{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,30]],"date-time":"2026-08-30T02:51:15Z","timestamp":1788058275103,"version":"build-2784847793"},"reference-count":169,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2024,10,25]],"date-time":"2024-10-25T00:00:00Z","timestamp":1729814400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key R&amp;D Program of China","doi-asserted-by":"publisher","award":["2023YFC3503400"],"award-info":[{"award-number":["2023YFC3503400"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key R&amp;D Program of China","doi-asserted-by":"publisher","award":["22JR5RA914"],"award-info":[{"award-number":["22JR5RA914"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key R&amp;D Program of China","doi-asserted-by":"publisher","award":["23JRRA1490"],"award-info":[{"award-number":["23JRRA1490"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key R&amp;D Program of China","doi-asserted-by":"publisher","award":["2019-ZD-38"],"award-info":[{"award-number":["2019-ZD-38"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key R&amp;D Program of China","doi-asserted-by":"publisher","award":["20240060086"],"award-info":[{"award-number":["20240060086"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key R&amp;D Program of China","doi-asserted-by":"publisher","award":["20240060088"],"award-info":[{"award-number":["20240060088"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key R&amp;D Program of China","doi-asserted-by":"publisher","award":["20240060133"],"award-info":[{"award-number":["20240060133"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key R&amp;D Program of China","doi-asserted-by":"publisher","award":["20240060146"],"award-info":[{"award-number":["20240060146"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key R&amp;D Program of China","doi-asserted-by":"publisher","award":["20240060002"],"award-info":[{"award-number":["20240060002"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key R&amp;D Program of China","doi-asserted-by":"publisher","award":["20230060038"],"award-info":[{"award-number":["20230060038"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Gansu Province Natural Science Foundation","award":["2023YFC3503400"],"award-info":[{"award-number":["2023YFC3503400"]}]},{"name":"Gansu Province Natural Science Foundation","award":["22JR5RA914"],"award-info":[{"award-number":["22JR5RA914"]}]},{"name":"Gansu Province Natural Science Foundation","award":["23JRRA1490"],"award-info":[{"award-number":["23JRRA1490"]}]},{"name":"Gansu Province Natural Science Foundation","award":["2019-ZD-38"],"award-info":[{"award-number":["2019-ZD-38"]}]},{"name":"Gansu Province Natural Science Foundation","award":["20240060086"],"award-info":[{"award-number":["20240060086"]}]},{"name":"Gansu Province Natural Science Foundation","award":["20240060088"],"award-info":[{"award-number":["20240060088"]}]},{"name":"Gansu Province Natural Science Foundation","award":["20240060133"],"award-info":[{"award-number":["20240060133"]}]},{"name":"Gansu Province Natural Science Foundation","award":["20240060146"],"award-info":[{"award-number":["20240060146"]}]},{"name":"Gansu Province Natural Science Foundation","award":["20240060002"],"award-info":[{"award-number":["20240060002"]}]},{"name":"Gansu Province Natural Science Foundation","award":["20230060038"],"award-info":[{"award-number":["20230060038"]}]},{"name":"Gansu Province Joint Research Foundation","award":["2023YFC3503400"],"award-info":[{"award-number":["2023YFC3503400"]}]},{"name":"Gansu Province Joint Research Foundation","award":["22JR5RA914"],"award-info":[{"award-number":["22JR5RA914"]}]},{"name":"Gansu Province Joint Research Foundation","award":["23JRRA1490"],"award-info":[{"award-number":["23JRRA1490"]}]},{"name":"Gansu Province Joint Research Foundation","award":["2019-ZD-38"],"award-info":[{"award-number":["2019-ZD-38"]}]},{"name":"Gansu Province Joint Research Foundation","award":["20240060086"],"award-info":[{"award-number":["20240060086"]}]},{"name":"Gansu Province Joint Research Foundation","award":["20240060088"],"award-info":[{"award-number":["20240060088"]}]},{"name":"Gansu Province Joint Research Foundation","award":["20240060133"],"award-info":[{"award-number":["20240060133"]}]},{"name":"Gansu Province Joint Research Foundation","award":["20240060146"],"award-info":[{"award-number":["20240060146"]}]},{"name":"Gansu Province Joint Research Foundation","award":["20240060002"],"award-info":[{"award-number":["20240060002"]}]},{"name":"Gansu Province Joint Research Foundation","award":["20230060038"],"award-info":[{"award-number":["20230060038"]}]},{"name":"Lanzhou Municipal Science and Technology Development Guidance Project","award":["2023YFC3503400"],"award-info":[{"award-number":["2023YFC3503400"]}]},{"name":"Lanzhou Municipal Science and Technology Development Guidance Project","award":["22JR5RA914"],"award-info":[{"award-number":["22JR5RA914"]}]},{"name":"Lanzhou Municipal Science and Technology Development Guidance Project","award":["23JRRA1490"],"award-info":[{"award-number":["23JRRA1490"]}]},{"name":"Lanzhou Municipal Science and Technology Development Guidance Project","award":["2019-ZD-38"],"award-info":[{"award-number":["2019-ZD-38"]}]},{"name":"Lanzhou Municipal Science and Technology Development Guidance Project","award":["20240060086"],"award-info":[{"award-number":["20240060086"]}]},{"name":"Lanzhou Municipal Science and Technology Development Guidance Project","award":["20240060088"],"award-info":[{"award-number":["20240060088"]}]},{"name":"Lanzhou Municipal Science and Technology Development Guidance Project","award":["20240060133"],"award-info":[{"award-number":["20240060133"]}]},{"name":"Lanzhou Municipal Science and Technology Development Guidance Project","award":["20240060146"],"award-info":[{"award-number":["20240060146"]}]},{"name":"Lanzhou Municipal Science and Technology Development Guidance Project","award":["20240060002"],"award-info":[{"award-number":["20240060002"]}]},{"name":"Lanzhou Municipal Science and Technology Development Guidance Project","award":["20230060038"],"award-info":[{"award-number":["20230060038"]}]},{"name":"Lanzhou University 2024 College Students Innovation and Entrepreneurship Project","award":["2023YFC3503400"],"award-info":[{"award-number":["2023YFC3503400"]}]},{"name":"Lanzhou University 2024 College Students Innovation and Entrepreneurship Project","award":["22JR5RA914"],"award-info":[{"award-number":["22JR5RA914"]}]},{"name":"Lanzhou University 2024 College Students Innovation and Entrepreneurship Project","award":["23JRRA1490"],"award-info":[{"award-number":["23JRRA1490"]}]},{"name":"Lanzhou University 2024 College Students Innovation and Entrepreneurship Project","award":["2019-ZD-38"],"award-info":[{"award-number":["2019-ZD-38"]}]},{"name":"Lanzhou University 2024 College Students Innovation and Entrepreneurship Project","award":["20240060086"],"award-info":[{"award-number":["20240060086"]}]},{"name":"Lanzhou University 2024 College Students Innovation and Entrepreneurship Project","award":["20240060088"],"award-info":[{"award-number":["20240060088"]}]},{"name":"Lanzhou University 2024 College Students Innovation and Entrepreneurship Project","award":["20240060133"],"award-info":[{"award-number":["20240060133"]}]},{"name":"Lanzhou University 2024 