{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T05:38:30Z","timestamp":1791005910041,"version":"4.1.0"},"reference-count":151,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2024,9,19]],"date-time":"2024-09-19T00:00:00Z","timestamp":1726704000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82371717"],"award-info":[{"award-number":["82371717"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["2024NSFSC0047"],"award-info":[{"award-number":["2024NSFSC0047"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Science and Technology Bureau of Sichuan Province","award":["82371717"],"award-info":[{"award-number":["82371717"]}]},{"name":"Science and Technology Bureau of Sichuan Province","award":["2024NSFSC0047"],"award-info":[{"award-number":["2024NSFSC0047"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biomolecules"],"abstract":"<jats:p>Lactate, an important metabolic product, provides energy to neural cells during energy depletion or high demand and acts as a signaling molecule in the central nervous system. Recent studies revealed that lactate-mediated protein lactylation regulates gene transcription and influences cell fate, metabolic processes, inflammation, and immune responses. This review comprehensively examines the regulatory roles and mechanisms of lactylation in neurodevelopment, neuropsychiatric disorders, brain tumors, and cerebrovascular diseases. This analysis indicates that lactylation has multifaceted effects on central nervous system function and pathology, particularly in hypoxia-induced brain damage. Highlighting its potential as a novel therapeutic target, lactylation may play a significant role in treating neurological diseases. By summarizing current findings, this review aims to provide insights and guide future research and clinical strategies for central nervous system disorders.<\/jats:p>","DOI":"10.3390\/biom14091175","type":"journal-article","created":{"date-parts":[[2024,9,19]],"date-time":"2024-09-19T04:59:54Z","timestamp":1726721994000},"page":"1175","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["Lactylation: A Novel Post-Translational Modification with Clinical Implications in CNS Diseases"],"prefix":"10.3390","volume":"14","author":[{"given":"Junyan","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Pediatrics\/Key Laboratory of Birth Defects and Related Diseases of Women and Children (Ministry of Education)\/NHC Key Laboratory of Chronobiology, West China Second University Hospital, Sichuan University, Chengdu 610041, China"},{"name":"Neonatal Intensive Care Unit, Binzhou Medical University Hospital, Binzhou 256600, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fengyan","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Pediatrics\/Key Laboratory of Birth Defects and Related Diseases of Women and Children (Ministry of Education)\/NHC Key Laboratory of Chronobiology, West China Second University Hospital, Sichuan University, Chengdu 610041, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9993-8810","authenticated-orcid":false,"given":"Yi","family":"Qu","sequence":"additional","affiliation":[{"name":"Department of Pediatrics\/Key Laboratory of Birth Defects and Related Diseases of Women and Children (Ministry of Education)\/NHC Key Laboratory of Chronobiology, West China Second University Hospital, Sichuan University, Chengdu 610041, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,9,19]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1745","DOI":"10.1113\/JP278810","article-title":"Revisiting the Warburg effect: Historical dogma versus current understanding","volume":"599","author":"Vaupel","year":"2021","journal-title":"J. Physiol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"e2003732","DOI":"10.1002\/advs.202003732","article-title":"DDIT3 Directs a Dual Mechanism to Balance Glycolysis and Oxidative Phosphorylation during Glutamine Deprivation","volume":"8","author":"Li","year":"2021","journal-title":"Adv. Sci."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1016\/j.tem.2022.07.004","article-title":"Understanding lactate sensing and signalling","volume":"33","author":"Certo","year":"2022","journal-title":"Trends Endocrinol. Metab. TEM"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1945","DOI":"10.1016\/j.ccell.2023.09.012","article-title":"Tumor-resident Lactobacillus iners confer chemoradiation resistance through lactate-induced metabolic rewiring","volume":"41","author":"Colbert","year":"2023","journal-title":"Cancer Cell"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1887","DOI":"10.1038\/s42255-023-00912-w","article-title":"PDK4-dependent hypercatabolism and lactate production of senescent cells promotes cancer malignancy","volume":"5","author":"Dou","year":"2023","journal-title":"Nat. Metab."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1038\/s41392-022-01151-3","article-title":"Lactate metabolism in human health and disease","volume":"7","author":"Li","year":"2022","journal-title":"Signal Transduct. Target. Ther."},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Wu, A., Lee, D., and Xiong, W.C. (2023). Lactate Metabolism, Signaling, and Function in Brain Development, Synaptic Plasticity, Angiogenesis, and Neurodegenerative Diseases. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms241713398"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1038\/s41586-019-1678-1","article-title":"Metabolic regulation of gene expression by histone lactylation","volume":"574","author":"Zhang","year":"2019","journal-title":"Nature"},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Wang, J., Wang, Z., Wang, Q., Li, X., and Guo, Y. (2024). Ubiquitous protein lactylation in health and diseases. Cell. Mol. Biol. Lett., 29.","DOI":"10.1186\/s11658-024-00541-5"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"e30726","DOI":"10.1016\/j.heliyon.2024.e30726","article-title":"Integrated single-cell and bulk RNA-sequencing data reveal molecular subtypes based on lactylation-related genes and prognosis and therapeutic response in glioma","volume":"10","author":"Lu","year":"2024","journal-title":"Heliyon"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1038\/s41467-023-44121-1","article-title":"Histone lactylation couples cellular metabolism with developmental gene regulatory networks","volume":"15","author":"Merkuri","year":"2024","journal-title":"Nat. Commun."