{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T22:11:58Z","timestamp":1792102318690,"version":"4.4.0"},"reference-count":59,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2024,6,14]],"date-time":"2024-06-14T00:00:00Z","timestamp":1718323200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32273067"],"award-info":[{"award-number":["32273067"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["HKL202303"],"award-info":[{"award-number":["HKL202303"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["KLAEMB-2023-02"],"award-info":[{"award-number":["KLAEMB-2023-02"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Key Laboratory of Tropical Animal Breeding and Disease Research","award":["32273067"],"award-info":[{"award-number":["32273067"]}]},{"name":"Key Laboratory of Tropical Animal Breeding and Disease Research","award":["HKL202303"],"award-info":[{"award-number":["HKL202303"]}]},{"name":"Key Laboratory of Tropical Animal Breeding and Disease Research","award":["KLAEMB-2023-02"],"award-info":[{"award-number":["KLAEMB-2023-02"]}]},{"name":"Key Laboratory of Animal Embryo Engineering and Molecular Breeding of Hubei Province","award":["32273067"],"award-info":[{"award-number":["32273067"]}]},{"name":"Key Laboratory of Animal Embryo Engineering and Molecular Breeding of Hubei Province","award":["HKL202303"],"award-info":[{"award-number":["HKL202303"]}]},{"name":"Key Laboratory of Animal Embryo Engineering and Molecular Breeding of Hubei Province","award":["KLAEMB-2023-02"],"award-info":[{"award-number":["KLAEMB-2023-02"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biomolecules"],"abstract":"<jats:p>Glaesserella parasuis (G. parasuis) causes serious inflammation and meningitis in piglets. Quercetin has anti-inflammatory and anti-bacterial activities; however, whether quercetin can alleviate brain inflammation and provide protective effects during G. parasuis infection has not been studied. Here, we established a mouse model of G. parasuis infection in vivo and in vitro to investigate transcriptome changes in the mouse cerebrum and determine the protective effects of quercetin on brain inflammation and blood\u2013brain barrier (BBB) integrity during G. parasuis infection. The results showed that G. parasuis induced brain inflammation, destroyed BBB integrity, and suppressed PI3K\/Akt\/Erk signaling-pathway activation in mice. Quercetin decreased the expression of inflammatory cytokines (Il-18, Il-6, Il-8, and Tnf-\u03b1) and BBB-permeability marker genes (Mmp9, Vegf, Ang-2, and Et-1), increased the expression of angiogenetic genes (Sema4D and PlexinB1), reduced G. parasuis-induced tight junction disruption, and reactivated G. parasuis-induced suppression of the PI3K\/Akt\/Erk signaling pathway in vitro. Thus, we concluded that quercetin may protect BBB integrity via the PI3K\/Akt\/Erk signaling pathway during G. parasuis infection. This was the first attempt to explore the protective effects of quercetin on brain inflammation and BBB integrity in a G. parasuis-infected mouse model. Our findings indicated that quercetin is a promising natural agent for the prevention and treatment of G. parasuis infection.<\/jats:p>","DOI":"10.3390\/biom14060696","type":"journal-article","created":{"date-parts":[[2024,6,14]],"date-time":"2024-06-14T08:52:10Z","timestamp":1718355130000},"page":"696","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Quercetin Protects Blood\u2013Brain Barrier Integrity via the PI3K\/Akt\/Erk Signaling Pathway in a Mouse Model of Meningitis Induced by Glaesserella parasuis"],"prefix":"10.3390","volume":"14","author":[{"given":"Peiyan","family":"Sun","sequence":"first","affiliation":[{"name":"Laboratory of Genetic Breeding, Reproduction and Precision Livestock Farming, School of Animal Science and Nutritional Engineering, Wuhan Polytechnic University, Wuhan 430023, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaqiong","family":"Yang","sequence":"additional","affiliation":[{"name":"Laboratory of Genetic Breeding, Reproduction and Precision Livestock Farming, School of Animal Science and Nutritional Engineering, Wuhan Polytechnic University, Wuhan 430023, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linrong","family":"Yang","sequence":"additional","affiliation":[{"name":"Laboratory of Genetic Breeding, Reproduction and Precision Livestock Farming, School of Animal Science and Nutritional Engineering, Wuhan Polytechnic University, Wuhan 430023, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanzhuo","family":"Qian","sequence":"additional","affiliation":[{"name":"Laboratory of Genetic Breeding, Reproduction and Precision Livestock Farming, School of Animal Science and Nutritional Engineering, Wuhan Polytechnic University, Wuhan 430023, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingxia","family":"Liang","sequence":"additional","affiliation":[{"name":"Laboratory of Genetic Breeding, Reproduction and Precision Livestock Farming, School of Animal Science and Nutritional Engineering, Wuhan Polytechnic University, Wuhan 430023, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongbo","family":"Chen","sequence":"additional","affiliation":[{"name":"Laboratory of Genetic Breeding, Reproduction and Precision Livestock Farming, School of Animal Science and Nutritional Engineering, Wuhan Polytechnic University, Wuhan 430023, China"},{"name":"Hubei Key Laboratory of Animal Nutrition and Feed Science, Wuhan Polytechnic University, Wuhan 430023, China"},{"name":"Hubei Collaborative Innovation Center for Animal Nutrition and Feed Safety, Wuhan 430023, China"},{"name":"Hubei Provincial Center of Technology Innovation for Domestic Animal Breeding, Wuhan 430023, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Zhang","sequence":"additional","affiliation":[{"name":"Laboratory of Genetic Breeding, Reproduction and Precision Livestock Farming, School of Animal Science and Nutritional Engineering, Wuhan Polytechnic University, Wuhan 430023, China"},{"name":"Hubei Key Laboratory of Animal Nutrition and Feed Science, Wuhan Polytechnic University, Wuhan 430023, China"},{"name":"Hubei Collaborative Innovation Center for Animal Nutrition and Feed Safety, Wuhan 430023, China"},{"name":"Hubei Provincial Center of Technology Innovation for Domestic Animal Breeding, Wuhan 430023, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yinsheng","family":"Qiu","sequence":"additional","affiliation":[{"name":"Hubei Key Laboratory of Animal Nutrition and Feed Science, Wuhan Polytechnic University, Wuhan 430023, China"},{"name":"Hubei Collaborative Innovation Center for Animal Nutrition and Feed Safety, Wuhan 430023, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-0968-232X","authenticated-orcid":false,"given":"Ling","family":"Guo","sequence":"additional","affiliation":[{"name":"Laboratory of Genetic Breeding, Reproduction and Precision Livestock Farming, School of Animal Science and Nutritional Engineering, Wuhan Polytechnic University, Wuhan 430023, China"},{"name":"Hubei Key Laboratory of Animal Nutrition and Feed Science, Wuhan Polytechnic University, Wuhan 430023, China"},{"name":"Hubei Collaborative Innovation Center for Animal Nutrition and Feed Safety, Wuhan 430023, China"},{"name":"Hubei Provincial Center of Technology Innovation for Domestic Animal Breeding, Wuhan 430023, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shulin","family":"Fu","sequence":"additional","affiliation":[{"name":"Hubei Key Laboratory of Animal Nutrition and Feed Science, Wuhan Polytechnic University, Wuhan 430023, China"},{"name":"Hubei Collaborative Innovation Center for Animal Nutrition and Feed Safety, Wuhan 430023, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,6,14]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"3686","DOI":"10.1099\/ijsem.0.004221","article-title":"Glaesserella australis sp. nov., isolated from the lungs of pigs","volume":"70","author":"Turni","year":"2020","journal-title":"Int. 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