{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T12:15:20Z","timestamp":1789128920524,"version":"build-2803163510"},"reference-count":207,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2024,3,12]],"date-time":"2024-03-12T00:00:00Z","timestamp":1710201600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Universidad Sim\u00f3n Bol\u00edvar, Barranquilla, Colombia"},{"name":"Universidad de C\u00e1diz, C\u00e1diz, Spain"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biomolecules"],"abstract":"<jats:p>Neurogenesis is the process of forming new neurons from neural stem cells (NSCs). In adults, this process takes place in specific areas of the brain, known as neurogenic niches. These regions have unique anatomical features that have been studied in animal models and in the human brain; however, there are differences between these models that need to be addressed. The most studied areas are the subventricular zone, the lateral and latero-dorsal walls of the lateral ventricles, and the dentate gyrus of the hippocampus (Hp), which are known as the canonical areas. Other, less-studied niches, such as the hypothalamus, the cerebellum, and the amygdala, are known as non-canonical areas. Anatomy occupies a relevant place in adult neurogenesis, in which the tissue architecture and cellular location are necessities for the interaction and release of diverse molecules that allow this phenomenon. The cell arrangement within the niche and the location of the niche itself are of particular relevance to the state in which the NSCs are found. Consequently, the majority of previous discoveries have been related to pathology. While many studies are based on animal models, discoveries related to neurogenesis in humans have also been made; however, in this case, opinions vary, leading to extensive controversy in recent years. In this review, we address the anatomical characteristics of the different brain regions to better understand their relationships within neurogenesis.<\/jats:p>","DOI":"10.3390\/biom14030335","type":"journal-article","created":{"date-parts":[[2024,3,12]],"date-time":"2024-03-12T03:55:34Z","timestamp":1710215734000},"page":"335","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Exploring the Intricacies of Neurogenic Niches: Unraveling the Anatomy and Neural Microenvironments"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6654-4217","authenticated-orcid":false,"given":"Ismael","family":"S\u00e1nchez-Gomar","sequence":"first","affiliation":[{"name":"Departamento de Biomedicina, Biotecnolog\u00eda y Salud P\u00fablica, \u00c1rea de Fisiolog\u00eda, Facultad de Medicina, Universidad de C\u00e1diz, 11003 Cadiz, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2149-9050","authenticated-orcid":false,"given":"Noelia","family":"Geribaldi-Dold\u00e1n","sequence":"additional","affiliation":[{"name":"Departamento de Anatom\u00eda y Embriolog\u00eda Humanas, Facultad de Medicina, Universidad de C\u00e1diz, 11003 Cadiz, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Celeste","family":"Santos-Rosendo","sequence":"additional","affiliation":[{"name":"Departamento de Biolog\u00eda, Universidad de C\u00e1diz, 11519 Cadiz, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ciro","family":"Sanguino-Caneva","sequence":"additional","affiliation":[{"name":"Programa de Especializaci\u00f3n en Neurolog\u00eda, Facultad de Ciencias de la Salud, Universidad Sim\u00f3n Bol\u00edvar, Barranquilla 080001, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6908-9806","authenticated-orcid":false,"given":"Carlos","family":"Carrillo-Chapman","sequence":"additional","affiliation":[{"name":"Programa de Especializaci\u00f3n en Neurolog\u00eda, Facultad de Ciencias de la Salud, Universidad Sim\u00f3n Bol\u00edvar, Barranquilla 080001, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1539-7584","authenticated-orcid":false,"given":"Ornella","family":"Fiorillo-Moreno","sequence":"additional","affiliation":[{"name":"Cl\u00ednica Iberoamerica, Barranquilla 080001, Colombia"},{"name":"Cl\u00ednica El Carmen, Barranquilla 080001, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7240-7462","authenticated-orcid":false,"given":"Jos\u00e9 Luis","family":"Villareal Camacho","sequence":"additional","affiliation":[{"name":"Programa de Medicina, Facultad de Ciencias de la Salud, Universidad Libre, Barranquilla 081007, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7567-6409","authenticated-orcid":false,"given":"Elkin Navarro","family":"Quiroz","sequence":"additional","affiliation":[{"name":"Centro de Investigaciones en Ciencias de la Vida, Facultad de Ciencias B\u00e1sicas y Biom\u00e9dicas, Universidad Sim\u00f3n Bol\u00edvar, Barranquilla 080001, Colombia"},{"name":"Programa de Medicina, Facultad de Ciencias de la Salud, Fundaci\u00f3n Universitaria San Martin, Barranquilla 080001, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9342-2127","authenticated-orcid":false,"given":"Cristina","family":"Ver\u00e1stegui","sequence":"additional","affiliation":[{"name":"Departamento de Anatom\u00eda y Embriolog\u00eda Humanas, Facultad de Medicina, Universidad de C\u00e1diz, 11003 Cadiz, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,3,12]]},"reference":[{"key":"ref_1","first-page":"365","article-title":"The aged brain: Genesis and fate of residual progenitor cells in the subventricular zone","volume":"9","year":"2015","journal-title":"Front. 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