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"29","DOI":"10.4103\/NRR.NRR-D-23-00805","article-title":"Microglia lactylation in relation to central nervous system diseases","volume":"20","author":"Yang","year":"2025","journal-title":"Neural Regen. Res."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1989","DOI":"10.1007\/s10571-022-01277-6","article-title":"Global-Scale Profiling of Differential Expressed Lysine-Lactylated Proteins in the Cerebral Endothelium of Cerebral Ischemia-Reperfusion Injury Rats","volume":"43","author":"Yao","year":"2023","journal-title":"Cell. Mol. Neurobiol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1038\/s42255-020-0243-4","article-title":"Lactate: The ugly duckling of energy metabolism","volume":"2","author":"Rabinowitz","year":"2020","journal-title":"Nat. Metab."},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Brooks, G.A. (2020). Lactate as a fulcrum of metabolism. Redox Biol., 35.","DOI":"10.1016\/j.redox.2020.101454"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1038\/s42255-020-0172-2","article-title":"We need to talk about the Warburg effect","volume":"2","author":"DeBerardinis","year":"2020","journal-title":"Nat. Metab."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/j.cmet.2017.06.021","article-title":"Neuronal Stimulation Triggers Neuronal Glycolysis and Not Lactate Uptake","volume":"26","author":"Mongeon","year":"2017","journal-title":"Cell Metab."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1111\/jnc.15867","article-title":"Lactate as a supplemental fuel for synaptic transmission and neuronal network oscillations: Potentials and limitations","volume":"168","author":"Kann","year":"2024","journal-title":"J. Neurochem."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1042\/EBC20220075","article-title":"Cross-talk between energy and redox metabolism in astrocyte-neuron functional cooperation","volume":"67","author":"Almeida","year":"2023","journal-title":"Essays Biochem."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1016\/j.cmet.2011.08.016","article-title":"Brain energy metabolism: Focus on astrocyte-neuron metabolic cooperation","volume":"14","author":"Allaman","year":"2011","journal-title":"Cell Metab."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1016\/j.cmet.2018.03.008","article-title":"The Science and Translation of Lactate Shuttle Theory","volume":"27","author":"Brooks","year":"2018","journal-title":"Cell Metab."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s13577-021-00622-z","article-title":"Lactate shuttle: From substance exchange to regulatory mechanism","volume":"35","author":"Wang","year":"2022","journal-title":"Hum. Cell"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1038\/s41467-023-36209-5","article-title":"Astrocytic lactate dehydrogenase A regulates neuronal excitability and depressive-like behaviors through lactate homeostasis in mice","volume":"14","author":"Yao","year":"2023","journal-title":"Nat. Commun."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"e71424","DOI":"10.7554\/eLife.71424","article-title":"Lactate is an energy substrate for rodent cortical neurons and enhances their firing activity","volume":"10","author":"Karagiannis","year":"2021","journal-title":"eLife"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1038\/ncb1881","article-title":"The bioenergetic and antioxidant status of neurons is controlled by continuous degradation of a key glycolytic enzyme by APC\/C-Cdh1","volume":"11","author":"Almeida","year":"2009","journal-title":"Nat. Cell Biol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1038\/s41583-022-00641-1","article-title":"Astrocyte contribution to dysfunction, risk and progression in neurodegenerative disorders","volume":"24","author":"Brandebura","year":"2023","journal-title":"Nat. Rev. Neurosci."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1042\/EBC20220080","article-title":"Astrocytes as metabolic suppliers to support neuronal activity and brain functions","volume":"67","author":"Roumes","year":"2023","journal-title":"Essays Biochem."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"2541","DOI":"10.1007\/s10571-023-01335-7","article-title":"Lactate and Lactylation in the Brain: Current Progress and Perspectives","volume":"43","author":"Li","year":"2023","journal-title":"Cell. Mol. Neurobiol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1038\/jcbfm.2013.222","article-title":"Glycolysis and oxidative phosphorylation in neurons and astrocytes during network activity in hippocampal slices","volume":"34","author":"Ivanov","year":"2014","journal-title":"J. Cereb. Blood Flow Metab. Off. J. Int. Soc. Cereb. Blood Flow Metab."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1152\/physrev.00062.2017","article-title":"Brain Glucose Metabolism: Integration of Energetics with Function","volume":"99","author":"Dienel","year":"2019","journal-title":"Physiol. Rev."