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For many decades, cognitive and motoric decline has been explained by the very apparent deterioration of neurons in various regions of the brain and spinal cord. However, more recent studies show that disease progression is greatly influenced by the vast population of glial cells. Astrocytes are traditionally considered star-shaped cells on which neurons rely heavily for their optimal homeostasis and survival. Increasing amounts of evidence depict how astrocytes lose their supportive functions while simultaneously gaining toxic properties during neurodegeneration. Many of these changes are similar across various neurodegenerative diseases, and in this review, we highlight these commonalities. We discuss how astrocyte dysfunction drives neuronal demise across a wide range of neurodegenerative diseases, but rather than categorizing based on disease, we aim to provide an overview based on currently known mechanisms. As such, this review delivers a different perspective on the disease causes of neurodegeneration in the hope to encourage further cross-disease studies into shared disease mechanisms, which might ultimately disclose potentially common therapeutic entry points across a wide panel of neurodegenerative diseases.<\/jats:p>","DOI":"10.3390\/biom14030289","type":"journal-article","created":{"date-parts":[[2024,2,28]],"date-time":"2024-02-28T09:26:17Z","timestamp":1709112377000},"page":"289","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":37,"title":["Astrocytes: The Stars in Neurodegeneration?"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2776-2892","authenticated-orcid":false,"given":"Katarina","family":"Stoklund Dittlau","sequence":"first","affiliation":[{"name":"Department of Veterinary and Animal Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, 1870 Frederiksberg, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9480-2386","authenticated-orcid":false,"given":"Kristine","family":"Freude","sequence":"additional","affiliation":[{"name":"Department of Veterinary and Animal Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, 1870 Frederiksberg, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,2,28]]},"reference":[{"key":"ref_1","unstructured":"Lenhoss\u00e9k, M. (1895). Der Feinere Bau Des Nervensystems Im Lichte Neuester Forschung, Fischer\u2019s Medicinische Buchhandlung H. Kornfield. [2nd ed.]."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1038\/s41582-023-00822-1","article-title":"Functional Roles of Reactive Astrocytes in Neuroinflammation and Neurodegeneration","volume":"19","author":"Patani","year":"2023","journal-title":"Nat. Rev. Neurol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1038\/nature21029","article-title":"Neurotoxic Reactive Astrocytes Are Induced by Activated Microglia","volume":"541","author":"Liddelow","year":"2017","journal-title":"Nature"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"6391","DOI":"10.1523\/JNEUROSCI.6221-11.2012","article-title":"Genomic Analysis of Reactive Astrogliosis","volume":"32","author":"Zamanian","year":"2012","journal-title":"J. Neurosci."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1152\/physrev.00042.2016","article-title":"Physiology of astroglia","volume":"98","author":"Verkhratsky","year":"2018","journal-title":"Physiol. Rev."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"4373","DOI":"10.1007\/s12035-020-02023-z","article-title":"The Role of Neurovascular System in Neurodegenerative Diseases","volume":"57","author":"Ahmad","year":"2020","journal-title":"Mol. Neurobiol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1126\/science.1222381","article-title":"Regional Astrocyte Allocation Regulates CNS Synaptogenesis and Repair","volume":"337","author":"Tsai","year":"2012","journal-title":"Science"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"17513","DOI":"10.1073\/pnas.0602841103","article-title":"Redefining the Concept of Reactive Astrocytes as Cells That Remain within Their Unique Domains upon Reaction to Injury","volume":"103","author":"Wilhelmsson","year":"2006","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1038\/s41593-020-0602-1","article-title":"Astrocyte Layers in the Mammalian Cerebral Cortex Revealed by a Single-Cell in Situ Transcriptomic Map","volume":"23","author":"Bayraktar","year":"2020","journal-title":"Nat. Neurosci."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1220","DOI":"10.1038\/s41467-019-14198-8","article-title":"Identification of Region-Specific Astrocyte Subtypes at Single Cell Resolution","volume":"11","author":"Batiuk","year":"2020","journal-title":"Nat. Commun."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"992","DOI":"10.1016\/j.neuron.2020.03.025","article-title":"Region-Specific Transcriptional Control of Astrocyte Function Oversees Local Circuit Activities","volume":"106","author":"Huang","year":"2020","journal-title":"Neuron"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1038\/s41583-022-00641-1","article-title":"Astrocyte Contribution to Dysfunction, Risk and Progression in Neurodegenerative Disorders","volume":"24","author":"Brandebura","year":"2023","journal-title":"Nat. Rev. Neurosci."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1038\/s41593-020-0624-8","article-title":"Disease-Associated Astrocytes in Alzheimer\u2019s Disease and Aging","volume":"23","author":"Habib","year":"2020","journal-title":"Nat. Neurosci."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/j.celrep.2017.12.039","article-title":"The Aging Astrocyte Transcriptome from Multiple Regions of the Mouse Brain","volume":"22","author":"Boisvert","year":"2018","journal-title":"Cell Rep."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"E1896","DOI":"10.1073\/pnas.1800165115","article-title":"Normal Aging Induces A1-like Astrocyte Reactivity","volume":"115","author":"Clarke","year":"2018","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.neurobiolaging.2013.07.008","article-title":"Acute Isolation and Transcriptome Characterization of Cortical Astrocytes and Microglia from Young and Aged Mice","volume":"35","author":"Orre","year":"2014","journal-title":"Neurobiol. Aging"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1038\/s41593-020-00783-4","article-title":"Reactive Astrocyte Nomenclature, Definitions, and Future Directions","volume":"24","author":"Escartin","year":"2021","journal-title":"Nat. Neurosci."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/j.tins.2020.01.003","article-title":"Astrocytes and Microglia: In Sickness and in Health","volume":"43","author":"Vainchtein","year":"2020","journal-title":"Trends Neurosci."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1590\/0004-282X20160101","article-title":"Are Astrocytes Executive Cells within the Central Nervous System?","volume":"74","author":"Sica","year":"2016","journal-title":"Arq. Neuropsiquiatr."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1016\/j.it.2020.07.004","article-title":"Astrocyte Reactivity: Subtypes, States, and Functions in CNS Innate Immunity","volume":"41","author":"Sofroniew","year":"2020","journal-title":"Trends Immunol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1788","DOI":"10.1016\/j.neuron.2022.03.008","article-title":"Astrocytes and Oligodendrocytes Undergo Subtype-Specific Transcriptional Changes in Alzheimer\u2019s Disease","volume":"110","author":"Sadick","year":"2022","journal-title":"Neuron"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1475","DOI":"10.1038\/s41593-021-00905-6","article-title":"Neuroinflammatory Astrocyte Subtypes in the Mouse Brain","volume":"24","author":"Hasel","year":"2021","journal-title":"Nat. Neurosci."},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"Galea, E., Weinstock, L.D., Larramona-Arcas, R., Pybus, A.F., Gim\u00e9nez-Llort, L., Escartin, C., and Wood, L.B. (2022). Multi-Transcriptomic Analysis Points to Early Organelle Dysfunction in Human Astrocytes in Alzheimer\u2019s Disease. Neurobiol. Dis., 166.","DOI":"10.1016\/j.nbd.2022.105655"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1038\/s41591-020-0815-6","article-title":"Large-Scale Proteomic Analysis of Alzheimer\u2019s Disease Brain and Cerebrospinal Fluid Reveals Early Changes in Energy Metabolism Associated with Microglia and Astrocyte Activation","volume":"26","author":"Johnson","year":"2020","journal-title":"Nat. Med."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1038\/s41583-021-00431-1","article-title":"Triad of TDP43 Control in Neurodegeneration: Autoregulation, Localization and Aggregation","volume":"22","author":"Tziortzouda","year":"2021","journal-title":"Nat. Rev. Neurosci."