{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T20:13:19Z","timestamp":1791490399882,"version":"4.3.4"},"reference-count":198,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2024,6,22]],"date-time":"2024-06-22T00:00:00Z","timestamp":1719014400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005046","name":"Heilongjiang Provincial Natural Science Foundation","doi-asserted-by":"publisher","award":["YQ2022H020"],"award-info":[{"award-number":["YQ2022H020"]}],"id":[{"id":"10.13039\/501100005046","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biomolecules"],"abstract":"<jats:p>Ischemia\u2013reperfusion (I\/R) injury, a prevalent pathological condition in medical practice, presents significant treatment challenges. Hydrogen sulfide (H2S), acknowledged as the third gas signaling molecule, profoundly impacts various physiological and pathophysiological processes. Extensive research has demonstrated that H2S can mitigate I\/R damage across multiple organs and tissues. This review investigates the protective effects of H2S in preventing I\/R damage in the heart, brain, liver, kidney, intestines, lungs, stomach, spinal cord, testes, eyes, and other tissues. H2S provides protection against I\/R damage by alleviating inflammation and endoplasmic reticulum stress; inhibiting apoptosis, oxidative stress, and mitochondrial autophagy and dysfunction; and regulating microRNAs. Significant advancements in understanding the mechanisms by which H2S reduces I\/R damage have led to the development and synthesis of H2S-releasing agents such as diallyl trisulfide-loaded mesoporous silica nanoparticles (DATS-MSN), AP39, zofenopril, and ATB-344, offering a new therapeutic avenue for I\/R injury.<\/jats:p>","DOI":"10.3390\/biom14070740","type":"journal-article","created":{"date-parts":[[2024,6,24]],"date-time":"2024-06-24T10:41:12Z","timestamp":1719225672000},"page":"740","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Therapeutic Potential of Hydrogen Sulfide in Ischemia and Reperfusion Injury"],"prefix":"10.3390","volume":"14","author":[{"given":"Xutao","family":"Sun","sequence":"first","affiliation":[{"name":"Department of Typhoid, School of Basic Medical Sciences, Heilongjiang University of Chinese Medicine, Harbin 150040, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siyu","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, School of Basic Medical Sciences, Heilongjiang University of Chinese Medicine, Harbin 150040, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caiyun","family":"Mao","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, School of Basic Medical Sciences, Heilongjiang University of Chinese Medicine, Harbin 150040, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Qu","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, School of Basic Medical Sciences, Heilongjiang University of Chinese Medicine, Harbin 150040, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zihang","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, School of Basic Medical Sciences, Heilongjiang University of Chinese Medicine, Harbin 150040, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Xie","sequence":"additional","affiliation":[{"name":"Department of Synopsis of the Golden Chamber, School of Basic Medical Sciences, Heilongjiang University of Chinese Medicine, Harbin 150040, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deyou","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Synopsis of the Golden Chamber, School of Basic Medical Sciences, Heilongjiang University of Chinese Medicine, Harbin 150040, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunjia","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, School of Basic Medical Sciences, Heilongjiang University of Chinese Medicine, Harbin 150040, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,6,22]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"126","DOI":"10.5152\/eajm.2013.24","article-title":"Ischemia-reperfusion damage","volume":"45","author":"Yapca","year":"2013","journal-title":"Eurasian J. Med."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1391","DOI":"10.1038\/nm.2507","article-title":"Ischemia and reperfusion\u2014From mechanism to translation","volume":"17","author":"Eltzschig","year":"2011","journal-title":"Nat. Med."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1097\/FJC.0000000000000943","article-title":"Role of Hydrogen Sulfide in Myocardial Ischemia-Reperfusion Injury","volume":"77","author":"Zhang","year":"2021","journal-title":"J. Cardiovasc. Pharmacol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/bs.mie.2014.11.041","article-title":"Attenuation of inflammatory responses by hydrogen sulfide (H2S) in ischemia\/reperfusion injury","volume":"555","author":"Sodha","year":"2015","journal-title":"Methods Enzymol."},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Lv, S., Wang, Z., Wang, J., and Wang, H. (2021). Exogenous Hydrogen Sulfide Plays an Important Role Through Regulating Autophagy in Ischemia\/Reperfusion Injury. Front. Mol. Biosci., 8.","DOI":"10.3389\/fmolb.2021.681676"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1650","DOI":"10.1159\/000489241","article-title":"Current Mechanistic Concepts in Ischemia and Reperfusion Injury","volume":"46","author":"Wu","year":"2018","journal-title":"Cell. Physiol. Biochem. Int. J. Exp. Cell. Physiol. Biochem. Pharmacol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1007\/978-3-319-18144-8_18","article-title":"Medicinal Chemistry: Insights into the Development of Novel H2S Donors","volume":"230","author":"Zhao","year":"2015","journal-title":"Handb. Exp. Pharmacol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/j.niox.2014.01.002","article-title":"The physiological role of hydrogen sulfide and beyond","volume":"41","author":"Kimura","year":"2014","journal-title":"Nitric Oxide Biol. Chem."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.redox.2012.11.006","article-title":"Redox Biology of Hydrogen Sulfide: Implications for Physiology, Pathophysiology, and Pharmacology","volume":"1","author":"Stein","year":"2013","journal-title":"Redox Biol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1152\/physrev.00017.2011","article-title":"Physiological implications of hydrogen sulfide: A whiff exploration that blossomed","volume":"92","author":"Wang","year":"2012","journal-title":"Physiol. Rev."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1587","DOI":"10.1111\/bph.12811","article-title":"The role of gasotransmitters NO, H2S and CO in myocardial ischaemia\/reperfusion injury and cardioprotection by preconditioning, postconditioning and remote conditioning","volume":"172","author":"Andreadou","year":"2015","journal-title":"Br. J. Pharmacol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/j.phrs.2010.06.002","article-title":"Hydrogen sulfide and ischemia-reperfusion injury","volume":"62","author":"Nicholson","year":"2010","journal-title":"Pharmacol. Res."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"3541","DOI":"10.1038\/s41598-017-03941-0","article-title":"A Long-Term and Slow-Releasing Hydrogen Sulfide Donor Protects against Myocardial Ischemia\/Reperfusion Injury","volume":"7","author":"Sun","year":"2017","journal-title":"Sci. Rep."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1111\/bph.13688","article-title":"AP39, a mitochondria-targeting hydrogen sulfide (H(2)S) donor, protects against myocardial reperfusion injury independently of salvage kinase signalling","volume":"174","author":"Karwi","year":"2017","journal-title":"Br. J. Pharmacol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"e003531","DOI":"10.1161\/JAHA.116.003531","article-title":"Zofenopril Protects Against Myocardial Ischemia-Reperfusion Injury by Increasing Nitric Oxide and Hydrogen Sulfide Bioavailability","volume":"5","author":"Donnarumma","year":"2016","journal-title":"J. Am. Heart Assoc."