},{"key":"ref_31","doi-asserted-by":"crossref","unstructured":"Bajaffer, A., Mineta, K., Magistretti, P., and Gojobori, T. (2022). Lactate-mediated neural plasticity genes emerged during the evolution of memory systems. Sci. Rep., 12.","DOI":"10.1038\/s41598-022-23784-8"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"2114","DOI":"10.1093\/cercor\/bhz226","article-title":"Ultrastructural Evidence for a Role of Astrocytes and Glycogen-Derived Lactate in Learning-Dependent Synaptic Stabilization","volume":"30","author":"Vezzoli","year":"2020","journal-title":"Cereb. Cortex"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1471-4159.2005.03168.x","article-title":"Monocarboxylate transporters in the central nervous system: Distribution, regulation and function","volume":"94","author":"Pierre","year":"2005","journal-title":"J. Neurochem."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"e2204619119","DOI":"10.1073\/pnas.2204619119","article-title":"Whole-brain neuronal MCT2 lactate transporter expression links metabolism to human brain structure and function","volume":"119","author":"Medel","year":"2022","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1007\/s13402-019-00479-3","article-title":"CD147 augmented monocarboxylate transporter-1\/4 expression through modulation of the Akt-FoxO3-NF-\u03baB pathway promotes cholangiocarcinoma migration and invasion","volume":"43","author":"Dana","year":"2020","journal-title":"Cell. Oncol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"1365","DOI":"10.1016\/j.neuron.2017.08.022","article-title":"Connexin 43-Mediated Astroglial Metabolic Networks Contribute to the Regulation of the Sleep-Wake Cycle","volume":"95","author":"Clasadonte","year":"2017","journal-title":"Neuron"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/0166-2236(96)10046-1","article-title":"Control of gap-junctional communication in astrocytic networks","volume":"19","author":"Giaume","year":"1996","journal-title":"Trends Neurosci."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1002\/jnr.23593","article-title":"The lactate receptor, G-protein-coupled receptor 81\/hydroxycarboxylic acid receptor 1: Expression and action in brain","volume":"93","author":"Morland","year":"2015","journal-title":"J. Neurosci. Res."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"109679","DOI":"10.1016\/j.isci.2024.109679","article-title":"The lactate receptor HCAR1: A key modulator of epileptic seizure activity","volume":"27","author":"Alessandri","year":"2024","journal-title":"iScience"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"1888","DOI":"10.1093\/brain\/awac419","article-title":"Glycolysis regulates neuronal excitability via lactate receptor, HCA1R","volume":"146","author":"Skwarzynska","year":"2023","journal-title":"Brain J. Neurol."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"4422","DOI":"10.1523\/JNEUROSCI.2092-18.2019","article-title":"The Lactate Receptor HCAR1 Modulates Neuronal Network Activity through the Activation of G(\u03b1) and G(\u03b2\u03b3) Subunits","volume":"39","author":"Briquet","year":"2019","journal-title":"J. Neurosci. Off. J. Soc. Neurosci."},{"key":"ref_42","doi-asserted-by":"crossref","unstructured":"Herrera-L\u00f3pez, G., Griego, E., and Galv\u00e1n, E.J. (2020). Lactate induces synapse-specific potentiation on CA3 pyramidal cells of rat hippocampus. PLoS ONE, 15.","DOI":"10.1371\/journal.pone.0242309"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1038\/nrn.2018.19","article-title":"Lactate in the brain: From metabolic end-product to signalling molecule","volume":"19","author":"Magistretti","year":"2018","journal-title":"Nat. Rev. Neurosci."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"810","DOI":"10.1016\/j.cell.2011.02.018","article-title":"Astrocyte-neuron lactate transport is required for long-term memory formation","volume":"144","author":"Suzuki","year":"2011","journal-title":"Cell"},{"key":"ref_45","doi-asserted-by":"crossref","unstructured":"Ding, R., Tan, Y., Du, A., Wen, G., Ren, X., Yao, H., Ren, W., Liu, H., Wang, X., and Yu, H. (2020). Redistribution of Monocarboxylate 1 and 4 in Hippocampus and Spatial Memory Impairment Induced by Long-term Ketamine Administration. Front. Behav. Neurosci., 14.","DOI":"10.3389\/fnbeh.2020.00060"},{"key":"ref_46","doi-asserted-by":"crossref","unstructured":"Tadi, M., Allaman, I., Lengacher, S., Grenningloh, G., and Magistretti, P.J. (2015). Learning-Induced Gene Expression in the Hippocampus Reveals a Role of Neuron -Astrocyte Metabolic Coupling in Long Term Memory. PLoS ONE, 10.","DOI":"10.1371\/journal.pone.0141568"},{"key":"ref_47","doi-asserted-by":"crossref","unstructured":"Netzahualcoyotzi, C., and Pellerin, L. (2020). Neuronal and astroglial monocarboxylate transporters play key but distinct roles in hippocampus-dependent learning and memory formation. Prog. Neurobiol., 194.","DOI":"10.1016\/j.pneurobio.2020.101888"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"2681","DOI":"10.1007\/s00429-022-02563-1","article-title":"Astrocyte-derived lactate\/NADH alters methamphetamine-induced memory consolidation and retrieval by regulating neuronal synaptic plasticity in the dorsal hippocampus","volume":"227","author":"Tan","year":"2022","journal-title":"Brain Struct. Funct."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"12228","DOI":"10.1073\/pnas.1322912111","article-title":"Lactate promotes plasticity gene expression by potentiating NMDA signaling in neurons","volume":"111","author":"Yang","year":"2014","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"2632","DOI":"10.1002\/jnr.22103","article-title":"N-methyl-D-aspartate-stimulated ERK1\/2 signaling and the transcriptional up-regulation of plasticity-related genes are developmentally regulated following in vitro neuronal maturation","volume":"87","author":"Zhou","year":"2009","journal-title":"J. Neurosci. Res."