{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T19:31:03Z","timestamp":1788982263792,"version":"build-2803163510"},"reference-count":184,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2024,4,30]],"date-time":"2024-04-30T00:00:00Z","timestamp":1714435200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005046","name":"Heilongjiang Provincial Natural Science Foundation","doi-asserted-by":"publisher","award":["YQ2022H020"],"award-info":[{"award-number":["YQ2022H020"]}],"id":[{"id":"10.13039\/501100005046","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biomolecules"],"abstract":"<jats:p>Hydrogen sulfide (H2S), previously regarded as a toxic exhaust and atmospheric pollutant, has emerged as the third gaseous signaling molecule following nitric oxide (NO) and carbon monoxide (CO). Recent research has revealed significant biological effects of H2S in a variety of systems, such as the nervous, cardiovascular, and digestive systems. Additionally, H2S has been found to impact reproductive system function and may have therapeutic implications for reproductive disorders. This paper explores the relationship between H2S and male reproductive disorders, specifically erectile dysfunction, prostate cancer, male infertility, and testicular damage. Additionally, it examines the impact of H2S regulation on the pathophysiology of the female reproductive system, including improvements in preterm birth, endometriosis, pre-eclampsia, fetal growth restriction, unexplained recurrent spontaneous abortion, placental oxidative damage, embryo implantation, recovery of myometrium post-delivery, and ovulation. The study delves into the regulatory functions of H2S within the reproductive systems of both genders, including its impact on the NO\/cGMP pathway, the activation of K+ channels, and the relaxation mechanism of the spongy smooth muscle through the ROCK pathway, aiming to broaden the scope of potential therapeutic strategies for treating reproductive system disorders in clinical settings.<\/jats:p>","DOI":"10.3390\/biom14050540","type":"journal-article","created":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T10:33:31Z","timestamp":1714559611000},"page":"540","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Therapeutic Potential of Hydrogen Sulfide in Reproductive System Disorders"],"prefix":"10.3390","volume":"14","author":[{"given":"Xutao","family":"Sun","sequence":"first","affiliation":[{"name":"Department of Typhoid, School of Basic Medical Sciences, Heilongjiang University of Chinese Medicine, No. 24, Heping Street, Harbin 150040, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caiyun","family":"Mao","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, School of Basic Medical Sciences, Heilongjiang University of Chinese Medicine, No. 24, Heping Street, Harbin 150040, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Xie","sequence":"additional","affiliation":[{"name":"Department of Synopsis of the Golden Chamber, School of Basic Medical Sciences, Heilongjiang University of Chinese Medicine, No. 24, Heping Street, Harbin 150040, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing","family":"Zhong","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, School of Basic Medical Sciences, Heilongjiang University of Chinese Medicine, No. 24, Heping Street, Harbin 150040, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rong","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, School of Basic Medical Sciences, Heilongjiang University of Chinese Medicine, No. 24, Heping Street, Harbin 150040, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deyou","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Synopsis of the Golden Chamber, School of Basic Medical Sciences, Heilongjiang University of Chinese Medicine, No. 24, Heping Street, Harbin 150040, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunjia","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, School of Basic Medical Sciences, Heilongjiang University of Chinese Medicine, No. 24, Heping Street, Harbin 150040, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,4,30]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1007\/s00418-021-02071-z","article-title":"Microenvironment for spermatogenesis and sperm maturation","volume":"157","author":"Miyaso","year":"2022","journal-title":"Histochem. Cell Biol."},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Magro-Lopez, E., and Mu\u00f1oz-Fern\u00e1ndez, M.\u00c1. (2021). The role of bmp signaling in female reproductive system development and function. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms222111927"},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Farsimadan, M., and Motamedifar, M. (2020). Bacterial infection of the male reproductive system causing infertility. J. Reprod. Immunol., 142.","DOI":"10.1016\/j.jri.2020.103183"},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Han, X., and Huang, Q. (2021). Environmental pollutants exposure and male reproductive toxicity: The role of epigenetic modifications. Toxicology, 456.","DOI":"10.1016\/j.tox.2021.152780"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.alcohol.2021.08.003","article-title":"Male subfertility effects of sub-chronic ethanol exposure during stress in a rat model","volume":"96","author":"Fozooni","year":"2021","journal-title":"Alcohol"},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"He, L., Gong, H., You, S., Zhang, C., Zhong, C., and Li, L. (2021). Mirna-138-5p suppresses cigarette smoke-induced apoptosis in testicular cells by targeting caspase-3 through the bcl-2 signaling pathway. J. Biochem. Mol. Toxicol., 35.","DOI":"10.1002\/jbt.22783"},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Chacra, L.A., Benatmane, A., Iwaza, R., Ly, C., Alibar, S., Armstrong, N., Mediannikov, O., Bretelle, F., and Fenollar, F. (2023). Culturomics reveals a hidden world of vaginal microbiota with the isolation of 206 bacteria from a single vaginal sample. Arch. Microbiol., 206.","DOI":"10.1007\/s00203-023-03742-2"},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Wu, X., Tian, Y., Zhu, H., Xu, P., Zhang, J., Hu, Y., Ji, X., Yan, R., Yue, H., and Sang, N. (2023). Invisible Hand behind Female Reproductive Disorders: Bisphenols, Recent Evidence and Future Perspectives. Toxics, 11.","DOI":"10.3390\/toxics11121000"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1007\/978-3-319-18144-8_4","article-title":"H2S and blood vessels: An overview","volume":"230","author":"Yang","year":"2015","journal-title":"Handb. Exp. Pharmacol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1152\/physrev.00028.2021","article-title":"Physiological roles of hydrogen sulfide in mammalian cells, tissues, and organs","volume":"103","author":"Cirino","year":"2023","journal-title":"Physiol. Rev."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1586\/ecp.10.125","article-title":"Hydrogen sulfide in the endocrine and reproductive systems","volume":"4","author":"Zhu","year":"2011","journal-title":"Expert Rev. Clin. Pharmacol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1089\/ars.2017.7079","article-title":"The Role of the Hydrogen Sulfide Pathway in Male and Female Urogenital System in Health and Disease","volume":"27","author":"Bianca","year":"2017","journal-title":"Antioxid. Redox Signal"},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Wang, R., and Tang, C. (2022). Hydrogen Sulfide Biomedical Research in China\u201420 Years of Hindsight. Antioxidants, 11.","DOI":"10.3390\/antiox11112136"},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Kadlec, M., Ros-Santaella, J.L., and Pintus, E. (2020). The Roles of NO and H2S in Sperm Biology: Recent Advances and New Perspectives. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21062174"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1877","DOI":"10.1097\/00029330-200611020-00006","article-title":"Localization of cystathionine beta synthase in mice ovaries and its expression profile during follicular development","volume":"119","author":"Liang","year":"2006","journal-title":"Chin. Med. J."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1875","DOI":"10.1111\/j.1743-6109.2009.01291.x","article-title":"Initial Characterization of Hydrogen Sulfide Effects in Female Sexual Function","volume":"6","author":"Srilatha","year":"2009","journal-title":"J. Sex. Med."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"4513","DOI":"10.1073\/pnas.0807974105","article-title":"Hydrogen sulfide as a mediator of human corpus cavernosum smooth-muscle relaxation","volume":"106","author":"Sorrentino","year":"2009","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1016\/j.ejphar.2006.02.001","article-title":"Possible role for the novel gasotransmitter hydrogen sulphide in erectile dysfunction\u2014A pilot study","volume":"535","author":"Srilatha","year":"2006","journal-title":"Eur. J. Pharmacol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.niox.2020.11.003","article-title":"Administration of h(2)s improves erectile dysfunction by inhibiting phenotypic modulation of corpus cavernosum smooth muscle in bilateral cavernous nerve injury rats","volume":"107","author":"Zeng","year":"2021","journal-title":"Nitric Oxide Biol. Chem."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1522","DOI":"10.1111\/j.1464-410X.2009.08415.x","article-title":"Effect of hydrogen sulphide-donating sildenafil (acs6) on erectile function and oxidative stress in rabbit isolated corpus cavernosum and in hypertensive rats","volume":"103","author":"Shukla","year":"2009","journal-title":"BJU Int."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1089\/ars.2005.7.781","article-title":"Cadmium Exposure Alters Metabolomics of Sulfur-Containing Amino Acids in Rat Testes","volume":"7","author":"Sugiura","year":"2005","journal-title":"Antioxid. Redox Signal."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"11426","DOI":"10.1038\/s41598-022-15360-x","article-title":"Evidence of endogenously produced hydrogen sulfide (h(2)s) and persulfidation in male reproduction","volume":"12","author":"Moravec","year":"2022","journal-title":"Sci. Rep."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"1833","DOI":"10.1016\/j.fertnstert.2010.11.001","article-title":"Endogenous hydrogen sulfide as a mediator of vas deferens smooth muscle relaxation","volume":"95","author":"Li","year":"2011","journal-title":"Fertil. Steril."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"2806","DOI":"10.1111\/j.1743-6109.2012.02879.x","article-title":"H2S Relaxes Vas Deferens Smooth Muscle by Modulating the Large Conductance Ca2+-Activated K+ (BKCa) Channels via a Redox Mechanism","volume":"9","author":"Li","year":"2012","journal-title":"J. Sex. Med."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1111\/j.1600-0773.2001.880407.x","article-title":"L-cysteine and sodium hydrosulphide inhibit spontaneous contractility in isolated pregnant rat uterine strips in vitro","volume":"88","author":"Sidhu","year":"2001","journal-title":"Pharmacol. Toxicol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"4107","DOI":"10.1038\/ncomms5107","article-title":"Dysregulation of hydrogen sulphide metabolism impairs oviductal transport of embryos","volume":"5","author":"Ning","year":"2014","journal-title":"Nat. Commun."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1152\/physiolgenomics.00189.2010","article-title":"Cystathionine \u03b2-synthase deficiency causes infertility by impairing decidualization and gene expression networks in uterus implantation sites","volume":"44","author":"Arnal","year":"2012","journal-title":"Physiol. Genom."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1152\/physrev.00017.2011","article-title":"Physiological Implications of Hydrogen Sulfide: A Whiff Exploration That Blossomed","volume":"92","author":"Wang","year":"2012","journal-title":"Physiol. Rev."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1038\/s41569-022-00741-6","article-title":"Sulfide regulation of cardiovascular function in health and disease","volume":"20","author":"Kolluru","year":"2023","journal-title":"Nat. Rev. Cardiol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"22457","DOI":"10.1074\/jbc.M109.010868","article-title":"Relative contributions of cystathionine beta-synthase and gam-ma-cystathionase to H2S biogenesis via alternative trans-sulfuration reactions","volume":"284","author":"Singh","year":"2009","journal-title":"J. Biol. Chem."},{"key":"ref_31","doi-asserted-by":"crossref","unstructured":"Munteanu, C., Rotariu, M., Turnea, M., Dogaru, G., Popescu, C., Sp\u00eenu, A., Andone, I., Postoiu, R., Ionescu, E.V., and Oprea, C. (2022). Recent Advances in Molecular Research on Hydrogen Sulfide (H2S) Role in Diabetes Mellitus (DM)\u2014A Systematic Review. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23126720"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.tips.2007.11.003","article-title":"Putative biological roles of hydrogen sulfide in health and disease: A breath of not so fresh air?","volume":"29","author":"Li","year":"2008","journal-title":"Trends Pharmacol. Sci."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1038\/nrd2425","article-title":"Hydrogen sulphide and its therapeutic potential","volume":"6","year":"2007","journal-title":"Nat. Rev. Drug Discov."},{"key":"ref_34","doi-asserted-by":"crossref","unstructured":"Liu, J., Mesfin, F.M., Hunter, C.E., Olson, K.R., Shelley, W.C., Brokaw, J.P., Manohar, K., and Markel, T.A. (2022). Recent Development of the Molecular and Cellular Mechanisms of Hydrogen Sulfide Gasotransmitter. Antioxidants, 11.","DOI":"10.3390\/antiox11091788"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.jare.2020.05.007","article-title":"Hydrogen sulfide and vascular regulation\u2014An update","volume":"27","author":"Lv","year":"2021","journal-title":"J. Adv. Res."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"2519","DOI":"10.1002\/nau.23788","article-title":"Possible role of hydrogen sulfide as an endogenous relaxation factor in the rat bladder and prostate","volume":"37","author":"Zou","year":"2018","journal-title":"Neurourol. Urodyn."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"1366","DOI":"10.1038\/ncomms2371","article-title":"A novel pathway for the production of hydrogen sulfide from D-cysteine in mammalian cells","volume":"4","author":"Shibuya","year":"2013","journal-title":"Nat. Commun."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"3352","DOI":"10.1111\/j.1742-4658.2008.06482.x","article-title":"Three enzymatic activities catalyze the oxidation of sulfide to thiosulfate in mammalian and invertebrate mitochondria","volume":"275","author":"Hildebrandt","year":"2008","journal-title":"FEBS J."