{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T23:09:00Z","timestamp":1785798540038,"version":"3.56.0"},"reference-count":67,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2024,9,25]],"date-time":"2024-09-25T00:00:00Z","timestamp":1727222400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Guangdong Medical Research Fund","award":["B2023366"],"award-info":[{"award-number":["B2023366"]}]},{"name":"Guangdong Medical Research Fund","award":["2020ST033"],"award-info":[{"award-number":["2020ST033"]}]},{"name":"Guangdong Provincial Science and Technology Major Projects","award":["B2023366"],"award-info":[{"award-number":["B2023366"]}]},{"name":"Guangdong Provincial Science and Technology Major Projects","award":["2020ST033"],"award-info":[{"award-number":["2020ST033"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biomolecules"],"abstract":"<jats:p>Chronic stress is a common cause of hair loss, involving inflammatory responses and changes in cellular signaling pathways. This study explores the mechanism of action of the SDF-1\/CXCR4 signaling axis in chronic stress-induced hair loss. The research indicates that SDF-1 promotes hair follicle growth through the PI3K\/Akt and JAK\/STAT signaling pathways. Transcriptome sequencing analysis was conducted to identify differentially expressed genes in the skin of normal and stressed mice, with key genes SDF-1\/CXCR4 selected through machine learning and a protein-protein interaction network established. A chronic stress mouse model was created, with injections of SDF-1 and AMD3100 administered to observe hair growth, weight changes, and behavioral alterations and validate hair follicle activity. Skin SDF-1 concentrations were measured, differentially expressed genes were screened, and pathways were enriched. Activation of the PI3K\/Akt and JAK\/STAT signaling pathways was assessed, and siRNA technology was used in vitro to inhibit the expression of SDF-1 or CXCR4. SDF-1 promoted hair follicle activity, with the combined injection of SDF-1 and AMD3100 weakening this effect. The activation of the PI3K\/Akt and JAK\/STAT signaling pathways was observed in the SDF-1 injection group, confirmed by Western blot and immunofluorescence. Silencing SDF-1 through siRNA-mediated inhibition reduced cell proliferation and migration abilities. SDF-1 promotes hair growth in chronic stress mice by activating the PI3K\/Akt and JAK\/STAT pathways, an effect reversible by AMD3100. The SDF-1\/CXCR4 axis may serve as a potential therapeutic target for stress-induced hair loss.<\/jats:p>","DOI":"10.3390\/biom14101206","type":"journal-article","created":{"date-parts":[[2024,9,25]],"date-time":"2024-09-25T16:16:37Z","timestamp":1727280997000},"page":"1206","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Impact of SDF-1 and AMD3100 on Hair Follicle Dynamics in a Chronic Stress Model"],"prefix":"10.3390","volume":"14","author":[{"given":"Yinglin","family":"Zhao","sequence":"first","affiliation":[{"name":"Department of Psychosomatic Medicine, Shantou University Mental Health Center, Wanji Industrial Zone, Taishan North Road, Shantou 515041, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenzi","family":"Liang","sequence":"additional","affiliation":[{"name":"Department of Histology and Embryology, Shantou University Medical College, No. 22 Xinling Road, Shantou 515041, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhehui","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Histology and Embryology, Shantou University Medical College, No. 22 Xinling Road, Shantou 515041, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiuwen","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Histology and Embryology, Shantou University Medical College, No. 22 Xinling Road, Shantou 515041, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changmin","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Histology and Embryology, Shantou University Medical College, No. 22 Xinling Road, Shantou 515041, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,9,25]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"NP631","DOI":"10.1093\/asj\/sjad073","article-title":"Use of Activated Platelet-Rich Plasma (A-PRP) on Alopecia: A Systematic Review and Meta-Analysis","volume":"43","author":"Morkuzu","year":"2023","journal-title":"Aesthetic Surg. 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