{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T04:33:53Z","timestamp":1787027633230,"version":"build-2736575974"},"reference-count":145,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2024,4,24]],"date-time":"2024-04-24T00:00:00Z","timestamp":1713916800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Natural Science Foundation of China","award":["32371184"],"award-info":[{"award-number":["32371184"]}]},{"name":"National Natural Science Foundation of China","award":["2023JH2\/101300072"],"award-info":[{"award-number":["2023JH2\/101300072"]}]},{"name":"National Natural Science Foundation of China","award":["22KJCX040"],"award-info":[{"award-number":["22KJCX040"]}]},{"name":"Liaoning Province Applied Basic Research Program","award":["32371184"],"award-info":[{"award-number":["32371184"]}]},{"name":"Liaoning Province Applied Basic Research Program","award":["2023JH2\/101300072"],"award-info":[{"award-number":["2023JH2\/101300072"]}]},{"name":"Liaoning Province Applied Basic Research Program","award":["22KJCX040"],"award-info":[{"award-number":["22KJCX040"]}]},{"name":"Science and Technology Innovation Program of the General Administration of Sport of China","award":["32371184"],"award-info":[{"award-number":["32371184"]}]},{"name":"Science and Technology Innovation Program of the General Administration of Sport of China","award":["2023JH2\/101300072"],"award-info":[{"award-number":["2023JH2\/101300072"]}]},{"name":"Science and Technology Innovation Program of the General Administration of Sport of China","award":["22KJCX040"],"award-info":[{"award-number":["22KJCX040"]}]},{"name":"X.-A.Z","award":["32371184"],"award-info":[{"award-number":["32371184"]}]},{"name":"X.-A.Z","award":["2023JH2\/101300072"],"award-info":[{"award-number":["2023JH2\/101300072"]}]},{"name":"X.-A.Z","award":["22KJCX040"],"award-info":[{"award-number":["22KJCX040"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biomolecules"],"abstract":"<jats:p>Musculoskeletal diseases (MSDs), including osteoarthritis (OA), osteosarcoma (OS), multiple myeloma (MM), intervertebral disc degeneration (IDD), osteoporosis (OP), and rheumatoid arthritis (RA), present noteworthy obstacles associated with pain, disability, and impaired quality of life on a global scale. In recent years, it has become increasingly apparent that N6-methyladenosine (m6A) is a key regulator in the expression of genes in a multitude of biological processes. m6A is composed of 0.1\u20130.4% adenylate residues, especially at the beginning of 3\u2032-UTR near the translation stop codon. The m6A regulator can be classified into three types, namely the \u201cwriter\u201d, \u201creader\u201d, and \u201ceraser\u201d. Studies have shown that the epigenetic modulation of m6A influences mRNA processing, nuclear export, translation, and splicing. Regulated cell death (RCD) is the autonomous and orderly death of cells under genetic control to maintain the stability of the internal environment. Moreover, distorted RCDs are widely used to influence the course of various diseases and receiving increasing attention from researchers. In the past few years, increasing evidence has indicated that m6A can regulate gene expression and thus influence different RCD processes, which has a central role in the etiology and evolution of MSDs. The RCDs currently confirmed to be associated with m6A are autophagy-dependent cell death, apoptosis, necroptosis, pyroptosis, ferroptosis, immunogenic cell death, NETotic cell death and oxeiptosis. The m6A\u2013RCD axis can regulate the inflammatory response in chondrocytes and the invasive and migratory of MM cells to bone remodeling capacity, thereby influencing the development of MSDs. This review gives a complete overview of the regulatory functions on the m6A\u2013RCD axis across muscle, bone, and cartilage. In addition, we also discuss recent advances in the control of RCD by m6A-targeted factors and explore the clinical application prospects of therapies targeting the m6A\u2013RCD in MSD prevention and treatment. These may provide new ideas and directions for understanding the pathophysiological mechanism of MSDs and the clinical prevention and treatment of these diseases.<\/jats:p>","DOI":"10.3390\/biom14050514","type":"journal-article","created":{"date-parts":[[2024,4,24]],"date-time":"2024-04-24T10:18:36Z","timestamp":1713953916000},"page":"514","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Novel Insights into the Links between N6-Methyladenosine and Regulated Cell Death in Musculoskeletal Diseases"],"prefix":"10.3390","volume":"14","author":[{"given":"Juanjuan","family":"Han","sequence":"first","affiliation":[{"name":"College of Exercise and Health, Shenyang Sport University, Shenyang 110100, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-9504-0579","authenticated-orcid":false,"given":"Cuijing","family":"Wang","sequence":"additional","affiliation":[{"name":"College of Exercise and Health, Shenyang Sport University, Shenyang 110100, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haolin","family":"Yang","sequence":"additional","affiliation":[{"name":"College of Pharmacy, Jilin University, Changchun 132000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiayi","family":"Luo","sequence":"additional","affiliation":[{"name":"College of Exercise and Health, Shenyang Sport University, Shenyang 110100, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyi","family":"Zhang","sequence":"additional","affiliation":[{"name":"College of Second Clinical Medical, China Medical University, Shenyang 110100, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7854-4134","authenticated-orcid":false,"given":"Xin-An","family":"Zhang","sequence":"additional","affiliation":[{"name":"College of Exercise and Health, Shenyang Sport University, Shenyang 110100, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,4,24]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1186\/s12943-023-01810-1","article-title":"Epigenetic modification of m6A regulator proteins in cancer","volume":"22","author":"Wang","year":"2023","journal-title":"Mol. 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