunes, J.P.S., Andrieux, P., Brochet, P., Almeida, R.R., Kuramoto Takara, A.C.K., Pereira, N.B., Abel, L., Cobat, A., and Zaniratto, R.C.F. (2022). Chagas Disease Megaesophagus Patients Carrying Variant MRPS18B P260A Display Nitro-Oxidative Stress and Mitochondrial Dysfunction in Response to IFN-\u03b3; Stimulus. Biomedicines, 10.","DOI":"10.3390\/biomedicines10092215"},{"key":"ref_65","doi-asserted-by":"crossref","unstructured":"Ricci, M.F., B\u00e9la, S.R., Moraes, M.M., Bahia, M.T., Mazzeti, A.L., Oliveira, A.C.S., Andrade, L.O., Rad\u00ed, R., Piacenza, L., and Arantes, R.M.E. (2020). Neuronal Parasitism, Early Myenteric Neurons Depopulation and Continuous Axonal Networking Damage as Underlying Mechanisms of the Experimental Intestinal Chagas\u2019 Disease. Front. Cell. Infect. Microbiol., 10.","DOI":"10.3389\/fcimb.2020.583899"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/S1357-2725(03)00142-0","article-title":"Oxidative damage and altered antioxidant enzyme activities in the small intestine of streptozotocin-induced diabetic rats","volume":"36","author":"Bhor","year":"2004","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1016\/j.bbadis.2014.11.018","article-title":"Time dependent changes in the intestinal Ca2+ absorption in rats with type I diabetes mellitus are associated with alterations in the intestinal redox state","volume":"1852","author":"Rivoira","year":"2015","journal-title":"Biochim. Biophys. Acta (BBA) Mol. Basis Dis."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"131-e26","DOI":"10.1111\/j.1365-2982.2010.01611.x","article-title":"Colonic motor dysfunction in human diabetes is associated with enteric neuronal loss and increased oxidative stress","volume":"23","author":"Chandrasekharan","year":"2011","journal-title":"Neurogastroenterol. Motil."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.jcmgh.2015.08.007","article-title":"Enteric Glia Mediate Neuron Death in Colitis Through Purinergic Pathways That Require Connexin-43 and Nitric Oxide","volume":"2","author":"Brown","year":"2016","journal-title":"Cell. Mol. Gastroenterol. Hepatol."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1097\/00054725-200401000-00003","article-title":"Oxidative DNA damage in the mucosa of ulcerative colitis increases with disease duration and dysplasia","volume":"10","author":"Cardin","year":"2004","journal-title":"Inflamm. Bowel Dis."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"1433","DOI":"10.1023\/B:DDAS.0000042242.22898.d9","article-title":"Decreased total and corrected antioxidant capacity in patients with inflammatory bowel disease","volume":"49","author":"Koutroubakis","year":"2004","journal-title":"Dig. Dis. Sci."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"2100","DOI":"10.2174\/0929867322666150416095114","article-title":"NADPH oxidases and inflammatory bowel disease","volume":"22","author":"Lam","year":"2015","journal-title":"Curr. Med. Chem."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"2078","DOI":"10.1007\/BF02093613","article-title":"Increased oxidative stress and decreased antioxidant defenses in mucosa of inflammatory bowel disease","volume":"41","author":"Powell","year":"1996","journal-title":"Dig. Dis. Sci."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"1316","DOI":"10.1093\/ecco-jcc\/jjw088","article-title":"DNA Damage and Oxidative DNA Damage in Inflammatory Bowel Disease","volume":"10","author":"Pereira","year":"2016","journal-title":"J. Crohn\u2019s Colitis"},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1007\/s00210-014-0985-1","article-title":"Review article: The role of oxidative stress in pathogenesis and treatment of inflammatory bowel diseases","volume":"387","author":"Fichna","year":"2014","journal-title":"Naunyn-Schmiedeberg\u2019s Arch. Pharmacol."},{"key":"ref_76","doi-asserted-by":"crossref","unstructured":"Stavely, R., Sahakian, L., Filippone, R.T., Stojanovska, V., Bornstein, J.C., Sakkal, S., and Nurgali, K. (2022). Oxidative Stress-Induced HMGB1 Translocation in Myenteric Neurons Contributes to Neuropathy in Colitis. Biomolecules, 12.","DOI":"10.3390\/biom12121831"},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"934","DOI":"10.1111\/nmo.12796","article-title":"Smooth muscle and neural dysfunction contribute to different phases of murine postoperative ileus","volume":"28","author":"Farro","year":"2016","journal-title":"Neurogastroenterol. Motil."