{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T22:27:13Z","timestamp":1789165633514,"version":"build-2803163510"},"reference-count":54,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2024,8,13]],"date-time":"2024-08-13T00:00:00Z","timestamp":1723507200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"The Research Council of Lithuania","award":["S-SEN-20-15."],"award-info":[{"award-number":["S-SEN-20-15."]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biomolecules"],"abstract":"<jats:p>The identification of mechanisms associated with Parkinson disease (PD) development in cognitive functioning would be of great usefulness to clarify PD pathogenesis and to develop preventive and therapeutic strategies. In this study, blood serum extracellular vesicle (EV) levels of the candidate microRNAs (small noncoding RNAs that play a role in gene expression regulation):,miR-7, miR-21, miR-153, miR-155, miR-200a and miR-214, have been investigated for association with PD in a group of 93 patients with cognitive parameters, PD symptoms, affected quality of life and some clinical characteristics. MiRNA was extracted from patients\u2019 blood serum EVs, transcribed into cDNA and their expression was evaluated using RT-PCR. The miR-153 and miR-200a showed the most plausible correlations with cognitive functioning parameters such as general intellectual functioning, psychomotor speed, mental flexibility, and nonverbal executive functions. Moreover, lower levels of miR-153 were associated with attention span, working memory and psychomotor speed with learning. Increased levels of miR-200a, miR-7, miR-214, and miR-155 were also linked with neurological functioning, such as bradykinesia, tremor, balance and others. Despite the fact that due to small sample size, our results should be considered as preliminary, our study suggests that miRNA expression in EVs could be associated with symptom severity, cognitive impairment and quality of life in PD.<\/jats:p>","DOI":"10.3390\/biom14081000","type":"journal-article","created":{"date-parts":[[2024,8,13]],"date-time":"2024-08-13T10:54:54Z","timestamp":1723546494000},"page":"1000","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Association of Serum Extracellular Vesicle miRNAs with Cognitive Functioning and Quality of Life in Parkinson\u2019s Disease"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3297-8882","authenticated-orcid":false,"given":"Paulina","family":"Vaitkien\u0117","sequence":"first","affiliation":[{"name":"Laboratory of Molecular Neurobiology, Neuroscience Institute, Medical Academy, Lithuanian University of Health Sciences, Eiveniu Str. 4, LT-50009 Kaunas, Lithuania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aist\u0117","family":"Pranckevi\u010dien\u0117","sequence":"additional","affiliation":[{"name":"Health Psychology Department, Faculty of Public Health, Medical Academy, Lithuania University of Health Sciences, Til\u017e\u0117s g. 18, LT-47181 Kaunas, Lithuania"},{"name":"Neuroscience Institute, Medical Academy, Lithuanian University of Health Sciences, Eiveniu Str. 4, LT-50009 Kaunas, Lithuania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4788-7919","authenticated-orcid":false,"given":"Andrius","family":"Rad\u017ei\u016bnas","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Medical Academy, Lithuanian University of Health Sciences, Kauno Klinikos, Eiveniu Str. 2, LT-50009 Kaunas, Lithuania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Augustina","family":"Mi\u0161eikait\u0117","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Neurobiology, Neuroscience Institute, Medical Academy, Lithuanian University of Health Sciences, Eiveniu Str. 4, LT-50009 Kaunas, Lithuania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giedr\u0117","family":"Miniotait\u0117","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Neurobiology, Neuroscience Institute, Medical Academy, Lithuanian University of Health Sciences, Eiveniu Str. 4, LT-50009 Kaunas, Lithuania"},{"name":"Faculty of Medicine, Medical Academy, Lithuanian University of Health Sciences, A. 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Neurol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1038\/s41419-023-05672-9","article-title":"Alpha-synuclein in Parkinson\u2019s disease and other synucleinopathies: From overt neurodegeneration back to early synaptic dysfunction","volume":"14","author":"Calabresi","year":"2023","journal-title":"Cell Death Dis."