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1038\/nn.3691","article-title":"Astrocyte Kir4.1 Ion Channel Deficits Contribute to Neuronal Dysfunction in Huntington\u2019s Disease Model Mice","volume":"17","author":"Tong","year":"2014","journal-title":"Nat. Neurosci."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1083\/jcb.200508072","article-title":"Expression of Mutant Huntingtin in Glial Cells Contributes to Neuronal Excitotoxicity","volume":"171","author":"Shin","year":"2005","journal-title":"J. Cell Biol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"3053","DOI":"10.1093\/hmg\/ddq212","article-title":"In Vivo Expression of Polyglutamine-Expanded Huntingtin by Mouse Striatal Astrocytes Impairs Glutamate Transport: A Correlation with Huntington\u2019s Disease Subjects","volume":"19","author":"Faideau","year":"2010","journal-title":"Hum. Mol. Genet."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"14474","DOI":"10.1038\/s41598-020-71329-8","article-title":"Metabolic Alterations in Parkinson\u2019s Disease Astrocytes","volume":"10","author":"Sonninen","year":"2020","journal-title":"Sci. Rep."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1007\/PL00007400","article-title":"NACP\/a-Synuclein-Positive Filamentous Inclusions in Astrocytes and Oligodendrocytes of Parkinson\u2019s Disease Brains","volume":"99","author":"Wakabayashi","year":"2000","journal-title":"Acta Neuropathol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1007\/s00401-007-0244-3","article-title":"Development of \u03b1-Synuclein Immunoreactive Astrocytes in the Forebrain Parallels Stages of Intraneuronal Pathology in Sporadic Parkinson\u2019s Disease","volume":"114","author":"Braak","year":"2007","journal-title":"Acta Neuropathol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"1047540","DOI":"10.3389\/fmmed.2023.1047540","article-title":"Why Should We Care about Astrocytes in a Motor Neuron Disease?","volume":"3","year":"2023","journal-title":"Front. Mol. Med."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1038\/s41467-021-27702-w","article-title":"Reactive Astrocytes Acquire Neuroprotective as Well as Deleterious Signatures in Response to Tau and A\u00df Pathology","volume":"13","author":"Jiwaji","year":"2022","journal-title":"Nat. Commun."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1038\/s41392-023-01628-9","article-title":"Astrocytes in Human Central Nervous System Diseases: A Frontier for New Therapies","volume":"8","author":"Verkhratsky","year":"2023","journal-title":"Signal Transduct. Target Ther."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1186\/s40478-020-0880-6","article-title":"Single-Nucleus RNA-Seq Identifies Huntington Disease Astrocyte States","volume":"8","author":"Sosunov","year":"2020","journal-title":"Acta Neuropathol. Commun."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1096\/fj.12-208660","article-title":"Attenuating Astrocyte Activation Accelerates Plaque Pathogenesis in APP\/PS1 Mice","volume":"27","author":"Kraft","year":"2013","journal-title":"FASEB J."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1186\/s40478-019-0735-1","article-title":"Complement 3+-Astrocytes Are Highly Abundant in Prion Diseases, but Their Abolishment Led to an Accelerated Disease Course and Early Dysregulation of Microglia","volume":"7","author":"Hartmann","year":"2020","journal-title":"Acta Neuropathol. Commun."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1093\/brain\/awac068","article-title":"Reactive Astrocytes Promote Proteostasis in Huntington\u2019s Disease through the JAK2-STAT3 Pathway","volume":"146","author":"Abjean","year":"2023","journal-title":"Brain"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1186\/s13024-021-00426-7","article-title":"Clusterin Secreted from Astrocyte Promotes Excitatory Synaptic Transmission and Ameliorates Alzheimer\u2019s Disease Neuropathology","volume":"16","author":"Chen","year":"2021","journal-title":"Mol. Neurodegener."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"1528","DOI":"10.1038\/s41593-022-01180-9","article-title":"CRISPRi Screens in Human IPSC-Derived Astrocytes Elucidate Regulators of Distinct Inflammatory Reactive States","volume":"25","author":"Leng","year":"2022","journal-title":"Nat. Neurosci."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1016\/0006-8993(88)90410-6","article-title":"Lamina-Specific Arrangement of Astrocytic Gliosis and Senile Plaques in Alzheimer\u2019s Disease Visual Cortex","volume":"463","author":"Beach","year":"1988","journal-title":"Brain Res."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"5422","DOI":"10.1038\/ncomms6422","article-title":"Metabotropic P2Y1 Receptor Signalling Mediates Astrocytic Hyperactivity in Vivo in an Alzheimer\u2019s Disease Mouse Model","volume":"5","author":"Delekate","year":"2014","journal-title":"Nat. Commun."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"e98697","DOI":"10.15252\/embj.201798697","article-title":"NF-\u03baB Activation in Astrocytes Drives a Stage-specific Beneficial Neuroimmunological Response in ALS","volume":"37","author":"Schurr","year":"2018","journal-title":"EMBO J."},{"key":"ref_44","doi-asserted-by":"crossref","unstructured":"Gerber, Y.N., Sabourin, J.C., Rabano, M., Vivanco, M., and Perrin, F.E. (2012). Early Functional Deficit and Microglial Disturbances in a Mouse Model of Amyotrophic Lateral Sclerosis. PLoS ONE, 7.","DOI":"10.1371\/journal.pone.0036000"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"1635","DOI":"10.1038\/s41593-019-0486-0","article-title":"Fragmented Mitochondria Released from Microglia Trigger A1 Astrocytic Response and Propagate Inflammatory Neurodegeneration","volume":"22","author":"Joshi","year":"2019","journal-title":"Nat. Neurosci."},{"key":"ref_46","doi-asserted-by":"crossref","unstructured":"Taylor, X., Cisternas, P., Jury, N., Martinez, P., Huang, X., You, Y., Redding-Ochoa, J., Vidal, R., Zhang, J., and Troncoso, J. (2022). Activated Endothelial Cells Induce a Distinct Type of Astrocytic Reactivity. Commun. Biol., 5.","DOI":"10.1038\/s42003-022-03237-8"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"4572","DOI":"10.1038\/s41598-019-41040-4","article-title":"Increased FUS Levels in Astrocytes Leads to Astrocyte and Microglia Activation and Neuronal Death","volume":"9","author":"Onori","year":"2019","journal-title":"Sci. Rep."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"17803","DOI":"10.1073\/pnas.1103141108","article-title":"Astrocytes Carrying the Superoxide Dismutase 1 (SOD1 G93A) Mutation Induce Wild-Type Motor Neuron Degeneration in Vivo","volume":"108","author":"Papadeas","year":"2011","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"729273","DOI":"10.3389\/fnmol.2021.729273","article-title":"Astrocytes in Neural Circuits: Key Factors in Synaptic Regulation and Potential Targets for Neurodevelopmental Disorders","volume":"14","author":"Liu","year":"2021","journal-title":"Front. Mol. Neurosci."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1016\/j.neuron.2017.09.056","article-title":"Cell Biology of Astrocyte-Synapse Interactions","volume":"96","author":"Allen","year":"2017","journal-title":"Neuron"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1097\/01.jnen.0000173893.01929.fc","article-title":"Astrocytes Produce Dendritic Cell-Attracting Chemokines In Vitro and in Multiple Sclerosis Lesions","volume":"64","author":"Ambrosini","year":"2005","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1186\/1742-2094-11-105","article-title":"Deletion of Astroglial CXCL10 Delays Clinical Onset but Does Not Affect Progressive Axon Loss in a Murine Autoimmune Multiple Sclerosis Model","volume":"11","author":"Ma","year":"2014","journal-title":"J. Neuroinflammation"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1093\/brain\/awh680","article-title":"Chemokines in Multiple Sclerosis: CXCL12 and CXCL13 up-Regulation Is Differentially Linked to CNS Immune Cell Recruitment","volume":"129","author":"Krumbholz","year":"2006","journal-title":"Brain"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"e1422011","DOI":"10.1038\/cddis.2011.17","article-title":"IFN-\u03b3 Signaling, with the Synergistic Contribution of TNF-\u03b1, Mediates Cell Specific Microglial and Astroglial Activation in Experimental Models of Parkinson\u2019s Disease","volume":"2","author":"Barcia","year":"2011","journal-title":"Cell Death Dis."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1002\/ana.25172","article-title":"High Complement Levels in Astrocyte-Derived Exosomes of Alzheimer Disease","volume":"83","author":"Goetzl","year":"2018","journal-title":"Ann. Neurol."