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1136\/gut.2008.155481","article-title":"Water-soluble CO-releasing molecules reduce the development of postoperative ileus via modulation of MAPK\/HO-1 signalling and reduction of oxidative stress","volume":"58","author":"Elinck","year":"2009","journal-title":"Gut"},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1007\/BF00691292","article-title":"Myenteric plexus neuropathy in infantile hypertrophic pyloric stenosis","volume":"78","author":"Dieler","year":"1989","journal-title":"Acta Neuropathol."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"G1198","DOI":"10.1152\/ajpgi.00221.2014","article-title":"Infantile hypertrophic pyloric stenosis (IHPS): A study of its pathophysiology utilizing the newborn hph-1 mouse model of the disease","volume":"307","author":"Welsh","year":"2014","journal-title":"Am. J. Physiol.-Gastrointest. Liver Physiol."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"1451","DOI":"10.1093\/brain\/awab056","article-title":"Biallelic variants in LIG3 cause a novel mitochondrial neurogastrointestinal encephalomyopathy","volume":"144","author":"Bonora","year":"2021","journal-title":"Brain"},{"key":"ref_82","doi-asserted-by":"crossref","unstructured":"Bianco, F., Lattanzio, G., Lorenzini, L., Mazzoni, M., Clavenzani, P., Calz\u00e0, L., Giardino, L., Sternini, C., Costanzini, A., and Bonora, E. (2022). Enteric Neuromyopathies: Highlights on Genetic Mechanisms Underlying Chronic Intestinal Pseudo-Obstruction. Biomolecules, 12.","DOI":"10.3390\/biom12121849"},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"1555","DOI":"10.1007\/s00383-022-05199-8","article-title":"Intrauterine exposure to oxidative stress induces caspase-1-dependent enteric nerve cell pyroptosis","volume":"38","author":"Zhou","year":"2022","journal-title":"Pediatr. Surg. Int."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1177\/1534735404270335","article-title":"Chemotherapy-associated oxidative stress: Impact on chemotherapeutic effectiveness","volume":"3","author":"Conklin","year":"2004","journal-title":"Integr. Cancer Ther."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1152\/physrev.00040.2012","article-title":"Oxidative stress: An essential factor in the pathogenesis of gastrointestinal mucosal diseases","volume":"94","author":"Bhattacharyya","year":"2014","journal-title":"Physiol. Rev."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1007\/978-3-642-38007-5_8","article-title":"Anti-inflammatory and anticancer drugs from nature","volume":"159","author":"Orlikova","year":"2014","journal-title":"Cancer Treat. Res."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"720620","DOI":"10.3389\/fonc.2021.720620","article-title":"Angelica Polysaccharide Antagonizes 5-FU-Induced Oxidative Stress Injury to Reduce Apoptosis in the Liver Through Nrf2 Pathway","volume":"11","author":"Zeng","year":"2021","journal-title":"Front. Oncol."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1186\/s13046-018-0909-x","article-title":"The role of cellular reactive oxygen species in cancer chemotherapy","volume":"37","author":"Yang","year":"2018","journal-title":"J. Exp. Clin. Cancer Res."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1207\/S15327914NC3701_1","article-title":"Dietary antioxidants during cancer chemotherapy: Impact on chemotherapeutic effectiveness and development of side effects","volume":"37","author":"Conklin","year":"2000","journal-title":"Nutr. Cancer"},{"key":"ref_90","first-page":"302","article-title":"Oxidative stress induces damage to epididymal epithelial tight junction protein ZO-1 and impairs epididymal function in varicocele rats","volume":"25","author":"Bai","year":"2019","journal-title":"Natl. J. Androl."},{"key":"ref_91","first-page":"7192646","article-title":"Cellular Stress Responses and Gut Microbiota in Inflammatory Bowel Disease","volume":"2018","author":"Cao","year":"2018","journal-title":"Gastroenterol. Res. Pr."