},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"G\u0142owacka, U., Magierowski, M., \u015aliwowski, Z., Cieszkowski, J., Szetela, M., W\u00f3jcik-Grzybek, D., Chmura, A., Brzozowski, T., Wallace, J.L., and Magierowska, K. (2023). Hydrogen Sulfide-Releasing Indomethacin-Derivative (ATB-344) Prevents the Development of Oxidative Gastric Mucosal Injuries. Antioxidants, 12.","DOI":"10.3390\/antiox12081545"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1161\/CIRCRESAHA.114.300505","article-title":"Emergence of hydrogen sulfide as an endogenous gaseous signaling molecule in cardiovascular disease","volume":"114","author":"Polhemus","year":"2014","journal-title":"Circ. Res."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.jare.2020.05.007","article-title":"Hydrogen sulfide and vascular regulation\u2014An update","volume":"27","author":"Lv","year":"2021","journal-title":"J. Adv. Res."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1152\/physrev.00028.2021","article-title":"Physiological roles of hydrogen sulfide in mammalian cells, tissues, and organs","volume":"103","author":"Cirino","year":"2023","journal-title":"Physiol. Rev."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1007\/s00726-004-0072-x","article-title":"Endogenous production of hydrogen sulfide in mammals","volume":"26","author":"Kamoun","year":"2004","journal-title":"Amino Acids"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1089\/ars.2010.3781","article-title":"The quantitative significance of the transsulfuration enzymes for H2S production in murine tissues","volume":"15","author":"Kabil","year":"2011","journal-title":"Antioxid. Redox Signal."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1007\/s00726-010-0510-x","article-title":"Hydrogen sulfide: Its production, release and functionsc","volume":"41","author":"Kimura","year":"2011","journal-title":"Amino Acids"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"R51","DOI":"10.1152\/ajpregu.00576.2009","article-title":"Hypoxic pulmonary vasodilation: A paradigm shift with a hydrogen sulfide mechanism","volume":"298","author":"Olson","year":"2010","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.bcp.2017.11.014","article-title":"A review of hydrogen sulfide (H(2)S) donors: Chemistry and potential therapeutic applications","volume":"149","author":"Powell","year":"2018","journal-title":"Biochem. Pharmacol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"716S","DOI":"10.1093\/jn\/136.3.716S","article-title":"Clarifying the real bioactive constituents of garlic","volume":"136","author":"Amagase","year":"2006","journal-title":"J. Nutr."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.niox.2018.09.001","article-title":"Donor heart preservation with a novel long-term and slow-releasing hydrogen sulfide system","volume":"81","author":"Sun","year":"2018","journal-title":"Nitric Oxide Biol. Chem."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1007\/s11095-021-03164-z","article-title":"Transdermal Delivery of a Hydrogen Sulphide Donor, ADT-OH Using Aqueous Gel Formulations for the Treatment of Impaired Vascular Function: An Ex Vivo Study","volume":"39","author":"Marwah","year":"2022","journal-title":"Pharm. Res."},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"Cai, F., Li, D., Xie, Y., Wang, X., Ma, H., Xu, H., Cheng, J., Zhuang, H., and Hua, Z. (2024). Sulfide:quinone oxidoreductase alleviates ferroptosis in acute kidney injury via ameliorating mitochondrial dysfunction of renal tubular epithelial cells. Redox Biol., 69.","DOI":"10.1016\/j.redox.2023.102973"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"8456852","DOI":"10.1155\/2023\/8456852","article-title":"A Water-Soluble Hydrogen Sulfide Donor Suppresses the Growth of Hepatocellular Carcinoma via Inhibiting the AKT\/GSK-3\u03b2\/\u03b2-Catenin and TGF-\u03b2\/Smad2\/3 Signaling Pathways","volume":"2023","author":"Duan","year":"2023","journal-title":"J. Oncol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"972","DOI":"10.1007\/s11684-023-0990-1","article-title":"ADT-OH improves intestinal barrier function and remodels the gut microbiota in DSS-induced colitis","volume":"17","author":"Bi","year":"2023","journal-title":"Front. Med."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"3139","DOI":"10.1111\/ajt.15539","article-title":"Supplementing preservation solution with mitochondria-targeted H(2) S donor AP39 protects cardiac grafts from prolonged cold ischemia-reperfusion injury in heart transplantation","volume":"19","author":"Zhu","year":"2019","journal-title":"Am. J. Transplant. Off. J. Am. Soc. Transplant. Am. Soc. Transplant. Surg."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1007\/s00059-018-4764-5","article-title":"ESC\/EACTS guidelines on myocardial revascularization 2018: The most important innovations","volume":"43","author":"Neumann","year":"2018","journal-title":"Herz"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"112389","DOI":"10.1016\/j.yexcr.2020.112389","article-title":"Activation of the CaR-CSE\/H2S pathway confers cardioprotection against ischemia-reperfusion injury","volume":"398","author":"Luo","year":"2021","journal-title":"Exp. Cell Res."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1177\/1535370214558024","article-title":"Beetroot juice reduces infarct size and improves cardiac function following ischemia-reperfusion injury: Possible involvement of endogenous H2S","volume":"240","author":"Salloum","year":"2015","journal-title":"Exp. Biol. Med."},{"key":"ref_35","first-page":"102","article-title":"The cystathionine \u03b3-lyase\/hydrogen sulfide pathway mediates the trimetazidine-induced protection of H9c2 cells against hypoxia\/reoxygenation-induced apoptosis and oxidative stress","volume":"22","author":"Zheng","year":"2019","journal-title":"Anat. J. Cardiol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1007\/s00395-015-0500-y","article-title":"Hydrogen sulfide mediates the cardioprotective effects of gene therapy with PKG-I\u03b1","volume":"110","author":"Das","year":"2015","journal-title":"Basic Res. Cardiol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"H1347","DOI":"10.1152\/ajpheart.00544.2011","article-title":"Cinaciguat, a novel activator of soluble guanylate cyclase, protects against ischemia\/reperfusion injury: Role of hydrogen sulfide","volume":"302","author":"Salloum","year":"2012","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"117699","DOI":"10.1016\/j.lfs.2020.117699","article-title":"LncRNA Oprm1 overexpression attenuates myocardial ischemia\/reperfusion injury by increasing endogenous hydrogen sulfide via Oprm1\/miR-30b-5p\/CSE axis","volume":"254","author":"Hu","year":"2020","journal-title":"Life Sci."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"2507","DOI":"10.21873\/invivo.12067","article-title":"Hydrogen Sulphide and Nitric Oxide Cooperate in Cardioprotection Against Ischemia\/Reperfusion Injury in Isolated Rat Heart","volume":"34","author":"Ustunova","year":"2020","journal-title":"In Vivo"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1097\/SHK.0b013e318180ff89","article-title":"Anti-apoptotic and anti-inflammatory effects of hydrogen sulfide in a rat model of regional myocardial I\/R","volume":"31","author":"Sivarajah","year":"2009","journal-title":"Shock"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"1248","DOI":"10.1139\/Y07-120","article-title":"Hydrogen sulfide contributes to cardioprotection during ischemia-reperfusion injury by opening K ATP channels","volume":"85","author":"Zhang","year":"2007","journal-title":"Can. J. Physiol. Pharmacol."},{"key":"ref_42","first-page":"7740","article-title":"Hydrogen sulfide preconditioning protects against myocardial ischemia\/reperfusion injury in rats through inhibition of endo\/sarcoplasmic reticulum stress","volume":"8","author":"Li","year":"2015","journal-title":"Int. J. Clin. Exp. Pathol."