{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T02:32:31Z","timestamp":1782268351554,"version":"3.54.5"},"reference-count":86,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2024,6,15]],"date-time":"2024-06-15T00:00:00Z","timestamp":1718409600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32071509"],"award-info":[{"award-number":["32071509"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["2023Z204"],"award-info":[{"award-number":["2023Z204"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Technology Bureau of Ningbo","award":["32071509"],"award-info":[{"award-number":["32071509"]}]},{"name":"Technology Bureau of Ningbo","award":["2023Z204"],"award-info":[{"award-number":["2023Z204"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biomolecules"],"abstract":"<jats:p>(1) Background: Phytochemicals are crucial antioxidants that play a significant role in preventing cancer. (2) Methods: We explored the use of methyl jasmonate (MeJA) in the in vitro cultivation of D. morbifera adventitious roots (DMAR) and evaluated its impact on secondary metabolite production in DMAR, optimizing concentration and exposure time for cost-effectiveness. We also assessed its anti-inflammatory and anti-lung cancer activities and related gene expression levels. (3) Results: MeJA treatment significantly increased the production of the phenolic compound 3,5-Di-caffeoylquinic acid (3,5-DCQA). The maximum 3,5-DCQA production was achieved with a MeJA treatment at 40 \u00b5M for 36 h. MeJA-DMARE displayed exceptional anti-inflammatory activity by inhibiting the production of nitric oxide (NO) and reactive oxygen species (ROS) in LPS-induced RAW 264.7 cells. Moreover, it downregulated the mRNA expression of key inflammation-related cytokines. Additionally, MeJA-DMARE exhibited anti-lung cancer activity by promoting ROS production in A549 lung cancer cells and inhibiting its migration. It also modulated apoptosis in lung cancer cells via the Bcl-2 and p38 MAPK pathways. (4) Conclusions: MeJA-treated DMARE with increased 3,5-DCQA production holds significant promise as a sustainable and novel material for pharmaceutical applications thanks to its potent antioxidant, anti-inflammatory, and anti-lung cancer properties.<\/jats:p>","DOI":"10.3390\/biom14060705","type":"journal-article","created":{"date-parts":[[2024,6,17]],"date-time":"2024-06-17T11:14:16Z","timestamp":1718622856000},"page":"705","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["3,5-DCQA as a Major Molecule in MeJA-Treated Dendropanax morbifera Adventitious Root to Promote Anti-Lung Cancer and Anti-Inflammatory Activities"],"prefix":"10.3390","volume":"14","author":[{"given":"Fengjiao","family":"Xu","sequence":"first","affiliation":[{"name":"State Key Laboratory of Plant Environmental Resilience, College of Life Sciences, Zhejiang University, Hangzhou 310058, China"},{"name":"School of Biological and Chemical Engineering, NingboTech University, Ningbo 315100, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anjali Kariyarath","family":"Valappil","sequence":"additional","affiliation":[{"name":"Department of Biopharmaceutical Biotechnology, College of Life Science, Kyung Hee University, Yongin-si 17104, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaojian","family":"Zheng","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Plant Environmental Resilience, College of Life Sciences, Zhejiang University, Hangzhou 310058, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6185-5641","authenticated-orcid":false,"given":"Bingsong","family":"Zheng","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Subtropical Silviculture, Zhejiang A&F University, Hangzhou 311300, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deokchun","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Biopharmaceutical Biotechnology, College of Life Science, Kyung Hee University, Yongin-si 17104, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5122-8318","authenticated-orcid":false,"given":"Qiang","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Biological and Chemical Engineering, NingboTech University, Ningbo 315100, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,6,15]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"688625","DOI":"10.3389\/fphar.2021.688625","article-title":"The Role of Tumor Inflammatory Microenvironment in Lung Cancer","volume":"12","author":"Tan","year":"2021","journal-title":"Front. Pharmacol."