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Although the exact mechanisms are not fully understood, aging-related processes like inflammation, oxidative stress, reduced mitochondrial capacity, and cell apoptosis contribute to this decline. Disruption of the circadian system with age may initiate these pathways in skeletal muscle, preceding the onset of sarcopenia. At present, there is no pharmacological treatment for sarcopenia, only resistance exercise and proper nutrition may delay its onset. Melatonin, derived from tryptophan, emerges as an exceptional candidate for treating sarcopenia due to its chronobiotic, antioxidant, and anti-inflammatory properties. Its impact on mitochondria and organelle, where it is synthesized and crucial in aging skeletal muscle, further highlights its potential. In this review, we discuss the influence of clock genes in muscular aging, with special reference to peripheral clock genes in the skeletal muscle, as well as their relationship with melatonin, which is proposed as a potential therapy against sarcopenia.<\/jats:p>","DOI":"10.3390\/biom13121779","type":"journal-article","created":{"date-parts":[[2023,12,12]],"date-time":"2023-12-12T04:28:31Z","timestamp":1702355311000},"page":"1779","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["From Chronodisruption to Sarcopenia: The Therapeutic Potential of Melatonin"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5593-6733","authenticated-orcid":false,"given":"Jos\u00e9","family":"Fern\u00e1ndez-Mart\u00ednez","sequence":"first","affiliation":[{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica, Facultad de Medicina, Departamento de Fisiolog\u00eda, Instituto de Biotecnolog\u00eda, Parque Tecnol\u00f3gico de Ciencias de la Salud, Universidad de Granada, 18016 Granada, Spain"},{"name":"Instituto de Investigaci\u00f3n Biosanitaria (Ibs.Granada), Hospital Universitario San Cecilio, 18016 Granada, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5855-0449","authenticated-orcid":false,"given":"Yolanda","family":"Ram\u00edrez-Casas","sequence":"additional","affiliation":[{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica, Facultad de Medicina, Departamento de Fisiolog\u00eda, Instituto de Biotecnolog\u00eda, Parque Tecnol\u00f3gico de Ciencias de la Salud, Universidad de Granada, 18016 Granada, Spain"},{"name":"Instituto de Investigaci\u00f3n Biosanitaria (Ibs.Granada), Hospital Universitario San Cecilio, 18016 Granada, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yang","family":"Yang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Resource Biology and Biotechnology in 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Tecnol\u00f3gico de Ciencias de la Salud, Universidad de Granada, 18016 Granada, Spain"},{"name":"Instituto de Investigaci\u00f3n Biosanitaria (Ibs.Granada), Hospital Universitario San Cecilio, 18016 Granada, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1256-7656","authenticated-orcid":false,"given":"Germaine","family":"Escames","sequence":"additional","affiliation":[{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica, Facultad de Medicina, Departamento de Fisiolog\u00eda, Instituto de Biotecnolog\u00eda, Parque Tecnol\u00f3gico de Ciencias de la Salud, Universidad de Granada, 18016 Granada, Spain"},{"name":"Instituto de Investigaci\u00f3n Biosanitaria (Ibs.Granada), Hospital Universitario San Cecilio, 18016 Granada, Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Fragilidad y Envejecimiento Saludable (CIBERFES), Instituto de Salud Carlos III (ISCIII), 28029 Madrid, 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