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1002\/glia.22331","article-title":"Complement Component C3 and Complement Receptor Type 3 Contribute to the Phagocytosis and Clearance of Fibrillar A\u03b2 by Microglia","volume":"60","author":"Fu","year":"2012","journal-title":"Glia"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1523\/JNEUROSCI.2117-15.2016","article-title":"Astrocyte-Microglia Cross Talk through Complement Activation Modulates Amyloid Pathology in Mouse Models of Alzheimer\u2019s Disease","volume":"36","author":"Lian","year":"2016","journal-title":"J. Neurosci."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"1730","DOI":"10.1523\/JNEUROSCI.2735-15.2016","article-title":"Single-Cell Detection of Secreted A\u03b2 and SAPP\u03b1 from Human IPSC-Derived Neurons and Astrocytes","volume":"36","author":"Liao","year":"2016","journal-title":"J. Neurosci."},{"key":"ref_59","doi-asserted-by":"crossref","unstructured":"LaRocca, T.J., Cavalier, A.N., Roberts, C.M., Lemieux, M.R., Ramesh, P., Garcia, M.A., and Link, C.D. (2021). Amyloid Beta Acts Synergistically as a Pro-Inflammatory Cytokine. Neurobiol. Dis., 159.","DOI":"10.1016\/j.nbd.2021.105493"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.stemcr.2021.09.013","article-title":"Astrocytic Reactivity Triggered by Defective Autophagy and Metabolic Failure Causes Neurotoxicity in Frontotemporal Dementia Type 3","volume":"16","author":"Chandrasekaran","year":"2021","journal-title":"Stem Cell Rep."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"24","DOI":"10.3389\/fncel.2014.00024","article-title":"Astrocytes Expressing Mutant SOD1 and TDP43 Trigger Motoneuron Death That Is Mediated via Sodium Channels and Nitroxidative Stress","volume":"8","author":"Rojas","year":"2014","journal-title":"Front. Cell Neurosci."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1016\/j.ebiom.2018.11.067","article-title":"Micro-RNAs Secreted through Astrocyte-Derived Extracellular Vesicles Cause Neuronal Network Degeneration in C9orf72 ALS","volume":"40","author":"Varcianna","year":"2019","journal-title":"EBioMedicine"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"1656","DOI":"10.1016\/j.neuron.2022.02.010","article-title":"Excessive Release of Inorganic Polyphosphate by ALS\/FTD Astrocytes Causes Non-Cell-Autonomous Toxicity to Motoneurons","volume":"110","author":"Arredondo","year":"2022","journal-title":"Neuron"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"1426","DOI":"10.1002\/glia.24183","article-title":"Targeting TNF\u03b1 Produced by Astrocytes Expressing Amyotrophic Lateral Sclerosis-Linked Mutant Fused in Sarcoma Prevents Neurodegeneration and Motor Dysfunction in Mice","volume":"70","author":"Jensen","year":"2022","journal-title":"Glia"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1186\/s12974-016-0698-0","article-title":"Astroglia Acquires a Toxic Neuroinflammatory Role in Response to the Cerebrospinal Fluid from Amyotrophic Lateral Sclerosis Patients","volume":"13","author":"Mishra","year":"2016","journal-title":"J. Neuroinflammation"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1186\/s12974-020-01963-6","article-title":"The Overexpression of TDP-43 in Astrocytes Causes Neurodegeneration via a PTP1B-Mediated Inflammatory Response","volume":"17","author":"Lee","year":"2020","journal-title":"J. Neuroinflammation"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1016\/j.stem.2008.10.001","article-title":"Non-Cell-Autonomous Effect of Human SOD1G37R Astrocytes on Motor Neurons Derived from Human Embryonic Stem Cells","volume":"3","author":"Marchetto","year":"2008","journal-title":"Cell Stem Cell"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"1016","DOI":"10.1002\/glia.23298","article-title":"Astrocytes Expressing ALS-Linked Mutant FUS Induce Motor Neuron Death through Release of Tumor Necrosis Factor-Alpha","volume":"66","author":"Kia","year":"2018","journal-title":"Glia"},{"key":"ref_69","doi-asserted-by":"crossref","unstructured":"Gomes, C., Sequeira, C., Likhite, S., Dennys, C.N., Kolb, S.J., Shaw, P.J., Vaz, A.R., Kaspar, B.K., Meyer, K., and Brites, D. (2022). Neurotoxic Astrocytes Directly Converted from Sporadic and Familial ALS Patient Fibroblasts Reveal Signature Diversities and MiR-146a Theragnostic Potential in Specific Subtypes. Cells, 11.","DOI":"10.3390\/cells11071186"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1016\/j.stem.2008.09.017","article-title":"Human Embryonic Stem Cell-Derived Motor Neurons Are Sensitive to the Toxic Effect of Glial Cells Carrying an ALS-Causing Mutation","volume":"3","author":"Boulting","year":"2008","journal-title":"Cell Stem Cell"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"574","DOI":"10.3389\/fnins.2019.00574","article-title":"Increased Interleukin-6 Levels in the Astrocyte-Derived Exosomes of Sporadic Amyotrophic Lateral Sclerosis Patients","volume":"13","author":"Chen","year":"2019","journal-title":"Front. Neurosci."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1038\/nn1876","article-title":"Astrocytes Expressing ALS-Linked Mutated SOD1 Release Factors Selectively Toxic to Motor Neurons","volume":"10","author":"Nagai","year":"2007","journal-title":"Nat. Neurosci."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1186\/s13024-022-00591-3","article-title":"FUS-ALS HiPSC-Derived Astrocytes Impair Human Motor Units through Both Gain-of-Toxicity and Loss-of-Support Mechanisms","volume":"18","author":"Terrie","year":"2023","journal-title":"Mol. Neurodegener."},{"key":"ref_74","doi-asserted-by":"crossref","unstructured":"Barbosa, M., Gomes, C., Sequeira, C., Gon\u00e7alves-Ribeiro, J., Pina, C.C., Carvalho, L.A., Moreira, R., Vaz, S.H., Vaz, A.R., and Brites, D. (2021). Recovery of Depleted MiR-146a in ALS Cortical Astrocytes Reverts Cell Aberrancies and Prevents Paracrine Pathogenicity on Microglia and Motor Neurons. Front. Cell Dev. Biol., 9.","DOI":"10.3389\/fcell.2021.634355"},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1016\/j.celrep.2015.03.053","article-title":"Astrocyte-Derived TGF-\u03921 Accelerates Disease Progression in ALS Mice by Interfering with the Neuroprotective Functions of Microglia and T Cells","volume":"11","author":"Endo","year":"2015","journal-title":"Cell Rep."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1186\/s13041-017-0300-4","article-title":"Amyotrophic Lateral Sclerosis Patient IPSC-Derived Astrocytes Impair Autophagy via Non-Cell Autonomous Mechanisms","volume":"10","author":"Madill","year":"2017","journal-title":"Mol. Brain"},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1016\/j.stemcr.2017.06.008","article-title":"Reactive Astrocytes Promote ALS-like Degeneration and Intracellular Protein Aggregation in Human Motor Neurons by Disrupting Autophagy through TGF-\u03921","volume":"9","author":"Tripathi","year":"2017","journal-title":"Stem Cell Rep."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"3753","DOI":"10.1038\/s41467-020-17514-9","article-title":"Knockout of Reactive Astrocyte Activating Factors Slows Disease Progression in an ALS Mouse Model","volume":"11","author":"Guttenplan","year":"2020","journal-title":"Nat. Commun."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1016\/j.stemcr.2017.03.003","article-title":"Sporadic ALS Astrocytes Induce Neuronal Degeneration In Vivo","volume":"8","author":"Qian","year":"2017","journal-title":"Stem Cell Rep."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1038\/nn1885","article-title":"Non-Cell Autonomous Effect of Glia on Motor Neurons in an Embryonic Stem Cell-Based ALS Model","volume":"10","author":"Carrasco","year":"2007","journal-title":"Nat. Neurosci."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1016\/j.neuron.2014.01.011","article-title":"Necroptosis Drives Motor Neuron Death in Models of Both Sporadic and Familial ALS","volume":"81","author":"Re","year":"2014","journal-title":"Neuron"},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1073\/pnas.1314085111","article-title":"Direct Conversion of Patient Fibroblasts Demonstrates Non-Cell Autonomous Toxicity of Astrocytes to Motor Neurons in Familial and Sporadic ALS","volume":"111","author":"Meyer","year":"2014","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"1917","DOI":"10.1038\/emboj.2013.122","article-title":"Expression of ALS-Linked TDP-43 Mutant in Astrocytes Causes Non-Cell-Autonomous Motor Neuron Death in Rats","volume":"32","author":"Tong","year":"2013","journal-title":"EMBO J."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"2803","DOI":"10.1152\/jn.00500.2012","article-title":"Mutant SOD1-Expressing Astrocytes Release Toxic Factors That Trigger Motoneuron Death by Inducing Hyperexcitability","volume":"109","author":"Fritz","year":"2013","journal-title":"J. Neurophysiol."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"4115","DOI":"10.1523\/JNEUROSCI.5308-07.2008","article-title":"Mitochondrial Dysfunction in SOD1G93A-Bearing Astrocytes Promotes Motor Neuron Degeneration: Prevention by Mitochondrial-Targeted Antioxidants","volume":"28","author":"Cassina","year":"2008","journal-title":"J. Neurosci."