{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T20:50:27Z","timestamp":1788468627530,"version":"build-2803163510"},"reference-count":145,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2024,1,22]],"date-time":"2024-01-22T00:00:00Z","timestamp":1705881600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Inserm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biomolecules"],"abstract":"<jats:p>Apoptosis, or programmed cell death, is a fundamental process that maintains tissue homeostasis, eliminates damaged or infected cells, and plays a crucial role in various biological phenomena. The deregulation of apoptosis is involved in many human diseases, including cancer. One of the emerging players in the intricate regulatory network of apoptosis is apoptosis inhibitor 5 (API5), also called AAC-11 (anti-apoptosis clone 11) or FIF (fibroblast growth factor-2 interacting factor). While it may not have yet the same level of notoriety as some other cancer-associated proteins, API5 has garnered increasing attention in the cancer field in recent years, as elevated API5 levels are often associated with aggressive tumor behavior, resistance to therapy, and poor patient prognosis. This review aims to shed light on the multifaceted functions and regulatory mechanisms of API5 in cell fate decisions as well as its interest as therapeutic target in cancer.<\/jats:p>","DOI":"10.3390\/biom14010136","type":"journal-article","created":{"date-parts":[[2024,1,22]],"date-time":"2024-01-22T05:42:31Z","timestamp":1705902151000},"page":"136","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Apoptosis Inhibitor 5: A Multifaceted Regulator of Cell Fate"],"prefix":"10.3390","volume":"14","author":[{"given":"Hafsia","family":"Abbas","sequence":"first","affiliation":[{"name":"Universit\u00e9 Oran 1, Ahmed Ben Bella, Oran 31000, Algeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dalia Kheira","family":"Derkaoui","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Oran 1, Ahmed Ben Bella, Oran 31000, Algeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Louise","family":"Jeammet","sequence":"additional","affiliation":[{"name":"Jalon Therapeutics, 75010 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emilie","family":"Adic\u00e9am","sequence":"additional","affiliation":[{"name":"Jalon Therapeutics, 75010 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00e9r\u00f4me","family":"Tiollier","sequence":"additional","affiliation":[{"name":"Jalon Therapeutics, 75010 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H\u00e9l\u00e8ne","family":"Sicard","sequence":"additional","affiliation":[{"name":"Jalon Therapeutics, 75010 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thorsten","family":"Braun","sequence":"additional","affiliation":[{"name":"Laboratoire de Transfert des Leuc\u00e9mies, EA3518, Institut de Recherche Saint Louis, H\u00f4pital Saint Louis, Universit\u00e9 de Paris, 75010 Paris, France"},{"name":"AP-HP, Service d\u2019H\u00e9matologie Clinique, H\u00f4pital Avicenne, Universit\u00e9 Paris XIII, 93000 Bobigny, France"},{"name":"OPALE Carnot Institute, The Organization for Partnerships in Leukemia, H\u00f4pital Saint-Louis, 75010 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3747-255X","authenticated-orcid":false,"given":"Jean-Luc","family":"Poyet","sequence":"additional","affiliation":[{"name":"INSERM UMRS976, Institut de Recherche Saint Louis, H\u00f4pital Saint Louis, 75010 Paris, France"},{"name":"Universit\u00e9 Paris Cit\u00e9, 75015 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,1,22]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1007\/s00277-005-1065-x","article-title":"Apoptosis: Mechanisms and relevance in cancer","volume":"84","author":"Vermeulen","year":"2005","journal-title":"Ann. 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