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plan","award":["62363028"],"award-info":[{"award-number":["62363028"]}]},{"name":"Jiangxi Provincial Science and Technology Department key research and development plan","award":["2024SSY06251"],"award-info":[{"award-number":["2024SSY06251"]}]},{"name":"Jiangxi Provincial Science and Technology Department key research and development plan","award":["GJJ218901"],"award-info":[{"award-number":["GJJ218901"]}]},{"name":"Jiangxi Provincial Science and Technology Department key research and development plan","award":["2024ZD003"],"award-info":[{"award-number":["2024ZD003"]}]},{"name":"Jiangxi Provincial Science and Technology Department key research and development plan","award":["20232BBG70026"],"award-info":[{"award-number":["20232BBG70026"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biomolecules"],"abstract":"<jats:p>Systemic sclerosis (SSc) is a chronic disease of the connective tissue characterized by its multifaceted impact on various bodily systems, yet its precise cause remains elusive. Central to its pathology are abnormal immune activation, vasculopathy, and consequent fibrosis affecting both the skin and internal organs. The intricate interplay between the innate and adaptive immune systems significantly influences the pathogenesis of SSc. Despite substantial research, the role of neutrophils, key players in innate immunity, in the context of SSc has remained enigmatic. Emerging evidence suggests that neutrophils not only contribute to the initiation and perpetuation of SSc but also inflict damage on organs and promote fibrosis\u2014a hallmark of the disease in many patients. This review aims to investigate the nuanced involvement of neutrophils in the development of SSc. By shedding light on the intricate mechanisms through which neutrophils influence the pathogenesis of SSc, we can gain deeper insights into the disease process and potentially identify novel therapeutic targets. Understanding the precise role of neutrophils may pave the way for more targeted and effective interventions to alleviate the burden of SSc on affected individuals.<\/jats:p>","DOI":"10.3390\/biom14091054","type":"journal-article","created":{"date-parts":[[2024,8,26]],"date-time":"2024-08-26T01:48:49Z","timestamp":1724636929000},"page":"1054","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["The Phenotypes and Functions of Neutrophils in Systemic Sclerosis"],"prefix":"10.3390","volume":"14","author":[{"given":"Jiao","family":"Luo","sequence":"first","affiliation":[{"name":"Jiangxi Province Key Laboratory of Immunity and Inflammation, Jiangxi Provincial People\u2019s Hospital, Nanchang 330000, China"},{"name":"Department of Rheumatology and Clinical Immunology, Jiangxi Provincial People\u2019s Hospital, the First Affiliated Hospital of Nanchang Medical College, Nanchang 330000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhongming","family":"Xie","sequence":"additional","affiliation":[{"name":"Jiangxi Province Key Laboratory of Immunity and Inflammation, Jiangxi Provincial People\u2019s Hospital, Nanchang 330000, China"},{"name":"Department of Rheumatology and Clinical Immunology, Jiangxi Provincial People\u2019s Hospital, the First Affiliated Hospital of Nanchang Medical College, Nanchang 330000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lihua","family":"Duan","sequence":"additional","affiliation":[{"name":"Jiangxi Province Key Laboratory of Immunity and Inflammation, Jiangxi Provincial People\u2019s Hospital, Nanchang 330000, China"},{"name":"Department of Rheumatology and Clinical Immunology, Jiangxi Provincial People\u2019s Hospital, the First Affiliated Hospital of Nanchang Medical College, Nanchang 330000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,8,25]]},"reference":[{"key":"ref_1","first-page":"202","article-title":"Scleroderma (systemic sclerosis): Classification, subsets and pathogenesis","volume":"15","author":"LeRoy","year":"1988","journal-title":"J. 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