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1038\/s41572-021-00280-3","article-title":"Parkinson disease-associated cognitive impairment","volume":"7","author":"Aarsland","year":"2021","journal-title":"Nat. Rev. Dis. Primers"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"2284","DOI":"10.1016\/S0140-6736(21)00218-X","article-title":"Parkinson\u2019s disease","volume":"397","author":"Bloem","year":"2021","journal-title":"Lancet"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"122358","DOI":"10.1016\/j.lfs.2023.122358","article-title":"Molecular mechanism of cognitive impairment associated with Parkinson\u2019s disease: A stroke perspective","volume":"337","author":"Gupta","year":"2024","journal-title":"Life Sci."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/S0140-6736(23)01429-0","article-title":"Medical, surgical, and physical treatments for Parkinson\u2019s disease","volume":"403","author":"Foltynie","year":"2024","journal-title":"Lancet"},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Huang, M., Xu, L., Liu, J., Huang, P., Tan, Y., and Chen, S. (2022). Cell\u2013Cell Communication Alterations via Intercellular Signaling Pathways in Substantia Nigra of Parkinson\u2019s Disease. Front. Aging Neurosci., 14.","DOI":"10.3389\/fnagi.2022.828457"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/j.nbd.2011.12.046","article-title":"MicroRNAs in Parkinson\u2019s disease","volume":"46","author":"Mouradian","year":"2012","journal-title":"Neurobiol. Dis."},{"key":"ref_9","first-page":"1743183","article-title":"MicroRNAs: Game Changers in the Regulation of \u03b1-Synuclein in Parkinson\u2019s Disease","volume":"2019","author":"Zhao","year":"2019","journal-title":"Parkinson\u2019s Dis."},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Santos-Lobato, B.L., Vidal, A.F., and Ribeiro-dos-Santos, \u00c2. (2021). Regulatory miRNA\u2013mRNA Networks in Parkinson\u2019s Disease. Cells, 10.","DOI":"10.3390\/cells10061410"},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Leggio, L., Vivarelli, S., L\u2019Episcopo, F., Tirolo, C., Caniglia, S., Testa, N., Marchetti, B., and Iraci, N. (2017). microRNAs in Parkinson\u2019s Disease: From Pathogenesis to Novel Diagnostic and Therapeutic Approaches. Int. J. Mol. Sci., 18.","DOI":"10.3390\/ijms18122698"},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Pistono, C., Bister, N., Stanov\u00e1, I., and Malm, T. (2021). Glia-Derived Extracellular Vesicles: Role in Central Nervous System Communication in Health and Disease. Front. Cell Dev. Biol., 8.","DOI":"10.3389\/fcell.2020.623771"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.parkreldis.2021.11.020","article-title":"Exosomal miRNA as peripheral biomarkers in Parkinson\u2019s disease and progressive supranuclear palsy: A pilot study","volume":"93","author":"Manna","year":"2021","journal-title":"Park. Relat. Disord."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"17455","DOI":"10.18632\/oncotarget.24736","article-title":"miRNA-based signatures in cerebrospinal fluid as potential diagnostic tools for early stage Parkinson\u2019s disease","volume":"9","author":"Correia","year":"2018","journal-title":"Oncotarget"},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Van Giau, V., Bagyinszky, E., and An, S.S.A. (2019). Potential Fluid Biomarkers for the Diagnosis of Mild Cognitive Impairment. Int. J. Mol. Sci., 20.","DOI":"10.3390\/ijms20174149"},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Hsu, Y.-F., Lin, S.-P., Chu, Y.-T., Tsai, Y.-T., Huang, J.-W., Phoa, F.K.H., and Wu, R.-M. (2024). Plasma miR-203a-3p as a Novel Predictor of Dementia in Patients with Parkinson\u2019s Disease. Int. J. Mol. Sci., 25.","DOI":"10.20944\/preprints202401.0410.v2"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"13518","DOI":"10.18632\/aging.103458","article-title":"Association of the serum microRNA-29 family with cognitive impairment in Parkinson\u2019s disease","volume":"12","author":"Han","year":"2020","journal-title":"Aging"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"12726","DOI":"10.1074\/jbc.M109.086827","article-title":"Post-transcriptional Regulation of \u03b1-Synuclein Expression by mir-7 and mir-153","volume":"285","author":"Doxakis","year":"2010","journal-title":"J. Biol. Chem."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1016\/j.biopha.2015.08.025","article-title":"MicroRNA-214 participates in the neuroprotective effect of Resveratrol via inhibiting \u03b1-synuclein expression in MPTP-induced Parkinson\u2019s disease mouse","volume":"74","author":"Wang","year":"2015","journal-title":"Biomed. Pharmacother."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"2383","DOI":"10.1523\/JNEUROSCI.3900-15.2016","article-title":"microRNA-155 Regulates Alpha-Synuclein-Induced Inflammatory Responses in Models of Parkinson Disease","volume":"36","author":"Thome","year":"2016","journal-title":"J. Neurosci."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.brainres.2016.05.011","article-title":"Geniposide reduces \u03b1-synuclein by blocking microRNA-21\/lysosome-associated membrane protein 2A interaction in Parkinson disease models","volume":"1644","author":"Su","year":"2016","journal-title":"Brain Res."