College Students Innovation and Entrepreneurship Project","award":["20240060146"],"award-info":[{"award-number":["20240060146"]}]},{"name":"Lanzhou University 2024 College Students Innovation and Entrepreneurship Project","award":["20240060002"],"award-info":[{"award-number":["20240060002"]}]},{"name":"Lanzhou University 2024 College Students Innovation and Entrepreneurship Project","award":["20230060038"],"award-info":[{"award-number":["20230060038"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biomolecules"],"abstract":"<jats:p>Cellular senescence is a state of permanent cell cycle arrest and plays an important role in many vascular lesions. This study found that the cells of diabetic patients have more characteristics of senescence, which may cause microvascular complications. Cell senescence, as one of the common fates of cells, links microangiopathy and diabetes. Cell senescence in a high-glucose environment can partially elucidate the mechanism of diabetic microangiopathy, and various types of cellular senescence induced by it can promote the progression of diabetic microangiopathy. Still, the molecular mechanism of microangiopathy-related cellular senescence has not yet been clearly studied. Building on recent research evidence, we herein summarize the fundamental mechanisms underlying the development of cellular senescence in various microangiopathies associated with diabetes. We gradually explain how cellular senescence serves as a key driver of diabetic microangiopathy. At the same time, the treatment of basic senescence mechanisms such as cellular senescence may have a great impact on the pathogenesis of the disease, may be more effective in preventing the development of diabetic microangiopathy, and may provide new ideas for the clinical treatment and prognosis of diabetic microangiopathy.<\/jats:p>","DOI":"10.3390\/biom14111361","type":"journal-article","created":{"date-parts":[[2024,10,25]],"date-time":"2024-10-25T10:50:08Z","timestamp":1729853408000},"page":"1361","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Cellular Senescence: A Bridge Between Diabetes and Microangiopathy"],"prefix":"10.3390","volume":"14","author":[{"given":"Jiahui","family":"Liu","sequence":"first","affiliation":[{"name":"The First Clinical Medical College, Lanzhou University, Lanzhou 730000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Buyu","family":"Guo","sequence":"additional","affiliation":[{"name":"The First Clinical Medical College, Lanzhou University, Lanzhou 730000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qianqian","family":"Liu","sequence":"additional","affiliation":[{"name":"The First Clinical Medical College, Lanzhou University, Lanzhou 730000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guomao","family":"Zhu","sequence":"additional","affiliation":[{"name":"The First Clinical Medical College, Lanzhou University, Lanzhou 730000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaqi","family":"Wang","sequence":"additional","affiliation":[{"name":"The First Clinical Medical College, Lanzhou University, Lanzhou 730000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Na","family":"Wang","sequence":"additional","affiliation":[{"name":"The First Clinical Medical College, Lanzhou University, Lanzhou 730000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yichen","family":"Yang","sequence":"additional","affiliation":[{"name":"The First Clinical Medical College, Lanzhou University, Lanzhou 730000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Songbo","family":"Fu","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, The First Hospital of Lanzhou University, Lanzhou 730000, China"},{"name":"Gansu Province Clinical Research Center for Endocrine Disease, Lanzhou 730000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,10,25]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1038\/nrendo.2011.106","article-title":"Diabetes mellitus and periodontitis: A tale of two common interrelated diseases","volume":"7","author":"Lalla","year":"2011","journal-title":"Nat. Rev. Endocrinol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"423","DOI":"10.2147\/CEOR.S247498","article-title":"Healthcare Costs of Diabetes and Microvascular and Macrovascular Disease in Individuals with Incident Type 2 Diabetes Mellitus: A Ten-Year Longitudinal Study","volume":"12","author":"Visaria","year":"2020","journal-title":"Clin. Outcomes Res."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"581","DOI":"10.2337\/dc14-1687","article-title":"Change in medical spending attributable to diabetes: National data from 1987 to 2011","volume":"38","author":"Zhuo","year":"2015","journal-title":"Diabetes Care"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"4343","DOI":"10.1210\/jc.2017-01922","article-title":"Diabetic Microvascular Disease: An Endocrine Society Scientific Statement","volume":"102","author":"Barrett","year":"2017","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"3082","DOI":"10.1161\/ATVBAHA.112.300291","article-title":"Microvascular dysfunction is associated with a higher incidence of type 2 diabetes mellitus: A systematic review and meta-analysis","volume":"32","author":"Muris","year":"2012","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1016\/j.diabres.2013.12.012","article-title":"Microvascular dysfunction as a link between obesity, insulin resistance and hypertension","volume":"103","author":"Karaca","year":"2014","journal-title":"Diabetes Res. Clin. Pract."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1007\/s10741-013-9378-7","article-title":"Role of microangiopathy in diabetic cardiomyopathy","volume":"19","author":"Adameova","year":"2014","journal-title":"Heart Fail. Rev."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1016\/j.tcb.2018.02.001","article-title":"Hallmarks of Cellular Senescence","volume":"28","author":"Nehme","year":"2018","journal-title":"Trends Cell Biol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1101\/gad.235184.113","article-title":"Cellular senescence and its effector programs","volume":"28","author":"Salama","year":"2014","journal-title":"Genes. Dev."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1016\/j.cjca.2015.11.022","article-title":"Sirtuins, Cell Senescence, and Vascular Aging","volume":"32","author":"Kida","year":"2016","journal-title":"Can. J. Cardiol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1016\/S0531-5565(00)00180-7","article-title":"Cellular and molecular mechanisms of stress-induced premature senescence (SIPS) of human diploid fibroblasts and melanocytes","volume":"35","author":"Toussaint","year":"2000","journal-title":"Exp. Gerontol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"966","DOI":"10.1172\/JCI64098","article-title":"Cellular senescence and the senescent secretory phenotype: Therapeutic opportunities","volume":"123","author":"Tchkonia","year":"2013","journal-title":"J. Clin. Investig."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1415","DOI":"10.1016\/S1357-2725(02)00034-1","article-title":"From the Hayflick mosaic to the mosaics of ageing. Role of stress-induced premature senescence in human ageing","volume":"34","author":"Toussaint","year":"2002","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/j.mad.2017.07.001","article-title":"Stress, cell senescence and organismal ageing","volume":"170","author":"Passos","year":"2018","journal-title":"Mech. Ageing Dev."