{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T13:51:42Z","timestamp":1790949102801,"version":"4.1.0"},"reference-count":121,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2024,8,8]],"date-time":"2024-08-08T00:00:00Z","timestamp":1723075200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation Youth Fund project","doi-asserted-by":"publisher","award":["82303471"],"award-info":[{"award-number":["82303471"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation Youth Fund project","doi-asserted-by":"publisher","award":["BK20230611"],"award-info":[{"award-number":["BK20230611"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation Youth Fund project","doi-asserted-by":"publisher","award":["JC2023046"],"award-info":[{"award-number":["JC2023046"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Natural Science Foundation of Jiangsu Province, Youth Fund project","award":["82303471"],"award-info":[{"award-number":["82303471"]}]},{"name":"Natural Science Foundation of Jiangsu Province, Youth Fund project","award":["BK20230611"],"award-info":[{"award-number":["BK20230611"]}]},{"name":"Natural Science Foundation of Jiangsu Province, Youth Fund project","award":["JC2023046"],"award-info":[{"award-number":["JC2023046"]}]},{"name":"Natural Science Foundation of Nantong, Youth Fund project","award":["82303471"],"award-info":[{"award-number":["82303471"]}]},{"name":"Natural Science Foundation of Nantong, Youth Fund project","award":["BK20230611"],"award-info":[{"award-number":["BK20230611"]}]},{"name":"Natural Science Foundation of Nantong, Youth Fund project","award":["JC2023046"],"award-info":[{"award-number":["JC2023046"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biomolecules"],"abstract":"<jats:p>As a critical part of the circulatory system, blood vessels transport oxygen and nutrients to every corner of the body, nourishing each cell, and also remove waste and toxins. Defects in vascular development and function are closely associated with many diseases, such as heart disease, stroke, and atherosclerosis. In the nervous system, the nervous and vascular systems are intricately connected in both development and function. First, peripheral blood vessels and nerves exhibit parallel distribution patterns. In the central nervous system (CNS), nerves and blood vessels form a complex interface known as the neurovascular unit. Second, the vascular system employs similar cellular and molecular mechanisms as the nervous system for its development. Third, the development and function of CNS vasculature are tightly regulated by CNS-specific signaling pathways and neural activity. Additionally, vascular endothelial cells within the CNS are tightly connected and interact with pericytes, astrocytes, neurons, and microglia to form the blood\u2013brain barrier (BBB). The BBB strictly controls material exchanges between the blood and brain, maintaining the brain\u2019s microenvironmental homeostasis, which is crucial for the normal development and function of the CNS. Here, we comprehensively summarize research on neural regulation of vascular and BBB development and propose directions for future research.<\/jats:p>","DOI":"10.3390\/biom14080966","type":"journal-article","created":{"date-parts":[[2024,8,9]],"date-time":"2024-08-09T09:48:54Z","timestamp":1723196934000},"page":"966","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Neural Regulation of Vascular Development: Molecular Mechanisms and Interactions"],"prefix":"10.3390","volume":"14","author":[{"given":"Yu","family":"Zhang","sequence":"first","affiliation":[{"name":"School of Life Sciences, Nantong University, Nantong 226019, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyu","family":"Shen","sequence":"additional","affiliation":[{"name":"School of Life Sciences, Nantong University, Nantong 226019, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shunze","family":"Deng","sequence":"additional","affiliation":[{"name":"School of Life Sciences, Nantong University, Nantong 226019, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiurong","family":"Chen","sequence":"additional","affiliation":[{"name":"School of Life Sciences, Nantong University, Nantong 226019, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-3621-0994","authenticated-orcid":false,"given":"Bing","family":"Xu","sequence":"additional","affiliation":[{"name":"School of Life Sciences, Nantong University, Nantong 226019, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,8,8]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1016\/bs.ctdb.2024.02.001","article-title":"Vascular development, remodeling and maturation","volume":"159","author":"Furtado","year":"2024","journal-title":"Curr. 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