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Brevican is integral to the formation of the ECM\u2019s neuroprotective perineuronal nets (PNNs). Decreased brevican levels were reported in vascular dementia (VaD) but not in Alzheimer\u2019s disease (AD). However, the status of brevican in clinical cohorts with high concomitance of AD pathological burden and cerebrovascular disease (CeVD) is unclear. In this study, 32 non-cognitively impaired (NCI), 97 cognitively impaired no dementia (CIND), 46 AD, and 23 VaD participants recruited from memory clinics based in Singapore underwent neuropsychological and neuroimaging assessments, together with measurements of serum brevican. Association analyses were performed between serum brevican and neuroimaging measures of CeVDs, including white matter hyperintensities (WMHs), lacunes, cortical infarcts, and cerebral microbleeds. Using an aggregated score for CeVD burden, only CIND participants showed lower brevican levels with higher CeVD compared to those with lower CeVD burden (p = 0.006). Among the CeVD subtypes assessed, only elevated WMH burden was associated with lower brevican levels (OR = 2.7; 95% CI = 1.3\u20135.5). Our findings suggest that brevican deficits may play a role in early cerebrovascular damage in participants at risk of developing dementia.<\/jats:p>","DOI":"10.3390\/biom14010075","type":"journal-article","created":{"date-parts":[[2024,1,8]],"date-time":"2024-01-08T07:59:20Z","timestamp":1704700760000},"page":"75","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Serum Brevican as a Biomarker of Cerebrovascular Disease in an Elderly Cognitively Impaired Cohort"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-0466-1967","authenticated-orcid":false,"given":"Rachel S. L.","family":"Chia","sequence":"first","affiliation":[{"name":"Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117600, Singapore"},{"name":"Memory Aging and Cognition Centre, National University Health System, Singapore 117600, Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karolina","family":"Minta","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117600, Singapore"},{"name":"Future Health Technologies, Singapore\u2013ETH Centre, Campus for Research Excellence and Technological Enterprise (CREATE), Singapore 138602, Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6504-638X","authenticated-orcid":false,"given":"Liu-Yun","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117600, Singapore"},{"name":"Memory Aging and Cognition Centre, National University Health System, Singapore 117600, Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-3615-0874","authenticated-orcid":false,"given":"Kaung H. T.","family":"Salai","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117600, Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuek Ling","family":"Chai","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117600, Singapore"},{"name":"Memory Aging and Cognition Centre, National University Health System, Singapore 117600, Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Saima","family":"Hilal","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117600, Singapore"},{"name":"Memory Aging and Cognition Centre, National University Health System, Singapore 117600, Singapore"},{"name":"Saw Swee Hock School of Public Health, National University of Singapore, Singapore 117597, Singapore"},{"name":"Departments of Epidemiology and Radiology & Nuclear Medicine, Erasmus University Medical Center, 3015 GD Rotterdam, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3593-6362","authenticated-orcid":false,"given":"Narayanaswamy","family":"Venketasubramanian","sequence":"additional","affiliation":[{"name":"Raffles Neuroscience Centre, Raffles Hospital, Singapore 188770, Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher P.","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117600, Singapore"},{"name":"Memory Aging and Cognition Centre, National University Health System, Singapore 117600, Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joyce R.","family":"Chong","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117600, Singapore"},{"name":"Memory Aging and Cognition Centre, National University Health System, Singapore 117600, Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7685-1424","authenticated-orcid":false,"given":"Mitchell K. P.","family":"Lai","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117600, Singapore"},{"name":"Memory Aging and Cognition Centre, National University Health System, Singapore 117600, Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,1,7]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"McAleese, K.E., Alafuzoff, I., Charidimou, A., De Reuck, J., Grinberg, L.T., Hainsworth, A.H., Hortobagyi, T., Ince, P., Jellinger, K., and Gao, J. (2016). Post-mortem assessment in vascular dementia: Advances and aspirations. 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