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"1130","DOI":"10.1016\/j.cell.2022.02.011","article-title":"Receptor-associated independent cAMP nanodomains mediate spatiotemporal specificity of GPCR signaling","volume":"185","author":"Anton","year":"2022","journal-title":"Cell"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1016\/S0092-8674(00)81904-2","article-title":"Genetic demonstration of a role for PKA in the late phase of LTP and in hippocampus-based long-term memory","volume":"88","author":"Abel","year":"1997","journal-title":"Cell"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.bpsgos.2023.07.006","article-title":"Enhancing Associative Learning in Rats With a Computationally Designed Training Protocol","volume":"4","author":"Zhang","year":"2024","journal-title":"Biol. Psychiatry Glob. Open Sci."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1038\/s41580-018-0029-7","article-title":"Regulation of chromatin and gene expression by metabolic enzymes and metabolites","volume":"19","author":"Li","year":"2018","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"1833","DOI":"10.7150\/ijbs.91492","article-title":"Histone lactylation: From tumor lactate metabolism to epigenetic regulation","volume":"20","author":"Yu","year":"2024","journal-title":"Int. J. Biol. Sci."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1093\/nar\/gkaa1176","article-title":"Identification of lysine isobutyrylation as a new histone modification mark","volume":"49","author":"Zhu","year":"2021","journal-title":"Nucleic Acids Res."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"1456","DOI":"10.1021\/acs.accounts.2c00115","article-title":"Chiral Posttranslational Modification to Lysine \u03b5-Amino Groups","volume":"55","author":"Monda","year":"2022","journal-title":"Acc. Chem. Res."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1016\/j.chembiol.2019.11.005","article-title":"Non-enzymatic Lysine Lactoylation of Glycolytic Enzymes","volume":"27","author":"Gaffney","year":"2020","journal-title":"Cell Chem. Biol."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"104630","DOI":"10.1016\/j.isci.2022.104630","article-title":"Identification of lysine-lactylated substrates in gastric cancer cells","volume":"25","author":"Yang","year":"2022","journal-title":"iScience"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1186\/s13071-022-05315-6","article-title":"Systematic identification of the lysine lactylation in the protozoan parasite Toxoplasma gondii","volume":"15","author":"Zhao","year":"2022","journal-title":"Parasites Vectors"},{"key":"ref_61","doi-asserted-by":"crossref","unstructured":"Song, Y., Liu, X., Stielow, J.B., de Hoog, S., and Li, R. (2022). Post-translational changes in Phialophora verrucosa via lysine lactylation during prolonged presence in a patient with a CARD9-related immune disorder. Front. Immunol., 13.","DOI":"10.3389\/fimmu.2022.966457"},{"key":"ref_62","doi-asserted-by":"crossref","unstructured":"Gao, M., Zhang, N., and Liang, W. (2020). Systematic Analysis of Lysine Lactylation in the Plant Fungal Pathogen Botrytis cinerea. Front. Microbiol., 11.","DOI":"10.3389\/fmicb.2020.594743"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"e2200437","DOI":"10.1002\/pmic.202200437","article-title":"Global profiling of lysine lactylation in human lungs","volume":"23","author":"Yang","year":"2023","journal-title":"Proteomics"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1038\/s41392-022-01245-y","article-title":"Protein acylation: Mechanisms, biological functions and therapeutic targets","volume":"7","author":"Shang","year":"2022","journal-title":"Signal Transduct. Target. Ther."},{"key":"ref_65","doi-asserted-by":"crossref","unstructured":"Zeng, Q., Wang, K., Zhao, Y., Ma, Q., Chen, Z., and Huang, W. (2023). Effects of the Acetyltransferase p300 on Tumour Regulation from the Novel Perspective of Posttranslational Protein Modification. Biomolecules, 13.","DOI":"10.3390\/biom13030417"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1038\/s41422-023-00844-w","article-title":"\u03b1-myosin heavy chain lactylation maintains sarcomeric structure and function and alleviates the development of heart failure","volume":"33","author":"Zhang","year":"2023","journal-title":"Cell Res."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"eadc9465","DOI":"10.1126\/sciadv.adc9465","article-title":"Lactate promotes endothelial-to-mesenchymal transition via Snail1 lactylation after myocardial infarction","volume":"9","author":"Fan","year":"2023","journal-title":"Sci. Adv."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1186\/s12974-023-02879-7","article-title":"H3K18 lactylation of senescent microglia potentiates brain aging and Alzheimer\u2019s disease through the NF\u03baB signaling pathway","volume":"20","author":"Wei","year":"2023","journal-title":"J. Neuroinflamm."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1016\/j.immuni.2024.04.006","article-title":"Glucose-driven histone lactylation promotes the immunosuppressive activity of monocyte-derived macrophages in glioblastoma","volume":"57","author":"Ugolini","year":"2024","journal-title":"Immunity"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"e2309290","DOI":"10.1002\/advs.202309290","article-title":"Histone H3K9 Lactylation Confers Temozolomide Resistance in Glioblastoma via LUC7L2-Mediated MLH1 Intron Retention","volume":"11","author":"Yue","year":"2024","journal-title":"Adv. Sci."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"dev200049","DOI":"10.1242\/dev.200049","article-title":"Dynamic profiling and functional interpretation of histone lysine crotonylation and lactylation during neural development","volume":"149","author":"Dai","year":"2022","journal-title":"Development"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"2588","DOI":"10.1038\/s41467-020-16246-0","article-title":"KAT3-dependent acetylation of cell type-specific genes maintains neuronal identity in the adult mouse brain","volume":"11","author":"Lipinski","year":"2020","journal-title":"Nat. Commun."