},{"key":"ref_92","doi-asserted-by":"crossref","unstructured":"Vivarelli, S., Salemi, R., Candido, S., Falzone, L., Santagati, M., Stefani, S., Torino, F., Banna, G.L., Tonini, G., and Libra, M. (2019). Gut Microbiota and Cancer: From Pathogenesis to Therapy. Cancers, 11.","DOI":"10.3390\/cancers11010038"},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"414","DOI":"10.3389\/fphar.2016.00414","article-title":"Chemotherapy-Induced Constipation and Diarrhea: Pathophysiology, Current and Emerging Treatments","volume":"7","author":"McQuade","year":"2016","journal-title":"Front. Pharmacol."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.maturitas.2017.04.021","article-title":"Impact of chemotherapy on gastrointestinal functions and the enteric nervous system","volume":"105","author":"Escalante","year":"2017","journal-title":"Maturitas"},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"245","DOI":"10.3389\/fphar.2018.00245","article-title":"Adverse effects of cancer chemotherapy: Anything new to improve tolerance and reduce sequelae?","volume":"9","author":"Nurgali","year":"2018","journal-title":"Front. Pharmacol."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1086\/599346","article-title":"Chemotherapy Treatment in Pediatric Patients with Acute Myeloid Leukemia Receiving Antimicrobial Prophylaxis Leads to a Relative Increase of Colonization with Potentially Pathogenic Bacteria in the Gut","volume":"49","author":"Tissing","year":"2009","journal-title":"Clin. Infect. Dis."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1186\/s13046-020-01715-7","article-title":"Oral mucositis: The hidden side of cancer therapy","volume":"39","author":"Pulito","year":"2020","journal-title":"J. Exp. Clin. Cancer Res."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1038\/nrc1318","article-title":"The pathobiology of mucositis","volume":"4","author":"Sonis","year":"2004","journal-title":"Nat. Rev. Cancer"},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1515\/jcim-2016-0043","article-title":"Alleviation of 5-fluorouracil-induced intestinal mucositis in rats by vitamin E via targeting oxidative stress and inflammatory markers","volume":"13","author":"Khan","year":"2016","journal-title":"J. Complement. Integr. Med."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"750507","DOI":"10.3389\/fphar.2022.750507","article-title":"Mechanisms of chemotherapy-induced neurotoxicity","volume":"13","author":"Was","year":"2022","journal-title":"Front. Pharmacol."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"65","DOI":"10.3892\/ijmm.2022.5121","article-title":"Molecular pathways associated with oxidative stress and their potential applications in radiotherapy","volume":"49","author":"Liu","year":"2022","journal-title":"Int. J. Mol. Med."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"21469","DOI":"10.18632\/oncotarget.7412","article-title":"Mitochondrial stress controls the radiosensitivity of the oxygen effect: Implications for radiotherapy","volume":"7","author":"Richardson","year":"2016","journal-title":"Oncotarget"},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/S0009-2797(02)00052-2","article-title":"Idiosyncratic NSAID drug induced oxidative stress","volume":"142","author":"Galati","year":"2002","journal-title":"Chem.-Biol. Interact."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"11501","DOI":"10.1021\/jf202621d","article-title":"Apple peel polyphenol extract protects against indomethacin-induced damage in Caco-2 cells by preventing mitochondrial complex I inhibition","volume":"59","author":"Gotteland","year":"2011","journal-title":"J. Agric. Food Chem."},{"key":"ref_105","first-page":"137","article-title":"Rebamipide attenuates nonsteroidal anti-inflammatory drugs (NSAID) induced lipid peroxidation by the manganese superoxide dismutase (MnSOD) overexpression in gastrointestinal epithelial cells","volume":"63","author":"Nagano","year":"2012","journal-title":"J. Physiol. Pharmacol."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"1163","DOI":"10.1023\/A:1018833503080","article-title":"Chronic intestinal pseudoobstruction associated with fetal alcohol syndrome","volume":"42","author":"Uc","year":"1997","journal-title":"Dig. Dis. Sci."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1089\/ars.2012.4580","article-title":"Oxidative damage in clinical ischemia\/reperfusion injury: A reappraisal","volume":"19","author":"Kortekaas","year":"2013","journal-title":"Antioxid. Redox Signal."