{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T15:01:59Z","timestamp":1791126119717,"version":"4.1.0"},"reference-count":174,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2024,6,7]],"date-time":"2024-06-07T00:00:00Z","timestamp":1717718400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Deutsche Forschungsgemeinschaft","award":["BR 2215"],"award-info":[{"award-number":["BR 2215"]}]},{"name":"Bausteinprogramm of the University Ulm","award":["BR 2215"],"award-info":[{"award-number":["BR 2215"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biomolecules"],"abstract":"<jats:p>An epilepsy diagnosis reduces a patient\u2019s quality of life tremendously, and it is a fate shared by over 50 million people worldwide. Temporal lobe epilepsy (TLE) is largely considered a nongenetic or acquired form of epilepsy that develops in consequence of neuronal trauma by injury, malformations, inflammation, or a prolonged (febrile) seizure. Although extensive research has been conducted to understand the process of epileptogenesis, a therapeutic approach to stop its manifestation or to reliably cure the disease has yet to be developed. In this review, we briefly summarize the current literature predominately based on data from excitotoxic rodent models on the cellular events proposed to drive epileptogenesis and thoroughly discuss the major molecular pathways involved, with a focus on neurogenesis-related processes and transcription factors. Furthermore, recent investigations emphasized the role of the genetic background for the acquisition of epilepsy, including variants of neurodevelopmental genes. Mutations in associated transcription factors may have the potential to innately increase the vulnerability of the hippocampus to develop epilepsy following an injury\u2014an emerging perspective on the epileptogenic process in acquired forms of epilepsy.<\/jats:p>","DOI":"10.3390\/biom14060669","type":"journal-article","created":{"date-parts":[[2024,6,7]],"date-time":"2024-06-07T11:56:48Z","timestamp":1717761408000},"page":"669","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Molecular Genetics of Acquired Temporal Lobe Epilepsy"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5831-0608","authenticated-orcid":false,"given":"Anne-Marie","family":"Neumann","sequence":"first","affiliation":[{"name":"Institute of Molecular and Cellular Anatomy, Ulm University, 89081 Ulm, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4379-3322","authenticated-orcid":false,"given":"Stefan","family":"Britsch","sequence":"additional","affiliation":[{"name":"Institute of Molecular and Cellular Anatomy, Ulm University, 89081 Ulm, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,6,7]]},"reference":[{"key":"ref_1","unstructured":"World Health Organization (2019). 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