},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Uryga, A.K., Grootaert, M.O.J., Garrido, A.M., Oc, S., Foote, K., Chappell, J., Finigan, A., Rossiello, F., d\u2019Adda di Fagagna, F., and Aravani, D. (2021). Telomere damage promotes vascular smooth muscle cell senescence and immune cell recruitment after vessel injury. Commun. Biol., 4.","DOI":"10.1038\/s42003-021-02123-z"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1802","DOI":"10.1016\/j.bbadis.2018.08.008","article-title":"Endothelial cell senescence in aging-related vascular dysfunction","volume":"1865","author":"Jia","year":"2019","journal-title":"Biochim. Biophys. Acta Mol. Basis Dis."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.thromres.2016.09.019","article-title":"Endothelial cell senescence and thrombosis: Ageing clots","volume":"147","author":"Bochenek","year":"2016","journal-title":"Thromb. Res."},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Abouhish, H., Thounaojam, M.C., Jadeja, R.N., Gutsaeva, D.R., Powell, F.L., Khriza, M., Martin, P.M., and Bartoli, M. (2020). Inhibition of HDAC6 Attenuates Diabetes-Induced Retinal Redox Imbalance and Microangiopathy. Antioxidants, 9.","DOI":"10.3390\/antiox9070599"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"2289","DOI":"10.2337\/db14-1820","article-title":"Cellular Senescence in Type 2 Diabetes: A Therapeutic Opportunity","volume":"64","author":"Palmer","year":"2015","journal-title":"Diabetes"},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Tsai, Y.C., Kuo, P.L., Kuo, M.C., Hung, W.W., Wu, L.Y., Chang, W.A., Wu, P.H., Lee, S.C., Chen, H.C., and Hsu, Y.L. (2018). The Interaction of miR-378i-Skp2 Regulates Cell Senescence in Diabetic Nephropathy. J. Clin. Med., 7.","DOI":"10.3390\/jcm7120468"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1083\/jcb.201009094","article-title":"Four faces of cellular senescence","volume":"192","author":"Rodier","year":"2011","journal-title":"J. Cell Biol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"3","DOI":"10.18632\/aging.100871","article-title":"Markers of cellular senescence. Telomere shortening as a marker of cellular senescence","volume":"8","author":"Bernadotte","year":"2016","journal-title":"Aging"},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"(2020). Oncogene-Induced Senescence Uniquely Alters Genome Architecture. Cancer Discov., 10, 639.","DOI":"10.1158\/2159-8290.CD-RW2020-052"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"4212","DOI":"10.1093\/emboj\/cdg417","article-title":"Reversal of human cellular senescence: Roles of the p53 and p16 pathways","volume":"22","author":"Krtolica","year":"2003","journal-title":"EMBO J."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1038\/nm.4054","article-title":"p16(Ink4a)-induced senescence of pancreatic beta cells enhances insulin secretion","volume":"22","author":"Helman","year":"2016","journal-title":"Nat. Med."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1038\/nrm1987","article-title":"Regulation of the INK4b-ARF-INK4a tumour suppressor locus: All for one or one for all","volume":"7","author":"Gil","year":"2006","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"1238","DOI":"10.1172\/JCI95148","article-title":"Mechanisms and functions of cellular senescence","volume":"128","author":"Herranz","year":"2018","journal-title":"J. Clin. Investig."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1038\/ncb2466","article-title":"Telomeric DNA damage is irreparable and causes persistent DNA-damage-response activation","volume":"14","author":"Fumagalli","year":"2012","journal-title":"Nat. Cell Biol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1016\/S1097-2765(04)00256-4","article-title":"Telomere shortening triggers senescence of human cells through a pathway involving ATM, p53, and p21(CIP1), but not p16(INK4a)","volume":"14","author":"Herbig","year":"2004","journal-title":"Mol. Cell"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"1160","DOI":"10.1126\/science.1140321","article-title":"ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage","volume":"316","author":"Matsuoka","year":"2007","journal-title":"Science"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"rs3","DOI":"10.1126\/scisignal.2001034","article-title":"ATM-dependent and -independent dynamics of the nuclear phosphoproteome after DNA damage","volume":"3","author":"Bensimon","year":"2010","journal-title":"Sci. Signal."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1038\/nrc2440","article-title":"Living on a break: Cellular senescence as a DNA-damage response","volume":"8","year":"2008","journal-title":"Nat. Rev. Cancer"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1038\/nature02118","article-title":"A DNA damage checkpoint response in telomere-initiated senescence","volume":"426","author":"Reaper","year":"2003","journal-title":"Nature"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1016\/S0092-8674(00)81902-9","article-title":"Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a","volume":"88","author":"Serrano","year":"1997","journal-title":"Cell"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1111\/j.1474-9726.2006.00224.x","article-title":"Insulin resistance, oxidative stress, hypertension, and leukocyte telomere length in men from the Framingham Heart Study","volume":"5","author":"Demissie","year":"2006","journal-title":"Aging Cell"},{"key":"ref_36","doi-asserted-by":"crossref","unstructured":"Zhao, J., Miao, K., Wang, H., Ding, H., and Wang, D.W. (2013). Association between telomere length and type 2 diabetes mellitus: A meta-analysis. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0079993"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"15918","DOI":"10.3390\/ijms160715918","article-title":"Mitochondrial Oxidative Stress, Mitochondrial DNA Damage and Their Role in Age-Related Vascular Dysfunction","volume":"16","author":"Mikhed","year":"2015","journal-title":"Int. J. Mol. Sci."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"2394","DOI":"10.1039\/C7FO00161D","article-title":"Effects of bioactive compounds on senescence and components of senescence associated secretory phenotypes in vitro","volume":"8","author":"Ingrid","year":"2017","journal-title":"Food Funct."},{"key":"ref_39","doi-asserted-by":"crossref","unstructured":"Cadet, J., and Wagner, J.R. (2013). DNA base damage by reactive oxygen species, oxidizing agents, and UV radiation. Cold Spring Harb. Perspect. Biol., 5.","DOI":"10.1101\/cshperspect.a012559"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1038\/nrc3891","article-title":"Therapeutic opportunities within the DNA damage response","volume":"15","author":"Pearl","year":"2015","journal-title":"Nat. Rev. Cancer"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1039\/b201230h","article-title":"UV-induced DNA damage and repair: A review","volume":"1","author":"Sinha","year":"2002","journal-title":"Photochem. Photobiol. Sci."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1146\/annurev-physchem-040513-103605","article-title":"Biomolecular damage induced by ionizing radiation: The direct and indirect effects of low-energy electrons on DNA","volume":"66","author":"Alizadeh","year":"2015","journal-title":"Annu. Rev. Phys. Chem."