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"14170","DOI":"10.1016\/S0021-9258(18)77283-9","article-title":"Proteolytic conversion of xanthine dehydrogenase from the NAD-dependent type to the O2-dependent type. Amino acid sequence of rat liver xanthine dehydrogenase and identification of the cleavage sites of the enzyme protein during irreversible conversion by trypsin","volume":"265","author":"Amaya","year":"1990","journal-title":"J. Biol. Chem."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1007\/s11357-997-0012-2","article-title":"Xanthine dehydrogenase\/xanthine oxidase and oxidative stress","volume":"20","author":"Chung","year":"1997","journal-title":"Age"},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1111\/j.1743-3150.2004.00558.x","article-title":"Mechanisms of postoperative ileus","volume":"16","author":"Bauer","year":"2004","journal-title":"Neurogastroenterol. Motil."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1097\/00000658-199811000-00004","article-title":"Surgical manipulation of the gut elicits an intestinal muscularis inflammatory response resulting in postsurgical ileus","volume":"228","author":"Kalff","year":"1998","journal-title":"Ann. Surg."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"G104","DOI":"10.1152\/ajpgi.00305.2017","article-title":"Role of transient receptor potential melastatin 2 in surgical inflammation and dysmotility in a mouse model of postoperative ileus","volume":"315","author":"Matsumoto","year":"2018","journal-title":"Am. J. Physiol.-Gastrointest. Liver Physiol."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.cmet.2005.12.001","article-title":"Mitochondrial medicine: A metabolic perspective on the pathology of oxidative phosphorylation disorders","volume":"3","author":"Smeitink","year":"2006","journal-title":"Cell Metab."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1016\/j.ydbio.2015.09.023","article-title":"Ibuprofen slows migration and inhibits bowel colonization by enteric nervous system precursors in zebrafish, chick and mouse","volume":"409","author":"Schill","year":"2016","journal-title":"Dev. Biol."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"1741","DOI":"10.1016\/S0140-6736(16)31711-1","article-title":"Crohn\u2019s Disease","volume":"389","author":"Torres","year":"2017","journal-title":"Lancet"},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"1756","DOI":"10.1016\/S0140-6736(16)32126-2","article-title":"Ulcerative Colitis","volume":"389","author":"Ungaro","year":"2017","journal-title":"Lancet"},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1111\/j.1463-1318.2006.00986.x","article-title":"Inflammatory bowel disease: The view of the surgeon","volume":"8","author":"Hancock","year":"2006","journal-title":"Color. Dis."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1186\/1742-2094-7-37","article-title":"Neuroinflammation in inflammatory bowel disease","volume":"7","author":"Lakhan","year":"2010","journal-title":"J. Neuroinflammation"},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1093\/ibd\/izaa161","article-title":"Inhibition of APE1\/Ref-1 redox signaling alleviates intestinal dysfunction and damage to myenteric neurons in a mouse model of spontaneous chronic colitis","volume":"27","author":"Sahakian","year":"2021","journal-title":"Inflamm. Bowel Dis."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"4535194","DOI":"10.1155\/2017\/4535194","article-title":"Pathomechanisms of oxidative stress in inflammatory bowel disease and potential antioxidant therapies","volume":"2017","author":"Tian","year":"2017","journal-title":"Oxidative Med. Cell. Longev."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"2015","DOI":"10.1007\/s10620-006-9622-2","article-title":"Oxidative stress and pathogenesis of inflammatory bowel disease: An epiphenomenon or the cause?","volume":"52","author":"Rezaie","year":"2007","journal-title":"Dig. Dis. Sci."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1016\/j.jpedsurg.2018.06.012","article-title":"New insights into necrotizing enterocolitis: From laboratory observation to personalized prevention and treatment","volume":"54","author":"Hackam","year":"2019","journal-title":"J. Pediatr. Surg."