{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T00:54:48Z","timestamp":1760144088888,"version":"build-2065373602"},"reference-count":62,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2024,3,20]],"date-time":"2024-03-20T00:00:00Z","timestamp":1710892800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Research Foundation of Korea","award":["NRF-2020R1A2C2007954","2021R1F1A1049849","HI21C1795","22-BR-02-04"],"award-info":[{"award-number":["NRF-2020R1A2C2007954","2021R1F1A1049849","HI21C1795","22-BR-02-04"]}]},{"name":"Korea Health Industry Development Institute (KHIDI)","award":["NRF-2020R1A2C2007954","2021R1F1A1049849","HI21C1795","22-BR-02-04"],"award-info":[{"award-number":["NRF-2020R1A2C2007954","2021R1F1A1049849","HI21C1795","22-BR-02-04"]}]},{"name":"Korea Brain Research Institute","award":["NRF-2020R1A2C2007954","2021R1F1A1049849","HI21C1795","22-BR-02-04"],"award-info":[{"award-number":["NRF-2020R1A2C2007954","2021R1F1A1049849","HI21C1795","22-BR-02-04"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biomolecules"],"abstract":"<jats:p>Although granule cell dispersion (GCD) in the hippocampus is known to be an important feature associated with epileptic seizures in temporal lobe epilepsy (TLE), the endogenous molecules that regulate GCD are largely unknown. In the present study, we have examined whether there is any change in AEG-1 expression in the hippocampus of a kainic acid (KA)-induced mouse model of TLE. In addition, we have investigated whether the modulation of astrocyte elevated gene-1 (AEG-1) expression in the dentate gyrus (DG) by intracranial injection of adeno-associated virus 1 (AAV1) influences pathological phenotypes such as GCD formation and seizure susceptibility in a KA-treated mouse. We have identified that the protein expression of AEG-1 is upregulated in the DG of a KA-induced mouse model of TLE. We further demonstrated that AEG-1 upregulation by AAV1 delivery in the DG-induced anticonvulsant activities such as the delay of seizure onset and inhibition of spontaneous recurrent seizures (SRS) through GCD suppression in the mouse model of TLE, while the inhibition of AEG-1 expression increased susceptibility to seizures. The present observations suggest that AEG-1 is a potent regulator of GCD formation and seizure development associated with TLE, and the significant induction of AEG-1 in the DG may have therapeutic potential against epilepsy.<\/jats:p>","DOI":"10.3390\/biom14030380","type":"journal-article","created":{"date-parts":[[2024,3,20]],"date-time":"2024-03-20T13:09:36Z","timestamp":1710940176000},"page":"380","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Inhibition of Granule Cell Dispersion and Seizure Development by Astrocyte Elevated Gene-1 in a Mouse Model of Temporal Lobe Epilepsy"],"prefix":"10.3390","volume":"14","author":[{"given":"Eunju","family":"Leem","sequence":"first","affiliation":[{"name":"BK21 FOUR KNU Creative BioResearch Group, School of Life Science, Kyungpook National University, Daegu 41566, Republic of Korea"},{"name":"Dementia Research Group, Korea Brain Research Institute, Daegu 41062, Republic of Korea"},{"name":"Efficacy Evaluation Department, New Drug Development Center, Daegu-Gyeongbuk Medical Innovation Foundation (K-MEDI Hub), Daegu 41061, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sehwan","family":"Kim","sequence":"additional","affiliation":[{"name":"BK21 FOUR KNU Creative BioResearch Group, School of Life Science, Kyungpook National University, Daegu 41566, Republic of Korea"},{"name":"Brain Science and Engineering Institute, Kyungpook National University, Daegu 41944, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chanchal","family":"Sharma","sequence":"additional","affiliation":[{"name":"BK21 FOUR KNU Creative BioResearch Group, School of Life Science, Kyungpook National University, Daegu 41566, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Youngpyo","family":"Nam","sequence":"additional","affiliation":[{"name":"Brain Science and Engineering Institute, Kyungpook National University, Daegu 41944, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tae Yeon","family":"Kim","sequence":"additional","affiliation":[{"name":"BK21 FOUR KNU Creative BioResearch Group, School of Life Science, Kyungpook National University, Daegu 41566, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8679-446X","authenticated-orcid":false,"given":"Minsang","family":"Shin","sequence":"additional","affiliation":[{"name":"Department of Microbiology, School of Medicine, Kyungpook National University, Daegu 