{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T19:07:11Z","timestamp":1793387231090,"version":"4.5.0"},"reference-count":166,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2024,8,10]],"date-time":"2024-08-10T00:00:00Z","timestamp":1723248000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biomolecules"],"abstract":"<jats:p>Hepatitis C virus (HCV) is a hepatotropic virus that can be transmitted through unsafe medical procedures, such as injections, transfusions, and dental treatment. The infection may be self-limiting or manifest as a chronic form that induces liver fibrosis, cirrhosis, or progression into hepatocellular carcinoma (HCC). Epigenetic mechanisms are major regulators of gene expression. These mechanisms involve DNA methylation, histone modifications, and the activity of non-coding RNAs, which can enhance or suppress gene expression. Abnormal activity or the dysregulated expression of epigenetic molecules plays an important role in the pathogenesis of various pathological disorders, including inflammatory diseases and malignancies. In this review, we summarise the current evidence on epigenetic mechanisms involved in HCV infection and progression to HCC.<\/jats:p>","DOI":"10.3390\/biom14080986","type":"journal-article","created":{"date-parts":[[2024,8,14]],"date-time":"2024-08-14T06:23:05Z","timestamp":1723616585000},"page":"986","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["The Role of Epigenetic Mechanisms in the Pathogenesis of Hepatitis C Infection"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-3477-3430","authenticated-orcid":false,"given":"Justyna","family":"\u017bychowska","sequence":"first","affiliation":[{"name":"Department of Physiology, Pomeranian Medical University, 70-111 Szczecin, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-1594-5646","authenticated-orcid":false,"given":"Maciej","family":"\u0106mil","sequence":"additional","affiliation":[{"name":"Department of Physiology, Pomeranian Medical University, 70-111 Szczecin, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-6080-6104","authenticated-orcid":false,"given":"Patryk","family":"Sk\u00f3rka","sequence":"additional","affiliation":[{"name":"Department of Physiology, Pomeranian Medical University, 70-111 Szczecin, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-0244-3526","authenticated-orcid":false,"given":"Joanna","family":"Olejnik-Wojciechowska","sequence":"additional","affiliation":[{"name":"Independent Laboratory of Community Nursing, Pomeranian Medical University, 71-210 Szczecin, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paulina","family":"Plewa","sequence":"additional","affiliation":[{"name":"Institute of Biology, University of Szczecin, 71-412 Szczecin, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Estera","family":"Bakinowska","sequence":"additional","affiliation":[{"name":"Department of Physiology, Pomeranian Medical University, 70-111 Szczecin, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8227-6753","authenticated-orcid":false,"given":"Kajetan","family":"Kie\u0142bowski","sequence":"additional","affiliation":[{"name":"Department of Physiology, Pomeranian Medical University, 70-111 Szczecin, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6557-1208","authenticated-orcid":false,"given":"Andrzej","family":"Pawlik","sequence":"additional","affiliation":[{"name":"Department of Physiology, Pomeranian Medical University, 70-111 Szczecin, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,8,10]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"623","DOI":"10.3350\/cmh.2022.0349","article-title":"Acute hepatitis C virus infection: Clinical update and remaining challenges","volume":"29","author":"Liu","year":"2023","journal-title":"Clin. Mol. Hepatol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1093\/infdis\/jis385","article-title":"Chronic hepatitis C virus infection increases mortality from hepatic and extrahepatic diseases: A community-based long-term prospective study","volume":"206","author":"Lee","year":"2012","journal-title":"J. Infect. Dis."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"E359","DOI":"10.1002\/ijc.29210","article-title":"Cancer incidence and mortality worldwide: Sources, methods and major patterns in GLOBOCAN 2012","volume":"136","author":"Ferlay","year":"2015","journal-title":"Int. J. Cancer"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"256","DOI":"10.21037\/jgo.2016.09.07","article-title":"Hepatocellular carcinoma (HCC): Beyond sorafenib-chemotherapy","volume":"8","author":"Kim","year":"2017","journal-title":"J. Gastrointest. Oncol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1042\/EBC20200032","article-title":"Non-coding RNA in cancer","volume":"65","author":"Yan","year":"2021","journal-title":"Essays Biochem."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1202","DOI":"10.1016\/j.jaci.2017.08.034","article-title":"MicroRNA","volume":"141","author":"Lu","year":"2018","journal-title":"J. Allergy Clin. Immunol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1080\/02648725.2018.1471642","article-title":"Non-coding RNAs in virology: An RNA genomics approach","volume":"34","author":"Isaac","year":"2018","journal-title":"Biotechnol. Genet. Eng. Rev."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"45","DOI":"10.32607\/actanaturae.11043","article-title":"DNA Methylation As an Epigenetic Mechanism in the Development of Multiple Sclerosis","volume":"13","author":"Kiselev","year":"2021","journal-title":"Acta Naturae"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1182","DOI":"10.1126\/science.aar7854","article-title":"A DNA methylation reader complex that enhances gene transcription","volume":"362","author":"Harris","year":"2018","journal-title":"Science"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1111\/jcmm.17693","article-title":"Integrative analysis of DNA methylation and gene expression through machine learning identifies stomach cancer diagnostic and prognostic biomarkers","volume":"27","author":"Hosseini","year":"2023","journal-title":"J. Cell Mol. Med."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1016\/S1665-2681(19)31251-7","article-title":"Promotor methylation: Does it affect response to therapy in chronic hepatitis C (G4) or fibrosis?","volume":"13","author":"NZekri","year":"2014","journal-title":"Ann. Hepatol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1186\/s12935-020-01638-5","article-title":"Identification of RASSF1A promoter hypermethylation as a biomarker for hepatocellular carcinoma","volume":"20","author":"Xu","year":"2020","journal-title":"Cancer Cell Int."