{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T00:19:55Z","timestamp":1789517995141,"version":"build-2803163510"},"reference-count":233,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2024,6,21]],"date-time":"2024-06-21T00:00:00Z","timestamp":1718928000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III (ISCIII)","doi-asserted-by":"publisher","award":["RD21\/0017\/0010"],"award-info":[{"award-number":["RD21\/0017\/0010"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III (ISCIII)","doi-asserted-by":"publisher","award":["RD21\/0017\/0001"],"award-info":[{"award-number":["RD21\/0017\/0001"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"name":"ERDF-Next Generation EU \u201cPlan de Recuperaci\u00f3n, Transformaci\u00f3n y Resiliencia\u201d","award":["RD21\/0017\/0010"],"award-info":[{"award-number":["RD21\/0017\/0010"]}]},{"name":"ERDF-Next Generation EU \u201cPlan de Recuperaci\u00f3n, Transformaci\u00f3n y Resiliencia\u201d","award":["RD21\/0017\/0001"],"award-info":[{"award-number":["RD21\/0017\/0001"]}]},{"name":"ERDF-Next Generation EU \u201cPlan de Recuperaci\u00f3n, Transformaci\u00f3n y Resiliencia\u201d","award":["RD21\/0017\/0010"],"award-info":[{"award-number":["RD21\/0017\/0010"]}]},{"name":"ERDF-Next Generation EU \u201cPlan de Recuperaci\u00f3n, Transformaci\u00f3n y Resiliencia\u201d","award":["RD21\/0017\/0001"],"award-info":[{"award-number":["RD21\/0017\/0001"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biomolecules"],"abstract":"<jats:p>Mesenchymal stem\/stromal cells (MSCs) are one of the most widely used cell types in advanced therapies due to their therapeutic potential in the regulation of tissue repair and homeostasis, and immune modulation. However, their use in cancer therapy is controversial: they can inhibit cancer cell proliferation, but also potentially promote tumour growth by supporting angiogenesis, modulation of the immune milieu and increasing cancer stem cell invasiveness. This opposite behaviour highlights the need for careful and nuanced use of MSCs in cancer treatment. To optimize their anti-cancer effects, diverse strategies have bioengineered MSCs to enhance their tumour targeting and therapeutic properties or to deliver anti-cancer drugs. In this review, we highlight the advanced uses of MSCs in cancer therapy, particularly as carriers of targeted treatments due to their natural tumour-homing capabilities. We also discuss the potential of MSC-derived extracellular vesicles to improve the efficiency of drug or molecule delivery to cancer cells. Ongoing clinical trials are evaluating the therapeutic potential of these cells and setting the stage for future advances in MSC-based cancer treatment. It is critical to identify the broad and potent applications of bioengineered MSCs in solid tumour targeting and anti-cancer agent delivery to position them as effective therapeutics in the evolving field of cancer therapy.<\/jats:p>","DOI":"10.3390\/biom14070734","type":"journal-article","created":{"date-parts":[[2024,6,21]],"date-time":"2024-06-21T08:50:08Z","timestamp":1718959808000},"page":"734","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Bioengineered Mesenchymal Stem\/Stromal Cells in Anti-Cancer Therapy: Current Trends and Future Prospects"],"prefix":"10.3390","volume":"14","author":[{"given":"Jes\u00fas I.","family":"Gil-Chinchilla","sequence":"first","affiliation":[{"name":"Hematopoietic Transplant and Cellular Therapy Unit, Instituto Murciano de Investigaci\u00f3n Biosanitaria (IMIB) Pascual Parrilla, Virgen de la Arrixaca University Hospital, University of Murcia, 30120 Murcia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agust\u00edn G.","family":"Zapata","sequence":"additional","affiliation":[{"name":"Department of Cell Biology, Complutense University, 28040 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9080-1466","authenticated-orcid":false,"given":"Jose M.","family":"Moraleda","sequence":"additional","affiliation":[{"name":"Hematopoietic Transplant and Cellular Therapy Unit, Instituto Murciano de Investigaci\u00f3n Biosanitaria (IMIB) Pascual Parrilla, Virgen de la Arrixaca University Hospital, University of Murcia, 30120 Murcia, Spain"},{"name":"Department of Medicine, University of Murcia, 30120 Murcia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6610-8442","authenticated-orcid":false,"given":"David","family":"Garc\u00eda-Bernal","sequence":"additional","affiliation":[{"name":"Hematopoietic Transplant and Cellular Therapy Unit, Instituto Murciano de Investigaci\u00f3n Biosanitaria (IMIB) Pascual Parrilla, Virgen de la Arrixaca University Hospital, University of Murcia, 30120 Murcia, Spain"},{"name":"Department of Biochemistry, Molecular Biology and Immunology, University of Murcia, 30120 Murcia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,6,21]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1126\/science.284.5411.143","article-title":"Multilineage potential of adult human mesenchymal stem cells","volume":"284","author":"Pittenger","year":"1999","journal-title":"Science"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1038\/nri2395","article-title":"Mesenchymal stem cells in health and disease","volume":"8","author":"Uccelli","year":"2008","journal-title":"Nat. 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