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"2102","DOI":"10.1002\/cbic.202000883","article-title":"Sirtuin 2 Regulates Protein LactoylLys Modifications","volume":"22","author":"Jennings","year":"2021","journal-title":"Chembiochem Eur. J. Chem. Biol."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1038\/s41421-022-00398-y","article-title":"SIRT2 functions as a histone delactylase and inhibits the proliferation and migration of neuroblastoma cells","volume":"8","author":"Zu","year":"2022","journal-title":"Cell Discov."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"eabi6696","DOI":"10.1126\/sciadv.abi6696","article-title":"Class I histone deacetylases (HDAC1-3) are histone lysine delactylases","volume":"8","author":"Zhang","year":"2022","journal-title":"Sci. Adv."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.1016\/j.neuron.2019.01.007","article-title":"HDAC1 and HDAC2 Regulate Intermediate Progenitor Positioning to Safeguard Neocortical Development","volume":"101","author":"Tang","year":"2019","journal-title":"Neuron"},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.1038\/nn.3165","article-title":"HMGA regulates the global chromatin state and neurogenic potential in neocortical precursor cells","volume":"15","author":"Kishi","year":"2012","journal-title":"Nat. Neurosci."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"882","DOI":"10.1038\/s42255-020-0267-9","article-title":"Glis1 facilitates induction of pluripotency via an epigenome-metabolome-epigenome signalling cascade","volume":"2","author":"Li","year":"2020","journal-title":"Nat. Metab."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/j.devcel.2020.03.005","article-title":"Metabolic Reprogramming Promotes Neural Crest Migration via Yap\/Tead Signaling","volume":"53","author":"Bhattacharya","year":"2020","journal-title":"Dev. Cell"},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.devcel.2023.11.018","article-title":"BACH1 changes microglial metabolism and affects astrogenesis during mouse brain development","volume":"59","author":"Wang","year":"2024","journal-title":"Dev. Cell"},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"109820","DOI":"10.1016\/j.celrep.2021.109820","article-title":"Protein lactylation induced by neural excitation","volume":"37","author":"Hagihara","year":"2021","journal-title":"Cell Rep."},{"key":"ref_82","doi-asserted-by":"crossref","unstructured":"Han, R., Liang, J., and Zhou, B. (2021). Glucose Metabolic Dysfunction in Neurodegenerative Diseases-New Mechanistic Insights and the Potential of Hypoxia as a Prospective Therapy Targeting Metabolic Reprogramming. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22115887"},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.schres.2020.09.003","article-title":"Evidence for altered energy metabolism, increased lactate, and decreased pH in schizophrenia brain: A focused review and meta-analysis of human postmortem and magnetic resonance spectroscopy studies","volume":"223","author":"Pruett","year":"2020","journal-title":"Schizophr. Res."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"1473","DOI":"10.4103\/1673-5374.387969","article-title":"Lactate: A prospective target for therapeutic intervention in psychiatric disease","volume":"19","author":"Cai","year":"2024","journal-title":"Neural Regen. Res."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1038\/s41586-022-04640-1","article-title":"Somatic genomic changes in single Alzheimer\u2019s disease neurons","volume":"604","author":"Miller","year":"2022","journal-title":"Nature"},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1038\/s41582-020-00435-y","article-title":"Neuroinflammation and microglial activation in Alzheimer disease: Where do we go from here?","volume":"17","author":"Leng","year":"2021","journal-title":"Nat. Rev. Neurol."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1186\/s12974-021-02309-6","article-title":"The semantics of microglia activation: Neuroinflammation, homeostasis, and stress","volume":"18","author":"Woodburn","year":"2021","journal-title":"J. Neuroinflamm."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1186\/s13024-022-00541-z","article-title":"Microglial lactate metabolism as a potential therapeutic target for Alzheimer\u2019s disease","volume":"17","author":"Zhao","year":"2022","journal-title":"Mol. Neurodegener."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1002\/glia.23760","article-title":"mTOR-mediated metabolic reprogramming shapes distinct microglia functions in response to lipopolysaccharide and ATP","volume":"68","author":"Hu","year":"2020","journal-title":"Glia"},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1111\/bpa.12704","article-title":"Iron accumulation in microglia triggers a cascade of events that leads to altered metabolism and compromised function in APP\/PS1 mice","volume":"29","author":"McIntosh","year":"2019","journal-title":"Brain Pathol."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"1327","DOI":"10.1111\/j.1471-4159.2005.03132.x","article-title":"Lactate induces tumour necrosis factor-alpha, interleukin-6 and interleukin-1beta release in microglial- and astroglial-enriched primary cultures","volume":"93","author":"Andersson","year":"2005","journal-title":"J. Neurochem."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1016\/j.cmet.2022.02.013","article-title":"Positive feedback regulation of microglial glucose metabolism by histone H4 lysine 12 lactylation in Alzheimer\u2019s disease","volume":"34","author":"Pan","year":"2022","journal-title":"Cell Metab."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1186\/s40035-024-00402-3","article-title":"Emerging role of senescent microglia in brain aging-related neurodegenerative diseases","volume":"13","author":"Rim","year":"2024","journal-title":"Transl. Neurodegener."