41944, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0060-5777","authenticated-orcid":false,"given":"Seok-Geun","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Biomedical Science & Technology and BioNanocomposite Research Center, Kyung Hee University, Seoul 02447, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jaekwang","family":"Kim","sequence":"additional","affiliation":[{"name":"Dementia Research Group, Korea Brain Research Institute, Daegu 41062, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0299-1613","authenticated-orcid":false,"given":"Sang Ryong","family":"Kim","sequence":"additional","affiliation":[{"name":"BK21 FOUR KNU Creative BioResearch Group, School of Life Science, Kyungpook National University, Daegu 41566, Republic of Korea"},{"name":"Brain Science and Engineering Institute, Kyungpook National University, Daegu 41944, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,3,20]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1111\/j.1528-1167.2009.02481.x","article-title":"Estimation of the burden of active and life-time epilepsy: A meta-analytic approach","volume":"51","author":"Ngugi","year":"2010","journal-title":"Epilepsia"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1212\/WNL.0000000000003509","article-title":"Prevalence and incidence of epilepsy: A systematic review and meta-analysis of international studies","volume":"88","author":"Fiest","year":"2017","journal-title":"Neurology"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"884","DOI":"10.1016\/S0140-6736(14)60456-6","article-title":"Epilepsy: New advances","volume":"385","author":"Moshe","year":"2015","journal-title":"Lancet"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"18024","DOI":"10.1038\/nrdp.2018.24","article-title":"Epilepsy","volume":"4","author":"Devinsky","year":"2018","journal-title":"Nat. Rev. Dis. Primers"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/0006-8993(90)91601-C","article-title":"Granule cell dispersion in the dentate gyrus of humans with temporal lobe epilepsy","volume":"535","author":"Houser","year":"1990","journal-title":"Brain Res."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1111\/nan.12150","article-title":"Review: Hippocampal sclerosis in epilepsy: A neuropathology review","volume":"40","author":"Thom","year":"2014","journal-title":"Neuropathol. Appl. Neurobiol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"266","DOI":"10.5607\/en.2017.26.5.266","article-title":"Beneficial Effects of Silibinin Against Kainic Acid-induced Neurotoxicity in the Hippocampus in vivo","volume":"26","author":"Kim","year":"2017","journal-title":"Exp. Neurobiol."},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Ying, Z., Li, J., and Li, M. (2011). Astrocyte elevated gene 1: Biological functions and molecular mechanism in cancer and beyond. Cell Biosci., 1.","DOI":"10.1186\/2045-3701-1-36"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.pharmthera.2011.01.008","article-title":"Astrocyte elevated gene-1 (AEG-1): A multifunctional regulator of normal and abnormal physiology","volume":"130","author":"Yoo","year":"2011","journal-title":"Pharmacol. Ther."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1629","DOI":"10.1007\/s00429-023-02676-1","article-title":"Expression patterns of AEG-1 in the normal brain","volume":"228","author":"Kim","year":"2023","journal-title":"Brain Struct. Funct."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"18227","DOI":"10.1074\/jbc.M115.661801","article-title":"Astrocyte Elevated Gene-1 (AEG-1) Regulates Lipid Homeostasis","volume":"290","author":"Robertson","year":"2015","journal-title":"J. Biol. Chem."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"4364","DOI":"10.1158\/0008-5472.CAN-14-0421","article-title":"AEG-1 regulates retinoid X receptor and inhibits retinoid signaling","volume":"74","author":"Srivastava","year":"2014","journal-title":"Cancer Res."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/bs.acr.2016.05.002","article-title":"AEG-1\/MTDH\/LYRIC: A Promiscuous Protein Partner Critical in Cancer, Obesity, and CNS Diseases","volume":"131","author":"Emdad","year":"2016","journal-title":"Adv. Cancer Res."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.tibs.2004.12.001","article-title":"The LxxLL motif: A multifunctional binding sequence in transcriptional regulation","volume":"30","author":"Plevin","year":"2005","journal-title":"Trends Biochem. Sci."