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1038\/s41419-020-2565-2","article-title":"Inhibition of the NLRP3-Inflammasome Prevents Cognitive Deficits in Experimental Autoimmune Encephalomyelitis Mice via the Alteration of Astrocyte Phenotype","volume":"11","author":"Hou","year":"2020","journal-title":"Cell Death Dis."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"824","DOI":"10.1038\/nbt.1957","article-title":"Astrocytes from Familial and Sporadic ALS Patients Are Toxic to Motor Neurons","volume":"29","author":"Hester","year":"2011","journal-title":"Nat. Biotechnol."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1093\/brain\/awab328","article-title":"Astrocytes Display Cell Autonomous and Diverse Early Reactive States in Familial Amyotrophic Lateral Sclerosis","volume":"145","author":"Taha","year":"2022","journal-title":"Brain"},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1080\/01677063.2018.1513508","article-title":"Cortical Astroglia Undergo Transcriptomic Dysregulation in the G93A SOD1 ALS Mouse Model","volume":"32","author":"Miller","year":"2018","journal-title":"J. Neurogenet."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1101\/gr.275939.121","article-title":"Meta-Analysis of Human and Mouse ALS Astrocytes Reveals Multi-Omic Signatures of Inflammatory Reactive States","volume":"32","author":"Ziff","year":"2022","journal-title":"Genome Res."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1186\/s40478-018-0606-1","article-title":"Modulation of Astrocyte Reactivity Improves Functional Deficits in Mouse Models of Alzheimer\u2019s Disease","volume":"6","author":"Denizot","year":"2018","journal-title":"Acta Neuropathol. Commun."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"2817","DOI":"10.1523\/JNEUROSCI.3516-14.2015","article-title":"The JAK\/STAT3 Pathway Is a Common Inducer of Astrocyte Reactivity in Alzheimer\u2019s and Huntington\u2019s Diseases","volume":"35","author":"Haim","year":"2015","journal-title":"J. Neurosci."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"9262","DOI":"10.1074\/jbc.M109.081125","article-title":"Direct Transfer of \u03b1-Synuclein from Neuron to Astroglia Causes Inflammatory Responses in Synucleinopathies","volume":"285","author":"Lee","year":"2010","journal-title":"J. Biol. Chem."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1038\/s41467-020-20322-w","article-title":"Filamentous Recombinant Human Tau Activates Primary Astrocytes via an Integrin Receptor Complex","volume":"12","author":"Wang","year":"2021","journal-title":"Nat. Commun."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1016\/j.cell.2011.07.022","article-title":"Astrocytes Are Endogenous Regulators of Basal Transmission at Central Synapses","volume":"146","author":"Panatier","year":"2011","journal-title":"Cell"},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"2192","DOI":"10.1523\/JNEUROSCI.3965-04.2005","article-title":"Properties of Synaptically Evoked Astrocyte Calcium Signal Reveal Synaptic Information Processing by Astrocytes","volume":"25","author":"Perea","year":"2005","journal-title":"J. Neurosci."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1002\/glia.23877","article-title":"Regionally Encoded Functional Heterogeneity of Astrocytes in Health and Disease: A Perspective","volume":"69","author":"Clarke","year":"2021","journal-title":"Glia"},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1186\/s13024-020-00382-8","article-title":"Sex-Dependent Calcium Hyperactivity Due to Lysosomal-Related Dysfunction in Astrocytes from APOE4 versus APOE3 Gene Targeted Replacement Mice","volume":"15","author":"Perea","year":"2020","journal-title":"Mol. Neurodegener."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"1649","DOI":"10.1084\/jem.20171487","article-title":"P2Y1 Receptor Blockade Normalizes Network Dysfunction and Cognition in an Alzheimer\u2019s Disease Model","volume":"215","author":"Reichenbach","year":"2018","journal-title":"J. Exp. Med."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.1126\/science.1169096","article-title":"Synchronous Hyperactivity and Intercellular Calcium Waves in Astrocytes in Alzheimer Mice","volume":"323","author":"Kuchibhotla","year":"2009","journal-title":"Science"},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"1885","DOI":"10.1016\/j.stemcr.2017.10.016","article-title":"PSEN1 Mutant IPSC-Derived Model Reveals Severe Astrocyte Pathology in Alzheimer\u2019s Disease","volume":"9","author":"Oksanen","year":"2017","journal-title":"Stem Cell Rep."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"111280","DOI":"10.1016\/j.celrep.2022.111280","article-title":"Astrocyte Calcium Dysfunction Causes Early Network Hyperactivity in Alzheimer\u2019s Disease","volume":"40","author":"Shah","year":"2022","journal-title":"Cell Rep."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"2331","DOI":"10.1523\/JNEUROSCI.2689-13.2014","article-title":"Abnormal Intracellular Calcium Signaling and SNARE Dependent Exocytosis Contributes to SOD1G93A Astrocyte- Mediated Toxicity in Amyotrophic Lateral Sclerosis","volume":"34","author":"Kawamata","year":"2014","journal-title":"J. Neurosci."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"826","DOI":"10.1093\/hmg\/ddr513","article-title":"The BH4 Domain of Bcl-X L Rescues Astrocyte Degeneration in Amyotrophic Lateral Sclerosis by Modulating Intracellular Calcium Signals","volume":"21","author":"Martorana","year":"2012","journal-title":"Hum. Mol. Genet."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"3453","DOI":"10.1523\/JNEUROSCI.3693-15.2016","article-title":"Dysfunctional Calcium and Glutamate Signaling in Striatal Astrocytes from Huntington\u2019s Disease Model Mice","volume":"36","author":"Jiang","year":"2016","journal-title":"J. Neurosci."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"eaaw8546","DOI":"10.1126\/scitranslmed.aaw8546","article-title":"Astrocyte Molecular Signatures in Huntington\u2019s Disease","volume":"11","author":"Gangwani","year":"2019","journal-title":"Sci. Transl. Med."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"1170","DOI":"10.1016\/j.neuron.2018.08.015","article-title":"Reducing Astrocyte Calcium Signaling In Vivo Alters Striatal Microcircuits and Causes Repetitive Behavior","volume":"99","author":"Yu","year":"2018","journal-title":"Neuron"},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1002\/glia.22777","article-title":"Disruption of Dopaminergic Transmission Remodels Tripartite Synapse Morphology and Astrocytic Calcium Activity within Substantia Nigra Pars Reticulata","volume":"63","author":"Bosson","year":"2015","journal-title":"Glia"},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1186\/s13024-017-0194-8","article-title":"TRPA1 Channels Promote Astrocytic Ca2+ Hyperactivity and Synaptic Dysfunction Mediated by Oligomeric Forms of Amyloid-\u03b2 Peptide","volume":"12","author":"Bosson","year":"2017","journal-title":"Mol. Neurodegener."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1093\/brain\/awab281","article-title":"Astrocyte-Neuron Interplay Is Critical for Alzheimer\u2019s Disease Pathogenesis and Is Rescued by TRPA1 Channel Blockade","volume":"145","author":"Paumier","year":"2022","journal-title":"Brain"},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"e81828","DOI":"10.1371\/journal.pone.0081828","article-title":"A7 Nicotinic Receptor-Mediated Astrocytic Gliotransmitter Release: A\u03b2 Effects in a Preclinical Alzheimer\u2019s Mouse Model","volume":"8","author":"Pirttimaki","year":"2013","journal-title":"PLoS ONE"},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"499","DOI":"10.3389\/fnins.2015.00499","article-title":"Gliotransmitter Release from Astrocytes: Functional, Developmental, and Pathological Implications in the Brain","volume":"9","author":"Harada","year":"2016","journal-title":"Front. Neurosci."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"2264","DOI":"10.1523\/JNEUROSCI.1871-20.2020","article-title":"A-Synuclein Oligomers Induce Glutamate Release from Astrocytes and Excessive Extrasynaptic NMDAR Activity in Neurons, Thus Contributing to Synapse Loss","volume":"41","author":"Trudler","year":"2021","journal-title":"J. Neurosci."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"1755","DOI":"10.2147\/JPR.S137131","article-title":"P2Y12 and P2Y13 Receptors Involved in ADPbetas Induced the Release of IL-1beta, IL-6 and TNF-Alpha from Cultured Dorsal Horn Microglia","volume":"10","author":"Liu","year":"2017","journal-title":"J. Pain Res."