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1038\/77083","article-title":"Epigenetic inactivation of a RAS association domain family protein from the lung tumour suppressor locus 3p21.3","volume":"25","author":"Dammann","year":"2000","journal-title":"Nat. Genet."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"8125","DOI":"10.1038\/sj.onc.1206984","article-title":"Control of microtubule stability by the RASSF1A tumor suppressor","volume":"22","author":"Liu","year":"2003","journal-title":"Oncogene"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"35669","DOI":"10.1074\/jbc.C000463200","article-title":"Ras uses the novel tumor suppressor RASSF1 as an effector to mediate apoptosis","volume":"275","author":"Vos","year":"2000","journal-title":"J. Biol. Chem."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1158\/1541-7786.MCR-12-0665","article-title":"RASSF1A-mediated regulation of AREG via the Hippo pathway in hepatocellular carcinoma","volume":"11","author":"Ahn","year":"2013","journal-title":"Mol. Cancer Res."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.canlet.2016.06.008","article-title":"Hepatitis C virus core protein inhibits E6AP expression via DNA methylation to escape from ubiquitin-dependent proteasomal degradation","volume":"380","author":"Kwak","year":"2016","journal-title":"Cancer Lett."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1096\/fj.02-0664fje","article-title":"IFN-\u03b1 antagonistic activity of HCV core protein involves induction of suppressor of cytokine signaling-3","volume":"17","author":"Bode","year":"2003","journal-title":"FASEB J."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1159\/000452526","article-title":"Inhibition of STAT Pathway Impairs Anti-Hepatitis C Virus Effect of Interferon Alpha","volume":"40","author":"Zhao","year":"2016","journal-title":"Cell Physiol. Biochem."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.canlet.2019.12.013","article-title":"Legumain-deficient macrophages promote senescence of tumor cells by sustaining JAK1\/STAT1 activation","volume":"472","author":"Shen","year":"2020","journal-title":"Cancer Lett."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"95","DOI":"10.3233\/CBM-210216","article-title":"Aberrant STAT1 methylation as a non-invasive biomarker in blood of HCV induced hepatocellular carcinoma","volume":"34","author":"Zakir","year":"2022","journal-title":"Cancer Biomark."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.chom.2011.06.006","article-title":"The membrane-bound transcription factor CREB3L1 is activated in response to virus infection to inhibit proliferation of virus-infected cells","volume":"10","author":"Denard","year":"2011","journal-title":"Cell Host Microbe"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1128\/JVI.01984-12","article-title":"Epigenetic silencing of antiviral genes renders clones of Huh-7 cells permissive for hepatitis C virus replication","volume":"87","author":"Chen","year":"2013","journal-title":"J. Virol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"2029","DOI":"10.1136\/annrheumdis-2015-208659","article-title":"Genome-wide DNA methylation analysis in multiple tissues in primary Sjogren\u2019s syndrome reveals regulatory effects at interferon-induced genes","volume":"75","author":"Sandling","year":"2016","journal-title":"Ann. Rheum. Dis."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1136\/annrheumdis-2018-213970","article-title":"Rheumatoid arthritis-associated DNA methylation sites in peripheral blood mononuclear cells","volume":"78","author":"Zhu","year":"2019","journal-title":"Ann. Rheum. Dis."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"1174","DOI":"10.1128\/JVI.01684-06","article-title":"E6AP ubiquitin ligase mediates ubiquitylation and degradation of hepatitis C virus core protein","volume":"81","author":"Shirakura","year":"2007","journal-title":"J. Virol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1038\/nrm.2017.47","article-title":"Understanding nucleosome dynamics and their links to gene expression and DNA replication","volume":"18","author":"Lai","year":"2017","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1038\/jhg.2013.66","article-title":"Histone modifications for human epigenome analysis","volume":"58","author":"Kimura","year":"2013","journal-title":"J. Hum. Genet."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/978-981-15-8104-5_1","article-title":"Overview of Histone Modification","volume":"Volume 1283","author":"Zhang","year":"2021","journal-title":"Histone Mutations and Cancer"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1016\/j.cell.2007.02.005","article-title":"Chromatin modifications and their function","volume":"128","author":"Kouzarides","year":"2007","journal-title":"Cell"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.virol.2012.09.023","article-title":"Snapshots: Chromatin control of viral infection","volume":"435","author":"Knipe","year":"2013","journal-title":"Virology"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/j.bbagrm.2009.06.007","article-title":"Chromatin at the intersection of viral infection and DNA damage","volume":"1799","author":"Lilley","year":"2010","journal-title":"Biochim. Biophys. Acta"},{"key":"ref_33","doi-asserted-by":"crossref","unstructured":"Domovitz, T., and Gal-Tanamy, M. (2021). Tracking Down the Epigenetic Footprint of HCV-Induced Hepatocarcinogenesis. J. Clin. Med., 10.","DOI":"10.3390\/jcm10030551"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"5209","DOI":"10.2147\/OTT.S170825","article-title":"Overexpression of long noncoding RNA","volume":"11","author":"Zhu","year":"2018","journal-title":"Onco Targets Ther."},{"key":"ref_35","doi-asserted-by":"crossref","unstructured":"Kim, S., Bolatkan, A., Kaneko, S., Ikawa, N., Asada, K., Komatsu, M., Hayami, S., Ojima, H., Abe, N., and Yamaue, H. (2019). Deregulation of the Histone Lysine-Specific Demethylase 1 Is Involved in Human Hepatocellular Carcinoma. Biomolecules, 9.","DOI":"10.3390\/biom9120810"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"3676","DOI":"10.1158\/0008-5472.CAN-18-3767","article-title":"HDAC3 Deficiency Promotes Liver Cancer through a Defect in H3K9ac\/H3K9me3 Transition","volume":"79","author":"Ji","year":"2019","journal-title":"Cancer Res."