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University","award":["2023815107"],"award-info":[{"award-number":["2023815107"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biomolecules"],"abstract":"<jats:p>Acute pancreatitis (AP) is a common acute abdomen disease characterized by the pathological activation of digestive enzymes and the self-digestion of pancreatic acinar cells. Secondary infection and sepsis are independent prognosticators for AP progression and increased mortality. Accumulating anatomical and epidemiological evidence suggests that the dysbiosis of gut microbiota affects the etiology and severity of AP through intestinal barrier disruption, local or systemic inflammatory response, bacterial translocation, and the regulatory role of microbial metabolites in AP patients and animal models. Recent studies discussing the interactions between gut microbiota and the pancreas have opened new scopes for AP, and new therapeutic interventions that target the bacteria community have received substantial attention. This review concentrates on the alterations of gut microbiota and its roles in modulating gut\u2013pancreas axis in AP. The potential therapies of targeting microbes as well as the major challenges of applying those interventions are explored. We expect to understand the roles of microbes in AP diagnosis and treatment.<\/jats:p>","DOI":"10.3390\/biom14010059","type":"journal-article","created":{"date-parts":[[2023,12,31]],"date-time":"2023-12-31T10:01:06Z","timestamp":1704016866000},"page":"59","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":58,"title":["The Interaction of Microbiome and Pancreas in Acute Pancreatitis"],"prefix":"10.3390","volume":"14","author":[{"given":"Can","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Pancreatic and Biliary Surgery, The First Affiliated Hospital of Harbin Medical University, Harbin 150001, China"},{"name":"Key Laboratory of Hepatosplenic Surgery, Ministry of Education, Harbin 150001, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guanqun","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Pancreatic and Biliary Surgery, The First Affiliated Hospital of Harbin Medical University, Harbin 150001, China"},{"name":"Key Laboratory of Hepatosplenic Surgery, Ministry of Education, Harbin 150001, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianqi","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Pancreatic and Biliary Surgery, The First Affiliated Hospital of Harbin Medical University, Harbin 150001, China"},{"name":"Key Laboratory of Hepatosplenic Surgery, Ministry of Education, Harbin 150001, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liwei","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Pancreatic and Biliary Surgery, The First Affiliated Hospital of Harbin Medical University, Harbin 150001, China"},{"name":"Key Laboratory of Hepatosplenic Surgery, Ministry of Education, Harbin 150001, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuhang","family":"Sui","sequence":"additional","affiliation":[{"name":"Department of Pancreatic and Biliary Surgery, The First Affiliated Hospital of Harbin Medical University, Harbin 150001, China"},{"name":"Key Laboratory of Hepatosplenic Surgery, Ministry of Education, Harbin 150001, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Bai","sequence":"additional","affiliation":[{"name":"Department of Pancreatic and Biliary Surgery, The First Affiliated Hospital of Harbin Medical University, Harbin 150001, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5610-2343","authenticated-orcid":false,"given":"Le","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Pancreatic and Biliary Surgery, The First Affiliated Hospital of Harbin Medical University, Harbin 150001, China"},{"name":"Key Laboratory of Hepatosplenic Surgery, Ministry of Education, Harbin 150001, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bei","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Pancreatic and Biliary Surgery, The First Affiliated Hospital of Harbin Medical University, Harbin 150001, China"},{"name":"Key Laboratory of Hepatosplenic Surgery, Ministry of Education, Harbin 150001, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,12,31]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1038\/s41575-019-0158-2","article-title":"New insights into acute pancreatitis","volume":"16","author":"Lee","year":"2019","journal-title":"Nat. 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