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"3592","DOI":"10.1038\/sj.onc.1205445","article-title":"Identification and cloning of human astrocyte genes displaying elevated expression after infection with HIV-1 or exposure to HIV-1 envelope glycoprotein by rapid subtraction hybridization, RaSH","volume":"21","author":"Su","year":"2002","journal-title":"Oncogene"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/S0378-1119(03)00404-9","article-title":"Customized rapid subtraction hybridization (RaSH) gene microarrays identify overlapping expression changes in human fetal astrocytes resulting from human immunodeficiency virus-1 infection or tumor necrosis factor-alpha treatment","volume":"306","author":"Su","year":"2003","journal-title":"Gene"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/B978-0-12-401676-7.00001-2","article-title":"AEG-1\/MTDH\/LYRIC, the beginning: Initial cloning, structure, expression profile, and regulation of expression","volume":"120","author":"Lee","year":"2013","journal-title":"Adv. Cancer Res."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1038\/ng.652","article-title":"Genome-wide association study of migraine implicates a common susceptibility variant on 8q22.1","volume":"42","author":"Anttila","year":"2010","journal-title":"Nat. Genet."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1038\/s41419-018-0491-3","article-title":"Upregulation of neuronal astrocyte elevated gene-1 protects nigral dopaminergic neurons in vivo","volume":"9","author":"Leem","year":"2018","journal-title":"Cell Death Dis."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/j.mcn.2015.08.009","article-title":"Downregulated AEG-1 together with inhibited PI3K\/Akt pathway is associated with reduced viability of motor neurons in an ALS model","volume":"68","author":"Yin","year":"2015","journal-title":"Mol. Cell Neurosci."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"e440","DOI":"10.1038\/emm.2017.261","article-title":"Protection of nigral dopaminergic neurons by AAV1 transduction with Rheb(S16H) against neurotoxic inflammation in vivo","volume":"50","author":"Kim","year":"2018","journal-title":"Exp. Mol. Med."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"226","DOI":"10.5607\/en.2018.27.3.226","article-title":"Morin Prevents Granule Cell Dispersion and Neurotoxicity via Suppression of mTORC1 in a Kainic Acid-induced Seizure Model","volume":"27","author":"Lee","year":"2018","journal-title":"Exp. Neurobiol."},{"key":"ref_23","unstructured":"Paxinos, G., and Franklin, K.B.J. (2004). The Mouse Brain in Stereotaxic Coordinates, Elsevier Academic Press. [2nd ed.]."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/j.eplepsyres.2016.03.001","article-title":"Naringin attenuates granule cell dispersion in the dentate gyrus in a mouse model of temporal lobe epilepsy","volume":"123","author":"Jang","year":"2016","journal-title":"Epilepsy Res."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1007\/s12035-014-8729-2","article-title":"Induction of GDNF and BDNF by hRheb(S16H) transduction of SNpc neurons: Neuroprotective mechanisms of hRheb(S16H) in a model of Parkinson\u2019s disease","volume":"51","author":"Nam","year":"2015","journal-title":"Mol. Neurobiol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1038\/mt.2014.241","article-title":"In vivo AAV1 transduction with hRheb(S16H) protects hippocampal neurons by BDNF production","volume":"23","author":"Jeon","year":"2015","journal-title":"Mol. Ther."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.eplepsyres.2015.06.001","article-title":"Effects of eugenol on granule cell dispersion in a mouse model of temporal lobe epilepsy","volume":"115","author":"Jeong","year":"2015","journal-title":"Epilepsy Res."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1002\/ana.22383","article-title":"Dopaminergic pathway reconstruction by Akt\/Rheb-induced axon regeneration","volume":"70","author":"Kim","year":"2011","journal-title":"Ann. Neurol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1038\/mt.2011.213","article-title":"AAV transduction of dopamine neurons with constitutively active Rheb protects from neurodegeneration and mediates axon regrowth","volume":"20","author":"Kim","year":"2012","journal-title":"Mol. Ther."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1016\/j.seizure.2011.01.003","article-title":"Critical review of current animal models of seizures and epilepsy used in the discovery and development of new antiepileptic drugs","volume":"20","author":"Loscher","year":"2011","journal-title":"Seizure"},{"key":"ref_31","doi-asserted-by":"crossref","unstructured":"Hartman, A.L., Santos, P., Dolce, A., and Hardwick, J.M. (2012). The mTOR Inhibitor Rapamycin Has Limited Acute Anticonvulsant Effects in Mice. PLoS ONE, 7.","DOI":"10.1371\/journal.pone.0045156"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"3226","DOI":"10.1093\/hmg\/dds156","article-title":"The differential effects of prenatal and\/or postnatal rapamycin on neurodevelopmental defects and cognition in a neuroglial mouse model of tuberous sclerosis complex","volume":"21","author":"Way","year":"2012","journal-title":"Hum. Mol. Genet."