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"30901","DOI":"10.1074\/jbc.M114.602664","article-title":"Organization of the Human Mitochondrial Hydrogen Sulfide Oxidation Pathway","volume":"289","author":"Libiad","year":"2014","journal-title":"J. Biol. Chem."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.bcp.2017.12.010","article-title":"H2S and polysulfide metabolism: Conventional and unconventional pathways","volume":"149","author":"Olson","year":"2018","journal-title":"Biochem. Pharmacol."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1089\/ars.2021.0088","article-title":"Methods for Suppressing Hydrogen Sulfide in Biological Systems","volume":"36","author":"Wang","year":"2022","journal-title":"Antioxid. Redox Signal."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"686","DOI":"10.3389\/fphar.2017.00686","article-title":"The role of hydrogen sulfide on cardiovascular homeostasis: An overview with update on im-munomodulation","volume":"8","author":"Pan","year":"2017","journal-title":"Front. Pharmacol."},{"key":"ref_43","doi-asserted-by":"crossref","unstructured":"Zhang, Y., Jing, M., Cai, C., Zhu, S., Zhang, C., Wang, Q., Zhai, Y., Ji, X., and Wu, D. (2023). Role of hydrogen sulphide in physiological and pathological angiogenesis. Cell Prolif., 56.","DOI":"10.1111\/cpr.13374"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"1","DOI":"10.4149\/gpb_2013001","article-title":"Hydrogen sulfide in cell signaling, signal transduction, cellular bioenergetics and physiology in C. elegans","volume":"32","author":"Wolanska","year":"2013","journal-title":"Gen. Physiol. Biophys."},{"key":"ref_45","doi-asserted-by":"crossref","unstructured":"Sunzini, F., De Stefano, S., Chimenti, M.S., and Melino, S. (2020). Hydrogen Sulfide as Potential Regulatory Gasotransmitter in Arthritic Diseases. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21041180"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"1346","DOI":"10.1016\/j.freeradbiomed.2009.09.018","article-title":"Making and working with hydrogen sulfide: The chemistry and generation of hy-drogen sulfide in vitro and its measurement in vivo: A review","volume":"47","author":"Hughes","year":"2009","journal-title":"Free Radic. Biol. Med."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"1304","DOI":"10.1111\/j.1743-6109.2007.00561.x","article-title":"Hydrogen Sulphide: A Novel Endogenous Gasotransmitter Facilitates Erectile Function","volume":"4","author":"Srilatha","year":"2007","journal-title":"J. Sex. Med."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1038\/aja.2013.32","article-title":"Further evidence of endogenous hydrogen sulphide as a mediator of relaxation in human and rat bladder","volume":"15","author":"Gai","year":"2013","journal-title":"Asian J. Androl."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"483.e1","DOI":"10.1016\/j.urology.2011.10.013","article-title":"Characterization of Hydrogen Sulfide and Its Synthases, Cystathionine \u03b2-Synthase and Cystathionine \u03b3-Lyase, in Human Prostatic Tissue and Cells","volume":"79","author":"Guo","year":"2012","journal-title":"Urology"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.1016\/j.bcp.2012.01.026","article-title":"Role of endogenous hydrogen sulfide in neurogenic relaxation of rat corpus cavernosum","volume":"83","author":"Ghasemi","year":"2012","journal-title":"Biochem. Pharmacol."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1016\/j.jsxm.2016.01.002","article-title":"Decreased Endogenous Hydrogen Sulfide Generation in Penile Tissues of Diabetic Rats with Erectile Dysfunction","volume":"13","author":"Zhang","year":"2016","journal-title":"J. Sex. Med."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.phrs.2016.08.015","article-title":"Hydrogen sulfide compensates nitric oxide deficiency in murine corpus cavernosum","volume":"113","author":"Dikmen","year":"2016","journal-title":"Pharmacol. Res."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.niox.2017.08.005","article-title":"The interaction of l-cysteine\/H2S pathway and muscarinic acetylcholine receptors (mAChRs) in mouse corpus cavernosum","volume":"70","author":"Aydinoglu","year":"2017","journal-title":"Nitric Oxide"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"20824","DOI":"10.1074\/jbc.M114.559518","article-title":"Hydrogen Sulfide Represses Androgen Receptor Transactivation by Targeting at the Second Zinc Finger Module","volume":"289","author":"Zhao","year":"2014","journal-title":"J. Biol. Chem."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.niox.2014.10.005","article-title":"Hydrogen sulfide protects testicular germ cells against heat-induced injury","volume":"46","author":"Li","year":"2015","journal-title":"Nitric Oxide"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"1886","DOI":"10.3389\/fphys.2018.01886","article-title":"Cellular Mechanism Underlying Hydrogen Sulfide Mediated Epithelial K+ Secretion in Rat Epididymis","volume":"9","author":"Gao","year":"2018","journal-title":"Front. Physiol."},{"key":"ref_57","doi-asserted-by":"crossref","unstructured":"Patel, P., Vatish, M., Heptinstall, J., Wang, R., and Carson, R.J. (2009). The endogenous production of hydrogen sulphide in intrauterine tissues. Reprod. Biol. Endocrinol., 7.","DOI":"10.1186\/1477-7827-7-10"},{"key":"ref_58","unstructured":"(2024, February 25). Hydrogen Sulfide Producing Enzymes in Pregnancy and Preeclampsia, Available online: https:\/\/pubmed.ncbi.nlm.nih.gov\/22391326\/."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.placenta.2017.02.012","article-title":"Mir133b is involved in endogenous hydrogen sulfide suppression of sFlt-1 production in human placenta","volume":"52","author":"Hu","year":"2017","journal-title":"Placenta"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"2514","DOI":"10.1161\/CIRCULATIONAHA.113.001631","article-title":"Ahmed, Dysregulation of hydrogen sulfide producing enzyme cystathionine \u03b3-lyase contributes to maternal hypertension and placental abnormalities in preeclampsia","volume":"127","author":"Wang","year":"2013","journal-title":"Circulation"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"1448","DOI":"10.1016\/j.ajpath.2013.01.001","article-title":"Reduced Cystathionine \u03b3-Lyase and Increased miR-21 Expression Are Associated with Increased Vascular Resistance in Growth-Restricted Pregnancies: Hydrogen Sulfide as a Placental Vasodilator","volume":"182","author":"Herrera","year":"2013","journal-title":"Am. J. Pathol."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1095\/biolreprod.116.143834","article-title":"Augmented H2S production via cystathionine-beta-synthase upregulation plays a role in pregnancy-associated uterine vasodilation","volume":"96","author":"Sheibani","year":"2017","journal-title":"Biol. Reprod."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"1630","DOI":"10.1093\/biolre\/ioz027","article-title":"Ovine uterine artery hydrogen sulfide biosynthesis in vivo: Effects of ovarian cycle and pregnancy","volume":"100","author":"Lechuga","year":"2019","journal-title":"Biol. Reprod."},{"key":"ref_64","doi-asserted-by":"crossref","unstructured":"Qi, Q.-R., Lechuga, T.J., Patel, B., Nguyen, N.A., Yang, Y.-H., Li, Y., Sarnthiyakul, S., Zhang, Q.-W., Bai, J., and Makhoul, J. (2020). Enhanced Stromal Cell CBS-H2S Production Promotes Estrogen-Stimulated Human Endometrial Angiogenesis. Endocrinology, 161.","DOI":"10.1210\/endocr\/bqaa176"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"798","DOI":"10.1016\/j.jsxm.2016.03.001","article-title":"Hydrogen Sulfide Facilitates Vaginal Lubrication by Activation of Epithelial ATP-Sensitive K+ Channels and Cystic Fibrosis Transmembrane Conductance Regulator","volume":"13","author":"Sun","year":"2016","journal-title":"J. Sex. Med."