},{"key":"ref_43","first-page":"1253","article-title":"Cisplatin induces cell cycle arrest and senescence via upregulating P53 and P21 expression in HepG2 cells","volume":"33","author":"Qu","year":"2013","journal-title":"Nan Fang Yi Ke Da Xue Xue Bao J. South. Med. Univ."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1016\/j.semcancer.2004.06.010","article-title":"Environmental and chemical carcinogenesis","volume":"14","author":"Wogan","year":"2004","journal-title":"Semin. Cancer Biol."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1038\/362709a0","article-title":"Instability and decay of the primary structure of DNA","volume":"362","author":"Lindahl","year":"1993","journal-title":"Nature"},{"key":"ref_46","doi-asserted-by":"crossref","unstructured":"Carusillo, A., and Mussolino, C. (2020). DNA Damage: From Threat to Treatment. Cells, 9.","DOI":"10.3390\/cells9071665"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1042\/bj20040095","article-title":"Senescence-associated changes in respiration and oxidative phosphorylation in primary human fibroblasts","volume":"380","author":"Hutter","year":"2004","journal-title":"Biochem. J."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/S0968-0004(02)02110-2","article-title":"Oxidative stress shortens telomeres","volume":"27","year":"2002","journal-title":"Trends Biochem. Sci."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"146","DOI":"10.2152\/jmi.51.146","article-title":"The p16INK4a-RB pathway: Molecular link between cellular senescence and tumor suppression","volume":"51","author":"Ohtani","year":"2004","journal-title":"J. Med. Investig."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/j.cell.2006.11.050","article-title":"PRAK is essential for ras-induced senescence and tumor suppression","volume":"128","author":"Sun","year":"2007","journal-title":"Cell"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1038\/nrendo.2011.138","article-title":"The role of mitochondria in insulin resistance and type 2 diabetes mellitus","volume":"8","author":"Szendroedi","year":"2011","journal-title":"Nat. Rev. Endocrinol."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1038\/414813a","article-title":"Biochemistry and molecular cell biology of diabetic complications","volume":"414","author":"Brownlee","year":"2001","journal-title":"Nature"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1002\/jcp.21063","article-title":"Oxidative stress and increased eNOS and NADPH oxidase expression in mouse microvessel endothelial cells","volume":"212","author":"Ding","year":"2007","journal-title":"J. Cell. Physiol."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"2795","DOI":"10.2337\/diabetes.52.11.2795","article-title":"Intermittent high glucose enhances apoptosis related to oxidative stress in human umbilical vein endothelial cells: The role of protein kinase C and NAD(P)H-oxidase activation","volume":"52","author":"Quagliaro","year":"2003","journal-title":"Diabetes"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.freeradbiomed.2018.10.417","article-title":"Mitochondria and cellular senescence: Implications for musculoskeletal ageing","volume":"132","author":"Habiballa","year":"2019","journal-title":"Free Radic. Biol. Med."},{"key":"ref_56","doi-asserted-by":"crossref","unstructured":"Ziegler, D.V., Martin, N., and Bernard, D. (2021). Cellular senescence links mitochondria-ER contacts and aging. Commun. Biol., 4.","DOI":"10.1038\/s42003-021-02840-5"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1016\/j.bbrc.2007.12.021","article-title":"Mitochondrial dysfunction is a possible cause of accelerated senescence of mesothelial cells exposed to high glucose","volume":"366","author":"Ksiazek","year":"2008","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1007\/s10545-009-1263-0","article-title":"Mitochondria and diabetes mellitus: Untangling a conflictive relationship?","volume":"32","author":"Schiff","year":"2009","journal-title":"J. Inherit. Metab. Dis."},{"key":"ref_59","doi-asserted-by":"crossref","unstructured":"Ferecatu, I., Le Floch, N., Bergeaud, M., Rodr\u00edguez-Enfedaque, A., Rincheval, V., Oliver, L., Vallette, F.M., Mignotte, B., and Vayssi\u00e8re, J.L. (2009). Evidence for a mitochondrial localization of the retinoblastoma protein. BMC Cell Biol., 10.","DOI":"10.1186\/1471-2121-10-50"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/acel.12287","article-title":"Mitochondrial effectors of cellular senescence: Beyond the free radical theory of aging","volume":"14","author":"Ziegler","year":"2015","journal-title":"Aging Cell"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1016\/j.bbrc.2017.07.094","article-title":"Endoplasmic reticulum stress participates in the progress of senescence and apoptosis of osteoarthritis chondrocytes","volume":"491","author":"Liu","year":"2017","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1038\/nrc3800","article-title":"The impact of the endoplasmic reticulum protein-folding environment on cancer development","volume":"14","author":"Wang","year":"2014","journal-title":"Nat. Reviews. Cancer"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"924","DOI":"10.1093\/gerona\/glu129","article-title":"ER Stress Response in Human Cellular Models of Senescence","volume":"70","author":"Matos","year":"2015","journal-title":"J. Gerontol. Ser. A Biol. Sci. Med. Sci."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"2443","DOI":"10.1242\/jcs.115.11.2443","article-title":"BiP is feed-back regulated by control of protein translation efficiency","volume":"115","author":"Bienert","year":"2002","journal-title":"J. Cell Sci."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"2422","DOI":"10.1096\/fj.201800836R","article-title":"The p38-activated ER stress-ATF6\u03b1 axis mediates cellular senescence","volume":"33","author":"Kim","year":"2019","journal-title":"Faseb J."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1038\/s41467-021-20993-z","article-title":"Calcium channel ITPR2 and mitochondria-ER contacts promote cellular senescence and aging","volume":"12","author":"Ziegler","year":"2021","journal-title":"Nat. Commun."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"67699","DOI":"10.18632\/oncotarget.11505","article-title":"ATF6\u03b1 regulates morphological changes associated with senescence in human fibroblasts","volume":"7","author":"Druelle","year":"2016","journal-title":"Oncotarget"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1016\/S0140-6736(13)60687-X","article-title":"Chronic kidney disease: Global dimension and perspectives","volume":"382","author":"Jha","year":"2013","journal-title":"Lancet"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.cellsig.2013.10.002","article-title":"Receptor for advanced glycation end-products promotes premature senescence of proximal tubular epithelial cells via activation of endoplasmic reticulum stress-dependent p21 signaling","volume":"26","author":"Liu","year":"2014","journal-title":"Cell Signal"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"C621","DOI":"10.1152\/ajpcell.00096.2014","article-title":"Impact of ER stress-regulated ATF4\/p16 signaling on the premature senescence of renal tubular epithelial cells in diabetic nephropathy","volume":"308","author":"Liu","year":"2015","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1038\/s41419-018-0794-4","article-title":"Glutathione depletion induces ferroptosis, autophagy, and premature cell senescence in retinal pigment epithelial cells","volume":"9","author":"Sun","year":"2018","journal-title":"Cell Death Dis."