{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T04:50:11Z","timestamp":1783572611920,"version":"3.55.0"},"reference-count":42,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2024,5,23]],"date-time":"2024-05-23T00:00:00Z","timestamp":1716422400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"2023 Research Grant from Kangwon National University","award":["IITP-2023-RS-2023-00260267"],"award-info":[{"award-number":["IITP-2023-RS-2023-00260267"]}]},{"name":"2023 Research Grant from Kangwon National University","award":["RS-2023-00213379"],"award-info":[{"award-number":["RS-2023-00213379"]}]},{"name":"2023 Research Grant from Kangwon National University","award":["2022RIS-005"],"award-info":[{"award-number":["2022RIS-005"]}]},{"name":"Ministry of Science and ICT (MSIT), Korea","award":["IITP-2023-RS-2023-00260267"],"award-info":[{"award-number":["IITP-2023-RS-2023-00260267"]}]},{"name":"Ministry of Science and ICT (MSIT), Korea","award":["RS-2023-00213379"],"award-info":[{"award-number":["RS-2023-00213379"]}]},{"name":"Ministry of Science and ICT (MSIT), Korea","award":["2022RIS-005"],"award-info":[{"award-number":["2022RIS-005"]}]},{"name":"National Research Foundation of Korea (NRF) grant under the auspices of the Korea government (MEST)","award":["IITP-2023-RS-2023-00260267"],"award-info":[{"award-number":["IITP-2023-RS-2023-00260267"]}]},{"name":"National Research Foundation of Korea (NRF) grant under the auspices of the Korea government (MEST)","award":["RS-2023-00213379"],"award-info":[{"award-number":["RS-2023-00213379"]}]},{"name":"National Research Foundation of Korea (NRF) grant under the auspices of the Korea government (MEST)","award":["2022RIS-005"],"award-info":[{"award-number":["2022RIS-005"]}]},{"name":"\u201cKorea and Regional Innovation Strategy (RIS)\u201d through the National Research Foundation of Korea (NRF) funded by the Ministry of Education (MOE)","award":["IITP-2023-RS-2023-00260267"],"award-info":[{"award-number":["IITP-2023-RS-2023-00260267"]}]},{"name":"\u201cKorea and Regional Innovation Strategy (RIS)\u201d through the National Research Foundation of Korea (NRF) funded by the Ministry of Education (MOE)","award":["RS-2023-00213379"],"award-info":[{"award-number":["RS-2023-00213379"]}]},{"name":"\u201cKorea and Regional Innovation Strategy (RIS)\u201d through the National Research Foundation of Korea (NRF) funded by the Ministry of Education (MOE)","award":["2022RIS-005"],"award-info":[{"award-number":["2022RIS-005"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biomolecules"],"abstract":"<jats:p>Platelets play essential roles in the formation of blood clots by clumping with coagulation factors at the site of vascular injury to stop bleeding; therefore, a reduction in the platelet number or disorder in their function causes bleeding risk. In our research, we developed a method to assess platelet aggregation using an optical approach within a microfluidic chip\u2019s channel by evaluating the size of laser speckles. These speckles, associated with slowed blood flow in the microfluidic channel, had a baseline size of 28.54 \u00b1 0.72 \u00b5m in whole blood. Removing platelets from the sample led to a notable decrease in speckle size to 27.04 \u00b1 1.23 \u00b5m. Moreover, the addition of an ADP-containing agonist, which activates platelets, resulted in an increased speckle size of 32.89 \u00b1 1.69 \u00b5m. This finding may provide a simple optical method via microfluidics that could be utilized to assess platelet functionality in diagnosing bleeding disorders and potentially in monitoring therapies that target platelets.<\/jats:p>","DOI":"10.3390\/biom14060612","type":"journal-article","created":{"date-parts":[[2024,5,23]],"date-time":"2024-05-23T03:49:03Z","timestamp":1716436143000},"page":"612","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Microfluidic System-Based Quantitative Analysis of Platelet Function through Speckle Size Measurement"],"prefix":"10.3390","volume":"14","author":[{"given":"Jong Hyeok","family":"Han","sequence":"first","affiliation":[{"name":"Department of Mechanical and Biomedical Engineering, Kangwon National University, Chuncheon 24341, Republic of Korea"},{"name":"Department of Smart Health Science and Technology, Kangwon National University, Chuncheon 24341, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Inkwon","family":"Yoon","sequence":"additional","affiliation":[{"name":"Department of Mechanical and Biomedical Engineering, Kangwon National University, Chuncheon 24341, Republic of Korea"},{"name":"Department of Smart Health Science and Technology, Kangwon National University, Chuncheon 24341, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hee-Jae","family":"Jeon","sequence":"additional","affiliation":[{"name":"Department of Mechanical and Biomedical Engineering, Kangwon National University, Chuncheon 24341, Republic of Korea"},{"name":"Department of Smart Health Science and Technology, Kangwon National University, Chuncheon 24341, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,5,23]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Jurk, K., and Shiravand, Y. 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