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"6665","DOI":"10.3748\/wjg.v21.i21.6665","article-title":"Proportions of acetyl-histone-positive hepatocytes indicate the functional status and prognosis of cirrhotic patients","volume":"21","author":"Zhou","year":"2015","journal-title":"World J. Gastroenterol."},{"key":"ref_38","doi-asserted-by":"crossref","unstructured":"Zhao, P., Malik, S., and Xing, S. (2021). Epigenetic Mechanisms Involved in HCV-Induced Hepatocellular Carcinoma (HCC). Front. Oncol., 11.","DOI":"10.3389\/fonc.2021.677926"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.jare.2019.12.002","article-title":"Circulatory miRNA-484, 524, 615 and 628 expression profiling in HCV mediated HCC among Egyptian patients; implications for diagnosis and staging of hepatic cirrhosis and fibrosis","volume":"22","author":"Adel","year":"2020","journal-title":"J. Adv. Res."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"e821","DOI":"10.1002\/mgg3.821","article-title":"STAT3 signaling pathway plays importantly genetic and functional roles in HCV infection","volume":"7","author":"Song","year":"2019","journal-title":"Mol. Genet. Genom. Med."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"1724","DOI":"10.1038\/onc.2012.177","article-title":"Vasohibin 2 is transcriptionally activated and promotes angiogenesis in hepatocellular carcinoma","volume":"32","author":"Xue","year":"2013","journal-title":"Oncogene"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1007\/s12250-018-0057-7","article-title":"Histone Deacetylase 3 Inhibitor Suppresses Hepatitis C Virus Replication by Regulating Apo-A1 and LEAP-1 Expression","volume":"33","author":"Zhou","year":"2018","journal-title":"Virol. Sin."},{"key":"ref_43","doi-asserted-by":"crossref","unstructured":"Wrensch, F., Crouchet, E., Ligat, G., Zeisel, M.B., Keck, Z.Y., Foung, S.K.H., Schuster, C., and Baumert, T.F. (2018). Hepatitis C Virus (HCV)-Apolipoprotein Interactions and Immune Evasion and Their Impact on HCV Vaccine Design. Front. Immunol., 9.","DOI":"10.3389\/fimmu.2018.01436"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1136\/gut.2010.211292","article-title":"Hepatitis C virus production requires apolipoprotein A-I and affects its association with nascent low-density lipoproteins","volume":"60","author":"Mancone","year":"2011","journal-title":"Gut"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1016\/j.jhep.2017.05.015","article-title":"Histone methyltransferase G9a promotes liver cancer development by epigenetic silencing of tumor suppressor gene RARRES3","volume":"67","author":"Wei","year":"2017","journal-title":"J. Hepatol."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"15342","DOI":"10.1128\/JVI.79.24.15342-15350.2005","article-title":"Upregulation of protein phosphatase 2Ac by hepatitis C virus modulates NS3 helicase activity through inhibition of protein arginine methyltransferase 1","volume":"79","author":"Duong","year":"2005","journal-title":"J. Virol."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1101\/gad.1279805","article-title":"Arginine methylation of MRE11 by PRMT1 is required for DNA damage checkpoint control","volume":"19","author":"Boisvert","year":"2005","journal-title":"Genes Dev."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1002\/jcp.21180","article-title":"Interplay between chromatin remodelers and protein arginine methyltransferases","volume":"213","author":"Pal","year":"2007","journal-title":"J. Cell Physiol."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1016\/j.jhep.2008.04.007","article-title":"Virus-induced over-expression of protein phosphatase 2A inhibits insulin signalling in chronic hepatitis C","volume":"49","author":"Bernsmeier","year":"2008","journal-title":"J. Hepatol."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1002\/hep.23388","article-title":"Hepatitis C virus-induced up-regulation of protein phosphatase 2A inhibits histone modification and DNA damage repair","volume":"51","author":"Duong","year":"2010","journal-title":"Hepatology"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1016\/j.jhep.2015.02.036","article-title":"Hepatitis C virus-mediated Aurora B kinase inhibition modulates inflammatory pathway and viral infectivity","volume":"63","author":"Sheldon","year":"2015","journal-title":"J. Hepatol."},{"key":"ref_52","doi-asserted-by":"crossref","unstructured":"Garc\u00eda-Crespo, C., Francisco-Recuero, I., Gallego, I., Camblor-Murube, M., Soria, M.E., L\u00f3pez-L\u00f3pez, A., de \u00c1vila, A.I., Madej\u00f3n, A., Garc\u00eda-Samaniego, J., and Domingo, E. (2023). Hepatitis C virus fitness can influence the extent of infection-mediated epigenetic modifications in the host cells. Front. Cell Infect. Microbiol., 13.","DOI":"10.3389\/fcimb.2023.1057082"},{"key":"ref_53","doi-asserted-by":"crossref","unstructured":"Zhang, J., Ma, J., Li, Y., An, Y., Du, W., Yang, Q., Huang, M., and Cai, X. (2024). Overexpression of Aurora Kinase B Is Correlated with Diagnosis and Poor Prognosis in Hepatocellular Carcinoma. Int. J. Mol. Sci., 25.","DOI":"10.3390\/ijms25042199"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1007\/s13148-011-0026-6","article-title":"Epigenetic mechanisms in virus-induced tumorigenesis","volume":"2","author":"Poreba","year":"2011","journal-title":"Clin. Epigenetics"},{"key":"ref_55","doi-asserted-by":"crossref","unstructured":"Schueller, F., Roy, S., Vucur, M., Trautwein, C., Luedde, T., and Roderburg, C. (2018). The Role of miRNAs in the Pathophysiology of Liver Diseases and Toxicity. Int. J. Mol. Sci., 19.","DOI":"10.3390\/ijms19010261"},{"key":"ref_56","doi-asserted-by":"crossref","unstructured":"Li, H.C., Yang, C.H., and Lo, S.Y. (2022). Roles of microRNAs in Hepatitis C Virus Replication and Pathogenesis. Viruses, 14.","DOI":"10.3390\/v14081776"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.ijid.2014.09.020","article-title":"Absolute quantification of serum microRNA-122 and its correlation with liver inflammation grade and serum alanine aminotransferase in chronic hepatitis C patients","volume":"30","author":"Wang","year":"2015","journal-title":"Int. J. Infect. Dis."