{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T22:03:16Z","timestamp":1794002596916,"version":"4.8.0"},"reference-count":85,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2024,4,18]],"date-time":"2024-04-18T00:00:00Z","timestamp":1713398400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"NIH"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biomolecules"],"abstract":"<jats:p>Thrombopoietin, the primary regulator of blood platelet production, was postulated to exist in 1958, but was only proven to exist when the cDNA for the hormone was cloned in 1994. Since its initial cloning and characterization, the hormone has revealed many surprises. For example, instead of acting as the postulated differentiation factor for platelet precursors, megakaryocytes, it is the most potent stimulator of megakaryocyte progenitor expansion known. Moreover, it also stimulates the survival, and in combination with stem cell factor leads to the expansion of hematopoietic stem cells. All of these growth-promoting activities have resulted in its clinical use in patients with thrombocytopenia and aplastic anemia, although the clinical development of the native molecule illustrated that \u201cit\u2019s not wise to mess with mother nature\u201d, as a highly engineered version of the native hormone led to autoantibody formation and severe thrombocytopenia. Finally, another unexpected finding was the role of the thrombopoietin receptor in stem cell biology, including the development of myeloproliferative neoplasms, an important disorder of hematopoietic stem cells. Overall, the past 30 years of clinical and basic research has yielded many important insights, which are reviewed in this paper.<\/jats:p>","DOI":"10.3390\/biom14040489","type":"journal-article","created":{"date-parts":[[2024,4,18]],"date-time":"2024-04-18T07:55:54Z","timestamp":1713426954000},"page":"489","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Thrombopoietin, the Primary Regulator of Platelet Production: From Mythos to Logos, a Thirty-Year Journey"],"prefix":"10.3390","volume":"14","author":[{"given":"Kenneth","family":"Kaushansky","sequence":"first","affiliation":[{"name":"Renaissance School of Medicine, Stony Brook University, Stony Brook, NY 11794, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,4,18]]},"reference":[{"key":"ref_1","first-page":"384","article-title":"Sur l\u2019activite hematopoietique des serum au cours de la regeneration du sang","volume":"3","author":"Carnot","year":"1906","journal-title":"Acad. Sci. M"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1002\/jcp.1030660309","article-title":"The cloning of normal mast cells in tissue culture","volume":"66","author":"Pluznik","year":"1965","journal-title":"J. Cell. Comp. Physiol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1038\/icb.1966.28","article-title":"The growth of mouse bone marrow cells in vitro","volume":"44","author":"Bradley","year":"1966","journal-title":"Aust. J. Exp. Biol. Med. Sci."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"5558","DOI":"10.1016\/S0021-9258(19)63387-9","article-title":"Purification of human erythropoietin","volume":"252","author":"Miyake","year":"1977","journal-title":"J. Biol. Chem."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1073\/pnas.86.1.302","article-title":"Human interleukin 7: Molecular cloning and growth factor activity on human and murine B-lineage cells","volume":"86","author":"Goodwin","year":"1989","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1126\/science.2420009","article-title":"Recombinant human granulocyte colony-stimulating factor: Effects on normal and leukemic myeloid cells","volume":"232","author":"Souza","year":"1986","journal-title":"Science"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"6706","DOI":"10.1073\/pnas.85.18.6706","article-title":"cDNA cloning and exoression of murine macrophage colony-stimulating factor from L929 cells","volume":"85","author":"Ladner","year":"1988","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"16580","DOI":"10.1016\/S0021-9258(18)49295-2","article-title":"Molecular cloning and structure of the human interleukin-5 gene","volume":"262","author":"Tanabe","year":"1987","journal-title":"J. Biol. Chem."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"6579","DOI":"10.1016\/S0021-9258(18)88821-4","article-title":"Purification of a multipotential colony-stimulating factor from pokeweed mitogen-stimulated mouse spleen cell conditioned medium","volume":"260","author":"Cutler","year":"1985","journal-title":"J. Biol. Chem."