},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Jin, Y.P., Rupa, E.J., Nahar, J., Ling, L., Puja, A.M., Akter, R., Yang, D.C., Kang, S.C., and Zhang, H. (2023). Hydroponic Ginseng ROOT Mediated with CMC Polymer-Coated Zinc Oxide Nanoparticles for Cellular Apoptosis via Downregulation of BCL-2 Gene Expression in A549 Lung Cancer Cell Line. Molecules, 28.","DOI":"10.3390\/molecules28020906"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1586\/14737140.8.4.605","article-title":"Inflammation in the development of lung cancer: Epidemiological evidence","volume":"8","author":"Engels","year":"2008","journal-title":"Expert Rev. Anticancer Ther."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"902","DOI":"10.1016\/j.msec.2018.07.053","article-title":"Biomimetic synthesis of silver nanoparticles using Matricaria chamomilla extract and their potential anticancer activity against human lung cancer cells","volume":"92","author":"Dadashpour","year":"2018","journal-title":"Mater. Sci. Eng. C-Mater. Biol. Appl."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"176013","DOI":"10.1016\/j.ejphar.2023.176013","article-title":"Cancer chemotherapy resistance: Mechanisms and recent breakthrough in targeted drug delivery","volume":"958","author":"Davodabadi","year":"2023","journal-title":"Eur. J. Pharmacol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1080\/03602532.2017.1316285","article-title":"The importance of drug metabolites synthesis: The case-study of cardiotoxic anticancer drugs","volume":"49","author":"Hrynchak","year":"2017","journal-title":"Drug Metab. Rev."},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Nahar, J., Boopathi, V., Rupa, E.J., Awais, M., Valappil, A.K., Morshed, M.N., Murugesan, M., Akter, R., Yang, D.U., and Mathiyalagan, R. (2023). Protective Effects of Aquilaria agallocha and Aquilaria malaccensis Edible Plant Extracts against Lung Cancer, Inflammation, and Oxidative Stress-In Silico and In Vitro Study. Appl. Sci., 13.","DOI":"10.3390\/app13106321"},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Ramadhania, Z.M., Nahar, J., Ahn, J.C., Yang, D.U., Kim, J.H., Lee, D.W., Kong, B.M., Mathiyalagan, R., Rupa, E.J., and Akter, R. (2022). Terminalia ferdinandiana (Kakadu Plum)-Mediated Bio-Synthesized ZnO Nanoparticles for Enhancement of Anti-Lung Cancer and Anti-Inflammatory Activities. Appl. Sci., 12.","DOI":"10.3390\/app12063081"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1089\/jmf.2017.4154","article-title":"Antiobesity and Cholesterol-Lowering Effects of Dendropanax morbifera Water Extracts in Mouse 3T3-L1 Cells","volume":"21","author":"Song","year":"2018","journal-title":"J. Med. Food"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1142\/S0192415X18500532","article-title":"Dendropanax morbifera Prevents Cardiomyocyte Hypertrophy by Inhibiting the Sp1\/GATA4 Pathway","volume":"46","author":"Sun","year":"2018","journal-title":"Am. J. Chin. Med."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1055\/s-2006-958139","article-title":"A Cytotoxic diacetylene from dendropanax-arboreus","volume":"61","author":"Setzer","year":"1995","journal-title":"Planta Medica"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1016\/j.bse.2009.06.004","article-title":"Chemical composition and larvicidal effects of essential oil of Dendropanax morbifera against Aedes aegypti L.","volume":"37","author":"Chung","year":"2009","journal-title":"Biochem. Syst. Ecol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1016\/j.jep.2003.11.002","article-title":"Isolation and anticomplement activity of compounds from Dendropanax morbifera","volume":"90","author":"Park","year":"2004","journal-title":"J. Ethnopharmacol."},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Jun-Hui, C., and Seung, K. (2019). Antioxidant and antithrombotic properties of Dendropanax morbifera Leveille (Araliaceae) and its ferments produced by fermentation processing. J. Food Biochem., 43.","DOI":"10.1111\/jfbc.13056"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1248\/bpb.b15-00823","article-title":"Potent Anti-inflammatory and Analgesic Actions of the Chloroform Extract of Dendropanax morbifera Mediated by the Nrf2\/HO-1 Pathway","volume":"39","author":"Akram","year":"2016","journal-title":"Biol. Pharm. Bull."