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1038\/nrendo.2014.35","article-title":"Autophagy\u2014A key player in cellular and body metabolism","volume":"10","author":"Kim","year":"2014","journal-title":"Nat. Rev. Endocrinol."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"808","DOI":"10.4161\/auto.23922","article-title":"Autophagy and senescence: A partnership in search of definition","volume":"9","author":"Gewirtz","year":"2013","journal-title":"Autophagy"},{"key":"ref_74","first-page":"2912","article-title":"Impaired mitophagy leads to cigarette smoke stress-induced cellular senescence: Implications for chronic obstructive pulmonary disease","volume":"29","author":"Ahmad","year":"2015","journal-title":"FASEB J. Off. Publ. Fed. Am. Soc. Exp. Biol."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"607","DOI":"10.14348\/molcells.2017.0151","article-title":"Autophagy Is Pro-Senescence When Seen in Close-Up, but Anti-Senescence in Long-Shot","volume":"40","author":"Kwon","year":"2017","journal-title":"Mol. Cells"},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.fct.2017.10.056","article-title":"Autophagic cell death and premature senescence: New mechanism of 5-fluorouracil and sulforaphane synergistic anticancer effect in MDA-MB-231 triple negative breast cancer cell line","volume":"111","author":"Milczarek","year":"2018","journal-title":"Food Chem. Toxicol."},{"key":"ref_77","doi-asserted-by":"crossref","unstructured":"Ding, L., Cai, M., Chen, L., Yan, H., Lu, S., Pang, S., and Yan, B. (2021). Identification and functional study of GATA4 gene regulatory variants in type 2 diabetes mellitus. BMC Endocr. Disord., 21.","DOI":"10.1186\/s12902-021-00739-0"},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"aaa5612","DOI":"10.1126\/science.aaa5612","article-title":"The DNA damage response induces inflammation and senescence by inhibiting autophagy of GATA4","volume":"349","author":"Kang","year":"2015","journal-title":"Science"},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"1006","DOI":"10.1016\/j.cell.2008.03.038","article-title":"Chemokine signaling via the CXCR2 receptor reinforces senescence","volume":"133","author":"Acosta","year":"2008","journal-title":"Cell"},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1016\/j.cell.2008.03.039","article-title":"Oncogene-induced senescence relayed by an interleukin-dependent inflammatory network","volume":"133","author":"Kuilman","year":"2008","journal-title":"Cell"},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1016\/j.cell.2007.12.032","article-title":"Oncogenic BRAF induces senescence and apoptosis through pathways mediated by the secreted protein IGFBP7","volume":"132","author":"Wajapeyee","year":"2008","journal-title":"Cell"},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/j.it.2003.10.013","article-title":"Inflammation: The link between insulin resistance, obesity and diabetes","volume":"25","author":"Dandona","year":"2004","journal-title":"Trends Immunol."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1111\/j.1474-9726.2009.00466.x","article-title":"Endothelial dysfunction in aged humans is related with oxidative stress and vascular inflammation","volume":"8","author":"Vallejo","year":"2009","journal-title":"Aging Cell"},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1016\/j.jash.2016.08.005","article-title":"Orthostatic changes in systolic blood pressure among SPRINT participants at baseline","volume":"10","author":"Townsend","year":"2016","journal-title":"J. Am. Soc. Hypertens. JASH"},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1016\/j.jash.2018.04.004","article-title":"Diastolic blood pressure and risk profile in renal and cardiovascular diseases. Results from the SPRINT trial","volume":"12","author":"Pietropaoli","year":"2018","journal-title":"J. Am. Soc. Hypertens. JASH"},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1038\/nature05327","article-title":"Oncogene-induced senescence is a DNA damage response triggered by DNA hyper-replication","volume":"444","author":"Fumagalli","year":"2006","journal-title":"Nature"},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1016\/j.ccr.2006.10.003","article-title":"A negative feedback signaling network underlies oncogene-induced senescence","volume":"10","author":"Reczek","year":"2006","journal-title":"Cancer Cell"},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"2936","DOI":"10.1093\/emboj\/cdf289","article-title":"INK4a-deficient human diploid fibroblasts are resistant to RAS-induced senescence","volume":"21","author":"Brookes","year":"2002","journal-title":"EMBO J."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"3008","DOI":"10.1101\/gad.12.19.3008","article-title":"Premature senescence involving p53 and p16 is activated in response to constitutive MEK\/MAPK mitogenic signaling","volume":"12","author":"Lin","year":"1998","journal-title":"Genes. Dev."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"2167","DOI":"10.1158\/0008-5472.CAN-08-3772","article-title":"A role for CXCR2 in senescence, but what about in cancer?","volume":"69","author":"Acosta","year":"2009","journal-title":"Cancer Res."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"798","DOI":"10.1101\/gad.519709","article-title":"Autophagy mediates the mitotic senescence transition","volume":"23","author":"Young","year":"2009","journal-title":"Genes. Dev."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1038\/nature12437","article-title":"Synthetic lethal metabolic targeting of cellular senescence in cancer therapy","volume":"501","author":"Yu","year":"2013","journal-title":"Nature"},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"e1089","DOI":"10.1038\/cddis.2014.63","article-title":"Glucose metabolism and hexosamine pathway regulate oncogene-induced senescence","volume":"5","author":"Gitenay","year":"2014","journal-title":"Cell Death Dis."},{"key":"ref_94","doi-asserted-by":"crossref","unstructured":"Zhang, Y., Qiao, X., Liu, L., Han, W., Liu, Q., Wang, Y., Xie, T., Tang, Y., Wang, T., and Meng, J. (2022). Long noncoding RNA MAGI2-AS3 regulates the H(2)O(2) level and cell senescence via HSPA8. Redox Biol., 54.","DOI":"10.1016\/j.redox.2022.102383"},{"key":"ref_95","doi-asserted-by":"crossref","unstructured":"Zhou, L., Zeng, Y., Liu, Y., Du, K., Luo, Y., Dai, Y., Pan, W., Zhang, L., Zhang, L., and Tian, F. (2024). Cellular senescence and metabolic reprogramming model based on bulk\/single-cell RNA sequencing reveals PTGER4 as a therapeutic target for ccRCC. BMC Cancer, 24.","DOI":"10.1186\/s12885-024-12234-5"},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1016\/j.tcb.2023.12.004","article-title":"Crosstalk between gut microbiota and cellular senescence: A vicious cycle leading to aging gut","volume":"34","author":"Kawamoto","year":"2024","journal-title":"Trends Cell Biol."