{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T02:41:05Z","timestamp":1783564865397,"version":"3.55.0"},"reference-count":181,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2023,11,13]],"date-time":"2023-11-13T00:00:00Z","timestamp":1699833600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Research Foundation of Korea (NRF)","award":["2017R1A5A2015391"],"award-info":[{"award-number":["2017R1A5A2015391"]}]},{"name":"National Research Foundation of Korea (NRF)","award":["2022R1C1C1006181"],"award-info":[{"award-number":["2022R1C1C1006181"]}]},{"name":"National Research Foundation of Korea (NRF)","award":["RS-2023-00208416"],"award-info":[{"award-number":["RS-2023-00208416"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biomolecules"],"abstract":"<jats:p>Oral lichen planus (OLP) is a chronic inflammatory disease that is characterized by the infiltration of T cells into the oral mucosa, causing the apoptosis of basal keratinocytes. OLP is a multifactorial disease of unknown etiology and is not solely caused by the malfunction of a single key gene but rather by various intracellular and extracellular factors. Non-coding RNAs play a critical role in immunological homeostasis and inflammatory response and are found in all cell types and bodily fluids, and their expression is closely regulated to preserve normal physiologies. The dysregulation of non-coding RNAs may be highly implicated in the onset and progression of diverse inflammatory disorders, including OLP. This narrative review summarizes the role of non-coding RNAs in molecular and cellular changes in the oral epithelium during OLP pathogenesis.<\/jats:p>","DOI":"10.3390\/biom13111646","type":"journal-article","created":{"date-parts":[[2023,11,13]],"date-time":"2023-11-13T08:35:52Z","timestamp":1699864552000},"page":"1646","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Non-Coding RNAs as Potential Targets for Diagnosis and Treatment of Oral Lichen Planus: A Narrative Review"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1991-995X","authenticated-orcid":false,"given":"Tae-Jun","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Pharmacology, School of Dentistry, Kyungpook National University, Daegu 41940, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu Gyung","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, School of Dentistry, Kyungpook National University, Daegu 41940, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8728-8013","authenticated-orcid":false,"given":"Won","family":"Jung","sequence":"additional","affiliation":[{"name":"Department of Oral Medicine, Institute of Oral Bioscience, School of Dentistry, Jeonbuk National University, Jeonju 54896, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6144-6899","authenticated-orcid":false,"given":"Sungil","family":"Jang","sequence":"additional","affiliation":[{"name":"Department of Oral Biochemistry, Institute of Oral Bioscience, School of Dentistry, Jeonbuk National University, Jeonju 54896, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyoung-Gon","family":"Ko","sequence":"additional","affiliation":[{"name":"Department of Anatomy and Neurobiology, School of Dentistry, Kyungpook National University, Daegu 41940, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1503-3476","authenticated-orcid":false,"given":"Chan Ho","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Dental Biomaterials, School of Dentistry, Kyungpook National University, Daegu 41940, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin-Seok","family":"Byun","sequence":"additional","affiliation":[{"name":"Department of Oral Medicine, School of Dentistry, Kyungpook National University, Daegu 41940, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2200-7396","authenticated-orcid":false,"given":"Do-Yeon","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, School of Dentistry, Kyungpook National University, Daegu 41940, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,11,13]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1111\/odi.13323","article-title":"Worldwide prevalence of oral lichen planus: A systematic review and meta-analysis","volume":"27","author":"Warnakulasuriya","year":"2021","journal-title":"Oral Dis."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.oraloncology.2019.07.012","article-title":"Malignant transformation risk of oral lichen planus: A systematic review and comprehensive meta-analysis","volume":"96","author":"Ayen","year":"2019","journal-title":"Oral Oncol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1001\/jamadermatol.2019.3797","article-title":"Global Prevalence and Incidence Estimates of Oral Lichen Planus: A Systematic Review and Meta-analysis","volume":"156","author":"Li","year":"2020","journal-title":"JAMA Dermatol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"101354","DOI":"10.1016\/j.jormas.2022.101354","article-title":"Gingival lichen planus: A clinical and pathological study","volume":"124","author":"Keller","year":"2023","journal-title":"J. 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