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1038\/nature05704","article-title":"UDP Acting at P2Y6 Receptors Is a Mediator of Microglial Phagocytosis","volume":"446","author":"Koizumi","year":"2007","journal-title":"Nature"},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"e73062","DOI":"10.7554\/eLife.73062","article-title":"The LRRK2 G2019S Mutation Alters Astrocyte-to-Neuron Communication via Extracellular Vesicles and Induces Neuron Atrophy in a Human Ipsc-Derived Model of Parkinson\u2019s Disease","volume":"10","author":"Tancredi","year":"2021","journal-title":"Elife"},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"12904","DOI":"10.1038\/s41598-017-11410-x","article-title":"Complement Protein C3 Suppresses Axon Growth and Promotes Neuron Loss","volume":"7","author":"Peterson","year":"2017","journal-title":"Sci. Rep."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/0896-6273(91)90128-M","article-title":"Gap Junctions in Cultured Astrocytes: Single-Channel Currents and Characterization of Channel-Forming Protein","volume":"6","author":"Giaume","year":"1991","journal-title":"Neuron"},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"1421","DOI":"10.1523\/JNEUROSCI.11-05-01421.1991","article-title":"Gap Junctions between Cultured Astrocytes: Immunocytochemical, Molecular, and Electrophysiological Analysis","volume":"11","author":"Dermietrel","year":"1991","journal-title":"J. Neurosci."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1002\/glia.440060309","article-title":"Heterogeneity in Gap Junction Expression in Astrocytes Cultured from Different Brain Regions","volume":"6","author":"Batter","year":"1992","journal-title":"Glia"},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1038\/nrn2757","article-title":"Astroglial Networks: A Step Further in Neuroglial and Gliovascular Interactions","volume":"11","author":"Giaume","year":"2010","journal-title":"Nat. Rev. Neurosci."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"1154","DOI":"10.1002\/glia.22989","article-title":"Connexin 43 in Astrocytes Contributes to Motor Neuron Toxicity in Amyotrophic Lateral Sclerosis","volume":"64","author":"Almad","year":"2016","journal-title":"Glia"},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"e2107391119","DOI":"10.1073\/pnas.2107391119","article-title":"Cx43 Hemichannels Contribute to Astrocyte-Mediated Toxicity in Sporadic and Familial ALS","volume":"119","author":"Almad","year":"2022","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.neuroscience.2010.08.001","article-title":"Astroglial Connexin Immunoreactivity Is Specifically Altered at \u03b2-Amyloid Plaques in \u03b2-Amyloid Precursor Protein\/Presenilin1 Mice","volume":"171","author":"Mei","year":"2010","journal-title":"Neuroscience"},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1007\/s12038-018-9811-0","article-title":"Connexin 43\/47 Channels Are Important for Astrocyte\/Oligodendrocyte Cross-Talk in Myelination and Demyelination","volume":"43","author":"Basu","year":"2018","journal-title":"J. Biosci."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"2160","DOI":"10.1073\/pnas.1901294117","article-title":"Oligodendroglial Connexin 47 Regulates Neuroinflammation upon Autoimmune Demyelination in a Novel Mouse Model of Multiple Sclerosis","volume":"117","author":"Zhao","year":"2020","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_127","doi-asserted-by":"crossref","unstructured":"Masaki, K., Suzuki, S.O., Matsushita, T., Matsuoka, T., Imamura, S., Yamasaki, R., Suzuki, M., Suenaga, T., Iwaki, T., and Kira, J.I. (2013). Connexin 43 Astrocytopathy Linked to Rapidly Progressive Multiple Sclerosis and Neuromyelitis Optica. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0072919"},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1007\/s00401-012-0978-4","article-title":"Gap Junction Pathology in Multiple Sclerosis Lesions and Normal-Appearing White Matter","volume":"123","author":"Markoullis","year":"2012","journal-title":"Acta Neuropathol."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"582934","DOI":"10.3389\/fnins.2020.582934","article-title":"Altered Expression of Glial Gap Junction Proteins Cx43, Cx30, and Cx47 in the 5XFAD Model of Alzheimer\u2019s Disease","volume":"14","author":"Angeli","year":"2020","journal-title":"Front. Neurosci."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"2133","DOI":"10.1002\/glia.22821","article-title":"Morphological Plasticity of Astroglia: Understanding Synaptic Microenvironment","volume":"63","author":"Heller","year":"2015","journal-title":"Glia"},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1016\/j.neuron.2020.08.030","article-title":"LTP Induction Boosts Glutamate Spillover by Driving Withdrawal of Perisynaptic Astroglia","volume":"108","author":"Henneberger","year":"2020","journal-title":"Neuron"},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"888","DOI":"10.1016\/j.neuron.2013.12.026","article-title":"A Local Glutamate-Glutamine Cycle Sustains Synaptic Excitatory Transmitter Release","volume":"81","author":"Tani","year":"2014","journal-title":"Neuron"},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.neuroscience.2008.08.043","article-title":"A Quantitative Assessment of Glutamate Uptake into Hippocampal Synaptic Terminals and Astrocytes: New Insights into a Neuronal Role for Excitatory Amino Acid Transporter 2 (EAAT2)","volume":"157","author":"Furness","year":"2008","journal-title":"Neuroscience"},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.neuint.2016.05.009","article-title":"Neuronal vs Glial Glutamate Uptake: Resolving the Conundrum","volume":"98","author":"Danbolt","year":"2016","journal-title":"Neurochem. Int."},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1016\/j.neuroscience.2014.07.019","article-title":"Localization of Excitatory Amino Acid Transporters EAAT1 and EAAT2 in Human Postmortem Cortex: A Light and Electron Microscopic Study","volume":"277","author":"Roberts","year":"2014","journal-title":"Neuroscience"},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1016\/S0896-6273(00)80086-0","article-title":"Knockout of Glutamate Transporters Reveals a Major Role for Astroglial Transport in Excitotoxicity and Clearance of Glutamate","volume":"16","author":"Rothstein","year":"1996","journal-title":"Neuron"},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"E2518","DOI":"10.1073\/pnas.1306832110","article-title":"A\u03b2 Induces Astrocytic Glutamate Release, Extrasynaptic NMDA Receptor Activation, and Synaptic Loss","volume":"110","author":"Talantova","year":"2013","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"5312","DOI":"10.1523\/JNEUROSCI.5274-12.2013","article-title":"Amyloid-\u03921-42 Slows Clearance of Synaptically Released Glutamate by Mislocalizing Astrocytic GLT-1","volume":"33","author":"Scimemi","year":"2013","journal-title":"J. Neurosci."},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"97","DOI":"10.3233\/JAD-2007-11113","article-title":"Alterations in Expression of Glutamatergic Transporters and Receptors in Sporadic Alzheimer\u2019s Disease","volume":"11","author":"Jacob","year":"2007","journal-title":"J. Alzheimer\u2019s Dis."},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1046\/j.1471-4159.2001.00451.x","article-title":"The Glial Glutamate Transporter, GLT-1, Is Oxidatively Modified by 4-Hydroxy-2-Nonenal in the Alzheimer\u2019s Disease Brain: The Role of A\u03b21-42","volume":"78","author":"Lauderback","year":"2001","journal-title":"J. Neurochem."},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1002\/ana.410400512","article-title":"Deficient Glutamate Transport Is Associated with Neurodegeneration in Alzheimer\u2019s Disease","volume":"40","author":"Masliah","year":"1996","journal-title":"Ann. Neurol."},{"key":"ref_142","doi-asserted-by":"crossref","unstructured":"Salcedo, C., Pozo Garcia, V., Garc\u00eda-Ad\u00e1n, B., Ameen, A.O., Gegelashvili, G., Waagepetersen, H.S., Freude, K.K., and Aldana, B.I. (2023). Increased Glucose Metabolism and Impaired Glutamate Transport in Human Astrocytes Are Potential Early Triggers of Abnormal Extracellular Glutamate Accumulation in HiPSC-Derived Models of Alzheimer\u2019s Disease. J. Neurochem., 1\u201319.","DOI":"10.1111\/jnc.16014"},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1021\/acschemneuro.9b00609","article-title":"Generation of a Novel Mouse Model of Parkinson\u2019s Disease via Targeted Knockdown of Glutamate Transporter GLT-1 in the Substantia Nigra","volume":"11","author":"Zhang","year":"2020","journal-title":"ACS Chem. Neurosci."},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1007\/s00401-022-02437-0","article-title":"Trafficking of the Glutamate Transporter Is Impaired in LRRK2-Related Parkinson\u2019s Disease","volume":"144","author":"Iovino","year":"2022","journal-title":"Acta Neuropathol."