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/j.ucl.2005.08.007","article-title":"Physiology of Penile Erection and Pathophysiology of Erectile Dysfunction","volume":"32","author":"Dean","year":"2005","journal-title":"Urol. Clin. N. Am."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"H835","DOI":"10.1152\/ajpheart.00293.2015","article-title":"Analysis of erectile responses to H2S donors in the anesthetized rat","volume":"309","author":"Jupiter","year":"2015","journal-title":"Am. J. Physiol. Circ. Physiol."},{"key":"ref_68","doi-asserted-by":"crossref","unstructured":"Yilmaz, E., Kaya-Sezginer, E., Yilmaz-Oral, D., Cengiz, T., Bayatli, N., and Gur, S. (2019). Effects of hydrogen sulphide donor, sodium hy-drosulphide treatment on the erectile dysfunction in l-name-induced hypertensive rats. Andrologia, 51.","DOI":"10.1111\/and.13240"},{"key":"ref_69","doi-asserted-by":"crossref","unstructured":"Zhong, L., Ding, W., Zeng, Q., He, B., Zhang, H., Wang, L., Fan, J., He, S., Zhang, Y., and Wei, A. (2020). Sodium tanshinone iia sulfonate attenuates erectile dysfunction in rats with hyperlipidemia. Oxid Med. Cell Longev., 2020.","DOI":"10.1155\/2020\/7286958"},{"key":"ref_70","doi-asserted-by":"crossref","unstructured":"La Fuente, J.M., Sevilleja-Ortiz, A., Garc\u00eda-Rojo, E., El Assar, M., Fern\u00e1ndez, A., Pepe-Cardoso, A.J., Mart\u00ednez-Salamanca, J.I., Romero-Otero, J., Rodr\u00edguez-Ma\u00f1as, L., and Angulo, J. (2020). Erectile dysfunction is associated with defective L-cysteine\/hydrogen sulfide pathway in human corpus cavernosum and penile arteries. Eur. J. Pharmacol., 884.","DOI":"10.1016\/j.ejphar.2020.173370"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"2004","DOI":"10.1111\/jsm.12993","article-title":"Resveratrol Stimulates Hydrogen Sulfide (H2S) Formation to Relax Murine Corpus Cavernosum","volume":"12","author":"Dereli","year":"2015","journal-title":"J. Sex. Med."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/j.eururo.2012.04.047","article-title":"Prevention and Management of Postprostatectomy Sexual Dysfunctions Part 2: Recovery and Preservation of Erectile Function, Sexual Desire, and Orgasmic Function","volume":"62","author":"Salonia","year":"2012","journal-title":"Eur. Urol."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"5531","DOI":"10.1073\/pnas.0931347100","article-title":"Involvement of beta 3-adrenergic receptor activation via cyclic gmp- but not no-dependent mechanisms in human corpus cavernosum function","volume":"100","author":"Cirino","year":"2003","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.phrs.2017.07.025","article-title":"\u0392(3) adrenergic receptor activation relaxes human corpus cavernosum and penile artery through a hydrogen sul-fide\/cgmp-dependent mechanism","volume":"124","author":"Mitidieri","year":"2017","journal-title":"Pharmacol. Res."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1111\/bju.13515","article-title":"Mirabegron causes relaxation of human and rat corpus cavernosum: Could it be a potential therapy for erectile dysfunction?","volume":"118","author":"Gur","year":"2016","journal-title":"BJU Int."},{"key":"ref_76","doi-asserted-by":"crossref","unstructured":"Dayar, E., Kara, E., Yetik-Anacak, G., Hocaoglu, N., Bozkurt, O., Gidener, S., and Durmus, N. (2018). Do penile haemodynamics change in the presence of hydrogen sulphide (H2S) donor in metabolic syndrome-induced erectile dysfunction?. Andrologia, 50.","DOI":"10.1111\/and.12885"},{"key":"ref_77","doi-asserted-by":"crossref","unstructured":"Qabazard, B., Yousif, M., Mousa, A., and Phillips, O.A. (2021). GYY4137 attenuates functional impairment of corpus cavernosum and reduces fibrosis in rats with STZ-induced diabetes by inhibiting the TGF-\u03b21\/Smad\/CTGF pathway. Biomed. Pharmacother., 138.","DOI":"10.1016\/j.biopha.2021.111486"},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1002\/nau.24333","article-title":"Evaluation of combined therapeutic effects of hydrogen sulfide donor sodium hydrogen sulfide and phosphodiesterase type-5 inhibitor tadalafil on erectile dysfunction in a partially bladder outlet obstructed rat model","volume":"39","author":"Oztekin","year":"2020","journal-title":"Neurourol. Urodyn."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1016\/S0008-6363(99)00135-2","article-title":"Nitric oxide and penile erection: Is erectile dysfunction another manifestation of vascular disease?","volume":"43","author":"Sullivan","year":"1999","journal-title":"Cardiovasc. Res."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"291","DOI":"10.3129\/i08-044","article-title":"Nitric oxide and cyclic guanosine monophosphate signaling in the eye","volume":"43","author":"Murad","year":"2008","journal-title":"Can. J. Ophthalmol."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1038\/ijir.2012.39","article-title":"Hydrogen sulfide promotes nitric oxide production in corpus cavernosum by en-hancing expression of endothelial nitric oxide synthase","volume":"25","author":"Meng","year":"2013","journal-title":"Int. J. Impot. Res."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1038\/s41443-018-0084-9","article-title":"Cavernosal hydrogen sulfide levels are associated with nitric oxide and hemeoxygenase levels in diabetic rats","volume":"31","author":"Mostafa","year":"2019","journal-title":"Int. J. Impot. Res."},{"key":"ref_83","doi-asserted-by":"crossref","unstructured":"Olivencia, M.A., Esposito, E., Brancaleone, V., Castaldo, S., Cirino, G., P\u00e9rez-Vizcaino, F., Sorrentino, R., di Villa Bianca, R.D.E., and Mitidieri, E. (2023). Hydrogen sulfide regulates the redox state of soluble guanylate cyclase in cse(-\/-) mice corpus cavernosum microcirculation. Pharmacol. Res., 194.","DOI":"10.1016\/j.phrs.2023.106834"},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.lfs.2017.09.013","article-title":"Potassium channels modulate the action but not the synthesis of hydrogen sulfide in rat corpus cavernosum","volume":"189","author":"Elmoneim","year":"2017","journal-title":"Life Sci."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1038\/s41443-018-0083-x","article-title":"Alleviation of impaired reactivity in the corpus cavernosum of STZ-diabetic rats by slow-release H2S donor GYY4137","volume":"31","author":"Qabazard","year":"2019","journal-title":"Int. J. Impot. Res."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.niox.2019.02.001","article-title":"Involvement of rhoa\/rho-kinase in l-cysteine\/H2S pathway-induced inhibition of agonist-mediated corpus cavernosal smooth muscle contraction","volume":"85","author":"Aydinoglu","year":"2019","journal-title":"Nitric Oxide Biol. Chem."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1016\/j.bcp.2015.08.005","article-title":"Functional upregulation of the H2S\/Cav3.2 channel pathway accelerates secretory function in neuroendocrine-differentiated human prostate cancer cells","volume":"97","author":"Fukami","year":"2015","journal-title":"Biochem. Pharmacol."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"37884","DOI":"10.1038\/srep37884","article-title":"Hydrogen Sulfide and\/or Ammonia Reduces Spermatozoa Motility through AMPK\/AKT Related Pathways","volume":"6","author":"Zhao","year":"2016","journal-title":"Sci. Rep."