{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T01:35:42Z","timestamp":1788572142646,"version":"build-2803163510"},"reference-count":157,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2024,1,15]],"date-time":"2024-01-15T00:00:00Z","timestamp":1705276800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Bio and Medical Technology Development Program of the National Research Foundation of Korea","award":["NRF-2022M3E5E8081191"],"award-info":[{"award-number":["NRF-2022M3E5E8081191"]}]},{"name":"Bio and Medical Technology Development Program of the National Research Foundation of Korea","award":["NRF-2022R1F1A1076127"],"award-info":[{"award-number":["NRF-2022R1F1A1076127"]}]},{"name":"National Research Foundation of Korea","award":["NRF-2022M3E5E8081191"],"award-info":[{"award-number":["NRF-2022M3E5E8081191"]}]},{"name":"National Research Foundation of Korea","award":["NRF-2022R1F1A1076127"],"award-info":[{"award-number":["NRF-2022R1F1A1076127"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biomolecules"],"abstract":"<jats:p>Chronic itch is a debilitating condition with limited treatment options, severely affecting quality of life. The identification of pruriceptors has sparked a growing interest in the therapeutic potential of TRP channels in the context of itch. In this regard, we provided a comprehensive overview of the site-specific expression of TRP channels and their associated functions in response to a range of pruritogens. Although several potent antipruritic compounds that target specific TRP channels have been developed and have demonstrated efficacy in various chronic itch conditions through experimental means, a more thorough understanding of the potential for adverse effects or interactions with other TRP channels or GPCRs is necessary to develop novel and selective therapeutics that target TRP channels for treating chronic itch. This review focuses on the mechanism of itch associated with TRP channels at specific sites, from the skin to the sensory neuron, with the aim of suggesting specific therapeutic targets for treating this condition.<\/jats:p>","DOI":"10.3390\/biom14010107","type":"journal-article","created":{"date-parts":[[2024,1,15]],"date-time":"2024-01-15T04:03:26Z","timestamp":1705291406000},"page":"107","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Site-Specific Transient Receptor Potential Channel Mechanisms and Their Characteristics for Targeted Chronic Itch Treatment"],"prefix":"10.3390","volume":"14","author":[{"given":"Eun Jin","family":"Go","sequence":"first","affiliation":[{"name":"Gachon Pain Center and Department of Physiology, College of Medicine, Gachon University, Incheon 21999, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji Yeon","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Pain Medicine, Gil Medical Center, Gachon University, Incheon 21565, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8704-3553","authenticated-orcid":false,"given":"Yong Ho","family":"Kim","sequence":"additional","affiliation":[{"name":"Gachon Pain Center and Department of Physiology, College of Medicine, Gachon University, Incheon 21999, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4152-3022","authenticated-orcid":false,"given":"Chul-Kyu","family":"Park","sequence":"additional","affiliation":[{"name":"Gachon Pain Center and Department of Physiology, College of Medicine, Gachon University, Incheon 21999, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,1,15]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"291","DOI":"10.2340\/00015555-0305","article-title":"Clinical classification of itch: A position paper of the International Forum for the Study of Itch","volume":"87","author":"Stander","year":"2007","journal-title":"Acta Derm. 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