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"1577","DOI":"10.1126\/science.1113329","article-title":"Modulation of hepatitis C virus RNA abundance by a liver-specific MicroRNA","volume":"309","author":"Jopling","year":"2005","journal-title":"Science"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"3193","DOI":"10.1073\/pnas.1012464108","article-title":"Masking the 5\u2019 terminal nucleotides of the hepatitis C virus genome by an unconventional microRNA-target RNA complex","volume":"108","author":"Machlin","year":"2011","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"2613","DOI":"10.1038\/s41467-018-05053-3","article-title":"microRNA-122 amplifies hepatitis C virus translation by shaping the structure of the internal ribosomal entry site","volume":"9","author":"Schult","year":"2018","journal-title":"Nat. Commun."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"e26572","DOI":"10.1016\/j.heliyon.2024.e26572","article-title":"miR-122\/PPAR\u03b2 axis is involved in hypoxic exercise and modulates fatty acid metabolism in skeletal muscle of obese rats","volume":"10","author":"Wang","year":"2024","journal-title":"Heliyon"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1016\/j.jhep.2012.10.015","article-title":"Hepatic and serum levels of miR-122 after chronic HCV-induced fibrosis","volume":"58","author":"Trebicka","year":"2013","journal-title":"J. Hepatol."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"6322","DOI":"10.3748\/wjg.v25.i42.6322","article-title":"MicroRNA signature in patients with hepatocellular carcinoma associated with type 2 diabetes","volume":"25","author":"Elemeery","year":"2019","journal-title":"World J. Gastroenterol."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"5914541","DOI":"10.1155\/2022\/5914541","article-title":"The Predictive Efficacy of Serum Exosomal microRNA-122 and microRNA-148a for Hepatocellular Carcinoma Based on Smart Healthcare","volume":"2022","author":"Deng","year":"2022","journal-title":"J. Healthc. Eng."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1016\/j.jhep.2014.10.004","article-title":"miR-122--a key factor and therapeutic target in liver disease","volume":"62","author":"Bandiera","year":"2015","journal-title":"J. Hepatol."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"4991","DOI":"10.1073\/pnas.1016606108","article-title":"MicroRNA-122 antagonism against hepatitis C virus genotypes 1-6 and reduced efficacy by host RNA insertion or mutations in the HCV 5\u2019 UTR","volume":"108","author":"Li","year":"2011","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"1685","DOI":"10.1056\/NEJMoa1209026","article-title":"Treatment of HCV infection by targeting microRNA","volume":"368","author":"Janssen","year":"2013","journal-title":"N. Engl. J. Med."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1128\/AAC.04220-14","article-title":"In vitro antiviral activity and preclinical and clinical resistance profile of miravirsen, a novel anti-hepatitis C virus therapeutic targeting the human factor miR-122","volume":"59","author":"Ottosen","year":"2015","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1186\/s40001-018-0317-x","article-title":"miRNAs regulate immune response and signaling during hepatitis C virus infection","volume":"23","author":"Zhu","year":"2018","journal-title":"Eur. J. Med. Res."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1016\/j.micinf.2015.05.007","article-title":"An update on the role of miRNA-155 in pathogenic microbial infections","volume":"17","author":"Zeng","year":"2015","journal-title":"Microbes Infect."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"1631","DOI":"10.1002\/hep.25849","article-title":"Hepatitis C virus-induced up-regulation of microRNA-155 promotes hepatocarcinogenesis by activating Wnt signaling","volume":"56","author":"Zhang","year":"2012","journal-title":"Hepatology"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1111\/imm.12463","article-title":"MicroRNA-155 regulates interferon-\u03b3 production in natural killer cells via Tim-3 signalling in chronic hepatitis C virus infection","volume":"145","author":"Cheng","year":"2015","journal-title":"Immunology"},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1186\/1479-5876-10-151","article-title":"Increased microRNA-155 expression in the serum and peripheral monocytes in chronic HCV infection","volume":"10","author":"Bala","year":"2012","journal-title":"J. Transl. Med."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1093\/labmed\/lmac045","article-title":"Highly Sensitive Serum miRNA Panel for the Diagnosis of Hepatocellular Carcinoma in Egyptian Patients with HCV-Related HCC","volume":"53","author":"Yosry","year":"2022","journal-title":"Lab. Med."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.ebiom.2017.08.020","article-title":"Treatment-Induced Viral Cure of Hepatitis C Virus-Infected Patients Involves a Dynamic Interplay among three Important Molecular Players in Lipid Homeostasis: Circulating microRNA (miR)-24, miR-223, and Proprotein Convertase Subtilisin\/Kexin Type 9","volume":"23","author":"Hyrina","year":"2017","journal-title":"EBioMedicine"},{"key":"ref_76","first-page":"e33881","article-title":"The Liver MicroRNA Expression Profiles Associated With Chronic Hepatitis C Virus (HCV) Genotype-4 Infection: A Preliminary Study","volume":"16","author":"Helwa","year":"2016","journal-title":"Hepat. Mon."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s12276-018-0153-7","article-title":"Role of miR-223 in the pathophysiology of liver diseases","volume":"50","author":"Ye","year":"2018","journal-title":"Exp. Mol. Med."},{"key":"ref_78","first-page":"2429","article-title":"miRNA-223-3p regulates NLRP3 to promote apoptosis and inhibit proliferation of hep3B cells","volume":"15","author":"Wan","year":"2018","journal-title":"Exp. Ther. Med."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1002\/mc.20712","article-title":"Circulating microRNAs, miR-21, miR-122, and miR-223, in patients with hepatocellular carcinoma or chronic hepatitis","volume":"50","author":"Xu","year":"2011","journal-title":"Mol. Carcinog."