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/0092-8674(90)90301-T","article-title":"Primary structure and functional expression of rat and human stem cell factor DNAs","volume":"63","author":"Martin","year":"1990","journal-title":"Cell"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1038\/309763a0","article-title":"Molecular cloning of cDNA encoding a murine haematopoietic growth regulator, granulocyte-macrophage colony stimulating factor","volume":"309","author":"Gough","year":"1984","journal-title":"Nature"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1159\/000205503","article-title":"Demonstration and some properties of human thrombopoietin in thrombocythemic sera","volume":"20","author":"Kelemen","year":"1958","journal-title":"Acta Haematol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.1016\/0092-8674(94)90450-2","article-title":"Identification and cloning of a megakaryocyte growth and development factor that is a ligand for the cytokine receptor Mpl","volume":"77","author":"Bartley","year":"1994","journal-title":"Cell"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/0014-5793(94)01008-0","article-title":"Molecular cloning and chromosomal localization of the human thrombopoietin gene","volume":"353","author":"Sohma","year":"1994","journal-title":"FEBS Lett."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1016\/0042-6822(86)90125-X","article-title":"A retrovirus complex inducing an acute myeloproliferative leukemia disorder in mice","volume":"149","author":"Wendling","year":"1986","journal-title":"Virology"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"5640","DOI":"10.1073\/pnas.89.12.5640","article-title":"Molecular cloning and characterization of MPL, the human homolog of the v-mpl oncogene: Identification of a member of the hematopoietic growth factor receptor superfamily","volume":"89","author":"Vigon","year":"1992","journal-title":"Proc. Nati. Acad. Sci. USA"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1233","DOI":"10.1126\/science.6177045","article-title":"HEL cells: A new human erythroleukemia cell line with spontaneous and induced globin expression","volume":"216","author":"Martin","year":"1982","journal-title":"Science"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1038\/369565a0","article-title":"Cloning and expression of murine thrombopoietin cDNA and stimulation of platelet production in vivo","volume":"369","author":"Lok","year":"1994","journal-title":"Nature"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1038\/369568a0","article-title":"Promotion of megakaryocyte progenitor expansion and differentiation by the c-Mpl ligand thrombopoietin","volume":"369","author":"Kaushansky","year":"1994","journal-title":"Nature"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1038\/369533a0","article-title":"Stimulation of megakaryocytopoiesis and thrombopoiesis by the c-Mpl ligand","volume":"369","author":"Hass","year":"1994","journal-title":"Nature"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1126\/science.1631562","article-title":"Unraveling the structure of IL-2","volume":"257","author":"Bazan","year":"1992","journal-title":"Science"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1707","DOI":"10.1126\/science.3500515","article-title":"Three dimensional structure of interleukin 2","volume":"238","author":"Brandhuber","year":"1987","journal-title":"Science"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"1816","DOI":"10.1073\/pnas.0308530100","article-title":"Structure of the receptor-binding domain of human thrombopoietin determined by complexation with a neutralizing antibody fragment","volume":"101","author":"Feese","year":"2004","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"856","DOI":"10.1107\/S0907444902004791","article-title":"2002 Crystallization of the functional domain of human thrombopoietin using an antigen-binding fragment derived from neutralizing monoclonal antibody","volume":"58","author":"Kuroki","year":"2002","journal-title":"Acta Crystallogr. D Biol. Crystallogr."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/j.ghir.2015.06.001","article-title":"The growth hormone receptor","volume":"28","author":"Waters","year":"2016","journal-title":"Growth Horm. IGF Res."