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1016\/j.bbrc.2015.02.017","article-title":"Hydrogen sulfide protects against myocardial ischemia and reperfusion injury by activating AMP-activated protein kinase to restore autophagic flux","volume":"458","author":"Xie","year":"2015","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"1496","DOI":"10.3109\/10715762.2012.731052","article-title":"Impact of SOD in eNOS uncoupling: A two-edged sword between hydrogen peroxide and peroxynitrite","volume":"46","author":"Kar","year":"2012","journal-title":"Free Radic Res."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"1583","DOI":"10.1089\/ars.2011.3999","article-title":"Superoxide dismutases: Role in redox signaling, vascular function, and diseases","volume":"15","author":"Fukai","year":"2011","journal-title":"Antioxid. Redox Signal."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1093\/cvr\/cvv198","article-title":"Cystathionine \u03b3-lyase regulates arteriogenesis through NO-dependent monocyte recruitment","volume":"107","author":"Kolluru","year":"2015","journal-title":"Cardiovasc. Res."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"9161","DOI":"10.1073\/pnas.1202916109","article-title":"Hydrogen sulfide and nitric oxide are mutually dependent in the regulation of angiogenesis and endothelium-dependent vasorelaxation","volume":"109","author":"Coletta","year":"2012","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"3182","DOI":"10.1073\/pnas.1321871111","article-title":"Hydrogen sulfide cytoprotective signaling is endothelial nitric oxide synthase-nitric oxide dependent","volume":"111","author":"King","year":"2014","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1093\/cvr\/cvv129","article-title":"Cardioprotection by H2S engages a cGMP-dependent protein kinase G\/phospholamban pathway","volume":"106","author":"Bibli","year":"2015","journal-title":"Cardiovasc. Res."},{"key":"ref_50","first-page":"221","article-title":"H(2)S protects myocardium against ischemia\/reperfusion injury and its effect on c-Fos protein expression in rats","volume":"60","author":"Zhu","year":"2008","journal-title":"Sheng Li Xue Bao Acta Physiol. Sin."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1159\/000492969","article-title":"Involvement of MicroRNA-133a in the Protective Effect of Hydrogen Sulfide against Ischemia\/Reperfusion-Induced Endoplasmic Reticulum Stress and Cardiomyocyte Apoptosis","volume":"103","author":"Ren","year":"2019","journal-title":"Pharmacology"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"906","DOI":"10.1016\/j.ejcts.2008.01.047","article-title":"The effects of therapeutic sulfide on myocardial apoptosis in response to ischemia-reperfusion injury","volume":"33","author":"Sodha","year":"2008","journal-title":"Eur. J. Cardio Thorac. Surg. Off. J. Eur. Assoc. Cardio Thorac. Surg."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"6845","DOI":"10.1007\/s11033-014-3570-2","article-title":"Involvement of miR-1 in the protective effect of hydrogen sulfide against cardiomyocyte apoptosis induced by ischemia\/reperfusion","volume":"41","author":"Kang","year":"2014","journal-title":"Mol. Biol. Rep."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1536\/ihj.15-506","article-title":"Exogenous Hydrogen Sulfide Postconditioning Protects Isolated Rat Hearts from Ischemia\/Reperfusion Injury Through Sirt1\/PGC-1\u03b1 Signaling Pathway","volume":"57","author":"Hu","year":"2016","journal-title":"Int. Heart J."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"898","DOI":"10.1590\/S0100-879X2012007500090","article-title":"Hydrogen sulfide postconditioning protects isolated rat hearts against ischemia and reperfusion injury mediated by the JAK2\/STAT3 survival pathway","volume":"45","author":"Luan","year":"2012","journal-title":"Braz. J. Med. Biol. Res. Rev. Bras. Pesqui. Med. Biol."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"203","DOI":"10.7555\/JBR.28.20140037","article-title":"GYY4137 protects against myocardial ischemia and reperfusion injury by attenuating oxidative stress and apoptosis in rats","volume":"29","author":"Meng","year":"2015","journal-title":"J. Biomed. Res."},{"key":"ref_57","first-page":"2054","article-title":"Effect of hydrogen sulfide on cardiomyocyte apoptosis in rats with myocardial ischemia-reperfusion injury via the JNK signaling pathway","volume":"24","author":"Li","year":"2020","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1007\/s12192-016-0682-8","article-title":"Hydrogen sulfide post-conditioning preserves interfibrillar mitochondria of rat heart during ischemia reperfusion injury","volume":"21","author":"Banu","year":"2016","journal-title":"Cell Stress Chaperones"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"15560","DOI":"10.1073\/pnas.0705891104","article-title":"Hydrogen sulfide attenuates myocardial ischemia-reperfusion injury by preservation of mitochondrial function","volume":"104","author":"Elrod","year":"2007","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/j.bbrc.2012.03.121","article-title":"Hydrogen sulfide decreases the levels of ROS by inhibiting mitochondrial complex IV and increasing SOD activities in cardiomyocytes under ischemia\/reperfusion","volume":"421","author":"Sun","year":"2012","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1620\/tjem.226.275","article-title":"Hydrogen sulfide protects cardiomyocytes from myocardial ischemia-reperfusion injury by enhancing phosphorylation of apoptosis repressor with caspase recruitment domain","volume":"226","author":"Yao","year":"2012","journal-title":"Tohoku J. Exp. Med."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"H1310","DOI":"10.1152\/ajpheart.00339.2009","article-title":"Hydrogen sulfide protects cardiomyocytes from hypoxia\/reoxygenation-induced apoptosis by preventing GSK-3beta-dependent opening of mPTP","volume":"298","author":"Yao","year":"2010","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"ref_63","doi-asserted-by":"crossref","unstructured":"Zhou, Y., Wang, D., Gao, X., Lew, K., Richards, A.M., and Wang, P. (2014). mTORC2 phosphorylation of Akt1: A possible mechanism for hydrogen sulfide-induced cardioprotection. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0099665"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"2444","DOI":"10.1159\/000438597","article-title":"Hydrogen Sulfide Attenuates Myocardial Hypoxia-Reoxygenation Injury by Inhibiting Autophagy via mTOR Activation","volume":"37","author":"Xiao","year":"2015","journal-title":"Cell. Physiol. Biochem. Int. J. Exp. Cell. Physiol. Biochem. Pharmacol."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/j.yexcr.2015.07.005","article-title":"PI3K\/SGK1\/GSK3\u03b2 signaling pathway is involved in inhibition of autophagy in neonatal rat cardiomyocytes exposed to hypoxia\/reoxygenation by hydrogen sulfide","volume":"345","author":"Jiang","year":"2016","journal-title":"Exp. Cell Res."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"H2410","DOI":"10.1152\/ajpheart.00044.2012","article-title":"The polysulfide diallyl trisulfide protects the ischemic myocardium by preservation of endogenous hydrogen sulfide and increasing nitric oxide bioavailability","volume":"302","author":"Predmore","year":"2012","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1196\/annals.1297.084","article-title":"Aging, exercise, and cardioprotection","volume":"1019","author":"Powers","year":"2004","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"1501","DOI":"10.2174\/0929867324666170616105639","article-title":"The Influence of Obese Insulin-Resistance on the Outcome of the Ischemia\/Reperfusion Insult to the Heart","volume":"25","author":"Shinlapawittayatorn","year":"2018","journal-title":"Curr. Med. Chem."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1002\/(SICI)1096-9896(200002)190:3<255::AID-PATH526>3.0.CO;2-6","article-title":"Pathophysiology of ischaemia-reperfusion injury","volume":"190","author":"Carden","year":"2000","journal-title":"J. Pathol."