{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T03:48:57Z","timestamp":1784000937725,"version":"3.55.0"},"reference-count":90,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2024,10,10]],"date-time":"2024-10-10T00:00:00Z","timestamp":1728518400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"St. Petersburg State University, St. Petersburg, Russia","award":["95444211"],"award-info":[{"award-number":["95444211"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biomolecules"],"abstract":"<jats:p>There is a gap in existing knowledge of stress-triggered neurochemical and behavioral adaptations in females. This study was designed to explore the short-term consequences of a single social defeat (SD) on accumbal dopamine (DA) dynamics and related behaviors in female Wistar rats. During the SD procedure, rats demonstrated different stress-handling strategies, which were defined as active and passive coping. The \u201cactive\u201d subjects expressed a significantly higher level of activity directed toward handling stress experience, while the \u201cpassive\u201d ones showed an escalated freezing pattern. Remarkably, these opposite behavioral manifestations were negatively correlated. Twenty-four hours following the SD exposure, decreased immobility latency in the Porsolt test and cognitive augmentation in the new object recognition evaluation were evident, along with an increase in electrically evoked mesolimbic DA release in passive coping rats. Rats exhibiting an active pattern of responses showed insignificant changes in immobility and cognitive performance as well as in evoked mesolimbic DA response. Furthermore, the dynamics of the decline and recovery of DA efflux under the depletion protocol were significantly altered in the passive but not active female rats. Taken together, these data suggest that female rats with a passive coping strategy are more susceptible to developing behavioral and neurochemical alterations within 24 h after stress exposure. This observation may represent both maladaptive and protective responses of an organism on a short timescale.<\/jats:p>","DOI":"10.3390\/biom14101280","type":"journal-article","created":{"date-parts":[[2024,10,10]],"date-time":"2024-10-10T11:34:36Z","timestamp":1728560076000},"page":"1280","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Accumbal Dopamine Responses Are Distinct between Female Rats with Active and Passive Coping Strategies"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1222-6926","authenticated-orcid":false,"given":"Vsevolod V.","family":"Nemets","sequence":"first","affiliation":[{"name":"Institute of Translational Biomedicine, Saint Petersburg State University, 199034 Saint Petersburg, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ekaterina P.","family":"Vinogradova","sequence":"additional","affiliation":[{"name":"Department of High Neuros Activity, Saint Petersburg State University, 199034 Saint Petersburg, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-6576-3373","authenticated-orcid":false,"given":"Vladislav","family":"Zavialov","sequence":"additional","affiliation":[{"name":"Institute of Translational Biomedicine, Saint Petersburg State University, 199034 Saint Petersburg, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3744-8231","authenticated-orcid":false,"given":"Vladimir P.","family":"Grinevich","sequence":"additional","affiliation":[{"name":"Department of Neurobiology, Sirius University of Science and Technology, 354340 Sirius, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evgeny A.","family":"Budygin","sequence":"additional","affiliation":[{"name":"Department of Neurobiology, Sirius University of Science and Technology, 354340 Sirius, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raul R.","family":"Gainetdinov","sequence":"additional","affiliation":[{"name":"Institute of Translational Biomedicine, Saint Petersburg State University, 199034 Saint Petersburg, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,10,10]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1038\/mp.2009.94","article-title":"Sex, Trauma, Stress Hormones and Depression","volume":"15","author":"Young","year":"2010","journal-title":"Mol. 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