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"1633","DOI":"10.1099\/0022-1317-67-8-1633","article-title":"Biological activities and receptor binding of two human recombinant interferons and their hybrids","volume":"67","author":"Meister","year":"1986","journal-title":"J. Gen. Virol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"1213","DOI":"10.1073\/pnas.86.4.1213","article-title":"The hematopoietic activity of granulocyte-macrophage colony-stimulating factor is dependent upon two distinct regions of the molecule: A functional analysis based upon the activities of hybrid growth factors","volume":"86","author":"Kaushansky","year":"1989","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"3500","DOI":"10.1182\/blood.V83.12.3500.3500","article-title":"Identification of residues in the first and fourth helices of human granulocyte-macrophage colony-stimulating factor involved in biologic activity and in binding to the alpha- and beta-chains of its receptor","volume":"83","author":"Hercus","year":"1994","journal-title":"Blood"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"14045","DOI":"10.1074\/jbc.271.24.14045","article-title":"Identification of a critical ligand binding determinant of the human erythropoietin receptor. Evidence for common ligand binding motifs in the cytokine receptor family","volume":"271","author":"Middleton","year":"1996","journal-title":"J. Biol. Chem."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"4189","DOI":"10.1016\/j.cell.2023.07.037","article-title":"Structure of the thrombopoietin-MPL receptor complex is a blueprint for biasing hematopoiesis","volume":"186","author":"Tsutsumi","year":"2023","journal-title":"Cell"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1016\/j.cell.2008.05.053","article-title":"The structure of the GM-CSF receptor complex reveals a distinct mode of cytokine receptor activation","volume":"134","author":"Hansen","year":"2008","journal-title":"Cell"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1038\/377591a0","article-title":"Cytokine receptor signalling","volume":"377","author":"Ihle","year":"1995","journal-title":"Nature"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1002\/bies.950160505","article-title":"Cytokine signal transduction and the JAK family of protein tyrosine kinases","volume":"16","author":"Wilks","year":"1994","journal-title":"Bioessays"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"990","DOI":"10.1126\/science.283.5404.990","article-title":"Erythropoietin receptor activation by a ligand-induced conformation change","volume":"283","author":"Remy","year":"1999","journal-title":"Science"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"4979","DOI":"10.1074\/jbc.270.10.4979","article-title":"Stimulation of tyrosine kinase activity by MPL-ligand (thrombopoietin)","volume":"270","author":"Drachman","year":"1995","journal-title":"J. Biol. Chem."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1007\/978-1-4939-2095-2_4","article-title":"Systems biology of megakaryocytes","volume":"844","author":"Kaushansky","year":"2014","journal-title":"Adv. Exp. Med. Biol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"3339","DOI":"10.1172\/JCI26674","article-title":"The molecular mechanisms that control thrombopoiesis","volume":"115","author":"Kaushansky","year":"2005","journal-title":"J. Clin. Investig."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"35240","DOI":"10.1074\/jbc.M201297200","article-title":"The glycan domain of thrombopoietin (TPO) acts in trans to enhance secretion of the hormone and other cytokines","volume":"277","author":"Linden","year":"2002","journal-title":"J. Biol. Chem."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1046\/j.1365-2141.1996.d01-1920.x","article-title":"The role of megakaryocyte growth and development factor in terminal stages of thrombopoiesis","volume":"95","author":"Choi","year":"1996","journal-title":"Br. J. Haematol."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"1683","DOI":"10.1172\/JCI118210","article-title":"Thrombopoietin expands erythroid progenitors, increases red cell production, and enhances erythroid recovery after myelosuppressive therapy","volume":"96","author":"Kaushansky","year":"1995","journal-title":"J. Clin. Investig."