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"1853","DOI":"10.1007\/s00210-023-02729-6","article-title":"Using mechanism-based combinations of H(2)S-donors to maximize the cardioprotective action of H(2)S","volume":"397","author":"Ravani","year":"2024","journal-title":"Naunyn-Schmiedeberg\u2019s Arch. Pharmacol."},{"key":"ref_71","doi-asserted-by":"crossref","unstructured":"Li, H., Wang, Y., Wei, C., Bai, S., Zhao, Y., Li, H., Wu, B., Wang, R., Wu, L., and Xu, C. (2015). Mediation of exogenous hydrogen sulfide in recovery of ischemic post-conditioning-induced cardioprotection via down-regulating oxidative stress and up-regulating PI3K\/Akt\/GSK-3\u03b2 pathway in isolated aging rat hearts. Cell Biosci., 5.","DOI":"10.1186\/s13578-015-0003-4"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1016\/j.ijcard.2016.06.200","article-title":"Involvement of exogenous H2S in recovery of cardioprotection from ischemic post-conditioning via increase of autophagy in the aged hearts","volume":"220","author":"Chen","year":"2016","journal-title":"Int. J. Cardiol."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"1745","DOI":"10.18632\/aging.101866","article-title":"H(2)S restores the cardioprotective effects of ischemic post-conditioning by upregulating HB-EGF\/EGFR signaling","volume":"11","author":"Zhang","year":"2019","journal-title":"Aging"},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1007\/s12031-014-0284-9","article-title":"Hydrogen sulfide protects the brain against ischemic reperfusion injury in a transient model of focal cerebral ischemia","volume":"54","author":"Gheibi","year":"2014","journal-title":"J. Mol. Neurosci. MN"},{"key":"ref_75","doi-asserted-by":"crossref","unstructured":"Yang, K., Li, W., Liu, Y., Wei, Y., Ren, Y., Mai, C., Zhang, S., Zuo, Y., Sun, Z., and Li, D. (2022). Hydrogen Sulfide Attenuates Neuroinflammation by Inhibiting the NLRP3\/Caspase-1\/GSDMD Pathway in Retina or Brain Neuron following Rat Ischemia\/Reperfusion. Brain Sci., 12.","DOI":"10.3390\/brainsci12091245"},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.brainresbull.2015.12.007","article-title":"Preconditioning of H2S inhalation protects against cerebral ischemia\/reperfusion injury by induction of HSP70 through PI3K\/Akt\/Nrf2 pathway","volume":"121","author":"Ji","year":"2016","journal-title":"Brain Res. Bull."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.brainresbull.2020.02.015","article-title":"GYY4137 protects against MCAO via p38 MAPK mediated anti-apoptotic signaling pathways in rats","volume":"158","author":"Han","year":"2020","journal-title":"Brain Res. Bull."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"2580","DOI":"10.1021\/acschemneuro.0c00674","article-title":"CSE-Derived H(2)S Inhibits Reactive Astrocytes Proliferation and Promotes Neural Functional Recovery after Cerebral Ischemia\/Reperfusion Injury in Mice Via Inhibition of RhoA\/ROCK(2) Pathway","volume":"12","author":"Zhang","year":"2021","journal-title":"ACS Chem. Neurosci."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1016\/j.brainres.2012.10.046","article-title":"Exogenous hydrogen sulfide protects against global cerebral ischemia\/reperfusion injury via its anti-oxidative, anti-inflammatory and anti-apoptotic effects in rats","volume":"1491","author":"Yin","year":"2013","journal-title":"Brain Res."},{"key":"ref_80","doi-asserted-by":"crossref","unstructured":"Wen, J., Wang, M., Li, Y., Jiang, H., Sun, X., and Chen, Z. (2018). Vascular Protection of Hydrogen Sulfide on Cerebral Ischemia\/Reperfusion Injury in Rats. Front. Neurol., 9.","DOI":"10.3389\/fneur.2018.00779"},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.alcohol.2018.08.005","article-title":"Influence of low-dose alcohol consumption on post-ischemic inflammation: Role of cystathionine \u03b3-lyase","volume":"76","author":"McCarter","year":"2019","journal-title":"Alcohol"},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"1539","DOI":"10.1159\/000430317","article-title":"ROS-Dependent Neuroprotective Effects of NaHS in Ischemia Brain Injury Involves the PARP\/AIF Pathway","volume":"36","author":"Yu","year":"2015","journal-title":"Cell. Physiol. Biochem. Int. J. Exp. Cell. Physiol. Biochem. Pharmacol."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"1768","DOI":"10.1161\/01.STR.26.10.1768","article-title":"Alcohol consumption and stroke mortality","volume":"26","author":"Hansagi","year":"1995","journal-title":"Stroke"},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"1187","DOI":"10.1139\/cjpp-2016-0100","article-title":"Exogenous hydrogen sulfide attenuates cerebral ischemia-reperfusion injury by inhibiting autophagy in mice","volume":"94","author":"Shui","year":"2016","journal-title":"Can. J. Physiol. Pharmacol."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"1449","DOI":"10.1007\/s11011-017-0014-4","article-title":"Increased autophagic degradation contributes to the neuroprotection of hydrogen sulfide against cerebral ischemia\/reperfusion injury","volume":"32","author":"Zhu","year":"2017","journal-title":"Metab. Brain Dis."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"1686","DOI":"10.1002\/2211-5463.12301","article-title":"Sodium hydrosulfide attenuates cerebral ischemia\/reperfusion injury by suppressing overactivated autophagy in rats","volume":"7","author":"Jiang","year":"2017","journal-title":"FEBS Open Bio"},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"18498","DOI":"10.1021\/acsomega.2c00996","article-title":"Roles of the RhoA-ROCK Signaling Pathway in the Endothelial H2S Production and Vasodilation in Rat Cerebral Arteries","volume":"7","author":"Chen","year":"2022","journal-title":"ACS Omega"},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"1565","DOI":"10.1021\/acschemneuro.8b00533","article-title":"Role of CSE-Produced H(2)S on Cerebrovascular Relaxation via RhoA-ROCK Inhibition and Cerebral Ischemia-Reperfusion Injury in Mice","volume":"10","author":"Wen","year":"2019","journal-title":"ACS Chem. Neurosci."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1016\/j.brainres.2015.07.001","article-title":"Hydrogen sulfide induces neuroprotection against experimental stroke in rats by down-regulation of AQP4 via activating PKC","volume":"1622","author":"Wei","year":"2015","journal-title":"Brain Res."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1016\/j.jstrokecerebrovasdis.2014.10.006","article-title":"Sirtuin 6 is essential for sodium sulfide-mediated cytoprotective effect in ischemia\/reperfusion-stimulated brain endothelial cells","volume":"24","author":"Hu","year":"2015","journal-title":"J. Stroke Cerebrovasc. Dis. Off. J. Natl. Stroke Assoc."},{"key":"ref_91","doi-asserted-by":"crossref","unstructured":"Huang, X., Gao, Y., Qin, J., and Lu, S. (2014). The role of miR-34a in the hepatoprotective effect of hydrogen sulfide on ischemia\/reperfusion injury in young and old rats. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0113305"},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"1162","DOI":"10.1016\/j.bbrc.2013.12.064","article-title":"Ethyl pyruvate inhibits proliferation and induces apoptosis of hepatocellular carcinoma via regulation of the HMGB1-RAGE and AKT pathways","volume":"443","author":"Cheng","year":"2014","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1248\/bpb.b17-00769","article-title":"MicroRNA-21-Regulated Activation of the Akt Pathway Participates in the Protective Effects of H2S against Liver Ischemia-Reperfusion Injury","volume":"41","author":"Lu","year":"2018","journal-title":"Biol. Pharm. Bull."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1016\/j.bbrc.2022.09.111","article-title":"The hepato-protective effect of H2S-modified and non-modified mesenchymal stem cell exosomes on liver ischemia-reperfusion injury in mice: The role of MALAT1","volume":"635","author":"Sameri","year":"2022","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"799","DOI":"10.3892\/etm.2021.10231","article-title":"Exogenous hydrogen sulfide protects against hepatic ischemia\/reperfusion injury by inhibiting endoplasmic reticulum stress and cell apoptosis","volume":"22","author":"Chen","year":"2021","journal-title":"Exp. Ther. Med."