{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T00:26:03Z","timestamp":1781223963870,"version":"3.54.1"},"reference-count":180,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2024,2,18]],"date-time":"2024-02-18T00:00:00Z","timestamp":1708214400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biomolecules"],"abstract":"<jats:p>Chronic pancreatitis (CP) is the end-stage of continuous inflammation and fibrosis in the pancreas evolving from acute- to recurrent acute-, early, and, finally, end-stage CP. Currently, prevention is the only way to reduce disease burden. In this setting, early detection is of great importance. Due to the anatomy and risks associated with direct sampling from pancreatic tissue, most of our information on the human pancreas arises from circulating biomarkers thought to be involved in pancreatic pathophysiology or injury. The present review provides the status of circulating biomarkers involved in the development of and progression to CP.<\/jats:p>","DOI":"10.3390\/biom14020239","type":"journal-article","created":{"date-parts":[[2024,2,19]],"date-time":"2024-02-19T05:39:56Z","timestamp":1708321196000},"page":"239","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Circulating Biomarkers Involved in the Development of and Progression to Chronic Pancreatitis\u2014A Literature Review"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-2605-107X","authenticated-orcid":false,"given":"Valborg Vang","family":"Poulsen","sequence":"first","affiliation":[{"name":"Pancreatitis Center East, Gastrounit, Copenhagen University Hospital\u2014Amager and Hvidovre, 2000 Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9481-6021","authenticated-orcid":false,"given":"Amer","family":"Hadi","sequence":"additional","affiliation":[{"name":"Pancreatitis Center East, Gastrounit, Copenhagen University Hospital\u2014Amager and Hvidovre, 2000 Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9980-1072","authenticated-orcid":false,"given":"Mikkel Parsberg","family":"Werge","sequence":"additional","affiliation":[{"name":"Pancreatitis Center East, Gastrounit, Copenhagen University Hospital\u2014Amager and Hvidovre, 2000 Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John G\u00e1sdal","family":"Karstensen","sequence":"additional","affiliation":[{"name":"Pancreatitis Center East, Gastrounit, Copenhagen University Hospital\u2014Amager and Hvidovre, 2000 Copenhagen, Denmark"},{"name":"Department of Clinical Medicine, University of Copenhagen, 2000 Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Srdan","family":"Novovic","sequence":"additional","affiliation":[{"name":"Pancreatitis Center East, Gastrounit, Copenhagen University Hospital\u2014Amager and Hvidovre, 2000 Copenhagen, Denmark"},{"name":"Department of Clinical Medicine, University of Copenhagen, 2000 Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,2,18]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1053\/j.gastro.2018.08.063","article-title":"Burden and Cost of Gastrointestinal, Liver, and Pancreatic Diseases in the United States: Update 2018","volume":"156","author":"Peery","year":"2019","journal-title":"Gastroenterology"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1007\/s00535-006-1945-4","article-title":"The M-ANNHEIM Classification of Chronic Pancreatitis: Introduction of a Unifying Classification System Based on a Review of Previous Classifications of the Disease","volume":"42","author":"Schneider","year":"2007","journal-title":"J. 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