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"4998","DOI":"10.1182\/blood.V87.12.4998.bloodjournal87124998","article-title":"The effect of thrombopoietin on the proliferation and differentiation of murine hematopoietic stem cells","volume":"87","author":"Sitnicka","year":"1996","journal-title":"Blood"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"4544","DOI":"10.1182\/blood.V87.11.4544.bloodjournal87114544","article-title":"Thrombopoietin, the ligand for the Mpl receptor, synergizes with steel factor and other early-acting cytokines in supporting proliferation of primitive hematopoietic progenitors of mice","volume":"87","author":"Ku","year":"1996","journal-title":"Blood"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"4045","DOI":"10.1182\/blood.V84.12.4045.bloodjournal84124045","article-title":"In vitro megakaryocytopoietic and thrombopoietic activity of c-mpl ligand (TPO) on purified murine hematopoietic stem cells","volume":"84","author":"Zeigler","year":"1994","journal-title":"Blood"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1182\/blood.V92.1.4.413k38_4_10","article-title":"Role of c-mpl in early hematopoiesis","volume":"92","author":"Solar","year":"1998","journal-title":"Blood"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1111\/j.1749-6632.2003.tb03228.x","article-title":"Thrombopoietin is essential for the maintenance of normal hematopoiesis in humans: Development of aplastic anemia in patients with congenital amegakaryocytic thrombocytopenia","volume":"996","author":"Ballmaier","year":"2003","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"2439","DOI":"10.3324\/haematol.2020.257972","article-title":"CAMT-MPL: Congenital amegakaryocytic thrombocytopenia caused by MPL mutations-heterogeneity of a monogenic disorder\u2014A comprehensive analysis of 56 patients","volume":"106","author":"Germeshausen","year":"2021","journal-title":"Haematologica"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1046\/j.1365-2141.1996.00297.x","article-title":"Proto-oncogene c-mpl is involved in spontaneous megakaryocytopoiesis in myeloproliferative disorders","volume":"92","author":"Li","year":"1996","journal-title":"Br. J. Haematol."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"1382","DOI":"10.1056\/NEJM197406132902419","article-title":"Letter: Bone-marrow responses in polycythemia vera","volume":"290","author":"Prchal","year":"1974","journal-title":"N. Engl. J. Med."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1182\/blood.V59.2.447.447","article-title":"Erythroid progenitors in polycythemia vera: Demonstration of their hypersensitivity to erythropoietin using serum free cultures","volume":"59","author":"Casadevall","year":"1982","journal-title":"Blood"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1002\/ajh.2830240104","article-title":"Megakaryocytic colony formation (CFU-Meg) in essential thrombocythemia: Quantitative and qualitative abnormalities of bone marrow CFU-Meg","volume":"24","author":"Kimura","year":"1987","journal-title":"Am. J. Hematol."},{"key":"ref_51","first-page":"S47","article-title":"The role of the MPL receptor in myeloproliferative disorders","volume":"12","author":"Kaushansky","year":"1998","journal-title":"Leukemia"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1053\/shem.2003.50027","article-title":"Etiology of the myeloproliferative disorders: The role of thrombopoietin","volume":"40","author":"Kaushansky","year":"2003","journal-title":"Sem. Hematol."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"1656","DOI":"10.1182\/blood.V88.5.1656.1656","article-title":"Ectopic expression of murine TPO receptor (c-mpl) in mice is pathogenic and induces erythroblastic proliferation","volume":"88","author":"Cocault","year":"1996","journal-title":"Blood"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1182\/blood.V82.3.877.877","article-title":"Expression of the c-mpl proto-oncogene in human hematologic malignancies","volume":"82","author":"Vigon","year":"1993","journal-title":"Blood"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"1144","DOI":"10.1038\/nature03546","article-title":"A unique clonal JAK2 mutation leading to constitutive signalling causes polycythaemia vera","volume":"434","author":"James","year":"2005","journal-title":"Nature"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1080\/17474086.2019.1617129","article-title":"The role of the thrombopoietin receptor MPL in myeloproliferative neoplasms: Recent findings and potential therapeutic applications","volume":"12","author":"Vainchenker","year":"2019","journal-title":"Expert Rev. Hematol."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"1779","DOI":"10.1056\/NEJMoa051113","article-title":"A gain-of-function mutation of JAK2 in myeloproliferative disorders","volume":"352","author":"Kralovics","year":"2005","journal-title":"N. Engl. J. Med."