},{"key":"ref_123","doi-asserted-by":"crossref","unstructured":"Nogueira, N.P., Saraiva, F.M.S., Sultano, P.E., Cunha, P.R.B.B., Laranja, G.A.T., Justo, G.A., Sabino, K.C.C., Coelho, M.G.P., Rossini, A., and Atella, G.C. (2015). Proliferation and Differentiation of Trypanosoma cruzi inside Its Vector Have a New Trigger: Redox Status. PLoS ONE, 10.","DOI":"10.1371\/journal.pone.0116712"},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1007\/s11938-018-0173-3","article-title":"The Natural History of IBD: Lessons Learned","volume":"16","author":"Weimers","year":"2018","journal-title":"Curr. Treat. Options Gastroenterol."},{"key":"ref_125","doi-asserted-by":"crossref","unstructured":"Yalchin, M., Baker, A.M., Graham, T.A., and Hart, A. (2021). Predicting Colorectal Cancer Occurrence in IBD. Cancers, 13.","DOI":"10.3390\/cancers13122908"},{"key":"ref_126","first-page":"4759","article-title":"Colorectal carcinogenesis: Role of oxidative stress and antioxidants","volume":"37","author":"Carini","year":"2017","journal-title":"Anticancer Res."},{"key":"ref_127","doi-asserted-by":"crossref","unstructured":"Peng, D., Zaika, A., Que, J., and El-Rifai, W. (2021). The antioxidant response in Barrett\u2019s tumorigenesis: A double-edged sword. Redox Biol., 41.","DOI":"10.1016\/j.redox.2021.101894"},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1136\/gutjnl-2013-304612","article-title":"Glutathione peroxidase 7 has potential tumour suppressor functions that are silenced by location-specific methylation in oesophageal adenocarcinoma","volume":"63","author":"Peng","year":"2014","journal-title":"Gut"},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1136\/gut.2007.146290","article-title":"DNA hypermethylation regulates the expression of members of the Mu-class glutathione S-transferases and glutathione peroxidases in Barrett\u2019s adenocarcinoma","volume":"58","author":"Peng","year":"2009","journal-title":"Gut"},{"key":"ref_130","first-page":"111419","article-title":"Ultra-processed diet, systemic oxidative stress, and breach of immunologic tolerance","volume":"91\u201392","year":"2021","journal-title":"Nutrition"},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"1428","DOI":"10.2174\/1389450121666200516173242","article-title":"Targeting Enteric Neurons and Plexitis for the Management of Inflammatory Bowel Disease","volume":"21","author":"Stavely","year":"2020","journal-title":"Curr. Drug Targets"},{"key":"ref_132","doi-asserted-by":"crossref","unstructured":"Furness, J.B. (2006). The Enteric Nervous System, Blackwell Publishing.","DOI":"10.1002\/9780470988756"},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1146\/annurev-physiol-021317-121515","article-title":"Unexpected Roles for the Second Brain: Enteric Nervous System as Master Regulator of Bowel Function","volume":"81","author":"Schneider","year":"2019","journal-title":"Annu. Rev. Physiol."},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1038\/nrgastro.2012.32","article-title":"The Enteric Nervous System and Neurogastroenterology","volume":"9","author":"Furness","year":"2012","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/j.ydbio.2016.03.032","article-title":"Clinical aspects of neurointestinal disease: Pathophysiology, diagnosis, and treatment","volume":"417","author":"Goldstein","year":"2016","journal-title":"Dev. Biol."},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1038\/s41531-021-00263-x","article-title":"Enteric \u03b1-synuclein impairs intestinal epithelial barrier through caspase-1-inflammasome signaling in Parkinson\u2019s disease before brain pathology","volume":"8","author":"Pellegrini","year":"2022","journal-title":"NPJ Park. Dis."},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1186\/s40035-019-0146-z","article-title":"Constipation, deficit in colon contractions and alpha-synuclein inclusions within the colon precede motor abnormalities and neurodegeneration in the central nervous system in a mouse model of alpha-synucleinopathy","volume":"8","author":"Rota","year":"2019","journal-title":"Transl. Neurodegener."},{"key":"ref_138","unstructured":"Friedman, J. (2011). Oxidative Stress and Free Radical Damage in Neurology, Springer."