{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T06:06:08Z","timestamp":1789625168121,"version":"build-2803163510"},"reference-count":99,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2024,11,28]],"date-time":"2024-11-28T00:00:00Z","timestamp":1732752000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Taizhou Fengcheng Talent Plan Young science and technology talent lifting project of 2022","award":["ZL202211"],"award-info":[{"award-number":["ZL202211"]}]},{"name":"Taizhou People\u2019s Hospital project","award":["ZL202211"],"award-info":[{"award-number":["ZL202211"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biomolecules"],"abstract":"<jats:p>Lung cancer, the leading cause of death worldwide, is associated with the highest morbidity. Non-small cell lung cancer (NSCLC) accounts for 80\u201385% of lung cancer cases. Advances in the domain of cancer treatment have improved the prognosis and quality of life of patients with metastatic NSCLC. Nevertheless, tumor progression or metastasis owing to treatment failure caused by primary or secondary drug resistance remains the cause of death in the majority of cases. Epithelial\u2013mesenchymal transition (EMT), a vital biological process wherein epithelial cancer cells lose their inherent adhesion and transform into more invasive mesenchymal-like cells, acts as a powerful engine driving tumor metastasis. EMT can also induce immunosuppression in the tumor environment, thereby promoting cancer development and poor prognosis among patients with NSCLC. This review aims to elucidate the effect of EMT on metastasis and the tumor immune microenvironment. Furthermore, it explores the possible roles of EMT inhibition in improving the treatment efficacy of NSCLC. Targeting EMT may be an ideal mechanism to inhibit tumor growth and progression at multiple steps.<\/jats:p>","DOI":"10.3390\/biom14121523","type":"journal-article","created":{"date-parts":[[2024,11,28]],"date-time":"2024-11-28T03:21:23Z","timestamp":1732764083000},"page":"1523","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Epithelial\u2013Mesenchymal Transition in Non-Small Cell Lung Cancer Management: Opportunities and Challenges"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2405-1326","authenticated-orcid":false,"given":"Yunyao","family":"Ye","sequence":"first","affiliation":[{"name":"Department of Oncology, Taizhou People\u2019s Hospital Affiliated to Nanjing Medical University, Taizhou 225300, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shanxun","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Oncology, Taizhou People\u2019s Hospital Affiliated to Nanjing Medical University, Taizhou 225300, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting","family":"Guo","sequence":"additional","affiliation":[{"name":"Central Lab, Taizhou People\u2019s Hospital Affiliated to Nanjing Medical University, Taizhou 225300, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sihui","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Oncology, Taizhou People\u2019s Hospital Affiliated to Nanjing Medical University, Taizhou 225300, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaozhou","family":"Shen","sequence":"additional","affiliation":[{"name":"Department of Oncology, Taizhou People\u2019s Hospital Affiliated to Nanjing Medical University, Taizhou 225300, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gaohua","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Oncology, Taizhou People\u2019s Hospital Affiliated to Nanjing Medical University, Taizhou 225300, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,11,28]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"7","DOI":"10.32471\/exp-oncology.2312-8852.vol-44-no-1.17411","article-title":"Current therapeutic strategies and challenges in nsclc treatment: A comprehensive review","volume":"44","author":"Kumar","year":"2022","journal-title":"Exp. 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