},{"key":"ref_33","doi-asserted-by":"crossref","unstructured":"Macias, M., Blazejczyk, M., Kazmierska, P., Caban, B., Skalecka, A., Tarkowski, B., Rodo, A., Konopacki, J., and Jaworski, J. (2013). Spatiotemporal characterization of mTOR kinase activity following kainic acid induced status epilepticus and analysis of rat brain response to chronic rapamycin treatment. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0064455"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"6964","DOI":"10.1523\/JNEUROSCI.0066-09.2009","article-title":"The mammalian target of rapamycin signaling pathway mediates epileptogenesis in a model of temporal lobe epilepsy","volume":"29","author":"Zeng","year":"2009","journal-title":"J. Neurosci."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.nbd.2010.05.024","article-title":"Pharmacological inhibition of the mammalian target of rapamycin pathway suppresses acquired epilepsy","volume":"40","author":"Huang","year":"2010","journal-title":"Neurobiol. Dis."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1038\/nn.3947","article-title":"Molecular mechanisms of epilepsy","volume":"18","author":"Staley","year":"2015","journal-title":"Nat. Neurosci."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1093\/advances\/nmz047","article-title":"Perspective: Therapeutic Potential of Flavonoids as Alternative Medicines in Epilepsy","volume":"10","author":"Kwon","year":"2019","journal-title":"Adv. Nutr."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"107855","DOI":"10.1016\/j.neuropharm.2019.107855","article-title":"Why we urgently need improved epilepsy therapies for adult patients","volume":"170","author":"Billakota","year":"2020","journal-title":"Neuropharmacology"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"992","DOI":"10.1016\/j.ajhg.2015.04.020","article-title":"Heterozygous reelin mutations cause autosomal-dominant lateral temporal epilepsy","volume":"96","author":"Dazzo","year":"2015","journal-title":"Am. J. Hum. Genet."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1146\/annurev-genom-120219-074937","article-title":"The Genetics of Epilepsy","volume":"21","author":"Perucca","year":"2020","journal-title":"Annu. Rev. Genomics Hum. Genet."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1016\/S0140-6736(18)32596-0","article-title":"Epilepsy in adults","volume":"393","author":"Thijs","year":"2019","journal-title":"Lancet"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1684\/epd.2020.1176","article-title":"Autosomal dominant lateral temporal lobe epilepsy associated with a novel reelin mutation","volume":"22","author":"Michelucci","year":"2020","journal-title":"Epileptic Disord."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"1002","DOI":"10.1096\/fj.10-168294","article-title":"Epileptiform activity interferes with proteolytic processing of Reelin required for dentate granule cell positioning","volume":"25","author":"Tinnes","year":"2011","journal-title":"FASEB J."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1002\/hipo.20793","article-title":"Impaired reelin processing and secretion by Cajal-Retzius cells contributes to granule cell dispersion in a mouse model of temporal lobe epilepsy","volume":"21","author":"Duveau","year":"2011","journal-title":"Hippocampus"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"2542","DOI":"10.1096\/fj.12-224899","article-title":"TIMP-1 inhibits the proteolytic processing of Reelin in experimental epilepsy","volume":"27","author":"Tinnes","year":"2013","journal-title":"FASEB J."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"5797","DOI":"10.1523\/JNEUROSCI.22-14-05797.2002","article-title":"Role for reelin in the development of granule cell dispersion in temporal lobe epilepsy","volume":"22","author":"Haas","year":"2002","journal-title":"J. Neurosci."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"183","DOI":"10.3389\/fncel.2016.00183","article-title":"Seizure-Induced Motility of Differentiated Dentate Granule Cells Is Prevented by the Central Reelin Fragment","volume":"10","author":"Orcinha","year":"2016","journal-title":"Front. Cell Neurosci."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1016\/j.expneurol.2008.12.029","article-title":"Exogenous reelin prevents granule cell dispersion in experimental epilepsy","volume":"216","author":"Muller","year":"2009","journal-title":"Exp. Neurol."