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1038\/d41586-019-03271-3","article-title":"Senescent cells feed on their neighbours","volume":"574","author":"Overholtzer","year":"2019","journal-title":"Nature"},{"key":"ref_95","doi-asserted-by":"crossref","unstructured":"Nohesara, S., Abdolmaleky, H.M., and Thiagalingam, S. (2024). Potential for New Therapeutic Approaches by Targeting Lactate and pH Mediated Epigenetic Dysregulation in Major Mental Diseases. Biomedicines, 12.","DOI":"10.3390\/biomedicines12020457"},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1186\/s12979-023-00390-4","article-title":"Exercise improves cognitive dysfunction and neuroinflammation in mice through Histone H3 lactylation in microglia","volume":"20","author":"Han","year":"2023","journal-title":"Immun. Ageing"},{"key":"ref_97","doi-asserted-by":"crossref","unstructured":"Qin, Q., Wang, D., Qu, Y., Li, J., An, K., Mao, Z., Li, J., Xiong, Y., Min, Z., and Xue, Z. (Res. Sq., 2023). Enhanced glycolysis-derived lactate promotes microglial activation in Parkinson\u2019s disease via histone lactylation, Res. Sq., preprint.","DOI":"10.21203\/rs.3.rs-3249462\/v1"},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"148409","DOI":"10.1016\/j.brainres.2023.148409","article-title":"Inhibition of glycolysis prevents behavioural changes in mice with MK801-induced SCZ model by alleviating lactate accumulation and lactylation","volume":"1812","author":"Xie","year":"2023","journal-title":"Brain Res."},{"key":"ref_99","doi-asserted-by":"crossref","unstructured":"Kozlakidis, Z., Shi, P., Abarbanel, G., Klein, C., and Sfera, A. (2023). Recent Developments in Protein Lactylation in PTSD and CVD: Novel Strategies and Targets. BioTech, 12.","DOI":"10.3390\/biotech12020038"},{"key":"ref_100","doi-asserted-by":"crossref","unstructured":"Khatibi, V.A., Salimi, M., Rahdar, M., Rezaei, M., Nazari, M., Dehghan, S., Davoudi, S., Raoufy, M.R., Mirnajafi-Zadeh, J., and Javan, M. (2023). Glycolysis inhibition partially resets epilepsy-induced alterations in the dorsal hippocampus-basolateral amygdala circuit involved in anxiety-like behavior. Sci. Rep., 13.","DOI":"10.1038\/s41598-023-33710-1"},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"216467","DOI":"10.1016\/j.canlet.2023.216467","article-title":"Histone lactylation-derived LINC01127 promotes the self-renewal of glioblastoma stem cells via the cis-regulating the MAP4K4 to activate JNK pathway","volume":"579","author":"Li","year":"2023","journal-title":"Cancer Lett."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1186\/s13046-023-02815-w","article-title":"Oxamate enhances the efficacy of CAR-T therapy against glioblastoma via suppressing ectonucleotidases and CCR8 lactylation","volume":"42","author":"Sun","year":"2023","journal-title":"J. Exp. Clin. Cancer Res. CR"},{"key":"ref_103","doi-asserted-by":"crossref","unstructured":"Zhang, M., Zhao, Y., Liu, X., Ruan, X., Wang, P., Liu, L., Wang, D., Dong, W., Yang, C., and Xue, Y. (2023). Pseudogene MAPK6P4-encoded functional peptide promotes glioblastoma vasculogenic mimicry development. Commun. Biol., 6.","DOI":"10.1038\/s42003-023-05438-1"},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"1336","DOI":"10.1007\/s12033-022-00643-5","article-title":"Inhibition of the Glycolysis Prevents the Cerebral Infarction Progression Through Decreasing the Lactylation Levels of LCP1","volume":"65","author":"Zhang","year":"2023","journal-title":"Mol. Biotechnol."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"2054","DOI":"10.1016\/j.cmet.2024.05.016","article-title":"Astrocytic LRP1 enables mitochondria transfer to neurons and mitigates brain ischemic stroke by suppressing ARF1 lactylation","volume":"36","author":"Zhou","year":"2024","journal-title":"Cell Metab."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1186\/s13045-024-01544-7","article-title":"Understanding the immunosuppressive microenvironment of glioma: Mechanistic insights and clinical perspectives","volume":"17","author":"Lin","year":"2024","journal-title":"J. Hematol. Oncol."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1016\/j.semcancer.2020.12.003","article-title":"Glioblastoma-initiating cell heterogeneity generated by the cell-of-origin, genetic\/epigenetic mutation and microenvironment","volume":"82","author":"Kondo","year":"2022","journal-title":"Semin. Cancer Biol."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1186\/s12943-023-01723-z","article-title":"CAR-cell therapy in the era of solid tumor treatment: Current challenges and emerging therapeutic advances","volume":"22","author":"Maalej","year":"2023","journal-title":"Mol. Cancer"},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/B978-0-12-394309-5.00006-7","article-title":"Cell biology of ischemia\/reperfusion injury","volume":"298","author":"Kalogeris","year":"2012","journal-title":"Int. Rev. Cell Mol. Biol."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"15","DOI":"10.3892\/ijmm.2021.5070","article-title":"Neuronal injuries in cerebral infarction and ischemic stroke: From mechanisms to treatment (Review)","volume":"49","author":"Zhao","year":"2022","journal-title":"Int. J. Mol. Med."