},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/S0896-6273(00)80272-X","article-title":"ALS-Linked SOD1 Mutant G85R Mediates Damage to Astrocytes and Promotes Rapidly Progressive Disease with SOD1-Containing Inclusions","volume":"18","author":"Bruijn","year":"1997","journal-title":"Neuron"},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"1068","DOI":"10.1016\/j.bbadis.2006.05.002","article-title":"The Role of Excitotoxicity in the Pathogenesis of Amyotrophic Lateral Sclerosis","volume":"1762","author":"Bogaert","year":"2006","journal-title":"Biochim. Biophys. Acta (BBA)\u2014Mol. Basis Dis."},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"2290","DOI":"10.1007\/s12035-020-01885-7","article-title":"Amyloid Fibril\u2013Induced Astrocytic Glutamate Transporter Disruption Contributes to Complement C1q-Mediated Microglial Pruning of Glutamatergic Synapses","volume":"57","author":"Wu","year":"2020","journal-title":"Mol. Neurobiol."},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"e2210719129","DOI":"10.1073\/pnas.2210719120","article-title":"Astrocytic Engagement of the Corticostriatal Synaptic Cleft Is Disrupted in a Mouse Model of Huntington s Disease","volume":"120","author":"Villanueva","year":"2023","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_149","doi-asserted-by":"crossref","unstructured":"Andersen, J.V., Christensen, S.K., Westi, E.W., Diaz-delCastillo, M., Tanila, H., Schousboe, A., Aldana, B.I., and Waagepetersen, H.S. (2021). Deficient Astrocyte Metabolism Impairs Glutamine Synthesis and Neurotransmitter Homeostasis in a Mouse Model of Alzheimer\u2019s Disease. Neurobiol. Dis., 148.","DOI":"10.1016\/j.nbd.2020.105198"},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"954","DOI":"10.1038\/s41419-021-04237-y","article-title":"Hippocampal Disruptions of Synaptic and Astrocyte Metabolism Are Primary Events of Early Amyloid Pathology in the 5xFAD Mouse Model of Alzheimer\u2019s Disease","volume":"12","author":"Andersen","year":"2021","journal-title":"Cell Death Dis."},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"736580","DOI":"10.3389\/fnagi.2021.736580","article-title":"Functional Metabolic Mapping Reveals Highly Active Branched-Chain Amino Acid Metabolism in Human Astrocytes, Which Is Impaired in IPSC-Derived Astrocytes in Alzheimer\u2019s Disease","volume":"13","author":"Salcedo","year":"2021","journal-title":"Front. Aging Neurosci."},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"2676","DOI":"10.1007\/s11064-021-03276-3","article-title":"Downregulation of GABA Transporter 3 (GAT3) Is Associated with Deficient Oxidative GABA Metabolism in Human Induced Pluripotent Stem Cell-Derived Astrocytes in Alzheimer\u2019s Disease","volume":"46","author":"Salcedo","year":"2021","journal-title":"Neurochem. Res."},{"key":"ref_153","doi-asserted-by":"crossref","unstructured":"Balu, D.T., Pantazopoulos, H., Huang, C.C.Y., Muszynski, K., Harvey, T.L., Uno, Y., Rorabaugh, J.M., Galloway, C.R., Botz-Zapp, C., and Berretta, S. (2019). Neurotoxic Astrocytes Express the D-Serine Synthesizing Enzyme, Serine Racemase, in Alzheimer\u2019s Disease. Neurobiol. Dis., 130.","DOI":"10.1016\/j.nbd.2019.104511"},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"886","DOI":"10.1038\/nm.3639","article-title":"GABA from Reactive Astrocytes Impairs Memory in Mouse Models of Alzheimer\u2019s Disease","volume":"20","author":"Jo","year":"2014","journal-title":"Nat. Med."},{"key":"ref_155","doi-asserted-by":"crossref","first-page":"1673","DOI":"10.1002\/glia.22548","article-title":"\u03b2-Amyloid and ATP-Induced Diffusional Trapping of Astrocyte and Neuronal Metabotropic Glutamate Type-5 Receptors","volume":"61","author":"Shrivastava","year":"2013","journal-title":"Glia"},{"key":"ref_156","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.neuron.2014.11.018","article-title":"NF\u03baB-Activated Astroglial Release of Complement C3 Compromises Neuronal Morphology and Function Associated with Alzheimer\u2019s Disease","volume":"85","author":"Lian","year":"2015","journal-title":"Neuron"},{"key":"ref_157","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1113\/jphysiol.2013.261735","article-title":"Astroglial Potassium Clearance Contributes to Short-Term Plasticity of Synaptically Evoked Currents at the Tripartite Synapse","volume":"592","author":"Sibille","year":"2014","journal-title":"J. Physiol."},{"key":"ref_158","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.neubiorev.2017.03.002","article-title":"Astrocytic Modulation of Neuronal Excitability through K + Spatial Buffering","volume":"77","author":"Morley","year":"2017","journal-title":"Neurosci. Biobehav. Rev."},{"key":"ref_159","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1016\/j.neuron.2018.03.010","article-title":"Kir4.1-Dependent Astrocyte-Fast Motor Neuron Interactions Are Required for Peak Strength","volume":"98","author":"Kelley","year":"2018","journal-title":"Neuron"},{"key":"ref_160","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.mcn.2017.04.009","article-title":"Extensive Uptake of \u03b1-Synuclein Oligomers in Astrocytes Results in Sustained Intracellular Deposits and Mitochondrial Damage","volume":"82","author":"Gustafsson","year":"2017","journal-title":"Mol. Cell. Neurosci."},{"key":"ref_161","doi-asserted-by":"crossref","first-page":"11835","DOI":"10.1523\/JNEUROSCI.0983-17.2017","article-title":"Human Astrocytes Transfer Aggregated Alpha-Synuclein via Tunneling Nanotubes","volume":"37","author":"Rostami","year":"2017","journal-title":"J. Neurosci."},{"key":"ref_162","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1016\/j.ebiom.2019.11.026","article-title":"Human IPSC-Derived Astrocytes from ALS Patients with Mutated C9ORF72 Show Increased Oxidative Stress and Neurotoxicity","volume":"50","author":"Birger","year":"2019","journal-title":"EBioMedicine"},{"key":"ref_163","doi-asserted-by":"crossref","unstructured":"Jiwaji, Z., and Hardingham, G.E. (2023). The Consequences of Neurodegenerative Disease on Neuron-Astrocyte Metabolic and Redox Interactions. Neurobiol. Dis., 185.","DOI":"10.1016\/j.nbd.2023.106255"},{"key":"ref_164","doi-asserted-by":"crossref","first-page":"13574","DOI":"10.1523\/JNEUROSCI.4099-08.2008","article-title":"Nrf2 Activation in Astrocytes Protects against Neurodegeneration in Mouse Models of Familial Amyotrophic Lateral Sclerosis","volume":"28","author":"Vargas","year":"2008","journal-title":"J. Neurosci."},{"key":"ref_165","doi-asserted-by":"crossref","first-page":"17775","DOI":"10.1523\/JNEUROSCI.3049-12.2012","article-title":"Astrocyte-Specific Overexpression of Nrf2 Delays Motor Pathology and Synuclein Aggregation throughout the CNS in the Alpha-Synuclein Mutant (A53T) Mouse Model","volume":"32","author":"Gan","year":"2012","journal-title":"J. Neurosci."},{"key":"ref_166","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/S0197-4580(03)00117-9","article-title":"Regional NAD(P)H:Quinone Oxidoreductase Activity in Alzheimer\u2019s Disease","volume":"25","author":"SantaCruz","year":"2004","journal-title":"Neurobiol. Aging"},{"key":"ref_167","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1038\/nrn.2018.19","article-title":"Lactate in the Brain: From Metabolic End-Product to Signalling Molecule","volume":"19","author":"Magistretti","year":"2018","journal-title":"Nat. Rev. Neurosci."},{"key":"ref_168","doi-asserted-by":"crossref","first-page":"4768","DOI":"10.1523\/JNEUROSCI.6612-10.2011","article-title":"Lactate Transport and Metabolism in the Human Brain: Implications for the Astrocyte-Neuron Lactate Shuttle Hypothesis","volume":"31","author":"Figley","year":"2011","journal-title":"J. Neurosci."},{"key":"ref_169","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1002\/glia.23114","article-title":"Wildtype Motoneurons, ALS-Linked SOD1 Mutation and Glutamate Profoundly Modify Astrocyte Metabolism and Lactate Shuttling","volume":"65","author":"Mavel","year":"2017","journal-title":"Glia"},{"key":"ref_170","doi-asserted-by":"crossref","first-page":"2627","DOI":"10.1093\/brain\/awr193","article-title":"Dysregulation of Astrocyte-Motoneuron Cross-Talk in Mutant Superoxide Dismutase 1-Related Amyotrophic Lateral Sclerosis","volume":"134","author":"Ferraiuolo","year":"2011","journal-title":"Brain"},{"key":"ref_171","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1093\/brain\/awy353","article-title":"Astrocyte Adenosine Deaminase Loss Increases Motor Neuron Toxicity in Amyotrophic Lateral Sclerosis","volume":"142","author":"Allen","year":"2019","journal-title":"Brain"},{"key":"ref_172","doi-asserted-by":"crossref","first-page":"3771","DOI":"10.1093\/brain\/awz302","article-title":"C9orf72 Expansion within Astrocytes Reduces Metabolic Flexibility in Amyotrophic Lateral Sclerosis","volume":"142","author":"Allen","year":"2019","journal-title":"Brain"},{"key":"ref_173","doi-asserted-by":"crossref","first-page":"1977","DOI":"10.1073\/pnas.90.5.1977","article-title":"Apolipoprotein E: High-Avidity Binding to B-Amyloid and Increased Frequency of Type 4 Allele in Late-Onset Familial Alzheimer Disease","volume":"90","author":"Strittmatter","year":"1993","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_174","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/j.neuron.2009.06.026","article-title":"The Role of Apolipoprotein E in Alzheimer\u2019s Disease","volume":"63","author":"Kim","year":"2009","journal-title":"Neuron"},{"key":"ref_175","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1038\/s41588-018-0311-9","article-title":"Genome-Wide Meta-Analysis Identifies New Loci and Functional Pathways Influencing Alzheimer\u2019s Disease Risk","volume":"51","author":"Jansen","year":"2019","journal-title":"Nat. Genet."