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/S1056-8719(00)00125-8","article-title":"The vascular system. An overview of structure and function","volume":"44","author":"Pugsley","year":"2000","journal-title":"J. Pharmacol. Toxicol. Methods"},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1016\/j.cmet.2021.01.011","article-title":"Pathological angiogenesis in retinopathy engages cellular senescence and is amenable to therapeutic elimination via BCL-xL inhibition","volume":"33","author":"Tsuruda","year":"2021","journal-title":"Cell Metab."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.1093\/cvr\/cvy059","article-title":"Neuregulin-1 attenuates stress-induced vascular senescence","volume":"114","author":"Shakeri","year":"2018","journal-title":"Cardiovasc. Res."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"174317","DOI":"10.1016\/j.ejphar.2021.174317","article-title":"Involvement of miR-199a-3p\/DDR1 in vascular endothelial cell senescence in diabetes","volume":"908","author":"Yan","year":"2021","journal-title":"Eur. J. Pharmacol."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1089\/ars.2016.6643","article-title":"Oxidative Stress-Induced miR-200c Disrupts the Regulatory Loop Among SIRT1, FOXO1, and eNOS","volume":"27","author":"Carlomosti","year":"2017","journal-title":"Antioxid. Redox Signal"},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1089\/ars.2011.4439","article-title":"The protein disulfide isomerase family: Key players in health and disease","volume":"16","author":"Benham","year":"2012","journal-title":"Antioxid. Redox Signal"},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"3565","DOI":"10.1016\/j.celrep.2018.05.054","article-title":"Redox Regulation of Mitochondrial Fission Protein Drp1 by Protein Disulfide Isomerase Limits Endothelial Senescence","volume":"23","author":"Kim","year":"2018","journal-title":"Cell Rep."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1186\/s12950-023-00366-7","article-title":"Colchicine prevents oxidative stress-induced endothelial cell senescence via blocking NF-\u03baB and MAPKs: Implications in vascular diseases","volume":"20","author":"Zhou","year":"2023","journal-title":"J Inflamm."},{"key":"ref_105","doi-asserted-by":"crossref","unstructured":"Zhou, H., Li, X., Rana, M., Cornelius, J.F., Khan, D., and Muhammad, S. (2023). mTOR Inhibitor Rapalink-1 Prevents Ethanol-Induced Senescence in Endothelial Cells. Cells, 12.","DOI":"10.3390\/cells12222609"},{"key":"ref_106","doi-asserted-by":"crossref","unstructured":"Wang, G., Han, B., Zhang, R., Liu, Q., Wang, X., Huang, X., Liu, D., Qiao, W., Yang, M., and Luo, X. (2021). C1q\/TNF-Related Protein 9 Attenuates Atherosclerosis by Inhibiting Hyperglycemia-Induced Endothelial Cell Senescence Through the AMPK\u03b1\/KLF4 Signaling Pathway. Front. Pharmacol., 12.","DOI":"10.3389\/fphar.2021.758792"},{"key":"ref_107","doi-asserted-by":"crossref","unstructured":"Sun, H., Zhu, X., Zhou, Y., Cai, W., and Qiu, L. (2017). C1q\/TNF-Related Protein-9 Ameliorates Ox-LDL-Induced Endothelial Dysfunction via PGC-1\u03b1\/AMPK-Mediated Antioxidant Enzyme Induction. Int. J. Mol. Sci., 18.","DOI":"10.3390\/ijms18061097"},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"2823","DOI":"10.1111\/jcmm.13196","article-title":"C1q\/TNF-related protein 9 inhibits the cholesterol-induced Vascular smooth muscle cell phenotype switch and cell dysfunction by activating AMP-dependent kinase","volume":"21","author":"Liu","year":"2017","journal-title":"J. Cell Mol. Med."},{"key":"ref_109","doi-asserted-by":"crossref","unstructured":"Ramdzan, Z.M., Vadnais, C., Pal, R., Vandal, G., Cadieux, C., Leduy, L., Davoudi, S., Hulea, L., Yao, L., and Karnezis, A.N. (2014). RAS transformation requires CUX1-dependent repair of oxidative DNA damage. PLoS Biol., 12.","DOI":"10.1371\/journal.pbio.1001807"},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"1056","DOI":"10.1002\/cbf.3543","article-title":"CircRNA-0077930 from hyperglycaemia-stimulated vascular endothelial cell exosomes regulates senescence in vascular smooth muscle cells","volume":"38","author":"Wang","year":"2020","journal-title":"Cell Biochem. Funct."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"1068","DOI":"10.1161\/STROKEAHA.115.010835","article-title":"Vascular Cell Senescence Contributes to Blood-Brain Barrier Breakdown","volume":"47","author":"Yamazaki","year":"2016","journal-title":"Stroke"},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1084\/jem.20150295","article-title":"The interaction of anticancer therapies with tumor-associated macrophages","volume":"212","author":"Mantovani","year":"2015","journal-title":"J. Exp. Med."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1016\/j.cmet.2017.07.019","article-title":"Regulation of Stem Cell Aging by Metabolism and Epigenetics","volume":"26","author":"Ren","year":"2017","journal-title":"Cell Metab."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"1146","DOI":"10.1002\/cbin.10833","article-title":"High glucose and free fatty acids induce endothelial progenitor cell senescence via PGC-1\u03b1\/SIRT1 signaling pathway","volume":"41","author":"Song","year":"2017","journal-title":"Cell Biol. Int."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/j.redox.2017.12.001","article-title":"Short-term sustained hyperglycaemia fosters an archetypal senescence-associated secretory phenotype in endothelial cells and macrophages","volume":"15","author":"Prattichizzo","year":"2018","journal-title":"Redox Biol."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"aay5356","DOI":"10.1126\/science.aay5356","article-title":"Neutrophil extracellular traps target senescent vasculature for tissue remodeling in retinopathy","volume":"369","author":"Binet","year":"2020","journal-title":"Science"},{"key":"ref_117","doi-asserted-by":"crossref","unstructured":"Lamoke, F., Shaw, S., Yuan, J., Ananth, S., Duncan, M., Martin, P., and Bartoli, M. (2015). Increased Oxidative and Nitrative Stress Accelerates Aging of the Retinal Vasculature in the Diabetic Retina. PLoS ONE, 10.","DOI":"10.1371\/journal.pone.0139664"},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"1643","DOI":"10.2337\/dc15-2171","article-title":"Global Estimates on the Number of People Blind or Visually Impaired by Diabetic Retinopathy: A Meta-analysis From 1990 to 2010","volume":"39","author":"Leasher","year":"2016","journal-title":"Diabetes Care"},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"412","DOI":"10.2337\/dc16-2641","article-title":"Diabetic Retinopathy: A Position Statement by the American Diabetes Association","volume":"40","author":"Solomon","year":"2017","journal-title":"Diabetes Care"},{"key":"ref_120","doi-asserted-by":"crossref","unstructured":"Santiago, A.R., Boia, R., Aires, I.D., Ambr\u00f3sio, A.F., and Fernandes, R. (2018). Sweet Stress: Coping With Vascular Dysfunction in Diabetic Retinopathy. Front. Physiol., 9.","DOI":"10.3389\/fphys.2018.00820"},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.freeradbiomed.2018.10.419","article-title":"Oxidative stress mediated by lipid metabolism contributes to high glucose-induced senescence in retinal pigment epithelium","volume":"130","author":"Chen","year":"2019","journal-title":"Free Radic. Biol. Med."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"e14331","DOI":"10.14814\/phy2.14331","article-title":"Glucose-induced oxidative stress and accelerated aging in endothelial cells are mediated by the depletion of mitochondrial SIRTs","volume":"8","author":"Liu","year":"2020","journal-title":"Physiol. Rep."