},{"key":"ref_89","doi-asserted-by":"crossref","unstructured":"Li, S., Ma, Y., Ye, S., Su, Y., Hu, D., and Xiao, F. (2022). Endogenous hydrogen sulfide counteracts polystyrene nanoplastics-induced mito-chondrial apoptosis and excessive autophagy via regulating nrf2 and pgc-1\u03b1 signaling pathway in mouse spermatocyte-derived gc-2spd(ts) cells. Food Chem. Toxicol. Int. J. Publ. Br. Ind. Biol. Res. Assoc., 164.","DOI":"10.1016\/j.fct.2022.113071"},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"40.e1","DOI":"10.1016\/j.jpurol.2019.10.006","article-title":"Protective effect of hydrogen sulfide on experimental testicular ischemia reperfusion in rats","volume":"16","author":"Bozkurt","year":"2020","journal-title":"J. Pediatr. Urol."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"3460","DOI":"10.1111\/jcmm.16428","article-title":"H2S catalysed by CBS regulates testosterone synthesis through affecting the sulfhydrylation of PDE","volume":"25","author":"Wang","year":"2021","journal-title":"J. Cell. Mol. Med."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"1447","DOI":"10.1089\/ars.2016.6968","article-title":"Hydrogen Sulfide As a Potential Target in Preventing Spermatogenic Failure and Testicular Dysfunction","volume":"28","author":"Wang","year":"2018","journal-title":"Antioxidants Redox Signal."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"6508","DOI":"10.1038\/s41598-020-63489-4","article-title":"Divergent effect of fast- and slow-releasing H2S donors on boar spermatozoa under oxidative stress","volume":"10","author":"Pintus","year":"2020","journal-title":"Sci. Rep."},{"key":"ref_94","first-page":"729","article-title":"GYY4137 a H2S donor, attenuates ipsilateral epididymis injury in experimentally varicocele-induced rats via activation of the PI3K\/Akt pathway","volume":"22","author":"Xia","year":"2019","journal-title":"Iran. J. Basic Med. Sci."},{"key":"ref_95","doi-asserted-by":"crossref","unstructured":"You, X.-J., Xu, C., Lu, J.-Q., Zhu, X.-Y., Gao, L., Cui, X.-R., Li, Y., Gu, H., and Ni, X. (2011). Expression of Cystathionine \u03b2-synthase and Cystathionine \u03b3-lyase in Human Pregnant Myometrium and Their Roles in the Control of Uterine Contractility. PLoS ONE, 6.","DOI":"10.1371\/journal.pone.0023788"},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"2753","DOI":"10.2147\/JIR.S308558","article-title":"Hydrogen sulfide contributes to uterine quiescence through inhibition of nlrp3 inflammasome activation by suppressing the tlr4\/nf-\u03bab signalling pathway","volume":"14","author":"Chen","year":"2021","journal-title":"J. Inflamm. Res."},{"key":"ref_97","doi-asserted-by":"crossref","unstructured":"Liu, W., Xu, C., You, X., Olson, D.M., Chemtob, S., Gao, L., and Ni, X. (2016). Hydrogen Sulfide Delays LPS-Induced Preterm Birth in Mice via Anti-Inflammatory Pathways. PLoS ONE, 11.","DOI":"10.1371\/journal.pone.0152838"},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"2288","DOI":"10.1210\/en.2015-1086","article-title":"Estrogen Replacement Therapy in Ovariectomized Nonpregnant Ewes Stimulates Uterine Artery Hydrogen Sulfide Biosynthesis by Selectively Up-Regulating Cystathionine \u03b2-Synthase Expression","volume":"156","author":"Lechuga","year":"2015","journal-title":"Endocrinology"},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"9264","DOI":"10.1002\/jcp.27606","article-title":"Estradiol-17\u03b2 stimulates H2S biosynthesis by er-dependent cbs and cse transcription in uterine artery smooth muscle cells in vitro","volume":"234","author":"Lechuga","year":"2019","journal-title":"J. Cell Physiol."},{"key":"ref_100","first-page":"4247","article-title":"H2S promotes proliferation of endometrial stromal cells via activating the nf-\u03bab pathway in endometriosis","volume":"10","author":"Lei","year":"2018","journal-title":"Am. J. Transl. Res."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"3168","DOI":"10.1093\/hmg\/ddl393","article-title":"Cystathionine beta-synthase is essential for female reproductive function","volume":"15","author":"Navarro","year":"2006","journal-title":"Hum. Mol. Genet."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/j.preghy.2012.04.065","article-title":"OS064. Contribute of the L-cysteine\/H2S pathway in placenta homeostasisin hypertensive disorders","volume":"2","author":"Sarno","year":"2012","journal-title":"Pregnancy Hypertens."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1016\/j.placenta.2015.05.007","article-title":"Increased ADAM10 expression in preeclamptic placentas is associated with decreased expression of hydrogen sulfide production enzymes","volume":"36","author":"Hu","year":"2015","journal-title":"Placenta"},{"key":"ref_104","doi-asserted-by":"crossref","unstructured":"Du, J., Wang, P., Gou, Q., Jin, S., Xue, H., Li, D., Tian, D., Sun, J., Zhang, X., and Teng, X. (2022). Hydrogen sulfide ameliorated preeclampsia via suppression of toll-like receptor 4-activated inflammation in the rostral ventrolateral medulla of rats. Biomed. Pharmacother., 150.","DOI":"10.1016\/j.biopha.2022.113018"},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.placenta.2016.01.019","article-title":"MiR 20a,-20b and -200c are involved in hydrogen sulfide stimulation of VEGF production in human placental trophoblasts","volume":"39","author":"Hu","year":"2016","journal-title":"Placenta"},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1093\/biolre\/iox105","article-title":"Human trophoblast-derived hydrogen sulfide stimulates placental artery endothelial cell angiogenesis","volume":"97","author":"Chen","year":"2017","journal-title":"Biol. Reprod."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.niox.2019.05.011","article-title":"The gasotransmitter hydrogen sulfide inhibits transepithelial anion secretion of pregnant mouse endometrial epithelium","volume":"90","author":"Xu","year":"2019","journal-title":"Nitric Oxide"},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"908","DOI":"10.1016\/j.ajpath.2016.12.002","article-title":"Placental stem villus arterial remodeling associated with reduced hydrogen sulfide synthesis contributes to human fetal growth restriction","volume":"187","author":"Lu","year":"2017","journal-title":"Am. J. Pathol."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"e4275","DOI":"10.1210\/clinem\/dgaa357","article-title":"Trophoblast H2S Maintains Early Pregnancy via Regulating Maternal-Fetal Interface Immune Hemostasis","volume":"105","author":"Wang","year":"2020","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"1815","DOI":"10.1159\/000492504","article-title":"Protective effects of hydrogen sulfide against cigarette smoke expo-sure-induced placental oxidative damage by alleviating redox imbalance via nrf2 pathway in rats","volume":"48","author":"Zhao","year":"2018","journal-title":"Cell. Physiol. Biochem. Int. J. Exp. Cell. Physiol. Biochem. Pharmacol."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"94","DOI":"10.3892\/etm.2021.11017","article-title":"NLRP3 inflammasome activation in gestational diabetes mellitus placentas is associated with hydrogen sulfide synthetase deficiency","volume":"23","author":"Wu","year":"2022","journal-title":"Exp. Ther. Med."