},{"key":"ref_80","doi-asserted-by":"crossref","unstructured":"\u00d6ks\u00fcz, Z., Gragnani, L., Lorini, S., Temel, G., Serin, M.S., and Zignego, A.L. (2023). Evaluation of Plasma miR-17-5p, miR-24-3p and miRNA-223-3p Profile of Hepatitis C Virus-Infected Patients after Treatment with Direct-Acting Antivirals. J. Pers. Med., 13.","DOI":"10.3390\/jpm13081188"},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"4132","DOI":"10.1096\/fj.201600696R","article-title":"Toll-like receptor 3-activated macrophages confer anti-HCV activity to hepatocytes through exosomes","volume":"30","author":"Zhou","year":"2016","journal-title":"FASEB J."},{"key":"ref_82","doi-asserted-by":"crossref","unstructured":"Ullah, A., Rehman, I.U., Ommer, K., Ahmed, N., Odenthal, M., Yu, X., Ahmad, J., Nadeem, T., Ali, Q., and Ahmad, B. (2023). Circulating miRNA-192 and miR-29a as Disease Progression Biomarkers in Hepatitis C Patients with a Prevalence of HCV Genotype 3. Genes, 14.","DOI":"10.3390\/genes14051056"},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"1701","DOI":"10.1016\/j.jcmgh.2022.02.013","article-title":"Autophagy-Related Activation of Hepatic Stellate Cells Reduces Cellular miR-29a by Promoting Its Vesicular Secretion","volume":"13","author":"Yu","year":"2022","journal-title":"Cell Mol. Gastroenterol. Hepatol."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"1753","DOI":"10.1093\/infdis\/jir186","article-title":"Hepatitis C virus infection and hepatic stellate cell activation downregulate miR-29: miR-29 overexpression reduces hepatitis C viral abundance in culture","volume":"203","author":"Bandyopadhyay","year":"2011","journal-title":"J. Infect. Dis."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1186\/1743-422X-9-109","article-title":"MicroRNAs and hepatitis C virus: Toward the end of miR-122 supremacy","volume":"9","author":"Hoffmann","year":"2012","journal-title":"Virol. J."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1038\/nature06205","article-title":"Interferon modulation of cellular microRNAs as an antiviral mechanism","volume":"449","author":"Pedersen","year":"2007","journal-title":"Nature"},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.omto.2018.12.011","article-title":"A Systematic Review of miR-29 in Cancer","volume":"12","author":"Kwon","year":"2019","journal-title":"Mol. Ther. Oncolytics"},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1002\/hep.23380","article-title":"Effects of microRNA-29 on apoptosis, tumorigenicity, and prognosis of hepatocellular carcinoma","volume":"51","author":"Xiong","year":"2010","journal-title":"Hepatology"},{"key":"ref_89","doi-asserted-by":"crossref","unstructured":"Badami, E., Carcione, C., Chinnici, C.M., Tinnirello, R., Conaldi, P.G., and Iannolo, G. (2021). HCV Interplay With Mir34a: Implications in Hepatocellular Carcinoma. Front. Oncol., 11.","DOI":"10.3389\/fonc.2021.803278"},{"key":"ref_90","doi-asserted-by":"crossref","unstructured":"Cabral, B.C.A., Hoffmann, L., Bottaro, T., Costa, P.F., Ramos, A.L.A., Coelho, H.S.M., Villela-Nogueira, C.A., \u00dcrm\u00e9nyi, T.P., Faffe, D.S., and Silva, R. (2020). Circulating microRNAs associated with liver fibrosis in chronic hepatitis C patients. Biochem. Biophys. Rep., 24.","DOI":"10.1016\/j.bbrep.2020.100814"},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"e02388-16","DOI":"10.1128\/JVI.02388-16","article-title":"A MicroRNA Screen Identifies the Wnt Signaling Pathway as a Regulator of the Interferon Response during Flavivirus Infection","volume":"91","author":"Smith","year":"2017","journal-title":"J. Virol."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"2417","DOI":"10.3748\/wjg.v28.i22.2417","article-title":"Hepatocellular carcinoma, hepatitis C virus infection and miRNA involvement: Perspectives for new therapeutic approaches","volume":"28","author":"Badami","year":"2022","journal-title":"World J. Gastroenterol."},{"key":"ref_93","doi-asserted-by":"crossref","unstructured":"Cermelli, S., Ruggieri, A., Marrero, J.A., Ioannou, G.N., and Beretta, L. (2011). Circulating microRNAs in patients with chronic hepatitis C and non-alcoholic fatty liver disease. PLoS ONE, 6.","DOI":"10.1371\/journal.pone.0023937"},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.virusres.2015.10.001","article-title":"HCV infection, IFN response and the coding and non-coding host cell genome","volume":"212","author":"Carnero","year":"2016","journal-title":"Virus Res."},{"key":"ref_95","doi-asserted-by":"crossref","unstructured":"Unfried, J.P., and Fortes, P. (2020). LncRNAs in HCV Infection and HCV-Related Liver Disease. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21062255"},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"2826","DOI":"10.7150\/ijbs.59227","article-title":"Long noncoding RNA UCA1 regulates HCV replication and antiviral response via miR-145-5p\/SOCS7\/IFN pathway","volume":"17","author":"Zeng","year":"2021","journal-title":"Int. J. Biol. Sci."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.15252\/embr.201541763","article-title":"Long noncoding RNA EGOT negatively affects the antiviral response and favors HCV replication","volume":"17","author":"Carnero","year":"2016","journal-title":"EMBO Rep."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.virusres.2015.09.023","article-title":"lncRNA-mediated regulation of the interferon response","volume":"212","author":"Valadkhan","year":"2016","journal-title":"Virus Res."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"1373","DOI":"10.1053\/j.gastro.2014.02.002","article-title":"Oxysterol-binding protein is a phosphatidylinositol 4-kinase effector required for HCV replication membrane integrity and cholesterol trafficking","volume":"146","author":"Wang","year":"2014","journal-title":"Gastroenterology"},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"1004","DOI":"10.1002\/hep.30266","article-title":"A Long Noncoding RNA Regulates Hepatitis C Virus Infection Through Interferon Alpha-Inducible Protein 6","volume":"69","author":"Liu","year":"2019","journal-title":"Hepatology"},{"key":"ref_101","doi-asserted-by":"crossref","unstructured":"Hong, Y., Zhang, Y., Zhao, H., Chen, H., Yu, Q.Q., and Cui, H. (2022). The roles of lncRNA functions and regulatory mechanisms in the diagnosis and treatment of hepatocellular carcinoma. Front. Cell Dev. Biol., 10.","DOI":"10.3389\/fcell.2022.1051306"},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"001809","DOI":"10.1099\/jgv.0.001809","article-title":"LncRNA NEAT1 regulates HCV-induced Hepatocellular carcinoma by modulating the miR-9-BGH3 axis","volume":"103","author":"Tripathi","year":"2022","journal-title":"J. Gen. Virol."