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1038\/s41580-020-0227-y","article-title":"Cellular adaptation to hypoxia through hypoxia inducible factors and beyond","volume":"21","author":"Lee","year":"2020","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1016\/S0092-8674(02)01085-1","article-title":"Regulation and destabilization of HIF-1alpha by ARD1-mediated acetylation","volume":"111","author":"Jeong","year":"2002","journal-title":"Cell"},{"key":"ref_113","doi-asserted-by":"crossref","unstructured":"Joo, H.Y., Jung, J.K., Kim, M.Y., Woo, S.R., Jeong, J.M., Park, E.R., Kim, Y.M., Park, J.J., Kim, J., and Yun, M. (2023). NADH elevation during chronic hypoxia leads to VHL-mediated HIF-1\u03b1 degradation via SIRT1 inhibition. Cell Biosci., 13.","DOI":"10.1186\/s13578-023-01130-3"},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"2225","DOI":"10.1016\/j.ijbiomac.2022.10.014","article-title":"HIF1\u03b1 lactylation enhances KIAA1199 transcription to promote angiogenesis and vasculogenic mimicry in prostate cancer","volume":"222","author":"Luo","year":"2022","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"1419","DOI":"10.1007\/s10753-022-01637-w","article-title":"Lactylation: A Passing Fad or the Future of Posttranslational Modification","volume":"45","author":"Xin","year":"2022","journal-title":"Inflammation"},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1038\/s41422-023-00864-6","article-title":"Hypoxia induces mitochondrial protein lactylation to limit oxidative phosphorylation","volume":"34","author":"Mao","year":"2024","journal-title":"Cell Res."},{"key":"ref_117","doi-asserted-by":"crossref","unstructured":"Zhao, Y., Jiang, J., Zhou, P., Deng, K., Liu, Z., Yang, M., Yang, X., Li, J., Li, R., and Xia, J. (2024). H3K18 lactylation-mediated VCAM1 expression promotes gastric cancer progression and metastasis via AKT-mTOR-CXCL1 axis. Biochem. Pharmacol., 222.","DOI":"10.1016\/j.bcp.2024.116120"},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1038\/s41420-024-01898-4","article-title":"Histone lactylation promotes malignant progression by facilitating USP39 expression to target PI3K\/AKT\/HIF-1\u03b1 signal pathway in endometrial carcinoma","volume":"10","author":"Wei","year":"2024","journal-title":"Cell Death Discov."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1038\/s41392-022-01064-1","article-title":"Signaling pathways involved in ischemic stroke: Molecular mechanisms and therapeutic interventions","volume":"7","author":"Qin","year":"2022","journal-title":"Signal Transduct. Target. Ther."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"1777","DOI":"10.1177\/0271678X221111600","article-title":"Cerebral ischemia in the developing brain","volume":"42","author":"Dietz","year":"2022","journal-title":"J. Cereb. Blood Flow Metab. Off. J. Int. Soc. Cereb. Blood Flow Metab."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1161\/CIRCRESAHA.122.320488","article-title":"Histone Lactylation Boosts Reparative Gene Activation Post-Myocardial Infarction","volume":"131","author":"Wang","year":"2022","journal-title":"Circ. Res."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"101923","DOI":"10.1016\/j.molmet.2024.101923","article-title":"Histone lactylation in macrophages is predictive for gene expression changes during ischemia induced-muscle regeneration","volume":"83","author":"Desgeorges","year":"2024","journal-title":"Mol. Metab."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1016\/j.kint.2024.04.016","article-title":"The glycolytic enzyme PFKFB3 drives kidney fibrosis through promoting histone lactylation-mediated NF-\u03baB family activation","volume":"106","author":"Wang","year":"2024","journal-title":"Kidney Int."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1038\/s41418-021-00841-9","article-title":"Lactate promotes macrophage HMGB1 lactylation, acetylation, and exosomal release in polymicrobial sepsis","volume":"29","author":"Yang","year":"2022","journal-title":"Cell Death Differ."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"3856","DOI":"10.7150\/thno.82607","article-title":"Hepatocyte HSPA12A inhibits macrophage chemotaxis and activation to attenuate liver ischemia\/reperfusion injury via suppressing glycolysis-mediated HMGB1 lactylation and secretion of hepatocytes","volume":"13","author":"Du","year":"2023","journal-title":"Theranostics"},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1093\/eurheartj\/ehac570","article-title":"Heart and brain interactions: Is small vessel disease a link?","volume":"44","author":"Pepine","year":"2023","journal-title":"Eur. Heart J."},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1038\/s41392-023-01673-4","article-title":"Gut liver brain axis in diseases: The implications for therapeutic interventions","volume":"8","author":"Yan","year":"2023","journal-title":"Signal Transduct. Target. Ther."},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1038\/s41392-023-01402-x","article-title":"A kidney-brain neural circuit drives progressive kidney damage and heart failure","volume":"8","author":"Cao","year":"2023","journal-title":"Signal Transduct. Target. Ther."},{"key":"ref_129","doi-asserted-by":"crossref","unstructured":"Mapunda, J.A., Tibar, H., Regragui, W., and Engelhardt, B. (2022). How Does the Immune System Enter the Brain?. Front. Immunol., 13.","DOI":"10.3389\/fimmu.2022.805657"},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.tig.2021.09.009","article-title":"Histone lactylation: Epigenetic mark of glycolytic switch","volume":"38","author":"Dai","year":"2022","journal-title":"Trends Genet. TIG"},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1186\/s12967-023-04842-9","article-title":"Post-translational protein lactylation modification in health and diseases: A double-edged sword","volume":"22","author":"Gong","year":"2024","journal-title":"J. Transl. Med."},{"key":"ref_132","doi-asserted-by":"crossref","unstructured":"Renner, O., Mayer, M., Leischner, C., Burkard, M., Berger, A., Lauer, U.M., Venturelli, S., and Bischoff, S.C. (2022). Systematic Review of Gossypol\/AT-101 in Cancer Clinical Trials. Pharmaceuticals, 15.","DOI":"10.3390\/ph15020144"},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"1362","DOI":"10.1126\/science.aaa1299","article-title":"Epilepsy treatment. Targeting LDH enzymes with a stiripentol analog to treat epilepsy","volume":"347","author":"Sada","year":"2015","journal-title":"Science"},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1007\/s00280-012-2045-1","article-title":"A phase I dose-escalation trial of 2-deoxy-D-glucose alone or combined with docetaxel in patients with advanced solid tumors","volume":"71","author":"Raez","year":"2013","journal-title":"Cancer Chemother. Pharmacol."