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.bbr.2016.06.013","article-title":"Anti-amnesic effect of Dendropanax morbifera via JNK signaling pathway on cognitive dysfunction in high-fat diet-induced diabetic mice","volume":"312","author":"Kim","year":"2016","journal-title":"Behav. Brain Res."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"3175214","DOI":"10.1155\/2018\/3175214","article-title":"Aqueous Extract of Dendropanax morbiferus Leaves Effectively Alleviated Neuroinflammation and Behavioral Impediments in MPTP-Induced Parkinson\u2019s Mouse Model","volume":"2018","author":"Park","year":"2018","journal-title":"Oxidative Med. Cell. Longev."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1947","DOI":"10.1016\/j.foodchem.2013.05.021","article-title":"Evaluation of anti-oxidant and anti-cancer properties of Dendropanax morbifera Leveille","volume":"141","author":"Hyun","year":"2013","journal-title":"Food Chem."},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Sachan, R., Kundu, A., Dey, P., Son, J.Y., Kim, K.S., Lee, D.E., Kim, H.R., Park, J.H., Lee, S.H., and Kim, J.-H. (2020). Dendropanax morbifera Protects against Renal Fibrosis in Streptozotocin-Induced Diabetic Rats. Antioxidants, 9.","DOI":"10.3390\/antiox9010084"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fnut.2023.1168095","article-title":"Discrimination of Dendropanax morbifera via HPLC fingerprinting and SNP analysis and its impact on obesity by modulating adipogenesis- and thermogenesis-related genes","volume":"10","author":"Awais","year":"2023","journal-title":"Front. Nutr."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1136","DOI":"10.1089\/jmf.2019.4424","article-title":"Dendropanax morbifera Branch Water Extract Increases the Immunostimulatory Activity of RAW264. 7 Macrophages and Primary Mouse Splenocytes","volume":"22","author":"Song","year":"2019","journal-title":"J. Med. Food"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"172","DOI":"10.4047\/jap.2016.8.3.172","article-title":"Antimicrobial, antioxidant and cytotoxic activities of Dendropanax morbifera L\u00e9veille extract for mouthwash and denture cleaning solution","volume":"8","author":"Kim","year":"2016","journal-title":"J. Adv. Prosthodont."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"1634","DOI":"10.1002\/ptr.2838","article-title":"In vitro evaluation of the antiplasmodial activity of Dendropanax morbifera against chloroquine-sensitive strains of Plasmodium falciparum","volume":"23","author":"Chung","year":"2009","journal-title":"Phytother. Res."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"111874","DOI":"10.1016\/j.jep.2019.111874","article-title":"Preclinical study of safety of Dendropanax morbifera Leveille leaf extract: General and genetic toxicology","volume":"238","author":"Yun","year":"2019","journal-title":"J. Ethnopharmacol."},{"key":"ref_25","first-page":"60","article-title":"Main trait variations according to planting season of Hwangchil tree in the southern island region","volume":"14","author":"Choi","year":"2001","journal-title":"J. Korean Resour. Plant Soc."},{"key":"ref_26","first-page":"126","article-title":"Selection of the high yield capacity of Hwangchil lacquer and identification of aromatic components in essential oil of Dendropanax morbifera Lev","volume":"10","author":"Ahn","year":"2002","journal-title":"Korean J. Med. Crop Sci."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"143","DOI":"10.14383\/cri.2013.8.2.143","article-title":"Characteristic of seed germination of Dendropanax morifera according to temperature and light factors for estimating change of habitat area in global warming","volume":"8","author":"Lee","year":"2013","journal-title":"J. Clim. Res."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"163","DOI":"10.5010\/JPB.2009.36.2.163","article-title":"Induction and in vitro proliferation of adventitious roots in Dendropanax morbifera","volume":"36","author":"Bae","year":"2009","journal-title":"J. Plant Biotechnol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"012024","DOI":"10.1088\/1755-1315\/293\/1\/012024","article-title":"Callus induction and in vitro mass culture of adventitious roots from leaf segment explants of Dendropanax morbifera Lev","volume":"293","author":"Sukweenadhi","year":"2019","journal-title":"IOP Conf. Ser. Earth Environ. Sci."},{"key":"ref_30","first-page":"60","article-title":"Elicitors in plant tissue culture","volume":"2","author":"Patel","year":"2013","journal-title":"J. Pharmacogn. Phytochem."