},{"key":"ref_103","doi-asserted-by":"crossref","unstructured":"Moon, S.L., Blackinton, J.G., Anderson, J.R., Dozier, M.K., Dodd, B.J., Keene, J.D., Wilusz, C.J., Bradrick, S.S., and Wilusz, J. (2015). XRN1 stalling in the 5\u2019 UTR of Hepatitis C virus and Bovine Viral Diarrhea virus is associated with dysregulated host mRNA stability. PLoS Pathog., 11.","DOI":"10.1371\/journal.ppat.1004708"},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1016\/j.stem.2015.03.003","article-title":"The long noncoding RNA lncTCF7 promotes self-renewal of human liver cancer stem cells through activation of Wnt signaling","volume":"16","author":"Wang","year":"2015","journal-title":"Cell Stem Cell"},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"1764","DOI":"10.1002\/hep.31530","article-title":"Gain of LINC00624 Enhances Liver Cancer Progression by Disrupting the Histone Deacetylase 6\/Tripartite Motif Containing 28\/Zinc Finger Protein 354C Corepressor Complex","volume":"73","author":"Li","year":"2021","journal-title":"Hepatology"},{"key":"ref_106","doi-asserted-by":"crossref","unstructured":"Gaber, D.A., Shaker, O., Younis, A.T., and El-Kassas, M. (2022). LncRNA HULC and miR-122 Expression Pattern in HCC-Related HCV Egyptian Patients. Genes, 13.","DOI":"10.3390\/genes13091669"},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1186\/s13287-019-1528-y","article-title":"Long noncoding RNA HULC accelerates the growth of human liver cancer stem cells by upregulating CyclinD1 through miR675-PKM2 pathway via autophagy","volume":"11","author":"Wang","year":"2020","journal-title":"Stem Cell Res. Ther."},{"key":"ref_108","doi-asserted-by":"crossref","unstructured":"Sharma, G., Tripathi, S.K., and Das, S. (2019). lncRNA HULC facilitates efficient loading of HCV-core protein onto lipid droplets and subsequent virus-particle release. Cell Microbiol., 21.","DOI":"10.1111\/cmi.13086"},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"100269","DOI":"10.1016\/j.aohep.2020.09.013","article-title":"Long noncoding RNA LINC01189 is associated with HCV-hepatocellular carcinoma and regulates cancer cell proliferation and chemoresistance through hsa-miR-155-5p","volume":"22","author":"Yao","year":"2021","journal-title":"Ann. Hepatol."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"3632","DOI":"10.3390\/cimb44080249","article-title":"The Transgene Expression of the Immature Form of the HCV Core Protein (C191) and the LncRNA MEG3 Increases Apoptosis in HepG2 Cells","volume":"44","author":"Mofed","year":"2022","journal-title":"Curr. Issues Mol. Biol."},{"key":"ref_111","first-page":"4089","article-title":"LncRNA meg3 suppresses hepatocellular carcinoma in vitro and vivo studies","volume":"11","author":"Zhang","year":"2019","journal-title":"Am. J. Transl. Res."},{"key":"ref_112","doi-asserted-by":"crossref","unstructured":"Gan, Y., Han, N., He, X., Yu, J., Zhang, M., Zhou, Y., Liang, H., Deng, J., Zheng, Y., and Ge, W. (2017). Long non-coding RNA CASC2 regulates cell biological behaviour through the MAPK signalling pathway in hepatocellular carcinoma. Tumour Biol., 39.","DOI":"10.1177\/1010428317706229"},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"e3112","DOI":"10.1002\/jgm.3112","article-title":"Long non-coding RNAs (CASC2 and TUG1) in hepatocellular carcinoma: Clinical significance","volume":"21","author":"Refai","year":"2019","journal-title":"J. Gene Med."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"651","DOI":"10.3233\/CBM-170727","article-title":"lncRNA-HEIH in serum and exosomes as a potential biomarker in the HCV-related hepatocellular carcinoma","volume":"21","author":"Zhang","year":"2018","journal-title":"Cancer Biomark."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1089\/gtmb.2020.0270","article-title":"LncRNA-HEIH is a Novel Diagnostic and Predictive Biomarker in Gastric Cancer","volume":"25","author":"Chen","year":"2021","journal-title":"Genet. Test. Mol. Biomarkers"},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"1679","DOI":"10.1002\/hep.24563","article-title":"Long noncoding RNA high expression in hepatocellular carcinoma facilitates tumor growth through enhancer of zeste homolog 2 in humans","volume":"54","author":"Yang","year":"2011","journal-title":"Hepatology"},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"1128","DOI":"10.1053\/jhep.2001.29202","article-title":"Immunohistologic study on the expressions of \u03b1-fetoprotein and protein induced by vitamin K absence or antagonist II in surgically resected small hepatocellular carcinoma","volume":"34","author":"Fujioka","year":"2001","journal-title":"Hepatology"},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1016\/j.biopha.2018.03.105","article-title":"Oncogenic long noncoding RNA MALAT1 and HCV-related hepatocellular carcinoma","volume":"102","author":"Toraih","year":"2018","journal-title":"Biomed. Pharmacother."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"5807","DOI":"10.2147\/OTT.S250796","article-title":"Long Non-Coding RNA MALAT1 as a Detection and Diagnostic Molecular Marker in Various Human Cancers: A Pooled Analysis Based on 3255 Subjects","volume":"13","author":"Zhao","year":"2020","journal-title":"Onco Targets Ther"},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"43770","DOI":"10.18632\/oncotarget.6087","article-title":"Long non-coding RNA expression profiles of hepatitis C virus-related dysplasia and hepatocellular carcinoma","volume":"6","author":"Zhang","year":"2015","journal-title":"Oncotarget"},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"1022","DOI":"10.1016\/j.tibs.2020.08.006","article-title":"Circular RNAs in Immune Response and Viral Infection","volume":"45","author":"Yan","year":"2020","journal-title":"Trends Biochem. Sci."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"4488","DOI":"10.1111\/febs.15639","article-title":"Viruses join the circular RNA world","volume":"288","author":"Tan","year":"2021","journal-title":"FEBS J."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"2296","DOI":"10.1016\/j.gendis.2022.04.009","article-title":"Critical involvement of circular RNAs in virus-associated cancers","volume":"10","author":"Zebardast","year":"2023","journal-title":"Genes Dis."