},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"1388","DOI":"10.1002\/pros.21172","article-title":"Targeting tumor metabolism with 2-deoxyglucose in patients with castrate-resistant prostate cancer and advanced malignancies","volume":"70","author":"Stein","year":"2010","journal-title":"Prostate"},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1007\/s10637-013-0047-4","article-title":"Phase 1 trial of dichloroacetate (DCA) in adults with recurrent malignant brain tumors","volume":"32","author":"Dunbar","year":"2014","journal-title":"Investig. New Drugs"},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1007\/s10637-022-01235-5","article-title":"Phase II study of dichloroacetate, an inhibitor of pyruvate dehydrogenase, in combination with chemoradiotherapy for unresected, locally advanced head and neck squamous cell carcinoma","volume":"40","author":"Powell","year":"2022","journal-title":"Investig. New Drugs"},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"1429","DOI":"10.1158\/1078-0432.CCR-22-2263","article-title":"A Phase I Dose-escalation Study of AZD3965, an Oral Monocarboxylate Transporter 1 Inhibitor, in Patients with Advanced Cancer","volume":"29","author":"Halford","year":"2023","journal-title":"Clin. Cancer Res. Off. J. Am. Assoc. Cancer Res."},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1038\/s41392-021-00603-6","article-title":"Safety and efficacy of meplazumab in healthy volunteers and COVID-19 patients: A randomized phase 1 and an exploratory phase 2 trial","volume":"6","author":"Bian","year":"2021","journal-title":"Signal Transduct. Target. Ther."},{"key":"ref_140","doi-asserted-by":"crossref","unstructured":"Wang, X., Fan, W., Li, N., Ma, Y., Yao, M., Wang, G., He, S., Li, W., Tan, J., and Lu, Q. (2023). YY1 lactylation in microglia promotes angiogenesis through transcription activation-mediated upregulation of FGF2. Genome Biol., 24.","DOI":"10.1186\/s13059-023-02931-y"},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"1406","DOI":"10.1016\/j.cmet.2023.06.013","article-title":"Hexokinase 2-mediated gene expression via histone lactylation is required for hepatic stellate cell activation and liver fibrosis","volume":"35","author":"Rho","year":"2023","journal-title":"Cell Metab."},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"3372","DOI":"10.1002\/cncr.34974","article-title":"Recent histone deacetylase inhibitors in cancer therapy","volume":"129","author":"Parveen","year":"2023","journal-title":"Cancer"},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"e56052","DOI":"10.15252\/embr.202256052","article-title":"SIRT3-dependent delactylation of cyclin E2 prevents hepatocellular carcinoma growth","volume":"24","author":"Jin","year":"2023","journal-title":"EMBO Rep."},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"8287","DOI":"10.1021\/acs.jafc.1c00760","article-title":"Comprehensive Analysis of Lysine Lactylation in Rice (Oryza sativa) Grains","volume":"69","author":"Meng","year":"2021","journal-title":"J. Agric. Food Chem."},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"4497","DOI":"10.1016\/j.csbj.2021.08.013","article-title":"FSL-Kla: A few-shot learning-based multi-feature hybrid system for lactylation site prediction","volume":"19","author":"Jiang","year":"2021","journal-title":"Comput. Struct. Biotechnol. J."},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"e11","DOI":"10.1002\/imt2.11","article-title":"DeepKla: An attention mechanism-based deep neural network for protein lysine lactylation site prediction","volume":"1","author":"Lv","year":"2022","journal-title":"iMeta"},{"key":"ref_147","doi-asserted-by":"crossref","unstructured":"Lai, F.L., and Gao, F. (2023). Auto-Kla: A novel web server to discriminate lysine lactylation sites using automated machine learning. Brief. Bioinform., 24.","DOI":"10.1093\/bib\/bbad070"},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"3561","DOI":"10.1038\/s41467-024-47900-6","article-title":"HBO1 catalyzes lysine lactylation and mediates histone H3K9la to regulate gene transcription","volume":"15","author":"Niu","year":"2024","journal-title":"Nat. Commun."},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"3027","DOI":"10.1016\/j.apsb.2024.03.008","article-title":"ASF1A-dependent P300-mediated histone H3 lysine 18 lactylation promotes atherosclerosis by regulating EndMT","volume":"14","author":"Dong","year":"2024","journal-title":"Acta Pharm. Sinica. B"},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"2375","DOI":"10.1016\/j.cell.2024.04.002","article-title":"Alanyl-tRNA synthetase, AARS1, is a lactate sensor and lactyltransferase that lactylates p53 and contributes to tumorigenesis","volume":"187","author":"Zong","year":"2024","journal-title":"Cell"},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"6628","DOI":"10.1038\/s41467-022-34399-y","article-title":"YiaC and CobB regulate lysine lactylation in Escherichia coli","volume":"13","author":"Dong","year":"2022","journal-title":"Nat. Commun."}],"container-title":["Biomolecules"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2218-273X\/14\/9\/1175\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T15:59:22Z","timestamp":1760111962000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2218-273X\/14\/9\/1175"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9,19]]},"references-count":151,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2024,9]]}},"alternative-id":["biom14091175"],"URL":"https:\/\/doi.org\/10.3390\/biom14091175","relation":{},"ISSN":["2218-273X"],"issn-type":[{"value":"2218-273X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,9,19]]}}}