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.reprotox.2007.04.002","article-title":"Cystathionine beta synthase participates in murine oocyte maturation mediated by homocysteine","volume":"24","author":"Liang","year":"2007","journal-title":"Reprod. Toxicol."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"1998","DOI":"10.1161\/ATVBAHA.110.209783","article-title":"Hydrogen Sulfide Is an Endogenous Inhibitor of Phosphodiesterase Activity","volume":"30","author":"Bucci","year":"2010","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"ref_114","doi-asserted-by":"crossref","unstructured":"La Fuente, J.M., Fern\u00e1ndez, A., Pepe-Cardoso, A.J., Mart\u00ednez-Salamanca, J.I., Louro, N., and Angulo, J. (2019). L-cysteine\/hydrogen sulfide pathway induces cgmp-dependent relaxation of corpus cavernosum and penile arteries from patients with erectile dysfunction and improves arterial vasodilation induced by pde5 inhibition. Eur. J. Pharmacol., 863.","DOI":"10.1016\/j.ejphar.2019.172675"},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"C799","DOI":"10.1152\/ajpcell.1995.268.4.C799","article-title":"Physiological roles and properties of potassium channels in arterial smooth muscle","volume":"268","author":"Nelson","year":"1995","journal-title":"Am. J. Physiol."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1002\/j.1939-4640.1993.tb00392.x","article-title":"Characterization of K Currents in Cultured Human Corporal Smooth Muscle Cells","volume":"14","author":"Christ","year":"1993","journal-title":"J. Androl."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1124\/jpet.104.074369","article-title":"Inhibition of Na+-K+ pump and l-type Ca2+ channel by glibenclamide in guinea pig ventricular myocytes","volume":"312","author":"Lee","year":"2005","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1038\/83258","article-title":"Antagonism of rho-kinase stim-ulates rat penile erection via a nitric oxide-independent pathway","volume":"7","author":"Chitaley","year":"2001","journal-title":"Nat. Med."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1016\/j.pharep.2017.02.018","article-title":"The role of arachidonic acid\/cyclooxygenase cascade, phosphodiesterase iv and rho-kinase in H2S-induced relaxation in the mouse corpus cavernosum","volume":"69","author":"Aydinoglu","year":"2017","journal-title":"Pharmacol. Rep. PR"},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"73","DOI":"10.7150\/ijbs.47850","article-title":"Role of hydrogen sulfide donors in cancer development and progression","volume":"17","author":"Ngowi","year":"2021","journal-title":"Int. J. Biol. Sci."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1016\/j.bcp.2011.12.018","article-title":"Hydrogen sul-fide-releasing nsaids inhibit the growth of human cancer cells: A general property and evidence of a tissue type-independent effect","volume":"83","author":"Chattopadhyay","year":"2012","journal-title":"Biochem. Pharmacol."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1007\/s10637-018-0590-0","article-title":"New NO- and H2S-releasing doxorubicins as targeted therapy against chemoresistance in castration-resistant prostate cancer: In vitro and in vivo evaluations","volume":"36","author":"Bigagli","year":"2018","journal-title":"Investig. New Drugs"},{"key":"ref_123","doi-asserted-by":"crossref","unstructured":"Zhou, B., Jia, B.-X., Zhang, M.-J., Tan, Y.-J., Liang, W.-Y., Gan, X., Li, H.-T., Yang, X., and Shen, X.-C. (2023). Zn2+-interference and H2S-mediated gas therapy based on ZnS-tannic acid nanoparticles synergistic enhancement of cell apoptosis for specific treatment of prostate cancer. Colloids Surf. B Biointerfaces, 226.","DOI":"10.1016\/j.colsurfb.2023.113313"},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.chemosphere.2017.11.164","article-title":"Decrease in male mouse fertility by hydrogen sulfide and\/or ammonia can Be inheritable","volume":"194","author":"Zhang","year":"2018","journal-title":"Chemosphere"},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/j.freeradbiomed.2020.10.315","article-title":"Changes in nitric oxide, carbon monoxide, hydrogen sulfide and male reproductive hormones in response to chronic restraint stress in rats","volume":"162","author":"Moustafa","year":"2021","journal-title":"Free Radic. Biol. Med."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"8119","DOI":"10.1007\/s11356-019-07266-5","article-title":"Assessment of the effect of sodium hydrogen sulfide (hydrogen sulfide donor) on cisplatin-induced testicular toxicity in rats","volume":"27","author":"Azarbarz","year":"2020","journal-title":"Environ. Sci. Pollut. Res."},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.ucl.2016.01.006","article-title":"Testosterone and male infertility","volume":"43","author":"Ohlander","year":"2016","journal-title":"Urol. Clin. N. Am."},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1093\/humrep\/dead250","article-title":"ROS-induced oxidative stress is a major contributor to sperm cryoinjury","volume":"39","author":"Shi","year":"2024","journal-title":"Hum. Reprod."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"145","DOI":"10.3409\/fb63_2.145","article-title":"Sodium hydrosulfide exerts a transitional at-tenuating effect on spermatozoa migration in vitro","volume":"63","author":"Gajda","year":"2015","journal-title":"Folia. Biol."},{"key":"ref_130","doi-asserted-by":"crossref","unstructured":"Kadlec, M., Pintus, E., and Ros-Santaella, J.L. (2022). The Interaction of NO and H2S in Boar Spermatozoa under Oxidative Stress. Animals, 12.","DOI":"10.3390\/ani12050602"},{"key":"ref_131","doi-asserted-by":"crossref","unstructured":"Pintus, E., Chinn, A.F., Kadlec, M., Garc\u00eda-V\u00e1zquez, F.A., Novy, P., Matson, J.B., and Ros-Santaella, J.L. (2023). N-thiocarboxyanhydrides, amino acid-derived enzyme-activated H2S donors, enhance sperm mitochondrial activity in presence and absence of oxidative stress. BMC Vet. Res., 19.","DOI":"10.1186\/s12917-023-03593-5"},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1071\/RD9960553","article-title":"Murdoch Regulation of the motility and metabolism of spermatozoa for storage in the epididymis of eutherian and marsupial mammals","volume":"8","author":"Jones","year":"1996","journal-title":"Reprod. Fertil. Dev."},{"key":"ref_133","doi-asserted-by":"crossref","unstructured":"Lorian, K., Kadkhodaee, M., Kianian, F., Abdi, A., Ranjbaran, M., Ashabi, G., and Seifi, B. (2020). Long-term nahs administration reduces ox-idative stress and apoptosis in a rat model of left-side varicocele. Andrologia, 52.","DOI":"10.1111\/and.13496"},{"key":"ref_134","first-page":"941","article-title":"Beneficial effects of combination therapy with testosterone and hydrogen sulfide by reducing oxidative stress and apoptosis: Rat experimental varicocele model","volume":"20","author":"Shafie","year":"2022","journal-title":"Int. J. Reprod. Biomed. (IJRM)"},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1177\/074823379000600303","article-title":"Growth and Development in the Rat during Sub-Chronic Exposure to Low Levels of Hydrogen Sulfide","volume":"6","author":"Hayden","year":"1990","journal-title":"Toxicol. Ind. Health"},{"key":"ref_136","doi-asserted-by":"crossref","unstructured":"Robinson, H., and Wray, S. (2012). A New Slow Releasing, H2S Generating Compound, GYY4137 Relaxes Spontaneous and Oxytocin-Stimulated Contractions of Human and Rat Pregnant Myometrium. PLoS ONE, 7.","DOI":"10.1371\/journal.pone.0046278"},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/j.phrs.2016.06.017","article-title":"l -Cys\/CSE\/H 2 S pathway modulates mouse uterus motility and sildenafil effect","volume":"111","author":"Mitidieri","year":"2016","journal-title":"Pharmacol. Res."