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/j.ccr.2005.03.023","article-title":"Activating mutation in the tyrosine kinase JAK2 in polycythemia vera, essential thrombocythemia, and myeloid metaplasia with myelofibrosis","volume":"7","author":"Levine","year":"2005","journal-title":"Cancer Cell"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"1054","DOI":"10.1016\/S0140-6736(05)71142-9","article-title":"Acquired mutation of the tyrosine kinase JAK2 in human myeloproliferative disorders","volume":"365","author":"Baxter","year":"2005","journal-title":"Lancet"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"3931","DOI":"10.1182\/blood-2007-08-107748","article-title":"Ratio of mutant JAK2-V617F to wild-type Jak2 determines the MPD phenotypes in transgenic mice","volume":"111","author":"Tiedt","year":"2008","journal-title":"Blood"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"3956","DOI":"10.1182\/blood-2014-07-587238","article-title":"The thrombopoietin receptor, c-MPL, is critical for development of JAK2V617F-positive MPNs","volume":"124","author":"Sangkhae","year":"2014","journal-title":"Blood"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"1307","DOI":"10.1182\/blood-2015-09-671172","article-title":"Activation of the thrombopoietin receptor by mutant calreticulin in CALR-mutant myeloproliferative neoplasms","volume":"127","author":"Araki","year":"2016","journal-title":"Blood"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"1325","DOI":"10.1182\/blood-2015-11-681932","article-title":"Thrombopoietin receptor activation by myeloproliferative neoplasm associated calreticulin mutants","volume":"127","author":"Chachoua","year":"2016","journal-title":"Blood"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"641613","DOI":"10.3389\/fonc.2021.641613","article-title":"The thrombopoietin receptor, MPL, is a therapeutic target of opportunity in the MPNs","volume":"11","author":"Spivak","year":"2021","journal-title":"Front. Oncol."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"3472","DOI":"10.1182\/blood-2006-04-018879","article-title":"MPL515 mutations in myeloproliferative and other myeloid disorders: A study of 1182 patients","volume":"108","author":"Pardanani","year":"2006","journal-title":"Blood"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"1909","DOI":"10.1182\/blood.2022017578","article-title":"Genetic basis and molecular profiling in myeloproliferative neoplasms","volume":"141","author":"Kralovics","year":"2023","journal-title":"Blood"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"3241","DOI":"10.1182\/blood.V98.12.3241","article-title":"Thrombocytopenia caused by the development of antibodies to thrombopoietin","volume":"98","author":"Li","year":"2001","journal-title":"Blood"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"2599","DOI":"10.1182\/blood.V99.7.2599","article-title":"Development of pancytopenia with neutralizing antibodies to thrombopoietin after multicycle chemotherapy supported by megakaryocyte growth and development factor","volume":"99","author":"Basser","year":"2002","journal-title":"Blood"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1111\/j.1365-2141.2010.08140.x","article-title":"Development of romiplostim for the treatment of patients with chronic immune thrombocytopenia: From bench to bedside","volume":"150","author":"Molineux","year":"2010","journal-title":"Br. J. Haematol."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1016\/S0140-6736(08)60203-2","article-title":"Efficacy of romiplostim in patients with chronic immune thrombocytopenic purpura: A double-blind randomised controlled trial","volume":"371","author":"Kuter","year":"2008","journal-title":"Lancet"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"e476","DOI":"10.3324\/haematol.2016.151886","article-title":"Remissions after long-term use of romiplostim for immune thrombocytopenia","volume":"101","author":"Marshall","year":"2016","journal-title":"Haematologica"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1002\/rth2.12457","article-title":"Tapering thrombopoietin receptor agonists in primary immune thrombocytopenia: Expert consensus based on the RAND\/UCLA modified Delphi panel method","volume":"5","author":"Cuker","year":"2020","journal-title":"Res. Pract. Thromb. Haemost."