},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Fu, J., Peng, L., Tao, T., Chen, Y., Li, Z., and Li, J. (2019). Regulatory roles of the miR-200 family in neurodegenerative diseases. Biomed. Pharmacother., 119.","DOI":"10.1016\/j.biopha.2019.109409"},{"key":"ref_23","unstructured":"Army Individual Test Battery (1944). Manual of Directions and Scoring, War Department, Adjutant General\u2019s Office."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"271","DOI":"10.2466\/pms.1958.8.3.271","article-title":"Validity of the Trail Making Test as an Indicator of Organic Brain Damage","volume":"8","author":"Reitan","year":"2016","journal-title":"Percept. Mot. Skills"},{"key":"ref_25","first-page":"286","article-title":"L\u2019examen psychologique dans les cas d\u2019encephopathie traumatique (The psychological examination of cases of traumatic encephalopathy)","volume":"28","author":"Rey","year":"1941","journal-title":"Arch. Psychol."},{"key":"ref_26","unstructured":"Lezak, M.D. (1983). Neuropsychological Assessment, Oxford University Press. [2nd ed.]."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1080\/09084280701280502","article-title":"A Compendium of Neuropsychological Tests: Administration, Norms, and Commentary","volume":"14","author":"Carone","year":"2007","journal-title":"Appl. Neuropsychol."},{"key":"ref_28","first-page":"324","article-title":"Kalbos sklandumo testo psichometrini\u0173 charakteristik\u0173 analiz\u0117 neurologini\u0173 sutrikim\u0173 neturin\u010di\u0173 suaugusi\u0173j\u0173 imtyje","volume":"16","year":"2012","journal-title":"Neurol. Semin."},{"key":"ref_29","doi-asserted-by":"crossref","unstructured":"Wechsler, D. (1997). WAIS-III: Administration and Scoring Manual: Wechsler Adult Intelligence Scale, Psychological Corporation. [3rd ed.].","DOI":"10.1037\/t49755-000"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"839","DOI":"10.2466\/pms.1982.55.3.839","article-title":"Children\u2019s Production on Verbal and Non-Verbal Fluency Tasks","volume":"55","author":"Regard","year":"1982","journal-title":"Percept. Mot. Skills"},{"key":"ref_31","doi-asserted-by":"crossref","unstructured":"Wechsler, D. (1999). Wechsler Abbreviated Scale of Intelligence (WASI) Manual, Psychological Corporation.","DOI":"10.1037\/t15170-000"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1007\/BF02260863","article-title":"The development and validation of a short measure of functioning and well being for individuals with Parkinson\u2019s disease","volume":"4","author":"Peto","year":"1995","journal-title":"Qual. Life Res."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"2129","DOI":"10.1002\/mds.22340","article-title":"Movement Disorder Society-sponsored revision of the Unified Parkinson\u2019s Disease Rating Scale (MDS-UPDRS): Scale presentation and clinimetric testing results","volume":"23","author":"Goetz","year":"2008","journal-title":"Mov. Disord."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1111\/ene.13529","article-title":"The Parkinson\u2019s Disease Composite Scale: Results of the first validation study","volume":"25","author":"Stocchi","year":"2018","journal-title":"Eur. J. Neurol."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1007\/978-3-319-53889-1_19","article-title":"Epigenetics in Parkinson\u2019s Disease","volume":"978","author":"Pavlou","year":"2017","journal-title":"Adv. Exp. Med. Biol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/j.jpha.2019.05.004","article-title":"Research advances in the detection of miRNA","volume":"9","author":"Ye","year":"2019","journal-title":"J. Pharm. Anal."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"2529","DOI":"10.1007\/s13311-021-01130-6","article-title":"MicroRNA-7 Protects Against Neurodegeneration Induced by \u03b1-Synuclein Preformed Fibrils in the Mouse Brain","volume":"18","author":"Zhang","year":"2021","journal-title":"Neurotherapeutics"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.neulet.2017.09.065","article-title":"Mitochondrial ROS-mediated post-transcriptional regulation of \u03b1-synuclein through miR-7 and miR-153","volume":"661","author":"Je","year":"2017","journal-title":"Neurosci. Lett."