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"394632017748841","DOI":"10.1177\/0394632017748841","article-title":"Ultrastructure of neurovascular changes in human diabetic retinopathy","volume":"31","author":"Taurone","year":"2018","journal-title":"Int. J. Immunopathol. Pharmacol."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"7495629","DOI":"10.1155\/2019\/7495629","article-title":"The Signaling of Cellular Senescence in Diabetic Nephropathy","volume":"2019","author":"Xiong","year":"2019","journal-title":"Oxid. Med. Cell Longev."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"1234059","DOI":"10.1155\/2020\/1234059","article-title":"Accelerated Kidney Aging in Diabetes Mellitus","volume":"2020","author":"Guo","year":"2020","journal-title":"Oxid. Med. Cell Longev."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1038\/s41419-017-0127-z","article-title":"Optineurin-mediated mitophagy protects renal tubular epithelial cells against accelerated senescence in diabetic nephropathy","volume":"9","author":"Chen","year":"2018","journal-title":"Cell Death Dis."},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/j.phymed.2018.09.030","article-title":"Effect of osthole on advanced glycation end products-induced renal tubular hypertrophy and role of klotho in its mechanism of action","volume":"53","author":"Kan","year":"2019","journal-title":"Phytomedicine"},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"8708236","DOI":"10.1155\/2020\/8708236","article-title":"Metformin Reduces the Senescence of Renal Tubular Epithelial Cells in Diabetic Nephropathy via the MBNL1\/miR-130a-3p\/STAT3 Pathway","volume":"2020","author":"Jiang","year":"2020","journal-title":"Oxid. Med. Cell Longev."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1007\/s11255-019-02165-7","article-title":"Role of tea polyphenols in delaying hyperglycemia-induced senescence in human glomerular mesangial cells via miR-126\/Akt-p53-p21 pathways","volume":"51","author":"Cao","year":"2019","journal-title":"Int. Urol. Nephrol."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1007\/s11596-018-1942-x","article-title":"Upregulation of MiR-126 Delays the Senescence of Human Glomerular Mesangial Cells Induced by High Glucose via Telomere-p53-p21-Rb Signaling Pathway","volume":"38","author":"Cao","year":"2018","journal-title":"Curr. Med. Sci."},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.mce.2015.09.024","article-title":"The function of miR-199a-5p\/Klotho regulating TLR4\/NF-\u03baB p65\/NGAL pathways in rat mesangial cells cultured with high glucose and the mechanism","volume":"417","author":"Wu","year":"2015","journal-title":"Mol. Cell Endocrinol."},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1055\/s-0044-101601","article-title":"Klotho Restraining Egr1\/TLR4\/mTOR Axis to Reducing the Expression of Fibrosis and Inflammatory Cytokines in High Glucose Cultured Rat Mesangial Cells","volume":"127","author":"Wu","year":"2019","journal-title":"Exp. Clin. Endocrinol. Diabetes"},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"2583","DOI":"10.2147\/DMSO.S256457","article-title":"The Effects of Puerarin on Autophagy Through Regulating of the PERK\/eIF2\u03b1\/ATF4 Signaling Pathway Influences Renal Function in Diabetic Nephropathy","volume":"13","author":"Xu","year":"2020","journal-title":"Diabetes Metab. Syndr. Obes."},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1016\/j.kint.2021.06.031","article-title":"The ketone body \u03b2-hydroxybutyrate mitigates the senescence response of glomerular podocytes to diabetic insults","volume":"100","author":"Fang","year":"2021","journal-title":"Kidney Int."},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1016\/j.bbrc.2020.11.061","article-title":"Klotho ameliorates diabetic nephropathy by activating Nrf2 signaling pathway in podocytes","volume":"534","author":"Xing","year":"2021","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"110490","DOI":"10.1016\/j.mce.2019.110490","article-title":"Klotho inhibits PKC\u03b1\/p66SHC-mediated podocyte injury in diabetic nephropathy","volume":"494","author":"Jiang","year":"2019","journal-title":"Mol. Cell Endocrinol."},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1016\/j.kint.2020.03.026","article-title":"Decoy receptor 2 mediation of the senescent phenotype of tubular cells by interacting with peroxiredoxin 1 presents a novel mechanism of renal fibrosis in diabetic nephropathy","volume":"98","author":"Jia","year":"2020","journal-title":"Kidney Int."},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"e13052","DOI":"10.1111\/cpr.13052","article-title":"Carbon monoxide alleviates senescence in diabetic nephropathy by improving autophagy","volume":"54","author":"Chen","year":"2021","journal-title":"Cell Prolif."},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1096\/fasebj.1.4.3308611","article-title":"The glomerular mesangial cell: An expanding role for a specialized pericyte","volume":"1","author":"Schlondorff","year":"1987","journal-title":"Faseb J."},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.ijcard.2017.08.068","article-title":"International standardization of diagnostic criteria for microvascular angina","volume":"250","author":"Ong","year":"2018","journal-title":"Int. J. Cardiol."},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/j.celrep.2013.01.005","article-title":"SIRT3 reverses aging-associated degeneration","volume":"3","author":"Brown","year":"2013","journal-title":"Cell Rep."},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"4203","DOI":"10.1093\/nar\/gkab161","article-title":"SIRT3 consolidates heterochromatin and counteracts senescence","volume":"49","author":"Diao","year":"2021","journal-title":"Nucleic Acids Res."},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1038\/s41401-020-0490-7","article-title":"Sirtuin 3 deficiency exacerbates diabetic cardiomyopathy via necroptosis enhancement and NLRP3 activation","volume":"42","author":"Song","year":"2021","journal-title":"Acta Pharmacol. Sin."},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"7355","DOI":"10.1007\/s00018-021-03979-4","article-title":"MicroRNA-34a: The bad guy in age-related vascular diseases","volume":"78","author":"Raucci","year":"2021","journal-title":"Cell Mol. Life Sci."},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1038\/nature11919","article-title":"MicroRNA-34a regulates cardiac ageing and function","volume":"495","author":"Boon","year":"2013","journal-title":"Nature"},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"1336","DOI":"10.1038\/s41418-017-0047-6","article-title":"Diabetes induces the activation of pro-ageing miR-34a in the heart, but has differential effects on cardiomyocytes and cardiac progenitor cells","volume":"25","author":"Saw","year":"2018","journal-title":"Cell Death Differ."},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1038\/s41419-017-0093-5","article-title":"Inhibition of p53 prevents diabetic cardiomyopathy by preventing early-stage apoptosis and cell senescence, reduced glycolysis, and impaired angiogenesis","volume":"9","author":"Gu","year":"2018","journal-title":"Cell Death Dis."