},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"900","DOI":"10.3109\/09513590.2010.551563","article-title":"Hydrogen sulfide inhibits the spontaneous and oxytocin-induced contractility of human pregnant myometrium","volume":"27","author":"Hu","year":"2011","journal-title":"Gynecol. Endocrinol. Off. J. Int. Soc. Gynecol. Endocrinol."},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1177\/1933719108329095","article-title":"Inflammation and pregnancy","volume":"16","author":"Challis","year":"2009","journal-title":"Reprod. Sci."},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1093\/molehr\/gag001","article-title":"Leukocyte density and pro-inflammatory cytokine expression in human fetal membranes, decidua, cervix and myometrium before and during labour at term","volume":"9","author":"Osman","year":"2003","journal-title":"Mol. Hum. Reprod."},{"key":"ref_141","doi-asserted-by":"crossref","unstructured":"Ray, A., Chakraborty, K., and Ray, P. (2013). Immunosuppressive MDSCs induced by TLR signaling during infection and role in resolution of inflammation. Front. Cell. Infect. Microbiol., 3.","DOI":"10.3389\/fcimb.2013.00052"},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1111\/micc.12093","article-title":"Regulation of Placental Angiogenesis","volume":"21","author":"Chen","year":"2014","journal-title":"Microcirculation"},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"12542","DOI":"10.1073\/pnas.0901647106","article-title":"De novo synthesis of estrogen in pregnant uterus is critical for stromal decidualization and angiogenesis","volume":"106","author":"Das","year":"2009","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1210\/jcem-35-6-887","article-title":"Estrone sulfate, estrone, estradiol and estriol plasma levels in human preg-nancy","volume":"35","author":"Loriaux","year":"1972","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_145","doi-asserted-by":"crossref","unstructured":"Bai, J., Lechuga, T.J., Makhoul, J., Yan, H., Major, C., Hameed, A., and Chen, D. (2023). Er\u03b1\/er\u03b2-directed cbs transcription mediates e2\u03b2-stimulated huaec H2S production. J. Mol. Endocrinol., 70.","DOI":"10.1530\/JME-22-0175"},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1093\/humupd\/dmv038","article-title":"Menstrual physiology: Implications for endometrial pathology and beyond","volume":"21","author":"Maybin","year":"2015","journal-title":"Hum. Reprod. Updat."},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"1112","DOI":"10.1038\/nm.2771","article-title":"Activation of the epithelial Na+ channel triggers prostaglandin E2 release and production required for embryo implantation","volume":"18","author":"Ruan","year":"2012","journal-title":"Nat. Med."},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1093\/humupd\/8.3.255","article-title":"New insights into the mechanisms underlying hydrosalpinx fluid formation and its ad-verse effect on ivf outcome","volume":"8","author":"Ajonuma","year":"2002","journal-title":"Hum. Reprod. Update"},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"884","DOI":"10.1161\/01.RES.0000147365.86159.f5","article-title":"Elevated placental soluble vascular endothelial growth factor receptor-1 inhibits angiogenesis in preeclampsia","volume":"95","author":"Ahmad","year":"2004","journal-title":"Circ. Res."},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/j.preghy.2014.04.013","article-title":"Molecular mechanisms and therapeutic implications of the carbon monoxide\/hmox1 and the hydrogen sulfide\/CSE pathways in the prevention of pre-eclampsia and fetal growth restriction","volume":"4","author":"Ahmed","year":"2014","journal-title":"Pregnancy Hypertens."},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/S0301-2115(97)00202-9","article-title":"Fetal arterial doppler-iugr and hypoxia","volume":"75","author":"Arbeille","year":"1997","journal-title":"Eur. J. Obstet. Gynecol. Reprod. Biol."},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1016\/S0167-5699(97)01127-4","article-title":"Th 1-type immunity is incompatible with successful pregnancy","volume":"18","author":"Raghupathy","year":"1997","journal-title":"Immunol. Today"},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.imlet.2014.06.013","article-title":"The immunology of pregnancy: Regulatory T cells control maternal immune tolerance toward the fetus","volume":"162","author":"Carbone","year":"2014","journal-title":"Immunol. Lett."},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/j.immuni.2015.07.017","article-title":"Hydrogen Sulfide Promotes Tet1- and Tet2-Mediated Foxp3 Demethylation to Drive Regulatory T Cell Differentiation and Maintain Immune Homeostasis","volume":"43","author":"Yang","year":"2015","journal-title":"Immunity"},{"key":"ref_155","doi-asserted-by":"crossref","first-page":"1875","DOI":"10.1084\/jem.20030152","article-title":"Conversion of peripheral cd4+cd25- naive t cells to cd4+cd25+ regulatory t cells by tgf-beta induction of transcription factor foxp3","volume":"198","author":"Chen","year":"2003","journal-title":"J. Exp. Med."},{"key":"ref_156","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.gde.2017.08.004","article-title":"The inflammation paradox in the evolution of mammalian pregnancy: Turning a foe into a friend","volume":"47","author":"Chavan","year":"2017","journal-title":"Curr. Opin. Genet. Dev."},{"key":"ref_157","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/0167-5699(93)90235-D","article-title":"Bidirectional cytokine interactions in the maternal-fetal relationship: Is successful pregnancy a th2 phenomenon?","volume":"14","author":"Wegmann","year":"1993","journal-title":"Immunol. Today"},{"key":"ref_158","doi-asserted-by":"crossref","first-page":"1010","DOI":"10.3109\/14767058.2015.1031741","article-title":"Does aberrant expression of cyclooxygenase-2 and prostaglandin-E2 receptor genes lead to abortion in Chlamydia trachomatis-infected women","volume":"29","author":"Singh","year":"2015","journal-title":"J. Matern. Neonatal Med."},{"key":"ref_159","first-page":"1543","article-title":"Role of cyclooxygenase-2 signaling pathway dysfunction in unexplained recurrent spontaneous abortion","volume":"123","author":"Wang","year":"2010","journal-title":"Chin. Med. J."},{"key":"ref_160","doi-asserted-by":"crossref","unstructured":"Schumacher, A. (2017). Human chorionic gonadotropin as a pivotal endocrine immune regulator initiating and preserving fetal tol-erance. Int. J. Mol. Sci., 18.","DOI":"10.3390\/ijms18102166"},{"key":"ref_161","doi-asserted-by":"crossref","first-page":"2650","DOI":"10.4049\/jimmunol.1202698","article-title":"Human Chorionic Gonadotropin as a Central Regulator of Pregnancy Immune Tolerance","volume":"190","author":"Schumacher","year":"2013","journal-title":"J. Immunol."},{"key":"ref_162","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.1177\/0300060513487642","article-title":"Indoleamine 2,3-dioxygenase levels at the normal and recurrent spontaneous abortion fetal-maternal interface","volume":"41","author":"Ban","year":"2013","journal-title":"J. Int. Med. Res."