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"73","DOI":"10.21037\/atm-22-6460","article-title":"Hydrogen sulfide alleviates ischemia induced liver injury by repressing the SPHK1\/S1P pathway","volume":"11","author":"Chen","year":"2023","journal-title":"Ann. Transl. Med."},{"key":"ref_97","doi-asserted-by":"crossref","unstructured":"Zhang, Q., Fu, H., Zhang, H., Xu, F., Zou, Z., Liu, M., Wang, Q., Miao, M., and Shi, X. (2013). Hydrogen sulfide preconditioning protects rat liver against ischemia\/reperfusion injury by activating Akt-GSK-3\u03b2 signaling and inhibiting mitochondrial permeability transition. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0074422"},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"1349","DOI":"10.1007\/s11357-020-00299-6","article-title":"Exogenous hydrogen sulfide and miR-21 antagonism attenuates macrophage-mediated inflammation in ischemia reperfusion injury of the aged kidney","volume":"43","author":"Pushpakumar","year":"2021","journal-title":"Geroscience"},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"1497","DOI":"10.1093\/ndt\/gfv226","article-title":"Hydrogen sulfide accelerates the recovery of kidney tubules after renal ischemia\/reperfusion injury","volume":"30","author":"Han","year":"2015","journal-title":"Nephrol. Dial. Transplant."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"12045","DOI":"10.1080\/21655979.2022.2062105","article-title":"IFC-305 attenuates renal ischemia-reperfusion injury by promoting the production of hydrogen sulfide (H2S) via suppressing the promoter methylation of cystathionine \u03b3-lyase (CSE)","volume":"13","author":"Jiang","year":"2022","journal-title":"Bioengineered"},{"key":"ref_101","doi-asserted-by":"crossref","unstructured":"Niu, Y., Du, C., Cui, C., Zhang, H., Deng, Y., Cai, J., Chen, Z., and Geng, B. (2021). Norswertianolin Promotes Cystathionine \u03b3-Lyase Activity and Attenuates Renal Ischemia\/Reperfusion Injury and Hypertension. Front. Pharmacol., 12.","DOI":"10.3389\/fphar.2021.677212"},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1097\/SHK.0b013e3181f0dc91","article-title":"Effects of intravenous sulfide during porcine aortic occlusion-induced kidney ischemia\/reperfusion injury","volume":"35","author":"Simon","year":"2011","journal-title":"Shock"},{"key":"ref_103","first-page":"99","article-title":"Hydrogen sulfide treatment protects against renal ischemia-reperfusion injury via induction of heat shock proteins in rats","volume":"22","author":"Du","year":"2019","journal-title":"Iran. J. Basic Med. Sci."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"119466","DOI":"10.1016\/j.lfs.2021.119466","article-title":"Hydrogen sulfide reduces pyroptosis and alleviates ischemia-reperfusion-induced acute kidney injury by inhibiting NLRP3 inflammasome","volume":"284","author":"Ni","year":"2021","journal-title":"Life Sci."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"1496","DOI":"10.1007\/s10620-012-2051-5","article-title":"Gastroprotective effect of NaHS against mucosal lesions induced by ischemia-reperfusion injury in rat","volume":"57","author":"Mard","year":"2012","journal-title":"Dig. Dis. Sci."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.ejphar.2014.01.009","article-title":"Hydrogen sulfide protected gastric epithelial cell from ischemia\/reperfusion injury by Keap1 s-sulfhydration, MAPK dependent anti-apoptosis and NF-\u03baB dependent anti-inflammation pathway","volume":"725","author":"Guo","year":"2014","journal-title":"Eur. J. Pharmacol."},{"key":"ref_107","doi-asserted-by":"crossref","unstructured":"Magierowski, M., Magierowska, K., Hubalewska-Mazgaj, M., Sliwowski, Z., Pajdo, R., Ginter, G., Kwiecien, S., and Brzozowski, T. (2017). Exogenous and Endogenous Hydrogen Sulfide Protects Gastric Mucosa against the Formation and Time-Dependent Development of Ischemia\/Reperfusion-Induced Acute Lesions Progressing into Deeper Ulcerations. Molecules, 22.","DOI":"10.3390\/molecules22020295"},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/j.jconrel.2022.05.051","article-title":"Mitochondria-targeted hydrogen sulfide donors versus acute oxidative gastric mucosal injury","volume":"348","author":"Magierowska","year":"2022","journal-title":"J. Control. Release"},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1211\/jpp.61.02.0010","article-title":"Hydrogen sulfide protects from intestinal ischaemia-reperfusion injury in rats","volume":"61","author":"Liu","year":"2009","journal-title":"J. Pharm. Pharmacol."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"G450","DOI":"10.1152\/ajpgi.00444.2016","article-title":"Hydrogen sulfide improves intestinal recovery following ischemia by endothelial nitric oxide-dependent mechanisms","volume":"312","author":"Jensen","year":"2017","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"ref_111","doi-asserted-by":"crossref","unstructured":"Wang, Z., Yan, Y., Wang, Y., and Tong, F. (2019). The interaction between CSE\/H2S and the iNOS\/NO-mediated resveratrol\/poly(ethylene glycol)-poly(phenylalanine) complex alleviates intestinal ischemia\/reperfusion injuries in diabetic rats. Biomed. Pharmacother., 112.","DOI":"10.1016\/j.biopha.2019.108736"},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"H1554","DOI":"10.1152\/ajpheart.01229.2009","article-title":"Antecedent hydrogen sulfide elicits an anti-inflammatory phenotype in postischemic murine small intestine: Role of BK channels","volume":"299","author":"Zuidema","year":"2010","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.lfs.2013.05.012","article-title":"Effects of sodium hydrosulfide on intestinal mucosal injury in a rat model of cardiac arrest and cardiopulmonary resuscitation","volume":"93","author":"Pan","year":"2013","journal-title":"Life Sci."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"1196","DOI":"10.1016\/j.lfs.2008.04.005","article-title":"Hydrogen sulfide protects rat lung from ischemia-reperfusion injury","volume":"82","author":"Fu","year":"2008","journal-title":"Life Sci."},{"key":"ref_115","first-page":"410","article-title":"H2S protecting against lung injury following limb ischemia-reperfusion by alleviating inflammation and water transport abnormality in rats","volume":"27","author":"Qi","year":"2014","journal-title":"Biomed. Environ. Sci."},{"key":"ref_116","doi-asserted-by":"crossref","unstructured":"Li, L., Jiang, H.K., Li, Y.P., and Guo, Y.P. (2015). Hydrogen sulfide protects spinal cord and induces autophagy via miR-30c in a rat model of spinal cord ischemia-reperfusion injury. J. Biomed. Sci., 22.","DOI":"10.1186\/s12929-015-0135-1"},{"key":"ref_117","first-page":"1275","article-title":"Inhalative preconditioning with hydrogen sulfide attenuated apoptosis after retinal ischemia\/reperfusion injury","volume":"17","author":"Biermann","year":"2011","journal-title":"Mol. Vis."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"e467","DOI":"10.1161\/CIR.0000000000000558","article-title":"Heart Disease and Stroke Statistics-2018 Update: A Report From the American Heart Association","volume":"137","author":"Benjamin","year":"2018","journal-title":"Circulation"},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"2936","DOI":"10.1161\/STROKEAHA.108.520288","article-title":"Alcohol consumption and mortality from stroke and coronary heart disease among Japanese men and women: The Japan collaborative cohort study","volume":"39","author":"Ikehara","year":"2008","journal-title":"Stroke"},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"d671","DOI":"10.1136\/bmj.d671","article-title":"Association of alcohol consumption with selected cardiovascular disease outcomes: A systematic review and meta-analysis","volume":"342","author":"Ronksley","year":"2011","journal-title":"BMJ"},{"key":"ref_121","doi-asserted-by":"crossref","unstructured":"Hrelia, S., Di Renzo, L., Bavaresco, L., Bernardi, E., Malaguti, M., and Giacosa, A. (2022). Moderate Wine Consumption and Health: A Narrative Review. Nutrients, 15.","DOI":"10.3390\/nu15010175"},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"12547","DOI":"10.1038\/s41598-017-12720-w","article-title":"Effect of Low-Dose Alcohol Consumption on Inflammation Following Transient Focal Cerebral Ischemia in Rats","volume":"7","author":"McCarter","year":"2017","journal-title":"Sci. Rep."