},{"key":"ref_124","first-page":"1032","article-title":"Functional sequestration of microRNA-122 from Hepatitis C Virus by circular RNA sponges","volume":"15","author":"Jost","year":"2018","journal-title":"RNA Biol."},{"key":"ref_125","doi-asserted-by":"crossref","unstructured":"Breuer, J., and Rossbach, O. (2020). Production and Purification of Artificial Circular RNA Sponges for Application in Molecular Biology and Medicine. Methods Protoc., 3.","DOI":"10.3390\/mps3020042"},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"116660","DOI":"10.1016\/j.lfs.2019.116660","article-title":"Circular RNAs in hepatocellular carcinoma: Biomarkers, functions and mechanisms","volume":"231","author":"Qiu","year":"2019","journal-title":"Life Sci."},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1016\/j.ncrna.2023.05.005","article-title":"Circular SERPINA3 and its target microRNA-944 as potential biomarkers in hepatitis C virus-induced hepatocellular carcinoma in Egyptian population","volume":"8","author":"Aborehab","year":"2023","journal-title":"Noncoding RNA Res."},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"1411","DOI":"10.31557\/APJCP.2024.25.4.1411","article-title":"Evaluation of Circular RNA SMARCA5 as a Novel Biomarker for Hepatocellular Carcinoma","volume":"25","author":"Bedair","year":"2024","journal-title":"Asian Pac. J. Cancer Prev."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"501","DOI":"10.3233\/CBM-181970","article-title":"Serum microRNA expression profiling identifies serum biomarkers for HCV-related hepatocellular carcinoma","volume":"26","author":"Li","year":"2019","journal-title":"Cancer Biomark."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.canlet.2020.01.022","article-title":"Exosome-transmitted circular RNA hsa_circ_0051443 suppresses hepatocellular carcinoma progression","volume":"475","author":"Chen","year":"2020","journal-title":"Cancer Lett."},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"2934","DOI":"10.1002\/ijc.33111","article-title":"The exosome encapsulated microRNAs as circulating diagnostic marker for hepatocellular carcinoma with low alpha-fetoprotein","volume":"147","author":"Ghosh","year":"2020","journal-title":"Int. J. Cancer"},{"key":"ref_132","doi-asserted-by":"crossref","unstructured":"Su, X., Su, J., He, H., Zhan, Y., and Liu, H. (2019). Hsa_circ_0070269 inhibits hepatocellular carcinoma progression through modulating miR-182\/NPTX1 axis. Biomed. Pharmacother., 120.","DOI":"10.1016\/j.biopha.2019.109497"},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1007\/s13402-020-00564-y","article-title":"Circular RNA circ-102,166 acts as a sponge of miR-182 and miR-184 to suppress hepatocellular carcinoma proliferation and invasion","volume":"44","author":"Li","year":"2021","journal-title":"Cell Oncol."},{"key":"ref_134","doi-asserted-by":"crossref","unstructured":"Chigbu, D.I., Loonawat, R., Sehgal, M., Patel, D., and Jain, P. (2019). Hepatitis C Virus Infection: Host\u207bVirus Interaction and Mechanisms of Viral Persistence. Cells, 8.","DOI":"10.3390\/cells8040376"},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"6072","DOI":"10.4049\/jimmunol.173.10.6072","article-title":"Negative regulation of NK cell activities by inhibitory receptor CD94\/NKG2A leads to altered NK cell-induced modulation of dendritic cell functions in chronic hepatitis C virus infection","volume":"173","author":"Jinushi","year":"2004","journal-title":"J. Immunol."},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1136\/gut.2005.076463","article-title":"Surface expression and cytolytic function of natural killer cell receptors is altered in chronic hepatitis C","volume":"55","author":"Nattermann","year":"2006","journal-title":"Gut"},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1002\/hep.24700","article-title":"Myeloid suppressor cells induced by hepatitis C virus suppress T-cell responses through the production of reactive oxygen species","volume":"55","author":"Tacke","year":"2012","journal-title":"Hepatology"},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1016\/S0198-8859(02)00781-4","article-title":"Lack of optimal T-cell reactivity against the hepatitis C virus is associated with the development of fibrosis\/cirrhosis during chronic hepatitis","volume":"64","author":"Sreenarasimhaiah","year":"2003","journal-title":"Hum. Immunol."},{"key":"ref_139","doi-asserted-by":"crossref","unstructured":"Kotsari, M., Dimopoulou, V., Koskinas, J., and Armakolas, A. (2023). Immune System and Hepatocellular Carcinoma (HCC): New Insights into HCC Progression. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms241411471"},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1038\/s41467-019-14137-7","article-title":"Targeting p53 and histone methyltransferases restores exhausted CD8+ T cells in HCV infection","volume":"11","author":"Barili","year":"2020","journal-title":"Nat. Commun."},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"4088","DOI":"10.2337\/db15-0197","article-title":"The Metabolic Regulator Histone Deacetylase 9 Contributes to Glucose Homeostasis Abnormality Induced by Hepatitis C Virus Infection","volume":"64","author":"Chen","year":"2015","journal-title":"Diabetes"},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"2757","DOI":"10.4049\/jimmunol.1400583","article-title":"Set7 facilitates hepatitis C virus replication via enzymatic activity-dependent attenuation of the IFN-related pathway","volume":"194","author":"Han","year":"2015","journal-title":"J. Immunol."},{"key":"ref_143","doi-asserted-by":"crossref","unstructured":"Kapellos, T.S., Bonaguro, L., Gem\u00fcnd, I., Reusch, N., Saglam, A., Hinkley, E.R., and Schultze, J.L. (2019). Human Monocyte Subsets and Phenotypes in Major Chronic Inflammatory Diseases. Front. Immunol., 10.","DOI":"10.3389\/fimmu.2019.02035"},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"e16","DOI":"10.1182\/blood-2010-12-326355","article-title":"Gene expression profiling reveals the defining features of the classical, intermediate, and nonclassical human monocyte subsets","volume":"118","author":"Wong","year":"2011","journal-title":"Blood"},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"15349","DOI":"10.1007\/s00432-023-05313-w","article-title":"Monocytes subsets altered distribution and dysregulated plasma hsa-miR-21-5p and hsa-miR-155-5p in HCV-linked liver cirrhosis progression to hepatocellular carcinoma","volume":"149","author":"Hammad","year":"2023","journal-title":"J. Cancer Res. Clin. Oncol."