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s11240-016-0985-6","article-title":"Chemical elicitors versus secondary metabolite production in vitro using plant cell, tissue and organ cultures: Recent trends and a sky eye view appraisal","volume":"126","author":"Giri","year":"2016","journal-title":"Plant Cell Tissue Organ Cult. (PCTOC)"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"6987","DOI":"10.1007\/s00253-015-6806-8","article-title":"Production of ginseng saponins: Elicitation strategy and signal transductions","volume":"99","author":"Rahimi","year":"2015","journal-title":"Appl. Microbiol. Biotechnol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"13541","DOI":"10.3390\/molecules190913541","article-title":"Elicitation: A tool for enriching the bioactive composition of foods","volume":"19","author":"Baenas","year":"2014","journal-title":"Molecules"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/j.biotechadv.2005.01.003","article-title":"Elicitor signal transduction leading to production of plant secondary metabolites","volume":"23","author":"Zhao","year":"2005","journal-title":"Biotechnol. Adv."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1007\/s10068-018-0352-y","article-title":"Antioxidant activity and contents of leaf extracts obtained from Dendropanax morbifera LEV are dependent on the collecting season and extraction conditions","volume":"28","author":"Youn","year":"2019","journal-title":"Food Sci. Biotechnol."},{"key":"ref_36","doi-asserted-by":"crossref","unstructured":"Pu, J.Y., Ramadhania, Z.M., Mathiyalagan, R., Huo, Y., Han, Y., Li, J.F., Ahn, J.C., Xu, F.J., Lee, D.W., and Zeng, X.H. (2021). Ginsenosides conversion and anti-oxidant activities in puffed cultured roots of mountain ginseng. Processes, 9.","DOI":"10.3390\/pr9122271"},{"key":"ref_37","doi-asserted-by":"crossref","unstructured":"Ramadhania, Z.M., Yang, D.U., Moektiwardojo, M., Han, Y., Park, J.K., Rupa, E.J., Yang, D.C., Lee, S.J., and Kang, S.C. (2022). Enhanced Anti-Skin Aging Effects of Fermented Black Ginseng (Panax ginseng CA Meyer) by Aspergillus niger KHNT-1. Appl. Sci., 13.","DOI":"10.3390\/app13010550"},{"key":"ref_38","doi-asserted-by":"crossref","unstructured":"Akter, R., Ling, L., Rupa, E.J., KyuPark, J., Mathiyalagan, R., Nahar, J., Won, L.J., Hyun, K.D., Murugesan, M., and Yang, D.C. (2022). Binary Effects of Gynostemma Gold Nanoparticles on Obesity and Inflammation via Downregulation of PPAR\u03b3\/CEPB\u03b1 and TNF-\u03b1 Gene Expression. Molecules, 27.","DOI":"10.3390\/molecules27092795"},{"key":"ref_39","doi-asserted-by":"crossref","unstructured":"Akter, R., Kwak, G.-Y., Ahn, J.C., Mathiyalagan, R., Ramadhania, Z.M., Yang, D.C., and Kang, S.C. (2021). Protective effect and potential antioxidant role of kakadu plum extracts on alcohol-induced oxidative damage in HepG2 cells. Appl. Sci., 12.","DOI":"10.3390\/app12010236"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1007\/s11627-019-09983-5","article-title":"Plant tissue culture media and practices: An overview","volume":"55","author":"Phillips","year":"2019","journal-title":"Vitr. Cell. Dev. Biol.-Plant"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"351","DOI":"10.3906\/tar-1809-54","article-title":"Effects of methyl jasmonate and salicylic acid on the production of camphor and phenolic compounds in cell suspension culture of endemic Turkish yarrow (Achillea gypsicola) species","volume":"43","author":"Acikgoz","year":"2019","journal-title":"Turk. J. Agric. For."},{"key":"ref_42","doi-asserted-by":"crossref","unstructured":"Gomes, E.P., Vanz Borges, C., Monteiro, G.C., Filiol Belin, M.A., Minatel, I.O., Pimentel Junior, A., Tecchio, M.A., and Lima, G.P.P. (2021). Preharvest salicylic acid treatments improve phenolic compounds and biogenic amines in \u2018Niagara Rosada\u2019 table grape. Postharvest Biol. Technol., 176.","DOI":"10.1016\/j.postharvbio.2021.111505"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"2555","DOI":"10.1002\/jsfa.6596","article-title":"Effect of methyl jasmonate, sodium selenate and chitosan as exogenous elicitors on the phenolic compounds profile of broccoli sprouts","volume":"94","author":"Mahn","year":"2014","journal-title":"J. Sci. Food Agric."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1166\/jcc.2014.1056","article-title":"Chitosan increased phenolic compound contents in tea (Camellia sinensis) leaves by pre-and post-treatments","volume":"2","author":"Srisornkompon","year":"2014","journal-title":"J. Chitin Chitosan Sci."