},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"G893","DOI":"10.1152\/ajpgi.2000.279.5.G893","article-title":"Actions of reactive oxygen species on AH\/type 2 myenteric neurons in guinea pig distal colon","volume":"279","author":"Tamura","year":"2000","journal-title":"Am. J. Physiol.-Gastrointest. Liver Physiol."},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"3725","DOI":"10.1113\/jphysiol.2013.254136","article-title":"Oxidative stress disrupts purinergic neuromuscular transmission in the inflamed colon","volume":"591","author":"Roberts","year":"2013","journal-title":"J. Physiol."},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1111\/bph.14114","article-title":"Oxaliplatin-induced enteric neuronal loss and intestinal dysfunction is prevented by co-treatment with BGP-15","volume":"175","author":"McQuade","year":"2018","journal-title":"Br. J. Pharmacol."},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"1082","DOI":"10.1096\/fj.09-139519","article-title":"Enteric glial cells protect neurons from oxidative stress in part via reduced glutathione","volume":"24","author":"Abdo","year":"2010","journal-title":"Faseb J."},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"G39","DOI":"10.1152\/ajpgi.00165.2017","article-title":"The antioxidant glutathione protects against enteric neuron death in situ, but its depletion is protective during colitis","volume":"314","author":"Brown","year":"2018","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1111\/j.1365-2982.2005.00703.x","article-title":"Indiscriminate loss of myenteric neurones in the TNBS-inflamed guinea-pig distal colon","volume":"17","author":"Linden","year":"2005","journal-title":"Neurogastroenterol. Motil."},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"G295","DOI":"10.1152\/ajpgi.00052.2013","article-title":"Paradoxical regulation of ChAT and nNOS expression in animal models of Crohn\u2019s colitis and ulcerative colitis","volume":"305","author":"Winston","year":"2013","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13287-015-0231-x","article-title":"Human adult stem cells derived from adipose tissue and bone marrow attenuate enteric neuropathy in the guinea-pig model of acute colitis","volume":"6","author":"Stavely","year":"2015","journal-title":"Stem Cell Res. Ther."},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1186\/s13287-015-0254-3","article-title":"Allogeneic guinea pig mesenchymal stem cells ameliorate neurological changes in experimental colitis","volume":"6","author":"Stavely","year":"2015","journal-title":"Stem Cell Res. Ther."},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"73","DOI":"10.3389\/fncel.2016.00073","article-title":"Sirtuin-3 Is Expressed by Enteric Neurons but It Does not Play a Major Role in Their Regulation of Oxidative Stress","volume":"10","author":"Bubenheimer","year":"2016","journal-title":"Front. Cell. Neurosci."},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1113\/jphysiol.2010.197707","article-title":"Morphological and functional changes in guinea-pig neurons projecting to the ileal mucosa at early stages after inflammatory damage","volume":"589","author":"Nurgali","year":"2011","journal-title":"J. Physiol."},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1007\/s00441-008-0684-7","article-title":"Immunohistochemical analysis of neuron types in the mouse small intestine","volume":"334","author":"Qu","year":"2008","journal-title":"Cell Tissue Res."},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"30","DOI":"10.3389\/fnins.2013.00030","article-title":"Effects of oxaliplatin on mouse myenteric neurons and colonic motility","volume":"7","author":"Wafai","year":"2013","journal-title":"Front. Neurosci."},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"1536","DOI":"10.1002\/ar.21192","article-title":"Chronic alcohol consumption affects gastrointestinal motility and reduces the proportion of neuronal NOS-immunoreactive myenteric neurons in the murine jejunum","volume":"293","author":"Krecsmarik","year":"2010","journal-title":"Anat. Record"},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1016\/j.diabres.2007.12.013","article-title":"Immediate insulin treatment prevents gut motility alterations and loss of nitrergic neurons in the ileum and colon of rats with streptozotocin-induced diabetes","volume":"80","author":"Wittman","year":"2008","journal-title":"Diabetes Res. Clin. Pract."