},{"key":"ref_176","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1038\/nature24016","article-title":"ApoE4 Markedly Exacerbates Tau-Mediated Neurodegeneration in a Mouse Model of Tauopathy","volume":"549","author":"Shi","year":"2017","journal-title":"Nature"},{"key":"ref_177","doi-asserted-by":"crossref","first-page":"8299","DOI":"10.1073\/pnas.0500579102","article-title":"Correlations between Apolipoprotein E \u03954 Gene Dose and Brain-Imaging Measurements of Regional Hypometabolism","volume":"102","author":"Reiman","year":"2005","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_178","doi-asserted-by":"crossref","unstructured":"Williams, H.C., Farmer, B.C., Piron, M.A., Walsh, A.E., Bruntz, R.C., Gentry, M.S., Sun, R.C., and Johnson, L.A. (2020). APOE Alters Glucose Flux through Central Carbon Pathways in Astrocytes. Neurobiol. Dis., 136.","DOI":"10.1016\/j.nbd.2020.104742"},{"key":"ref_179","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.1016\/j.neuron.2018.05.008","article-title":"APOE4 Causes Widespread Molecular and Cellular Alterations Associated with Alzheimer\u2019s Disease Phenotypes in Human IPSC-Derived Brain Cell Types","volume":"98","author":"Lin","year":"2018","journal-title":"Neuron"},{"key":"ref_180","doi-asserted-by":"crossref","first-page":"2213","DOI":"10.1016\/j.cell.2022.05.017","article-title":"Cholesterol and Matrisome Pathways Dysregulated in Astrocytes and Microglia","volume":"185","author":"TCW","year":"2022","journal-title":"Cell"},{"key":"ref_181","doi-asserted-by":"crossref","first-page":"690","DOI":"10.1038\/cdd.2014.162","article-title":"Disruption of Astrocyte-Neuron Cholesterol Cross Talk Affects Neuronal Function in Huntington\u2019s Disease","volume":"22","author":"Valenza","year":"2015","journal-title":"Cell Death Differ."},{"key":"ref_182","doi-asserted-by":"crossref","first-page":"3175","DOI":"10.1093\/brain\/awab186","article-title":"SREBP2 Gene Therapy Targeting Striatal Astrocytes Ameliorates Huntington\u2019s Disease Phenotypes","volume":"144","author":"Birolini","year":"2021","journal-title":"Brain"},{"key":"ref_183","doi-asserted-by":"crossref","first-page":"28823","DOI":"10.1038\/srep28823","article-title":"DJ-1 Deficiency Impairs Glutamate Uptake into Astrocytes via the Regulation of Flotillin-1 and Caveolin-1 Expression","volume":"6","author":"Kim","year":"2016","journal-title":"Sci. Rep."},{"key":"ref_184","doi-asserted-by":"crossref","first-page":"4805","DOI":"10.1093\/hmg\/ddt332","article-title":"DJ-1 Associates with Lipid Rafts by Palmitoylation and Regulates Lipid Rafts-Dependent Endocytosis in Astrocytes","volume":"22","author":"Kim","year":"2013","journal-title":"Hum. Mol. Genet."},{"key":"ref_185","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1038\/s41586-021-03960-y","article-title":"Neurotoxic Reactive Astrocytes Induce Cell Death via Saturated Lipids","volume":"599","author":"Guttenplan","year":"2021","journal-title":"Nature"},{"key":"ref_186","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1002\/(SICI)1098-1136(199903)26:1<47::AID-GLIA5>3.0.CO;2-5","article-title":"Immunogold Evidence Suggests That Coupling of K+ Siphoning and Water Transport in Rat Retinal Muller Cells Is Mediated by a Coenrichment of Kir4.1 and AQP4 in Specific Membrane Domains","volume":"26","author":"Nagelhus","year":"1999","journal-title":"Glia"},{"key":"ref_187","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1016\/j.neuroscience.2004.08.053","article-title":"Aquaporin-4 in the Central Nervous System: Cellular and Subcellular Distribution and Coexpression with KIR4.1","volume":"129","author":"Nagelhus","year":"2004","journal-title":"Neuroscience"},{"key":"ref_188","doi-asserted-by":"crossref","first-page":"13615","DOI":"10.1073\/pnas.2336064100","article-title":"Delayed K+ Clearance Associated with Aquaporin-4 Mislocalization: Phenotypic Defects in Brains of \u03b1-Syntrophin-Null Mice","volume":"100","author":"Williamson","year":"2003","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_189","doi-asserted-by":"crossref","first-page":"780","DOI":"10.1523\/JNEUROSCI.1865-20.2020","article-title":"Mutant Huntingtin Is Cleared from the Brain via Active Mechanisms in Huntington Disease","volume":"41","author":"Caron","year":"2021","journal-title":"J. Neurosci."},{"key":"ref_190","doi-asserted-by":"crossref","first-page":"147ra111","DOI":"10.1126\/scitranslmed.3003748","article-title":"A Paravascular Pathway Facilitates CSF Flow through the Brain Parenchyma and the Clearance of Interstitial Solutes, Including Amyloid \u03b2","volume":"4","author":"Iliff","year":"2012","journal-title":"Sci. Transl. Med."},{"key":"ref_191","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1186\/s13024-015-0056-1","article-title":"Deletion of Aquaporin-4 in APP\/PS1 Mice Exacerbates Brain A\u03b2 Accumulation and Memory Deficits","volume":"10","author":"Xu","year":"2015","journal-title":"Mol. Neurodegener."},{"key":"ref_192","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1097\/NEN.0b013e3182632566","article-title":"Characteristics of Aquaporin Expression Surrounding Senile Plaques and Cerebral Amyloid Angiopathy in Alzheimer Disease","volume":"71","author":"Hoshi","year":"2012","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"ref_193","doi-asserted-by":"crossref","first-page":"89ra57","DOI":"10.1126\/scitranslmed.3002156","article-title":"Human ApoE Isoforms Differentially Regulate Brain Amyloid-\u03b2 Peptide Clearance","volume":"3","author":"Castellano","year":"2011","journal-title":"Sci. Transl. Med."},{"key":"ref_194","doi-asserted-by":"crossref","first-page":"3119","DOI":"10.1007\/s12035-021-02327-8","article-title":"Parkinson\u2019s Disease-Associated LRRK2 Interferes with Astrocyte-Mediated Alpha-Synuclein Clearance","volume":"58","author":"Giusti","year":"2021","journal-title":"Mol. Neurobiol."},{"key":"ref_195","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1007\/s00401-017-1746-2","article-title":"\u03b1-Synuclein Transfer between Neurons and Astrocytes Indicates That Astrocytes Play a Role in Degradation Rather than in Spreading","volume":"134","author":"Loria","year":"2017","journal-title":"Acta Neuropathol."},{"key":"ref_196","doi-asserted-by":"crossref","unstructured":"Dilsizoglu Senol, A., Samarani, M., Syan, S., Guardia, C.M., Nonaka, T., Liv, N., Latour-Lambert, P., Hasegawa, M., Klumperman, J., and Bonifacino, J.S. (2021). \u03b1-Synuclein Fibrils Subvert Lysosome Structure and Function for the Propagation of Protein Misfolding between Cells through Tunneling Nanotubes. PLoS. Biol., 19.","DOI":"10.1371\/journal.pbio.3001287"},{"key":"ref_197","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.cell.2011.06.001","article-title":"Gaucher Disease Glucocerebrosidase and \u03b1-Synuclein Form a Bidirectional Pathogenic Loop in Synucleinopathies","volume":"146","author":"Mazzulli","year":"2011","journal-title":"Cell"},{"key":"ref_198","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1038\/s41467-024-44732-2","article-title":"Disruption of Lysosomal Proteolysis in Astrocytes Facilitates Midbrain Organoid Proteostasis Failure in an Early-Onset Parkinson\u2019s Disease Model","volume":"15","author":"Coccia","year":"2024","journal-title":"Nat. Commun."},{"key":"ref_199","doi-asserted-by":"crossref","first-page":"442","DOI":"10.3389\/fnins.2019.00442","article-title":"Extracellular Monomeric Tau Is Internalized by Astrocytes","volume":"13","author":"Perea","year":"2019","journal-title":"Front. Neurosci."},{"key":"ref_200","doi-asserted-by":"crossref","first-page":"2087","DOI":"10.1038\/s41593-019-0539-4","article-title":"A Single-Cell Atlas of Entorhinal Cortex from Individuals with Alzheimer\u2019s Disease Reveals Cell-Type-Specific Gene Expression Regulation","volume":"22","author":"Grubman","year":"2019","journal-title":"Nat. Neurosci."