},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1111\/jvh.12537","article-title":"HCV-induced miR146a controls SOCS1\/STAT3 and cytokine expression in monocytes to promote regulatory T-cell development","volume":"23","author":"Ren","year":"2016","journal-title":"J. Viral Hepat."},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"1436","DOI":"10.1074\/jbc.M110.145870","article-title":"Up-regulation of microRNA-155 in macrophages contributes to increased tumor necrosis factor \u03b1 (TNF\u03b1) production via increased mRNA half-life in alcoholic liver disease","volume":"286","author":"Bala","year":"2011","journal-title":"J. Biol. Chem."},{"key":"ref_148","doi-asserted-by":"crossref","unstructured":"Kondo, Y., Kogure, T., Ninomiya, M., Fukuda, R., Monma, N., Ikeo, K., and Tanaka, Y. (2019). The reduction of miR146b-5p in monocytes and T cells could contribute to the immunopathogenesis of hepatitis C virus infection. Sci. Rep., 9.","DOI":"10.1038\/s41598-019-49706-9"},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1038\/s41577-020-00490-y","article-title":"Myeloid-derived suppressor cells in the era of increasing myeloid cell diversity","volume":"21","author":"Veglia","year":"2021","journal-title":"Nat. Rev. Immunol."},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1038\/s41392-021-00670-9","article-title":"Myeloid-derived suppressor cells as immunosuppressive regulators and therapeutic targets in cancer","volume":"6","author":"Li","year":"2021","journal-title":"Signal Transduct. Target. Ther."},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1111\/imm.12680","article-title":"Decline of miR-124 in myeloid cells promotes regulatory T-cell development in hepatitis C virus infection","volume":"150","author":"Ren","year":"2017","journal-title":"Immunology"},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1038\/s41421-018-0052-z","article-title":"HCV-associated exosomes promote myeloid-derived suppressor cell expansion via inhibiting miR-124 to regulate T follicular cell differentiation and function","volume":"4","author":"Wang","year":"2018","journal-title":"Cell Discov."},{"key":"ref_153","doi-asserted-by":"crossref","unstructured":"Chen, Y., Chen, J., Wang, H., Shi, J., Wu, K., Liu, S., Liu, Y., and Wu, J. (2013). HCV-induced miR-21 contributes to evasion of host immune system by targeting MyD88 and IRAK1. PLoS Pathog., 9.","DOI":"10.1371\/journal.ppat.1003248"},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"1382","DOI":"10.1128\/JVI.06242-11","article-title":"Establishment of a novel permissive cell line for the propagation of hepatitis C virus by expression of microRNA miR122","volume":"86","author":"Kambara","year":"2012","journal-title":"J. Virol."},{"key":"ref_155","doi-asserted-by":"crossref","first-page":"4354","DOI":"10.3748\/wjg.v22.i17.4354","article-title":"Inhibitory effect of miR-125b on hepatitis C virus core protein-induced TLR2\/MyD88 signaling in THP-1 cells","volume":"22","author":"Peng","year":"2016","journal-title":"World J. Gastroenterol."},{"key":"ref_156","doi-asserted-by":"crossref","first-page":"e0190321","DOI":"10.1128\/jvi.01903-21","article-title":"MicroRNA 122 Affects both the Initiation and the Maintenance of Hepatitis C Virus Infections","volume":"96","author":"Panigrahi","year":"2022","journal-title":"J. Virol."},{"key":"ref_157","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1111\/jvh.12131","article-title":"MicroRNA-130a inhibits HCV replication by restoring the innate immune response","volume":"21","author":"Li","year":"2014","journal-title":"J. Viral Hepat."},{"key":"ref_158","doi-asserted-by":"crossref","first-page":"1163","DOI":"10.1002\/hep.27634","article-title":"Hepatitis C virus-induced reduction in miR-181a impairs CD4(+) T-cell responses through overexpression of DUSP6","volume":"61","author":"Li","year":"2015","journal-title":"Hepatology"},{"key":"ref_159","doi-asserted-by":"crossref","first-page":"e0020722","DOI":"10.1128\/jvi.00207-22","article-title":"The Role of Long Noncoding RNA BST2-2 in the Innate Immune Response to Viral Infection","volume":"96","author":"Chen","year":"2022","journal-title":"J. Virol."},{"key":"ref_160","doi-asserted-by":"crossref","first-page":"e0095221","DOI":"10.1128\/JVI.00952-21","article-title":"Hepatitis C Virus Evades Interferon Signaling by Suppressing Long Noncoding RNA Linc-Pint Involving C\/EBP-\u03b2","volume":"95","author":"Khatun","year":"2021","journal-title":"J. Virol."},{"key":"ref_161","doi-asserted-by":"crossref","unstructured":"Thakuri, B.K.C., Zhang, J., Zhao, J., Nguyen, L.N., Nguyen, L.N.T., Khanal, S., Cao, D., Dang, X., Schank, M., and Wu, X.Y. (2020). LncRNA HOTAIRM1 promotes MDSC expansion and suppressive functions through the HOXA1-miR124 axis during HCV infection. Sci. Rep., 10.","DOI":"10.1038\/s41598-020-78786-1"},{"key":"ref_162","doi-asserted-by":"crossref","unstructured":"Lefkowitz, R.B., Miller, C.M., Martinez-Caballero, J.D., and Ramos, I. (2024). Epigenetic Control of Innate Immunity: Consequences of Acute Respiratory Virus Infection. Viruses, 16.","DOI":"10.3390\/v16020197"},{"key":"ref_163","doi-asserted-by":"crossref","unstructured":"Torne, A.S., and Robertson, E.S. (2024). Epigenetic Mechanisms in Latent Epstein-Barr Virus Infection and Associated Cancers. Cancers, 16.","DOI":"10.3390\/cancers16050991"},{"key":"ref_164","doi-asserted-by":"crossref","unstructured":"Kim, S.Y., Koh, J.Y., Lee, D.H., Kim, H.D., Choi, S.J., Ko, Y.Y., Lee, H.S., Lee, J.S., Choi, I.A., and Lee, E.Y. (J. Hepatol., 2024). Epigenetic scars in regulatory T cells are retained after successful treatment of chronic hepatitis C with direct-acting antivirals, J. Hepatol., in press.","DOI":"10.1016\/j.jhep.2024.06.011"},{"key":"ref_165","first-page":"72","article-title":"Changes in DNA methylation profile in liver tissue during progression of HCV-induced fibrosis to hepatocellular carcinoma","volume":"27","author":"Goncharova","year":"2023","journal-title":"Vavilovskii Zhurnal Genet. Sel."},{"key":"ref_166","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/j.omtn.2018.11.018","article-title":"MicroRNA-Based Prophylaxis in a Mouse Model of Cirrhosis and Liver Cancer","volume":"14","author":"Callegari","year":"2019","journal-title":"Mol. Ther. 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