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1080\/00015458.2003.11679472","article-title":"Ischemic preconditioning: Enough evidence to support clinical application in liver surgery and transplantation?","volume":"103","author":"Berrevoet","year":"2003","journal-title":"Acta Chir. Belg."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"63","DOI":"10.5812\/atr.12501","article-title":"Hepatic ischemia and reperfusion injury and trauma: Current concepts","volume":"2","author":"Papadopoulos","year":"2013","journal-title":"Arch. Trauma Res."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.trre.2011.10.006","article-title":"Current strategies to minimize hepatic ischemia-reperfusion injury by targeting reactive oxygen species","volume":"26","author":"Jaeschke","year":"2012","journal-title":"Transplant. Rev."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1016\/j.gde.2005.08.005","article-title":"How microRNAs control cell division, differentiation and death","volume":"15","author":"Miska","year":"2005","journal-title":"Curr. Opin. Genet. Dev."},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.mad.2010.12.004","article-title":"Increased expression of miR-34a and miR-93 in rat liver during aging, and their impact on the expression of Mgst1 and Sirt1","volume":"132","author":"Li","year":"2011","journal-title":"Mech. Ageing Dev."},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1042\/BJ20041860","article-title":"Pi class glutathione S-transferase genes are regulated by Nrf 2 through an evolutionarily conserved regulatory element in zebrafish","volume":"388","author":"Suzuki","year":"2005","journal-title":"Biochem. J."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1080\/01635581.2014.894092","article-title":"Orally administered lycopene attenuates diethylnitrosamine-induced hepatocarcinogenesis in rats by modulating Nrf-2\/HO-1 and Akt\/mTOR pathways","volume":"66","author":"Sahin","year":"2014","journal-title":"Nutr. Cancer"},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"4848","DOI":"10.1016\/j.bbagen.2013.06.028","article-title":"The activation of HO-1\/Nrf-2 contributes to the protective effects of diallyl disulfide (DADS) against ethanol-induced oxidative stress","volume":"1830","author":"Zeng","year":"2013","journal-title":"Biochim. Biophys. Acta"},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"5434275","DOI":"10.1155\/2016\/5434275","article-title":"Corrigendum to \u201cEthyl Pyruvate Ameliorates Hepatic Ischemia-Reperfusion Injury by Inhibiting Intrinsic Pathway of Apoptosis and Autophagy\u201d","volume":"2016","author":"Shen","year":"2016","journal-title":"Mediat. Inflamm."},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1016\/j.ejps.2012.01.010","article-title":"Ferulic acid attenuates ischemia\/reperfusion-induced hepatocyte apoptosis via inhibition of JNK activation","volume":"45","author":"Kim","year":"2012","journal-title":"Eur. J. Pharm. Sci."},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"7661","DOI":"10.4049\/jimmunol.175.11.7661","article-title":"Hepatic ischemia\/reperfusion injury involves functional TLR4 signaling in nonparenchymal cells","volume":"175","author":"Tsung","year":"2005","journal-title":"J. Immunol."},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"935251","DOI":"10.1155\/2014\/935251","article-title":"Hydrogen sulfide ameliorates ischemia\/reperfusion-induced hepatitis by inhibiting apoptosis and autophagy pathways","volume":"2014","author":"Cheng","year":"2014","journal-title":"Mediat. Inflamm."},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"3715037","DOI":"10.1155\/2017\/3715037","article-title":"Hydrogen Sulfide Prevents Formation of Reactive Oxygen Species through PI3K\/Akt Signaling and Limits Ventilator-Induced Lung Injury","volume":"2017","author":"Spassov","year":"2017","journal-title":"Oxid. Med. Cell. Longev."},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"954","DOI":"10.4161\/auto.19927","article-title":"The role of AKT1 and autophagy in the protective effect of hydrogen sulphide against hepatic ischemia\/reperfusion injury in mice","volume":"8","author":"Wang","year":"2012","journal-title":"Autophagy"},{"key":"ref_137","doi-asserted-by":"crossref","unstructured":"Suo, L., Kang, K., Wang, X., Cao, Y., Zhao, H., Sun, X., Tong, L., and Zhang, F. (2014). Carvacrol alleviates ischemia reperfusion injury by regulating the PI3K-Akt pathway in rats. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0104043"},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1016\/j.bbrc.2013.12.047","article-title":"MicroRNA-21 accelerates hepatocyte proliferation in vitro via PI3K\/Akt signaling by targeting PTEN","volume":"443","author":"Bai","year":"2014","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"83","DOI":"10.12659\/MSM.896157","article-title":"MicroRNA-21 Contributes to Liver Regeneration by Targeting PTEN","volume":"22","author":"Chen","year":"2016","journal-title":"Med. Sci. Monit."},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"G794","DOI":"10.1152\/ajpgi.00292.2016","article-title":"Inhibition of miR-21 rescues liver regeneration after partial hepatectomy in ethanol-fed rats","volume":"311","author":"Juskeviciute","year":"2016","journal-title":"Am. J. Physiol. Gastrointest Liver Physiol."},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"e703","DOI":"10.1097\/CCM.0000000000002363","article-title":"MicroRNA-21 Is Required for Local and Remote Ischemic Preconditioning in Multiple Organ Protection Against Sepsis","volume":"45","author":"Jia","year":"2017","journal-title":"Crit. Care Med."},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"5217","DOI":"10.4049\/jimmunol.1002513","article-title":"Convergence of the mammalian target of rapamycin complex 1- and glycogen synthase kinase 3-\u03b2-signaling pathways regulates the innate inflammatory response","volume":"186","author":"Wang","year":"2011","journal-title":"J. Immunol."},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"8188","DOI":"10.3390\/ijms14048188","article-title":"Endoplasmic reticulum (ER) stress response and its physiological roles in plants","volume":"14","author":"Deng","year":"2013","journal-title":"Int. J. Mol. Sci."},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1002\/path.1798","article-title":"Distinct endoplasmic reticulum stress responses are triggered during human liver transplantation","volume":"207","author":"Emadali","year":"2005","journal-title":"J. Pathol."},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"104243","DOI":"10.1016\/j.cellimm.2020.104243","article-title":"Neutrophil recruitment mediated by sphingosine 1-phosphate (S1P)\/S1P receptors during chronic liver injury","volume":"359","author":"Zhao","year":"2021","journal-title":"Cell. Immunol."},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"23282","DOI":"10.1074\/jbc.M115.677542","article-title":"Sphingosine Kinase 1 Protects Hepatocytes from Lipotoxicity via Down-regulation of IRE1\u03b1 Protein Expression","volume":"290","author":"Qi","year":"2015","journal-title":"J. Biol. Chem."