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"4739","DOI":"10.1182\/blood-2006-11-057968","article-title":"Phase 1 clinical study of eltrombopag, an oral, nonpeptide thrombopoietin receptor agonist","volume":"109","author":"Jenkins","year":"2007","journal-title":"Blood"},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1182\/blood-2012-04-425512","article-title":"EXTEND Study Group Safety and efficacy of eltrombopag for treatment of chronic immune thrombocytopenia: Results of the long-term, open-label EXTEND study","volume":"121","author":"Saleh","year":"2013","journal-title":"Blood"},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"1540","DOI":"10.1056\/NEJMoa1613878","article-title":"Eltrombopag Added to Standard Immunosuppression for Aplastic Anemia","volume":"376","author":"Townsley","year":"2017","journal-title":"N. Engl. J. Med."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"1689","DOI":"10.1007\/s40265-019-01197-8","article-title":"Lusutrombopag: A review in thrombocytopenia in patients with chronic liver disease prior to a scheduled procedure","volume":"79","author":"Shirley","year":"2019","journal-title":"Drugs"},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1053\/j.gastro.2018.05.025","article-title":"Avatrombopag before procedures reduces need for platelet transfusion in patients with chronic liver disease and thrombocytopenia","volume":"155","author":"Terrault","year":"2018","journal-title":"Gastroenterology"},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1111\/bjh.18081","article-title":"Adults with immune thrombocytopenia who switched to avatrombopag following prior treatment with eltrombopag or romiplostim: A multicentre US study","volume":"197","author":"Jiang","year":"2022","journal-title":"Br. J. Haematol."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"20406207231191310","DOI":"10.1177\/20406207231191310","article-title":"Comparison of Eltrombopag and avatrombopag in the treatment of refractory\/relapsed aplastic anemia: A single-center retrospective study in China","volume":"14","author":"Zhang","year":"2023","journal-title":"Ther. Adv. Hematol."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"1243","DOI":"10.3324\/haematol.2021.279512","article-title":"Treatment of chemotherapy-induced thrombocytopenia in patients with non-hematologic malignancies","volume":"107","author":"Kuter","year":"2022","journal-title":"Haematologica"},{"key":"ref_81","doi-asserted-by":"crossref","unstructured":"Al-Samkari, H. (2022). Thrombopoietin receptor agonists for chemotherapy-induced thrombocytopenia: A new solution for an old problem. Am. Soc. Hematol. Educ. Program, 286\u2013295.","DOI":"10.1182\/hematology.2022000374"},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1002\/ajh.26497","article-title":"Cost-effectiveness of second-line therapies in adults with chronic immune thrombocytopenia","volume":"98","author":"Goshua","year":"2023","journal-title":"Am. J. Hematol."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1016\/j.clinthera.2020.02.020","article-title":"The Cost-effectiveness of Eltrombopag for the Treatment of Immune Thrombocytopenia in the United States","volume":"42","author":"Tremblay","year":"2020","journal-title":"Clin. Ther."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1111\/bjh.12888","article-title":"The temporary use of thrombopoietin-receptor agonists may induce a prolonged remission in adult chronic immune thrombocytopenia. Results of a French observational study","volume":"165","author":"Fain","year":"2014","journal-title":"Br. J. Hematol."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"2170999","DOI":"10.1080\/09537104.2023.2170999","article-title":"European Delphi panel to build consensus on tapering and discontinuing thrombopoietin receptor agonists in immune thrombocytopenia","volume":"34","author":"Barlassina","year":"2023","journal-title":"Platelets"}],"container-title":["Biomolecules"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2218-273X\/14\/4\/489\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T14:29:51Z","timestamp":1760106591000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2218-273X\/14\/4\/489"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4,18]]},"references-count":85,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2024,4]]}},"alternative-id":["biom14040489"],"URL":"https:\/\/doi.org\/10.3390\/biom14040489","relation":{},"ISSN":["2218-273X"],"issn-type":[{"value":"2218-273X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,4,18]]}}}