},{"key":"ref_201","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1186\/s12974-021-02158-3","article-title":"Crosstalk between Astrocytes and Microglia Results in Increased Degradation of \u03b1-Synuclein and Amyloid-\u03b2 Aggregates","volume":"18","author":"Rostami","year":"2021","journal-title":"J. Neuroinflammation"},{"key":"ref_202","doi-asserted-by":"crossref","first-page":"1209","DOI":"10.1242\/jcs.196352","article-title":"New Insights into Autophagosome\u2013Lysosome Fusion","volume":"130","author":"Nakamura","year":"2017","journal-title":"J. Cell Sci."},{"key":"ref_203","doi-asserted-by":"crossref","first-page":"1651","DOI":"10.1080\/15548627.2019.1703354","article-title":"Differential Regulation of Autophagy during Metabolic Stress in Astrocytes and Neurons","volume":"16","author":"Kulkarni","year":"2020","journal-title":"Autophagy"},{"key":"ref_204","doi-asserted-by":"crossref","first-page":"4837","DOI":"10.1242\/jcs.01370","article-title":"Role for Rab7 in Maturation of Late Autophagic Vacuoles","volume":"117","author":"Bucci","year":"2004","journal-title":"J. Cell Sci."},{"key":"ref_205","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1038\/s10038-022-01058-5","article-title":"Molecular Genetics of Parkinson\u2019s Disease: Contributions and Global Trends","volume":"68","author":"Funayama","year":"2023","journal-title":"J. Hum. Genet."},{"key":"ref_206","doi-asserted-by":"crossref","first-page":"498","DOI":"10.3389\/fnins.2020.00498","article-title":"LRRK2: Autophagy and Lysosomal Activity","volume":"14","author":"Madureira","year":"2020","journal-title":"Front. Neurosci."},{"key":"ref_207","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/j.stemcr.2018.12.011","article-title":"Patient-Specific IPSC-Derived Astrocytes Contribute to Non-Cell-Autonomous Neurodegeneration in Parkinson\u2019s Disease","volume":"12","author":"Carola","year":"2019","journal-title":"Stem Cell Rep."},{"key":"ref_208","doi-asserted-by":"crossref","first-page":"1542","DOI":"10.1038\/s41593-021-00923-4","article-title":"Human ALS\/FTD Brain Organoid Slice Cultures Display Distinct Early Astrocyte and Targetable Neuronal Pathology","volume":"24","author":"Wenger","year":"2021","journal-title":"Nat. Neurosci."},{"key":"ref_209","doi-asserted-by":"crossref","first-page":"1170.e1","DOI":"10.1016\/j.cell.2015.08.029","article-title":"SnapShot: Astrocytes in Health and Disease","volume":"162","author":"Liddelow","year":"2015","journal-title":"Cell"},{"key":"ref_210","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1002\/ar.20838","article-title":"Aquaporin-4 Overexpression in Rat ALS Model","volume":"292","author":"Nicaise","year":"2009","journal-title":"Anat. Rec."},{"key":"ref_211","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.brainres.2007.04.044","article-title":"Ultrastructure of Blood-Brain Barrier and Blood-Spinal Cord Barrier in SOD1 Mice Modeling ALS","volume":"1157","author":"Haller","year":"2007","journal-title":"Brain Res."},{"key":"ref_212","doi-asserted-by":"crossref","unstructured":"Garbuzova-Davis, S., Saporta, S., Haller, E., Kolomey, I., Bennett, S.P., Potter, H., and Sanberg, P.R. (2007). Evidence of Compromised Blood-Spinal Cord Barrier in Early and Late Symptomatic SOD1 Mice Modeling ALS. PLoS ONE, 2.","DOI":"10.1371\/journal.pone.0001205"},{"key":"ref_213","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1002\/jnr.22594","article-title":"Disruption of Neurovascular Unit Prior to Motor Neuron Degeneration in Amyotrophic Lateral Sclerosis","volume":"89","author":"Miyazaki","year":"2011","journal-title":"J. Neurosci. Res."},{"key":"ref_214","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1007\/s00401-012-1039-8","article-title":"Blood-Spinal Cord Barrier Breakdown and Pericyte Reductions in Amyotrophic Lateral Sclerosis","volume":"125","author":"Winkler","year":"2013","journal-title":"Acta Neuropathol."},{"key":"ref_215","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1038\/jcbfm.2015.44","article-title":"Accelerated Pericyte Degeneration and Blood-Brain Barrier Breakdown in Apolipoprotein E4 Carriers with Alzheimer\u2019s Disease","volume":"36","author":"Halliday","year":"2016","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"ref_216","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1038\/nature11087","article-title":"Apolipoprotein E Controls Cerebrovascular Integrity via Cyclophilin A","volume":"485","author":"Bell","year":"2012","journal-title":"Nature"},{"key":"ref_217","doi-asserted-by":"crossref","first-page":"17536","DOI":"10.1074\/jbc.M111.225532","article-title":"Apolipoprotein E Regulates the Integrity of Tight Junctions in an Isoform-Dependent Manner in an in Vitro Blood-Brain Barrier Model","volume":"286","author":"Nishitsuji","year":"2011","journal-title":"J. Biol. Chem."},{"key":"ref_218","doi-asserted-by":"crossref","first-page":"337","DOI":"10.3389\/fncel.2019.00337","article-title":"Astrocytes Modify Migration of Pbmcs Induced by \u03b2-Amyloid in a Blood-Brain Barrier in Vitro Model","volume":"13","author":"Spampinato","year":"2019","journal-title":"Front. Cell Neurosci."},{"key":"ref_219","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1002\/ana.24428","article-title":"Aberrant Astrocytes Impair Vascular Reactivity in Huntington Disease","volume":"78","author":"Hsiao","year":"2015","journal-title":"Ann. Neurol."},{"key":"ref_220","doi-asserted-by":"crossref","first-page":"3651","DOI":"10.1038\/s41467-023-39038-8","article-title":"The Contribution of Inflammatory Astrocytes to BBB Impairments in a Brain-Chip Model of Parkinson\u2019s Disease","volume":"14","author":"Alpaugh","year":"2023","journal-title":"Nat. Commun."},{"key":"ref_221","doi-asserted-by":"crossref","first-page":"1394","DOI":"10.3389\/fimmu.2020.01394","article-title":"Fibrotic Scar in Neurodegenerative Diseases","volume":"11","author":"Apolloni","year":"2020","journal-title":"Front. Immunol."},{"key":"ref_222","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1038\/nature17623","article-title":"Astrocyte Scar Formation Aids Central Nervous System Axon Regeneration","volume":"532","author":"Anderson","year":"2016","journal-title":"Nature"},{"key":"ref_223","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1002\/glia.23526","article-title":"Reactive Astrocytes in Multiple Sclerosis Impair Neuronal Outgrowth through TRPM7-Mediated Chondroitin Sulfate Proteoglycan Production","volume":"67","author":"Kamermans","year":"2019","journal-title":"Glia"},{"key":"ref_224","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1002\/jnr.24127","article-title":"Aberrant Astrocytic Expression of Chondroitin Sulfate Proteoglycan Receptors in a Rat Model of Amyotrophic Lateral Sclerosis","volume":"96","author":"Shijo","year":"2018","journal-title":"J. Neurosci. Res."},{"key":"ref_225","doi-asserted-by":"crossref","first-page":"2512","DOI":"10.1002\/jnr.21702","article-title":"Accumulation of Chondroitin Sulfate Proteoglycans in the Microenvironment of Spinal Motor Neurons in Amyotrophic Lateral Sclerosis Transgenic Rats","volume":"86","author":"Mizuno","year":"2008","journal-title":"J. Neurosci. Res."},{"key":"ref_226","doi-asserted-by":"crossref","first-page":"669","DOI":"10.3389\/fneur.2017.00669","article-title":"The TGF-\u03b2 System as a Potential Pathogenic Player in Disease Modulation of Amyotrophic Lateral Sclerosis","volume":"8","author":"Peters","year":"2017","journal-title":"Front. Neurol."},{"key":"ref_227","doi-asserted-by":"crossref","first-page":"5843","DOI":"10.1523\/JNEUROSCI.0137-10.2010","article-title":"Fibrinogen Triggers Astrocyte Scar Formation by Promoting the Availability of Active TGF-\u03b2 after Vascular Damage","volume":"30","author":"Schachtrup","year":"2010","journal-title":"J. Neurosci."},{"key":"ref_228","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1002\/glia.20537","article-title":"Transcriptional Regulation of Scar Gene Expression in Primary Astrocytes","volume":"55","author":"Gris","year":"2007","journal-title":"Glia"},{"key":"ref_229","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1111\/jnc.13424","article-title":"Signaling Pathways Regulating Neuron\u2013Glia Interaction and Their Implications in Alzheimer\u2019s Disease","volume":"136","author":"Lian","year":"2016","journal-title":"J. Neurochem."},{"key":"ref_230","doi-asserted-by":"crossref","first-page":"7231","DOI":"10.1523\/JNEUROSCI.1709-08.2008","article-title":"STAT3 Is a Critical Regulator of Astrogliosis and Scar Formation after Spinal Cord Injury","volume":"28","author":"Herrmann","year":"2008","journal-title":"J. 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