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/j.foodchem.2016.01.086","article-title":"Improvement of grape and wine phenolic content by foliar application to grapevine of three different elicitors: Methyl jasmonate, chitosan, and yeast extract","volume":"201","author":"Portu","year":"2016","journal-title":"Food Chem."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"110784","DOI":"10.1016\/j.plantsci.2020.110784","article-title":"Application of methyl jasmonate and salicylic acid lead to contrasting effects on the plant\u2019s metabolome and herbivory","volume":"303","author":"Wei","year":"2021","journal-title":"Plant Sci."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"1479","DOI":"10.1007\/s00299-014-1632-5","article-title":"Methyl jasmonate represses growth and affects cell cycle progression in cultured Taxus cells","volume":"33","author":"Patil","year":"2014","journal-title":"Plant Cell Rep."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/S1369-703X(00)00059-0","article-title":"Quantitative determination of cultured strawberry-cell heterogeneity by image analysis: Effects of medium modification on anthocyanin accumulation","volume":"5","author":"Miyanaga","year":"2000","journal-title":"Biochem. Eng. J."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"1930","DOI":"10.1104\/pp.113.214908","article-title":"Jasmonate Controls Leaf Growth by Repressing Cell Proliferation and the Onset of Endoreduplication while Maintaining a Potential Stand-By Mode","volume":"161","author":"Noir","year":"2013","journal-title":"Plant Physiol."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"607","DOI":"10.3390\/12030607","article-title":"Methyl jasmonate and salicylic acid induced oxidative stress and accumulation of phenolics in Panax ginseng bioreactor root suspension cultures","volume":"12","author":"Ali","year":"2007","journal-title":"Molecules"},{"key":"ref_51","doi-asserted-by":"crossref","unstructured":"Harborne, J.B., and Mabry, T.J. (1982). The Flavonoids: Advances in Research, Springer. [3rd ed.].","DOI":"10.1007\/978-1-4899-2915-0"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1002\/(SICI)1097-0010(199607)71:3<313::AID-JSFA586>3.0.CO;2-N","article-title":"Developmental changes in enzymes of flavonoid biosynthesis in the skins of red and green apple cultivars","volume":"71","author":"Lister","year":"1996","journal-title":"J. Sci. Food Agric."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.indcrop.2017.03.043","article-title":"Enhanced phenolic acids production in regenerated shoot cultures of Salvia virgata Jacq. after elicitation with Ag+ ions, methyl jasmonate and yeast extract","volume":"103","author":"Abrishamchi","year":"2017","journal-title":"Ind. Crops Prod."},{"key":"ref_54","doi-asserted-by":"crossref","unstructured":"Manivannan, A., Soundararajan, P., Park, Y.G., and Jeong, B.R. (2016). Chemical Elicitor-Induced Modulation of Antioxidant Metabolism and Enhancement of Secondary Metabolite Accumulation in Cell Suspension Cultures of Scrophularia kakudensis Franch. Int. J. Mol. Sci., 17.","DOI":"10.3390\/ijms17030399"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"1092","DOI":"10.1093\/pcp\/pcn086","article-title":"Methyl jasmonate induces production of reactive oxygen species and alterations in mitochondrial dynamics that precede photosynthetic dysfunction and subsequent cell death","volume":"49","author":"Zhang","year":"2008","journal-title":"Plant Cell Physiol."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"5767","DOI":"10.1021\/nn301714n","article-title":"Cytotoxic effects of gold nanoparticles: A multiparametric study","volume":"6","author":"Soenen","year":"2012","journal-title":"ACS Nano"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/j.bbagen.2010.04.007","article-title":"Toxicology of engineered nanomaterials: Focus on biocompatibility, biodistribution and biodegradation","volume":"1810","author":"Kunzmann","year":"2011","journal-title":"Biochim. Biophys. Acta (BBA)-Gen. Subj."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.toxlet.2005.07.001","article-title":"In vitro cytotoxicity assays: Comparison of LDH, neutral red, MTT and protein assay in hepatoma cell lines following exposure to cadmium chloride","volume":"160","author":"Fotakis","year":"2006","journal-title":"Toxicol. Lett."