},{"key":"ref_163","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.1126\/science.281.5380.1191","article-title":"Prevention of Allogeneic Fetal Rejection by Tryptophan Catabolism","volume":"281","author":"Munn","year":"1998","journal-title":"Science"},{"key":"ref_164","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1084\/jem.20020121","article-title":"Tryptophan-derived Catabolites Are Responsible for Inhibition of T and Natural Killer Cell Proliferation Induced by Indoleamine 2,3-Dioxygenase","volume":"196","author":"Frumento","year":"2002","journal-title":"J. Exp. Med."},{"key":"ref_165","doi-asserted-by":"crossref","first-page":"2061","DOI":"10.1182\/blood-2009-11-252940","article-title":"Thymic stromal lymphopoietin from trophoblasts induces dendritic cell\u2013mediated regulatory TH2 bias in the decidua during early gestation in humans","volume":"116","author":"Guo","year":"2010","journal-title":"Blood"},{"key":"ref_166","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1080\/19336918.2015.1089376","article-title":"Function and control of human invasive trophoblast subtypes: Intrinsic vs. maternal control","volume":"10","author":"Velicky","year":"2016","journal-title":"Cell Adhes. Migr."},{"key":"ref_167","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1007\/s00228-008-0609-0","article-title":"Smoking in pregnancy and lactation: A review of risks and cessation strategies","volume":"65","author":"Einarson","year":"2009","journal-title":"Eur. J. Clin. Pharmacol."},{"key":"ref_168","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1016\/j.earlhumdev.2007.07.016","article-title":"Morphological and biological effects of maternal exposure to tobacco smoke on the feto-placental unit","volume":"83","author":"Jauniaux","year":"2007","journal-title":"Early Hum. Dev."},{"key":"ref_169","doi-asserted-by":"crossref","unstructured":"Olmos-Ortiz, A., Flores-Espinosa, P., D\u00edaz, L., Vel\u00e1zquez, P., Ram\u00edrez-Isarraraz, C., and Zaga-Clavellina, V. (2021). Immunoendocrine Dysregulation during Gestational Diabetes Mellitus: The Central Role of the Placenta. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22158087"},{"key":"ref_170","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.freeradbiomed.2019.03.028","article-title":"The endogenous hydrogen sulfide generating system regulates ovulation","volume":"138","author":"Estienne","year":"2019","journal-title":"Free. Radic. Biol. Med."},{"key":"ref_171","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.theriogenology.2023.11.025","article-title":"Metabolic stressful environment drives epigenetic modifications in oviduct epithelial cells","volume":"215","author":"Fontes","year":"2024","journal-title":"Theriogenology"},{"key":"ref_172","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1038\/sj.ijir.3901523","article-title":"Reactive oxygen species and erectile dysfunction: Possible role of NADPH oxidase","volume":"19","author":"Jeremy","year":"2007","journal-title":"Int. J. Impot. Res."},{"key":"ref_173","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1016\/S0008-6363(99)00171-6","article-title":"Nitric oxide and the proliferation of vascular smooth muscle cells","volume":"43","author":"Jeremy","year":"1999","journal-title":"Cardiovasc. Res."},{"key":"ref_174","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1111\/j.1464-410X.2005.05643.x","article-title":"Sildenafil inhibits the formation of superoxide and the expression of gp47 nad[p]h oxidase induced by the thromboxane a2 mimetic, u46619, in corpus cavernosal smooth muscle cells","volume":"96","author":"Koupparis","year":"2005","journal-title":"BJU Int."},{"key":"ref_175","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1016\/j.ejphar.2005.05.012","article-title":"Effect of sildenafil citrate and a nitric oxide donating sildenafil derivative, NCX 911, on cavernosal relaxation and superoxide formation in hypercholesterolaemic rabbits","volume":"517","author":"Shukla","year":"2005","journal-title":"Eur. J. Pharmacol."},{"key":"ref_176","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/j.plefa.2008.01.008","article-title":"Acute inhibition of superoxide for-mation and rac1 activation by nitric oxide and iloprost in human vascular smooth muscle cells in response to the thromboxane a2 analogue, u46619","volume":"78","author":"Muzaffar","year":"2008","journal-title":"Prostaglandins Leukot. Essent. Fat. Acids"},{"key":"ref_177","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1016\/j.jtcvs.2007.06.017","article-title":"Nitric oxide-donating aspirin (ncx 4016) inhibits neoin-timal thickening in a pig model of saphenous vein-carotid artery interposition grafting: A comparison with aspirin and mor-pholinosydnonimine (sin-1)","volume":"134","author":"Wan","year":"2007","journal-title":"J. Thorac. Cardiovasc. Surg."},{"key":"ref_178","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1111\/j.1745-7262.2008.00380.x","article-title":"Homocysteine and copper interact to promote type 5 phosphodiesterase expression in rabbit cavernosal smooth muscle cells","volume":"10","author":"Hotston","year":"2008","journal-title":"Asian J. Androl."},{"key":"ref_179","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1136\/thorax.58.7.598","article-title":"Role of the endothelium and nitric oxide synthases in modulating superoxide formation induced by endotoxin and cytokines in porcine pulmonary arteries","volume":"58","author":"Muzaffar","year":"2003","journal-title":"Thorax"},{"key":"ref_180","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1159\/000129686","article-title":"Exogenous Hydrogen Sulfide Inhibits Superoxide Formation, NOX-1 Expression and Rac1 Activity in Human Vascular Smooth Muscle Cells","volume":"45","author":"Muzaffar","year":"2008","journal-title":"J. Vasc. Res."},{"key":"ref_181","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.niox.2014.12.004","article-title":"Role of cgmp in hydrogen sulfide signaling","volume":"46","author":"Bibli","year":"2015","journal-title":"Nitric Oxide Biol. Chem."},{"key":"ref_182","doi-asserted-by":"crossref","unstructured":"Song, Y., Qu, Y., Mao, C., Zhang, R., Jiang, D., and Sun, X. (2023). Post-translational modifications of Keap1: The state of the art. Front. Cell Dev. Biol., 11.","DOI":"10.3389\/fcell.2023.1332049"},{"key":"ref_183","doi-asserted-by":"crossref","first-page":"1259","DOI":"10.1161\/CIRCRESAHA.111.240242","article-title":"Hydrogen Sulfide as Endothelium-Derived Hyperpolarizing Factor Sulfhydrates Potassium Channels","volume":"109","author":"Mustafa","year":"2011","journal-title":"Circ. Res."},{"key":"ref_184","doi-asserted-by":"crossref","first-page":"31888","DOI":"10.18632\/oncotarget.16649","article-title":"Sulfhydration-associated phosphodiesterase 5A dimerization mediates vasorelaxant effect of hydrogen sulfide","volume":"8","author":"Sun","year":"2017","journal-title":"Oncotarget"}],"container-title":["Biomolecules"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2218-273X\/14\/5\/540\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T14:37:15Z","timestamp":1760107035000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2218-273X\/14\/5\/540"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4,30]]},"references-count":184,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2024,5]]}},"alternative-id":["biom14050540"],"URL":"https:\/\/doi.org\/10.3390\/biom14050540","relation":{},"ISSN":["2218-273X"],"issn-type":[{"value":"2218-273X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,4,30]]}}}