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"15","DOI":"10.18632\/oncotarget.13905","article-title":"MicroRNA expressing profiles in A53T mutant alpha-synuclein transgenic mice and Parkinsonian","volume":"8","author":"Mo","year":"2017","journal-title":"Oncotarget"},{"key":"ref_40","first-page":"5278","article-title":"Circulating exosomal miRNAs as diagnostic biomarkers in Parkinson\u2019s disease","volume":"22","author":"Yao","year":"2018","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"3939","DOI":"10.1212\/WNL.0000000000203629","article-title":"Blood microRNA-7 as a Progression Biomarker in men with Parkinson\u2019s disease","volume":"100","author":"Schiess","year":"2023","journal-title":"Neurology"},{"key":"ref_42","doi-asserted-by":"crossref","unstructured":"Citterio, L.A., Mancuso, R., Agostini, S., Meloni, M., and Clerici, M. (2023). Serum and Exosomal miR-7-1-5p and miR-223-3p as Possible Biomarkers for Parkinson\u2019s Disease. Biomolecules, 13.","DOI":"10.3390\/biom13050865"},{"key":"ref_43","doi-asserted-by":"crossref","unstructured":"Li, S., Bi, G., Han, S., and Huang, R. (2022). MicroRNAs Play a Role in Parkinson\u2019s Disease by Regulating Microglia Function: From Pathogenetic Involvement to Therapeutic Potential. Front. Mol. Neurosci., 14.","DOI":"10.3389\/fnmol.2021.744942"},{"key":"ref_44","doi-asserted-by":"crossref","unstructured":"Wu, L., Xu, Q., Zhou, M., Chen, Y., Jiang, C., Jiang, Y., Lin, Y., He, Q., Zhao, L., and Dong, Y. (2022). Plasma miR-153 and miR-223 Levels as Potential Biomarkers in Parkinson\u2019s Disease. Front. Neurosci., 16.","DOI":"10.3389\/fnins.2022.865139"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"37043","DOI":"10.18632\/oncotarget.6158","article-title":"Altered microRNA profiles in cerebrospinal fluid exosome in Parkinson disease and Alzheimer disease","volume":"6","author":"Gui","year":"2015","journal-title":"Oncotarget"},{"key":"ref_46","doi-asserted-by":"crossref","unstructured":"Dong, H., Yan, J., Huang, P., Wang, X., Zhang, R., Zhang, C., Wang, W., Qian, W., Zhou, J., and Zhao, Y. (2024). miR-214-3p promotes the pathogenesis of Parkinson\u2019s disease by inhibiting autophagy. Biomed. Pharmacother., 171.","DOI":"10.1016\/j.biopha.2024.116123"},{"key":"ref_47","doi-asserted-by":"crossref","unstructured":"Li, L., Ren, J., Pan, C., Li, Y., Xu, J., Dong, H., Chen, Y., and Liu, W. (2021). Serum miR-214 Serves as a Biomarker for Prodromal Parkinson\u2019s Disease. Front. Aging Neurosci., 13.","DOI":"10.3389\/fnagi.2021.700959"},{"key":"ref_48","first-page":"8683877","article-title":"Diagnostic Test to Identify Parkinson\u2019s Disease from the Blood Sera of Chinese Population: A Cross-Sectional Study","volume":"2022","author":"Tong","year":"2022","journal-title":"Park. Dis."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"1945","DOI":"10.4103\/1673-5374.221147","article-title":"MicroRNAs in Parkinson\u2019s disease and emerging therapeutic targets","volume":"12","author":"Martinez","year":"2017","journal-title":"Neural Regen. Res."},{"key":"ref_50","doi-asserted-by":"crossref","unstructured":"Anastasi, F., Masciandaro, S.M., Carratore, R.D., Dell\u2019Anno, M.T., Signore, G., Falleni, A., McDonnel, L.A., and Bongioanni, P. (2021). Proteomics Profiling of Neuron-Derived Small Extracellular Vesicles from Human Plasma: Enabling Single-Subject Analysis. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22062951"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"1914","DOI":"10.1007\/s12035-022-03179-6","article-title":"Exosomes from Inflamed Macrophages Promote the Progression of Parkinson\u2019s Disease by Inducing Neuroinflammation","volume":"60","author":"Jin","year":"2023","journal-title":"Mol. Neurobiol."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ensci.2018.09.002","article-title":"Differential expression of miRNA 155 and miRNA 146a in Parkinson\u2019s disease patients","volume":"13","author":"Caggiu","year":"2018","journal-title":"eNeurologicalSci"},{"key":"ref_53","doi-asserted-by":"crossref","unstructured":"Nies, Y.H., Mohamad Najib, N.H., Lim, W.L., Kamaruzzaman, M.A., Yahaya, M.F., and Heoh, S.L. (2021). MicroRNA Dysregulation in Parkinson\u2019s Disease: A Narrative Review. Front. Neurosci., 15.","DOI":"10.3389\/fnins.2021.660379"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"1020","DOI":"10.1007\/s11064-020-02977-5","article-title":"Astrocyte-Derived Exosomal microRNA miR-200a-3p Prevents MPP+-Induced Apoptotic Cell Death through Down-Regulation of MKK4","volume":"45","author":"Shakespear","year":"2020","journal-title":"Neurochem. Res."}],"container-title":["Biomolecules"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2218-273X\/14\/8\/1000\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T15:35:58Z","timestamp":1760110558000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2218-273X\/14\/8\/1000"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8,13]]},"references-count":54,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2024,8]]}},"alternative-id":["biom14081000"],"URL":"https:\/\/doi.org\/10.3390\/biom14081000","relation":{},"ISSN":["2218-273X"],"issn-type":[{"value":"2218-273X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,8,13]]}}}