},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"2132","DOI":"10.2337\/db13-0731","article-title":"The histone acetylase activator pentadecylidenemalonate 1b rescues proliferation and differentiation in the human cardiac mesenchymal cells of type 2 diabetic patients","volume":"63","author":"Vecellio","year":"2014","journal-title":"Diabetes"},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"2983","DOI":"10.1093\/eurheartj\/ehz919","article-title":"Senescence-induced inflammation: An important player and key therapeutic target in atherosclerosis","volume":"41","author":"Fiedler","year":"2020","journal-title":"Eur. Heart J."},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1038\/s41392-021-00765-3","article-title":"Mesenchymal stem cell-derived small extracellular vesicles mitigate oxidative stress-induced senescence in endothelial cells via regulation of miR-146a\/Src","volume":"6","author":"Xiao","year":"2021","journal-title":"Signal Transduct. Target. Ther."},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1002\/biof.1399","article-title":"Role of resveratrol in regulation of cellular defense systems against oxidative stress","volume":"44","author":"Truong","year":"2018","journal-title":"Biofactors"},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.canlet.2021.05.001","article-title":"Resveratrol for cancer therapy: Challenges and future perspectives","volume":"515","author":"Ren","year":"2021","journal-title":"Cancer Lett."},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1002\/biof.1400","article-title":"Effect of resveratrol and pterostilbene on aging and longevity","volume":"44","author":"Li","year":"2018","journal-title":"Biofactors"},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"4465","DOI":"10.1080\/10408398.2021.1875980","article-title":"Resveratrol supplementation and type 2 diabetes: A systematic review and meta-analysis","volume":"62","author":"Delpino","year":"2022","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"ref_155","doi-asserted-by":"crossref","first-page":"5435","DOI":"10.1007\/s11033-021-06550-3","article-title":"Protective effects of Quercetin and Resveratrol on aging markers in kidney under high glucose condition: In vivo and in vitro analysis","volume":"48","author":"Abharzanjani","year":"2021","journal-title":"Mol. Biol. Rep."},{"key":"ref_156","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1016\/j.phrs.2018.11.041","article-title":"Resveratrol ameliorates endothelial dysfunction in diabetic and obese mice through sirtuin 1 and peroxisome proliferator-activated receptor \u03b4","volume":"139","author":"Cheang","year":"2019","journal-title":"Pharmacol. Res."},{"key":"ref_157","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/j.bbrc.2015.10.126","article-title":"Effect of resveratrol on sirtuins expression and cardiac complications in diabetes","volume":"468","author":"Bagul","year":"2015","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_158","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/j.freeradbiomed.2016.04.013","article-title":"Ergothioneine oxidation in the protection against high-glucose induced endothelial senescence: Involvement of SIRT1 and SIRT6","volume":"96","author":"Servillo","year":"2016","journal-title":"Free Radic. Biol. Med."},{"key":"ref_159","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1007\/s12192-015-0601-4","article-title":"Donepezil attenuates high glucose-accelerated senescence in human umbilical vein endothelial cells through SIRT1 activation","volume":"20","author":"Zhang","year":"2015","journal-title":"Cell Stress. Chaperones"},{"key":"ref_160","doi-asserted-by":"crossref","first-page":"5999","DOI":"10.1002\/fsn3.1885","article-title":"Effects of Cudrania tricuspidata on anti-senescence in high glucose-treated endothelial cells via the Akt\/p53\/p21 pathway","volume":"8","author":"Kim","year":"2020","journal-title":"Food Sci. Nutr."},{"key":"ref_161","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1016\/j.ebiom.2019.08.069","article-title":"Senolytics decrease senescent cells in humans: Preliminary report from a clinical trial of Dasatinib plus Quercetin in individuals with diabetic kidney disease","volume":"47","author":"Hickson","year":"2019","journal-title":"EBioMedicine"},{"key":"ref_162","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1007\/s10916-019-1412-4","article-title":"Basic Research in Diabetic Nephropathy Health Care: A study of the Renoprotective Mechanism of Metformin","volume":"43","author":"Xue","year":"2019","journal-title":"J. Med. Syst."},{"key":"ref_163","doi-asserted-by":"crossref","first-page":"154799","DOI":"10.1016\/j.metabol.2021.154799","article-title":"Diabetes and kidney disease: Emphasis on treatment with SGLT-2 inhibitors and GLP-1 receptor agonists","volume":"120","author":"Prattichizzo","year":"2021","journal-title":"Metabolism"},{"key":"ref_164","doi-asserted-by":"crossref","first-page":"2561","DOI":"10.1111\/dom.14503","article-title":"Sodium-glucose cotransporter-2 inhibition reduces cellular senescence in the diabetic kidney by promoting ketone body-induced NRF2 activation","volume":"23","author":"Kim","year":"2021","journal-title":"Diabetes Obes. Metab."},{"key":"ref_165","doi-asserted-by":"crossref","first-page":"1344","DOI":"10.2337\/dc07-0233","article-title":"Dipeptidyl peptidase-4 inhibitors: Clinical data and clinical implications","volume":"30","year":"2007","journal-title":"Diabetes Care"},{"key":"ref_166","doi-asserted-by":"crossref","first-page":"750","DOI":"10.21037\/atm-21-393","article-title":"Effects of anagliptin on the stress induced accelerated senescence of human umbilical vein endothelial cells","volume":"9","author":"Kang","year":"2021","journal-title":"Ann. Transl. Med."},{"key":"ref_167","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1007\/s11684-017-0586-8","article-title":"Preventive effect of Shenkang injection against high glucose-induced senescence of renal tubular cells","volume":"13","author":"Fu","year":"2019","journal-title":"Front. Med."},{"key":"ref_168","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1007\/s12013-021-01058-w","article-title":"Astragalus Polysaccharides Reduce High-glucose-induced Rat Aortic Endothelial Cell Senescence and Inflammasome Activation by Modulating the Mitochondrial Na+\/Ca2+ Exchanger","volume":"80","author":"Miao","year":"2022","journal-title":"Cell Biochem. Biophys."},{"key":"ref_169","doi-asserted-by":"crossref","first-page":"7151946","DOI":"10.1155\/2020\/7151946","article-title":"Ginseng-Sanqi-Chuanxiong (GSC) Extracts Ameliorate Diabetes-Induced Endothelial Cell Senescence through Regulating Mitophagy via the AMPK Pathway","volume":"2020","author":"Wang","year":"2020","journal-title":"Oxid. Med. Cell Longev."}],"container-title":["Biomolecules"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2218-273X\/14\/11\/1361\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T16:20:45Z","timestamp":1760113245000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2218-273X\/14\/11\/1361"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10,25]]},"references-count":169,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2024,11]]}},"alternative-id":["biom14111361"],"URL":"https:\/\/doi.org\/10.3390\/biom14111361","relation":{},"ISSN":["2218-273X"],"issn-type":[{"value":"2218-273X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,10,25]]}}}