},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1016\/S0006-291X(03)00618-1","article-title":"Mitochondrial permeability transition: A common pathway to necrosis and apoptosis","volume":"304","author":"Kim","year":"2003","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1016\/j.cardiores.2003.09.024","article-title":"New directions for protecting the heart against ischaemia-reperfusion injury: Targeting the Reperfusion Injury Salvage Kinase (RISK)-pathway","volume":"61","author":"Hausenloy","year":"2004","journal-title":"Cardiovasc. Res."},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.molmed.2006.12.002","article-title":"Role of the JAK-STAT pathway in myocardial injury","volume":"13","author":"Barry","year":"2007","journal-title":"Trends Mol. Med."},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/j.kint.2019.02.009","article-title":"Regulated necrosis in kidney ischemia-reperfusion injury","volume":"96","author":"Pefanis","year":"2019","journal-title":"Kidney Int."},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"2574","DOI":"10.1097\/01.ju.0000144203.30718.19","article-title":"The molecular pathology of experimental testicular torsion suggests adjunct therapy to surgical repair","volume":"172","author":"Turner","year":"2004","journal-title":"J. Urol."},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"16.e1","DOI":"10.1016\/j.jpurol.2021.11.019","article-title":"The effect of hydrogen sulfide on ischem\u00efa\/reperfusion injury in an experimental testicular torsion model","volume":"18","author":"Yuksel","year":"2022","journal-title":"J. Pediatr. Urol."},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"40.e1","DOI":"10.1016\/j.jpurol.2019.10.006","article-title":"Protective effect of hydrogen sulfide on experimental testicular ischemia reperfusion in rats","volume":"16","author":"Bozkurt","year":"2020","journal-title":"J. Pediatr. Urol."},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/0016-5085(88)90604-X","article-title":"Studies on the mechanism of ethanol-induced gastric damage in rats","volume":"94","author":"Oates","year":"1988","journal-title":"Gastroenterology"},{"key":"ref_155","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1038\/aps.2009.29","article-title":"The protective effect of genistein postconditioning on hypoxia\/reoxygenation-induced injury in human gastric epithelial cells","volume":"30","author":"Li","year":"2009","journal-title":"Acta Pharmacol. Sin."},{"key":"ref_156","doi-asserted-by":"crossref","first-page":"S644","DOI":"10.1016\/S0003-4975(02)04686-6","article-title":"Cellular mechanisms of ischemia-reperfusion injury","volume":"75","author":"Piper","year":"2003","journal-title":"Ann. Thorac. Surg."},{"key":"ref_157","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.ejphar.2010.06.060","article-title":"The protective effect of 17beta-estradiol postconditioning against hypoxia\/reoxygenation injury in human gastric epithelial cells","volume":"645","author":"Liu","year":"2010","journal-title":"Eur. J. Pharmacol."},{"key":"ref_158","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1139\/cjpp-2012-0293","article-title":"H(2)S signaling in redox regulation of cellular functions","volume":"91","author":"Ju","year":"2013","journal-title":"Can. J. Physiol. Pharmacol."},{"key":"ref_159","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1016\/j.freeradbiomed.2006.12.011","article-title":"Anti-inflammatory and gastrointestinal effects of a novel diclofenac derivative","volume":"42","author":"Li","year":"2007","journal-title":"Free Radic. Biol. Med."},{"key":"ref_160","doi-asserted-by":"crossref","first-page":"1082","DOI":"10.1097\/00029330-200706020-00010","article-title":"Role of mitogen-activated protein kinases in the regulation of paraventricular nucleus to gastric ischemia-reperfusion injuries","volume":"120","author":"Li","year":"2007","journal-title":"Chin. Med. J."},{"key":"ref_161","doi-asserted-by":"crossref","first-page":"1500","DOI":"10.1016\/j.bbabio.2010.04.004","article-title":"Oxidation of hydrogen sulfide remains a priority in mammalian cells and causes reverse electron transfer in colonocytes","volume":"1797","author":"Lagoutte","year":"2010","journal-title":"Biochim. Biophys. Acta"},{"key":"ref_162","first-page":"81","article-title":"Remifentanil reduces multiple organ and energy metabolism disturbances in a rat sepsis model","volume":"73","author":"Yang","year":"2022","journal-title":"J. Physiol. Pharmacol."},{"key":"ref_163","first-page":"71","article-title":"Status of prooxidant and antioxidant systems in the sperm and seminal plasma of breeding boars of large white breed and SS23 synthetic line","volume":"73","author":"Polishchuk","year":"2022","journal-title":"J. Physiol. Pharmacol."},{"key":"ref_164","doi-asserted-by":"crossref","first-page":"671","DOI":"10.3892\/mmr.2021.12310","article-title":"SOD2 overexpression in bone marrow-derived mesenchymal stem cells ameliorates hepatic ischemia\/reperfusion injury","volume":"24","author":"Li","year":"2021","journal-title":"Mol. Med. Rep."},{"key":"ref_165","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/j.freeradbiomed.2013.05.027","article-title":"SOD2 in mitochondrial dysfunction and neurodegeneration","volume":"62","author":"Flynn","year":"2013","journal-title":"Free Radic. Biol. Med."},{"key":"ref_166","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1089\/ars.2019.7962","article-title":"Mitochondrial Superoxide Dismutase: What the Established, the Intriguing, and the Novel Reveal About a Key Cellular Redox Switch","volume":"32","author":"Palma","year":"2020","journal-title":"Antioxid. Redox Signal."},{"key":"ref_167","doi-asserted-by":"crossref","first-page":"1359","DOI":"10.1023\/B:DDAS.0000042232.98927.91","article-title":"Ischemia-reperfusion injury of the intestine and protective strategies against injury","volume":"49","author":"Mallick","year":"2004","journal-title":"Dig. Dis. Sci."},{"key":"ref_168","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.neuint.2007.05.016","article-title":"Hydrogen sulfide: Neurochemistry and neurobiology","volume":"52","author":"Qu","year":"2008","journal-title":"Neurochem. Int."},{"key":"ref_169","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1684\/ecn.2014.0345","article-title":"Mesenteric ischemia-reperfusion injury up-regulates certain CC, CXC, and XC chemokines and results in multi-organ injury in a time-dependent manner","volume":"24","author":"Jawa","year":"2013","journal-title":"Eur. Cytokine Netw."},{"key":"ref_170","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1136\/gut.2008.151175","article-title":"Interleukin-6 is an important in vivo inhibitor of intestinal epithelial cell death in mice","volume":"59","author":"Jin","year":"2010","journal-title":"Gut"},{"key":"ref_171","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1016\/j.jpedsurg.2018.02.072","article-title":"The route and timing of hydrogen sulfide therapy critically impacts intestinal recovery following ischemia and reperfusion injury","volume":"53","author":"Jensen","year":"2018","journal-title":"J. Pediatr. Surg."},{"key":"ref_172","doi-asserted-by":"crossref","first-page":"1642","DOI":"10.1111\/j.1440-1746.2010.06380.x","article-title":"Hydrogen sulfide attenuates intestinal ischemia-reperfusion injury when delivered in the post-ischemic period","volume":"25","author":"Henderson","year":"2010","journal-title":"J. Gastroenterol. Hepatol."},{"key":"ref_173","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1007\/s10495-022-01786-1","article-title":"Regulation of autophagy of the heart in ischemia and reperfusion","volume":"28","author":"Popov","year":"2023","journal-title":"Apoptosis"},{"key":"ref_174","doi-asserted-by":"crossref","first-page":"3205","DOI":"10.1378\/chest.128.5.3205","article-title":"Endogenous hydrogen sulfide in patients with COPD","volume":"128","author":"Chen","year":"2005","journal-title":"Chest"},{"key":"ref_175","doi-asserted-by":"crossref","first-page":"L960","DOI":"10.1152\/ajplung.00388.2006","article-title":"Hydrogen sulfide acts as an inflammatory mediator in cecal ligation and puncture-induced sepsis in mice by upregulating the production of cytokines and chemokines via NF-kappaB","volume":"292","author":"Zhang","year":"2007","journal-title":"Am. J. Physiol. Lung Cell. Mol. Physiol."