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"730811","DOI":"10.3389\/fnmol.2021.730811","article-title":"Reelin Is Required for Maintenance of Granule Cell Lamination in the Healthy and Epileptic Hippocampus","volume":"14","author":"Orcinha","year":"2021","journal-title":"Front. Mol. Neurosci."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"87","DOI":"10.14581\/jer.19010","article-title":"Recent Aspects of Pediatric Epilepsy Surgery","volume":"9","author":"Kwon","year":"2019","journal-title":"J. Epilepsy Res."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1089\/jmf.2016.3712","article-title":"Control of Granule Cell Dispersion by Natural Materials Such as Eugenol and Naringin: A Potential Therapeutic Strategy Against Temporal Lobe Epilepsy","volume":"19","author":"Kim","year":"2016","journal-title":"J. Med. Food"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/S0022-510X(97)00220-7","article-title":"Granule cell dispersion is correlated with early epileptic events in human temporal lobe epilepsy","volume":"154","author":"Lurton","year":"1998","journal-title":"J. Neurol. Sci."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1007\/s00401-009-0512-5","article-title":"Towards a clinico-pathological classification of granule cell dispersion in human mesial temporal lobe epilepsies","volume":"117","author":"Blumcke","year":"2009","journal-title":"Acta Neuropathol."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1186\/s40478-020-00928-3","article-title":"Hippocampal granule cell dispersion: A non-specific finding in pediatric patients with no history of seizures","volume":"8","author":"Roy","year":"2020","journal-title":"Acta Neuropathol. Commun."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"976","DOI":"10.1111\/ejn.12835","article-title":"Activation of mTOR signaling pathway is secondary to neuronal excitability in a mouse model of mesio-temporal lobe epilepsy","volume":"41","author":"Shima","year":"2015","journal-title":"Eur. J. Neurosci."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.gene.2005.04.006","article-title":"Cloning and characterization of HIV-1-inducible astrocyte elevated gene-1, AEG-1","volume":"353","author":"Kang","year":"2005","journal-title":"Gene"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"11929","DOI":"10.1523\/JNEUROSCI.1860-14.2014","article-title":"An RNA-sequencing transcriptome and splicing database of glia, neurons, and vascular cells of the cerebral cortex","volume":"34","author":"Zhang","year":"2014","journal-title":"J. Neurosci."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.neuron.2015.11.013","article-title":"Purification and Characterization of Progenitor and Mature Human Astrocytes Reveals Transcriptional and Functional Differences with Mouse","volume":"89","author":"Zhang","year":"2016","journal-title":"Neuron"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1016\/S1535-6108(04)00079-0","article-title":"Metadherin, a cell surface protein in breast tumors that mediates lung metastasis","volume":"5","author":"Brown","year":"2004","journal-title":"Cancer Cell"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"1114","DOI":"10.1038\/sj.onc.1210713","article-title":"Astrocyte elevated gene-1 activates cell survival pathways through PI3K-Akt signaling","volume":"27","author":"Lee","year":"2008","journal-title":"Oncogene"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"8529","DOI":"10.1158\/0008-5472.CAN-09-1846","article-title":"Astrocyte Elevated Gene-1: Far More Than Just a Gene Regulated in Astrocytes","volume":"69","author":"Sarkar","year":"2009","journal-title":"Cancer Res."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"547","DOI":"10.4161\/auto.7.5.15078","article-title":"Astrocyte elevated gene-1 activates AMPK in response to cellular metabolic stress and promotes protective autophagy","volume":"7","author":"Bhutia","year":"2011","journal-title":"Autophagy"}],"container-title":["Biomolecules"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2218-273X\/14\/3\/380\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T14:16:55Z","timestamp":1760105815000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2218-273X\/14\/3\/380"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3,20]]},"references-count":62,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2024,3]]}},"alternative-id":["biom14030380"],"URL":"https:\/\/doi.org\/10.3390\/biom14030380","relation":{},"ISSN":["2218-273X"],"issn-type":[{"type":"electronic","value":"2218-273X"}],"subject":[],"published":{"date-parts":[[2024,3,20]]}}}