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The typical clinical symptoms include chronic pelvic pain, abnormal uterine bleeding, and subfertility, all of which significantly impact quality of life. There are no effective prevention or treatment strategies for adenomyosis, partly due to a limited understanding of the pathological mechanisms underlying the initiation and progression of the disease. Given that signaling pathways play a crucial role in the development of adenomyosis, a better understanding of these signaling pathways is essential for identifying therapeutic targets and advancing drug development. The occurrence and progression of adenomyosis are closely linked to various underlying pathophysiological mechanisms, including proliferation, migration, invasion, fibrosis, angiogenesis, inflammation, oxidative stress, immune response, and epigenetic changes. This review summarizes the signaling pathways and targets associated with the pathogenesis of adenomyosis, including CXCL\/CXCR, NLRP3, NF-\u03baB, TGF-\u03b2\/smad, VEGF, Hippo\/YAP, PI3K\/Akt\/mTOR, JAK\/STAT, and other relevant pathways. In addition, it identifies promising future targets for the development of adenomyosis treatment, such as m6A, GSK3\u03b2, sphks, etc.<\/jats:p>","DOI":"10.3390\/biom14111402","type":"journal-article","created":{"date-parts":[[2024,11,4]],"date-time":"2024-11-04T03:57:34Z","timestamp":1730692654000},"page":"1402","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Research Advances in Adenomyosis-Related Signaling Pathways and Promising Targets"],"prefix":"10.3390","volume":"14","author":[{"given":"Hongyu","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Gynecology, The Second Hospital & Clinical Medical School, Lanzhou University, Lanzhou 730000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chaoming","family":"Li","sequence":"additional","affiliation":[{"name":"Departmemt of Urology, The First People\u2019s Hospital of Longnan, Longnan 742500, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenyan","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Gynecology, The Second Hospital & Clinical Medical School, Lanzhou University, Lanzhou 730000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenhu","family":"Xin","sequence":"additional","affiliation":[{"name":"Department of Gynecology, The Second Hospital & Clinical Medical School, Lanzhou University, Lanzhou 730000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tiansheng","family":"Qin","sequence":"additional","affiliation":[{"name":"Department of Gynecology, The Second Hospital & Clinical Medical School, Lanzhou University, Lanzhou 730000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,11,4]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Oral, E. 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