},{"key":"ref_176","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1139\/Y09-039","article-title":"Hydrogen sulfide attenuates the pathogenesis of pulmonary fibrosis induced by bleomycin in rats","volume":"87","author":"Fang","year":"2009","journal-title":"Can. J. Physiol. Pharmacol."},{"key":"ref_177","doi-asserted-by":"crossref","first-page":"1164","DOI":"10.1038\/s41418-021-00907-8","article-title":"USP11 regulates autophagy-dependent ferroptosis after spinal cord ischemia-reperfusion injury by deubiquitinating Beclin 1","volume":"29","author":"Rong","year":"2022","journal-title":"Cell Death Differ."},{"key":"ref_178","doi-asserted-by":"crossref","first-page":"1088","DOI":"10.1053\/j.jvca.2013.12.015","article-title":"A modern theory of spinal cord ischemia\/injury in thoracoabdominal aortic surgery and its implications for prevention of paralysis","volume":"28","author":"Wynn","year":"2014","journal-title":"J. Cardiothorac. Vasc. Anesth."},{"key":"ref_179","doi-asserted-by":"crossref","first-page":"S152","DOI":"10.1161\/CIRCULATIONAHA.112.000024","article-title":"Toll-like receptor 4-dependent microglial activation mediates spinal cord ischemia-reperfusion injury","volume":"128","author":"Bell","year":"2013","journal-title":"Circulation"},{"key":"ref_180","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/j.ejvs.2004.06.004","article-title":"Erdosteine ameliorates neurological outcome and oxidative stress due to ischemia\/reperfusion injury in rabbit spinal cord","volume":"28","author":"Ege","year":"2004","journal-title":"Eur. J. Vasc. Endovasc. Surg."},{"key":"ref_181","doi-asserted-by":"crossref","first-page":"3030","DOI":"10.1093\/hmg\/ddn201","article-title":"A set of differentially expressed miRNAs, including miR-30a-5p, act as post-transcriptional inhibitors of BDNF in prefrontal cortex","volume":"17","author":"Mellios","year":"2008","journal-title":"Hum. Mol. Genet."},{"key":"ref_182","doi-asserted-by":"crossref","first-page":"1279","DOI":"10.1007\/s11064-014-1310-6","article-title":"Down-regulation of miRNA-30a alleviates cerebral ischemic injury through enhancing beclin 1-mediated autophagy","volume":"39","author":"Wang","year":"2014","journal-title":"Neurochem. Res."},{"key":"ref_183","doi-asserted-by":"crossref","unstructured":"Valente, G., Morani, F., Nicotra, G., Fusco, N., Peracchio, C., Titone, R., Alabiso, O., Arisio, R., Katsaros, D., and Benedetto, C. (2014). Expression and clinical significance of the autophagy proteins BECLIN 1 and LC3 in ovarian cancer. BioMed. Res. Int., 2014.","DOI":"10.1155\/2014\/462658"},{"key":"ref_184","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1254\/jphs.12235SC","article-title":"Altered microRNA expression in the ischemic-reperfusion spinal cord with atorvastatin therapy","volume":"121","author":"Hu","year":"2013","journal-title":"J. Pharmacol. Sci."},{"key":"ref_185","doi-asserted-by":"crossref","first-page":"1233","DOI":"10.1189\/jlb.0405221","article-title":"TNF-alpha-induced chemokine production and apoptosis in human neural precursor cells","volume":"78","author":"Sheng","year":"2005","journal-title":"J. Leukoc. Biol."},{"key":"ref_186","doi-asserted-by":"crossref","first-page":"2359","DOI":"10.1128\/MCB.15.5.2359","article-title":"Tumor necrosis factor alpha-induced apoptosis in human neuronal cells: Protection by the antioxidant N-acetylcysteine and the genes bcl-2 and crmA","volume":"15","author":"Talley","year":"1995","journal-title":"Mol. Cell. Biol."},{"key":"ref_187","doi-asserted-by":"crossref","first-page":"578","DOI":"10.2176\/nmc.oa.2015-0022","article-title":"Inflammation Level after Decompression Surgery for a Rat Model of Chronic Severe Spinal Cord Compression and Effects on Ischemia-Reperfusion Injury","volume":"55","author":"Yang","year":"2015","journal-title":"Neurol. Med. Chir."},{"key":"ref_188","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1016\/j.jvs.2012.11.087","article-title":"Intrathecal transplantation of bone marrow stromal cells attenuates blood-spinal cord barrier disruption induced by spinal cord ischemia-reperfusion injury in rabbits","volume":"58","author":"Fang","year":"2013","journal-title":"J. Vasc. Surg."},{"key":"ref_189","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.mrfmmm.2015.04.004","article-title":"Functional interaction between hMYH and hTRADD in the TNF-\u03b1-mediated survival and death pathways of HeLa cells","volume":"777","author":"Hahm","year":"2015","journal-title":"Mutat. Res."},{"key":"ref_190","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1111\/j.1471-4159.2007.04790.x","article-title":"Tumor necrosis factor receptor-1-induced neuronal death by TRADD contributes to the pathogenesis of Japanese encephalitis","volume":"103","author":"Swarup","year":"2007","journal-title":"J. Neurochem."},{"key":"ref_191","doi-asserted-by":"crossref","first-page":"7513","DOI":"10.1158\/0008-5472.CAN-04-0592","article-title":"Modulation of gene expression in human central nervous system tumors under methionine deprivation-induced stress","volume":"64","author":"Kokkinakis","year":"2004","journal-title":"Cancer Res."},{"key":"ref_192","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.1016\/j.bbrc.2013.12.068","article-title":"Death domain complex of the TNFR-1, TRADD, and RIP1 proteins for death-inducing signaling","volume":"443","author":"Park","year":"2014","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_193","doi-asserted-by":"crossref","first-page":"1304","DOI":"10.1016\/j.bbrc.2016.08.116","article-title":"Hydrogen sulfide protects against TNF-\u03b1 induced neuronal cell apoptosis through miR-485-5p\/TRADD signaling","volume":"478","author":"Chen","year":"2016","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_194","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1097\/00061198-199610000-00010","article-title":"Retinal ganglion cell death in glaucoma: The how, the why, and the maybe","volume":"5","author":"Nickells","year":"1996","journal-title":"J. Glaucoma"},{"key":"ref_195","first-page":"713","article-title":"Necrosis and apoptosis after retinal ischemia: Involvement of NMDA-mediated excitotoxicity and p53","volume":"40","author":"Joo","year":"1999","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"ref_196","doi-asserted-by":"crossref","unstructured":"Tobalem, S., Schutz, J.S., and Chronopoulos, A. (2018). Central retinal artery occlusion\u2014Rethinking retinal survival time. BMC Ophthalmol., 18.","DOI":"10.1186\/s12886-018-0768-4"},{"key":"ref_197","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1080\/02713680490503679","article-title":"Correlation of retinal function with retinal histopathology following ischemia-reperfusion in rat eyes","volume":"28","author":"Mukaida","year":"2004","journal-title":"Curr. Eye Res."},{"key":"ref_198","doi-asserted-by":"crossref","first-page":"1735","DOI":"10.1167\/iovs.06-1037","article-title":"Long-term tolerance to retinal ischemia by repetitive hypoxic preconditioning: Role of HIF-1alpha and heme oxygenase-1","volume":"48","author":"Zhu","year":"2007","journal-title":"Investig. Ophthalmol. Vis. Sci."}],"container-title":["Biomolecules"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2218-273X\/14\/7\/740\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T15:02:56Z","timestamp":1760108576000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2218-273X\/14\/7\/740"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6,22]]},"references-count":198,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2024,7]]}},"alternative-id":["biom14070740"],"URL":"https:\/\/doi.org\/10.3390\/biom14070740","relation":{},"ISSN":["2218-273X"],"issn-type":[{"value":"2218-273X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,6,22]]}}}