},{"key":"ref_154","doi-asserted-by":"crossref","unstructured":"B\u00f3di, N., Szalai, Z., and Bagy\u00e1nszki, M. (2019). Nitrergic Enteric Neurons in Health and Disease-Focus on Animal Models. Int. J. Mol. Sci., 20.","DOI":"10.3390\/ijms20082003"},{"key":"ref_155","doi-asserted-by":"crossref","first-page":"964-e411","DOI":"10.1111\/j.1365-2982.2011.01778.x","article-title":"Selective responses of myenteric neurons to oxidative stress and diabetic stimuli","volume":"23","author":"Voukali","year":"2011","journal-title":"Neurogastroenterol. Motil."},{"key":"ref_156","doi-asserted-by":"crossref","first-page":"6962","DOI":"10.1523\/JNEUROSCI.22-16-06962.2002","article-title":"Mitochondrial Ca2+ uptake regulates the excitability of myenteric neurons","volume":"22","author":"Berghe","year":"2002","journal-title":"J. Neurosci."},{"key":"ref_157","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1016\/j.bbabio.2010.02.016","article-title":"Redox-optimized ROS balance: A unifying hypothesis","volume":"1797","author":"Aon","year":"2010","journal-title":"Biochim. Biophys. Acta"},{"key":"ref_158","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1007\/s10495-021-01661-5","article-title":"New insights into targeting mitochondria in ischemic injury","volume":"26","author":"Jia","year":"2021","journal-title":"Apoptosis"},{"key":"ref_159","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1203\/01.pdr.0000239817.39407.61","article-title":"The effect of hyperoxia on reactive oxygen species (ROS) in rat petrosal ganglion neurons during development using organotypic slices","volume":"60","author":"Kwak","year":"2006","journal-title":"Pediatr. Res."},{"key":"ref_160","doi-asserted-by":"crossref","first-page":"1030","DOI":"10.1152\/jn.01003.2006","article-title":"Superoxide (O2.\u2212) production in CA1 neurons of rat hippocampal slices exposed to graded levels of oxygen","volume":"98","author":"Putnam","year":"2007","journal-title":"J. Neurophysiol."},{"key":"ref_161","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1042\/BJ20081386","article-title":"How mitochondria produce reactive oxygen species","volume":"417","author":"Murphy","year":"2009","journal-title":"Biochem. J."},{"key":"ref_162","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.neuroscience.2014.03.017","article-title":"Normobaric hyperoxia (95% O2) stimulates CO2-sensitive and CO2-insensitive neurons in the caudal solitary complex of rat medullary tissue slices maintained in 40% O2","volume":"270","author":"Matott","year":"2014","journal-title":"Neuroscience"},{"key":"ref_163","doi-asserted-by":"crossref","first-page":"1142","DOI":"10.1007\/s11064-007-9282-4","article-title":"Effect of hyperoxia on cortical neuronal nuclear function and programmed cell death mechanisms","volume":"32","author":"Chang","year":"2007","journal-title":"Neurochem. Res."},{"key":"ref_164","doi-asserted-by":"crossref","unstructured":"Wang, J., Xiao, J., Meng, X., Chu, X., Zhuansun, D.D., Xiong, B., and Feng, J. (2021). NOX5 is expressed aberrantly but not a critical pathogenetic gene in Hirschsprung disease. BMC Pediatr., 21.","DOI":"10.1186\/s12887-021-02611-5"},{"key":"ref_165","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1016\/j.redox.2015.08.010","article-title":"Calcium and ROS: A mutual interplay","volume":"6","author":"Bertram","year":"2015","journal-title":"Redox Biol."},{"key":"ref_166","doi-asserted-by":"crossref","first-page":"C1","DOI":"10.1152\/ajpcell.1998.275.1.C1","article-title":"Interaction of reactive oxygen species with ion transport mechanisms","volume":"275","author":"Kourie","year":"1998","journal-title":"Am. J. Physiol.-Cell Physiol."},{"key":"ref_167","doi-asserted-by":"crossref","first-page":"2563","DOI":"10.4103\/1673-5374.339473","article-title":"The \u201cmitochondrial stress responses\u201d: The \u201cDr. Jekyll and Mr. Hyde\u201d of neuronal disorders","volume":"17","author":"Patergnani","year":"2022","journal-title":"Neural Regen. Res."