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"5073","DOI":"10.1021\/jf0702693","article-title":"Anti-inflammatory effect of \u03b1-linolenic acid and its mode of action through the inhibition of nitric oxide production and inducible nitric oxide synthase gene expression via NF-\u03baB and mitogen-activated protein kinase pathways","volume":"55","author":"Ren","year":"2007","journal-title":"J. Agric. Food Chem."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"471","DOI":"10.2174\/1568010054526359","article-title":"Nitric oxide production and signaling in inflammation","volume":"4","author":"Korhonen","year":"2005","journal-title":"Curr. Drug Targets-Inflamm. Allergy"},{"key":"ref_61","doi-asserted-by":"crossref","unstructured":"Kim, Y.J., and Park, W. (2016). Anti-Inflammatory Effect of Quercetin on RAW 264.7 Mouse Macrophages Induced with Polyinosinic-Polycytidylic Acid. Molecules, 21.","DOI":"10.3390\/molecules21040450"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.jep.2007.05.021","article-title":"Nobiletin from citrus fruit peel inhibits the DNA-binding activity of NF-\u03baB and ROS production in LPS-activated RAW 264.7 cells","volume":"113","author":"Choi","year":"2007","journal-title":"J. Ethnopharmacol."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"171040","DOI":"10.1016\/j.peptides.2023.171040","article-title":"Cbf-14, a cationic peptide derived from cathelin-domain, exhibits anti-inflammation activity via inhibiting PI3K- Akt \/ROS\/ NF-\u03baB signaling pathway","volume":"166","author":"Xie","year":"2023","journal-title":"Peptides"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/j.indcrop.2015.05.002","article-title":"Anti-inflammatory activity and phenolic composition of Dendropanax morbifera leaf extracts","volume":"74","author":"Hyun","year":"2015","journal-title":"Ind. Crops Prod."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1007\/s10068-015-0034-y","article-title":"Antioxidant and anti-inflammatory activities of 3, 5-dicaffeoylquinic acid isolated from Ligularia fischeri leaves","volume":"24","author":"Hong","year":"2015","journal-title":"Food Sci. Biotechnol."},{"key":"ref_66","doi-asserted-by":"crossref","unstructured":"Park, J., Kim, Y., Lee, C., and Kim, Y.T. (2022). 3, 5-Dicaffeoylquinic acid attenuates microglial activation-mediated inflammatory pain by enhancing autophagy through the suppression of MCP3\/JAK2\/STAT3 signaling. Biomed. Pharmacother., 153.","DOI":"10.1016\/j.biopha.2022.113549"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1016\/j.fct.2013.04.002","article-title":"Short-term heating reduces the anti-inflammatory effects of fresh raw garlic extracts on the LPS-induced production of NO and pro-inflammatory cytokines by downregulating allicin activity in RAW 264.7 macrophages","volume":"58","author":"Shin","year":"2013","journal-title":"Food Chem. Toxicol."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"1309","DOI":"10.1016\/j.archoralbio.2013.07.005","article-title":"Curcumin abrogates LPS-induced pro-inflammatory cytokines in RAW 264.7 macrophages. Evidence for novel mechanisms involving SOCS-1,-3 and p38 MAPK","volume":"58","author":"Leite","year":"2013","journal-title":"Arch. Oral Biol."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"130","DOI":"10.5053\/ejobios.2009.3.0.17","article-title":"Suppression of pro-inflammatory cytokines, iNOS, and COX-2 expression by brown algae Sargassum micracanthum in RAW 264.7 macrophages","volume":"3","author":"Yoon","year":"2009","journal-title":"EurAsian J. BioSciences"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"R453","DOI":"10.1016\/j.cub.2014.03.034","article-title":"ROS function in redox signaling and oxidative stress","volume":"24","author":"Schieber","year":"2014","journal-title":"Curr. Biol."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.canlet.2015.07.008","article-title":"Reactive oxygen species in redox cancer therapy","volume":"367","author":"Tong","year":"2015","journal-title":"Cancer Lett."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1038\/nrd2803","article-title":"Targeting cancer cells by ROS-mediated mechanisms: A radical therapeutic approach?","volume":"8","author":"Trachootham","year":"2009","journal-title":"Nat. Rev. Drug Discov."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"382","DOI":"10.3109\/10715762.2011.653969","article-title":"Mechanisms of free radical-induced damage to DNA","volume":"46","author":"Dizdaroglu","year":"2012","journal-title":"Free Radic. Res."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/j.freeradbiomed.2017.01.004","article-title":"Reactive oxygen species and cancer paradox: To promote or to suppress?","volume":"104","author":"Galadari","year":"2017","journal-title":"Free Radic. Biol. Med."},{"key":"ref_75","doi-asserted-by":"crossref","unstructured":"Phan, T.N., Kim, O., Ha, M.T., Hwangbo, C., Min, B.-S., and Lee, J.-H. (2020). Albanol B from Mulberries Exerts Anti-Cancer Effect through Mitochondria ROS Production in Lung Cancer Cells and Suppresses In Vivo Tumor Growth. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21249502"},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1016\/S0002-9440(10)64570-1","article-title":"Protection from lethal apoptosis in lipopolysaccharide-induced acute lung injury in mice by a caspase inhibitor","volume":"157","author":"Kawasaki","year":"2000","journal-title":"Am. J. Pathol."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.canlet.2016.03.042","article-title":"Reactive oxygen species (ROS) and cancer: Role of antioxidative nutraceuticals","volume":"387","author":"Prasad","year":"2017","journal-title":"Cancer Lett."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.mam.2018.02.003","article-title":"Redox control in cancer development and progression","volume":"63","author":"Helfinger","year":"2018","journal-title":"Mol. Asp. Med."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.1111\/j.1745-7254.2007.00595.x","article-title":"Prevention of lipopolysaccharide-induced injury by 3, 5-dicaffeoylquinic acid in endothelial cells","volume":"28","author":"Zha","year":"2007","journal-title":"Acta Pharmacol. Sin."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"827901","DOI":"10.3389\/fphar.2022.827901","article-title":"An Optimized Two-Herb Chinese Food as Medicine Formula Reduces Cisplatin-Induced Nephrotoxicity in the Treatment of Lung Cancer in Mice","volume":"13","author":"Shi","year":"2022","journal-title":"Front. Pharmacol."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"e11","DOI":"10.1016\/j.jid.2016.11.020","article-title":"Research techniques made simple: Analysis of collective cell migration using the wound healing assay","volume":"137","author":"Grada","year":"2017","journal-title":"J. Investig. Dermatol."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.redox.2012.10.001","article-title":"The Keap1-Nrf2 pathway: Mechanisms of activation and dysregulation in cancer","volume":"1","author":"Kansanen","year":"2013","journal-title":"Redox Biol."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"153445","DOI":"10.1016\/j.phymed.2020.153445","article-title":"n-BuOH extract of Bletilla striata exerts chemopreventive effects on lung against SiO2 nanoparticles through activation of Nrf2 pathway","volume":"82","author":"Chen","year":"2021","journal-title":"Phytomedicine"},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1080\/03602530600971974","article-title":"Mechanistic studies of the Nrf2-Keap1 signaling pathway","volume":"38","author":"Zhang","year":"2006","journal-title":"Drug Metab. Rev."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"1322","DOI":"10.1126\/science.281.5381.1322","article-title":"The Bcl-2 protein family: Arbiters of cell survival","volume":"281","author":"Jm","year":"1998","journal-title":"Science"},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/j.canlet.2004.12.044","article-title":"Involvement of Bcl-2 family, cytochrome c and caspase 3 in induction of apoptosis by beauvericin in human non-small cell lung cancer cells","volume":"230","author":"Lin","year":"2005","journal-title":"Cancer Lett."}],"container-title":["Biomolecules"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2218-273X\/14\/6\/705\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T14:59:12Z","timestamp":1760108352000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2218-273X\/14\/6\/705"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6,15]]},"references-count":86,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2024,6]]}},"alternative-id":["biom14060705"],"URL":"https:\/\/doi.org\/10.3390\/biom14060705","relation":{},"ISSN":["2218-273X"],"issn-type":[{"value":"2218-273X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,6,15]]}}}