},{"key":"ref_168","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1097\/01.nrl.0000106919.06469.04","article-title":"Mitochondrial neurogastrointestinal encephalomyopathy (MNGIE): A disease of two genomes","volume":"10","author":"Hirano","year":"2004","journal-title":"Neurologist"},{"key":"ref_169","doi-asserted-by":"crossref","first-page":"1529","DOI":"10.1016\/S0006-2952(03)00067-4","article-title":"Rabbit chronic ileitis leads to up-regulation of adenosine A1\/A3 gene products, oxidative stress, and immune modulation","volume":"65","author":"Sundaram","year":"2003","journal-title":"Biochem. Pharmacol."},{"key":"ref_170","doi-asserted-by":"crossref","first-page":"G41","DOI":"10.1152\/ajpgi.00358.2010","article-title":"Differential immune and genetic responses in rat models of Crohn\u2019s colitis and ulcerative colitis","volume":"300","author":"Shi","year":"2010","journal-title":"Am. J. Physiol.-Gastrointest. Liver Physiol."},{"key":"ref_171","doi-asserted-by":"crossref","first-page":"G768","DOI":"10.1152\/ajpgi.00036.2016","article-title":"Prucalopride exerts neuroprotection in human enteric neurons","volume":"310","author":"Bianco","year":"2016","journal-title":"Am. J. Physiol.-Gastrointest. Liver Physiol."},{"key":"ref_172","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/j.neulet.2012.04.036","article-title":"Differing effects of NT-3 and GDNF on dissociated enteric ganglion cells exposed to hydrogen peroxide in vitro","volume":"517","author":"Korsak","year":"2012","journal-title":"Neurosci. Lett."},{"key":"ref_173","doi-asserted-by":"crossref","first-page":"G228","DOI":"10.1152\/ajpgi.90705.2008","article-title":"Discrete responses of myenteric neurons to structural and functional damage by neurotoxins in vitro","volume":"297","author":"Lourenssen","year":"2009","journal-title":"Am. J. Physiol.-Gastrointest. Liver Physiol."},{"key":"ref_174","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.ejphar.2009.04.066","article-title":"Effects of H2O2 at rat myenteric neurones in culture","volume":"615","author":"Pouokam","year":"2009","journal-title":"Eur. J. Pharmacol."},{"key":"ref_175","doi-asserted-by":"crossref","unstructured":"Gong, G., Xiang, L., Yuan, L., Hu, L., Wu, W., Cai, L., Yin, L., and Dong, H. (2014). Protective effect of glycyrrhizin, a direct HMGB1 inhibitor, on focal cerebral ischemia\/reperfusion-induced inflammation, oxidative stress, and apoptosis in rats. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0089450"},{"key":"ref_176","doi-asserted-by":"crossref","first-page":"22076","DOI":"10.1038\/s41598-022-26634-9","article-title":"SIRT3 activation promotes enteric neurons survival and differentiation","volume":"12","author":"Balasubramaniam","year":"2022","journal-title":"Sci. Rep."},{"key":"ref_177","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1007\/978-3-031-05843-1_21","article-title":"Molecular Targets to Alleviate Enteric Neuropathy and Gastrointestinal Dysfunction","volume":"1383","author":"Sahakian","year":"2022","journal-title":"Adv. Exp. Med. Biol."},{"key":"ref_178","first-page":"1","article-title":"Colitis promotes neuronal differentiation of Sox2+ and PLP1+ enteric cells","volume":"7","author":"Graham","year":"2017","journal-title":"Sci. Rep."},{"key":"ref_179","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1097\/MIB.0000000000000326","article-title":"Colitis Induces Enteric Neurogenesis Through a 5-HT4\u2013dependent Mechanism","volume":"21","author":"Hotta","year":"2015","journal-title":"Inflamm. Bowel Dis."},{"key":"ref_180","unstructured":"Huang, T.-T., Zou, Y., and Corniola, R. (2012). Seminars in Cell & Developmental Biology, Academic Press."}],"container-title":["Biomolecules"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2218-273X\/13\/11\/1586\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T21:12:57Z","timestamp":1760130777000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2218-273X\/13\/11\/1586"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,10,27]]},"references-count":180,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2023,11]]}},"alternative-id":["biom13111586"],"URL":"https:\/\/doi.org\/10.3390\/biom13111586","relation":{},"ISSN":["2218-273X"],"issn-type":[{"value":"2218-273X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,10,27]]}}}