{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T21:01:32Z","timestamp":1791925292736,"version":"4.3.4"},"reference-count":188,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2024,12,12]],"date-time":"2024-12-12T00:00:00Z","timestamp":1733961600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Fujian Provincial Natural Science Foundation","award":["2020J01176"],"award-info":[{"award-number":["2020J01176"]}]},{"name":"Fujian Provincial Natural Science Foundation","award":["2022J01172"],"award-info":[{"award-number":["2022J01172"]}]},{"name":"Fujian Provincial Natural Science Foundation","award":["2024J01458"],"award-info":[{"award-number":["2024J01458"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biomolecules"],"abstract":"<jats:p>HIF-1\u03b1 plays a crucial regulatory role in vascular calcification (VC), primarily influencing the osteogenic differentiation of VSMCs through oxygen-sensing mechanisms. Under hypoxic conditions, the stability of HIF-1\u03b1 increases, avoiding PHD and VHL protein-mediated degradation, which promotes its accumulation in cells and then activates gene expressions related to calcification. Additionally, HIF-1\u03b1 modulates the metabolic state of VSMCs by regulating the pathways that govern the switch between glycolysis and oxidative phosphorylation, thereby further advancing the calcification process. The interaction between HIF-1\u03b1 and other signaling pathways, such as nuclear factor-\u03baB, Notch, and Wnt\/\u03b2-catenin, creates a complex regulatory network that serves as a critical driving force in VC. Therefore, a deeper understanding of the role and regulatory mechanism of the HIF-1\u03b1 signaling during the development and progression of VC is of great significance, as it is not only a key molecular marker for understanding the pathological mechanisms of VC but also represents a promising target for future anti-calcification therapies.<\/jats:p>","DOI":"10.3390\/biom14121592","type":"journal-article","created":{"date-parts":[[2024,12,12]],"date-time":"2024-12-12T12:25:54Z","timestamp":1734006354000},"page":"1592","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["The Physiological Functions and Therapeutic Potential of Hypoxia-Inducible Factor-1\u03b1 in Vascular Calcification"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4309-0221","authenticated-orcid":false,"given":"Zhenghong","family":"Zhang","sequence":"first","affiliation":[{"name":"Provincial Key Laboratory for Developmental Biology and Neurosciences, College of Life Sciences, Fujian Normal University, Fuzhou 350007, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Defan","family":"Wang","sequence":"additional","affiliation":[{"name":"Fujian Provincial Key Laboratory of Reproductive Health Research, School of Medicine, Xiamen University, Xiamen 361102, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1487-6308","authenticated-orcid":false,"given":"Renfeng","family":"Xu","sequence":"additional","affiliation":[{"name":"Provincial Key Laboratory for Developmental Biology and Neurosciences, College of Life Sciences, Fujian Normal University, Fuzhou 350007, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiang","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Pharmacological and Pharmaceutical Sciences, College of Pharmacy, University of Houston, Houston, TX 77204, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7439-9630","authenticated-orcid":false,"given":"Zhengchao","family":"Wang","sequence":"additional","affiliation":[{"name":"Provincial Key Laboratory for Developmental Biology and Neurosciences, College of Life Sciences, Fujian Normal University, Fuzhou 350007, China"},{"name":"Department of Pharmacological and Pharmaceutical Sciences, College of Pharmacy, University of Houston, Houston, TX 77204, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8338-3013","authenticated-orcid":false,"given":"Yang","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Pharmacological and Pharmaceutical Sciences, College of Pharmacy, University of Houston, Houston, TX 77204, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,12,12]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Zhu, D., Mackenzie, N.C., Farquharson, C., and Macrae, V.E. (2012). Mechanisms and clinical consequences of vascular calcification. Front. Endocrinol., 3.","DOI":"10.3389\/fendo.2012.00095"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1590\/S1679-45082013000300021","article-title":"Vascular calcification: Pathophysiology and clinical implications","volume":"11","author":"Liberman","year":"2013","journal-title":"Einstein"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"2205","DOI":"10.1007\/s40620-022-01432-8","article-title":"Hypoxia-inducible factor signaling in vascular calcification in chronic kidney disease patients","volume":"35","author":"Copur","year":"2022","journal-title":"J. Nephrol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1046\/j.1523-1755.2001.060002472.x","article-title":"Pathophysiological mechanisms of vascular calcification in end-stage renal disease","volume":"60","author":"Davies","year":"2001","journal-title":"Kidney Int."},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Dube, P., DeRiso, A., Patel, M., Battepati, D., Khatib-Shahidi, B., Sharma, H., Gupta, R., Malhotra, D., Dworkin, L., and Haller, S. (2021). Vascular calcification in chronic kidney disease: Diversity in the vessel wall. Biomedicines, 9.","DOI":"10.3390\/biomedicines9040404"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"961","DOI":"10.4070\/kcj.2021.0995","article-title":"Vascular calcification in chronic kidney disease: Distinct features of pathogenesis and clinical implication","volume":"51","author":"Kim","year":"2021","journal-title":"Korean Circ. J."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1093\/ndt\/gfv111","article-title":"Vascular calcification in chronic kidney disease: An update","volume":"31","author":"Schlieper","year":"2016","journal-title":"Nephrol. Dial. Transplant."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"673","DOI":"10.14336\/AD.2021.1024","article-title":"Vascular calcification in chronic kidney disease: An update and perspective","volume":"13","author":"Ren","year":"2022","journal-title":"Aging Dis."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1093\/ajh\/hps028","article-title":"Coronary artery calcification is associated with the development of hypertension","volume":"26","author":"Grossman","year":"2013","journal-title":"Am. J. Hypertens."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"796","DOI":"10.1161\/HYPERTENSIONAHA.118.11212","article-title":"Interaction between hypertension and arterial stiffness","volume":"72","author":"Safar","year":"2018","journal-title":"Hypertension"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1078","DOI":"10.1161\/ATVBAHA.120.313131","article-title":"Arterial stiffness: A focus on vascular calcification and its link to bone mineralization","volume":"40","author":"Chen","year":"2020","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1159\/000484941","article-title":"The role of vascular calcification in heart failure and cognitive decline","volume":"5","author":"Cheng","year":"2018","journal-title":"Pulse"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"4461311","DOI":"10.1155\/2021\/4461311","article-title":"Epidemiological research advances in vascular calcification in diabetes","volume":"2021","author":"Yao","year":"2021","journal-title":"J. Diabetes Res."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1038\/s41392-023-01400-z","article-title":"Diabetic vascular diseases: Molecular mechanisms and therapeutic strategies","volume":"8","author":"Li","year":"2023","journal-title":"Signal. Transduct. Target. Ther."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1515","DOI":"10.1093\/eurheartj\/ehu163","article-title":"Medial vascular calcification revisited: Review and perspectives","volume":"35","author":"Lanzer","year":"2014","journal-title":"Eur. Heart J."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1878","DOI":"10.1161\/STROKEAHA.111.648667","article-title":"Intracranial carotid artery atherosclerosis: Prevalence and risk factors in the general population","volume":"43","author":"Bos","year":"2012","journal-title":"Stroke"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"S85","DOI":"10.3109\/07853890.2012.660498","article-title":"Vascular calcification and hypertension: Cause and effect","volume":"44","author":"Kalra","year":"2012","journal-title":"Ann. Med."},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Ni, X., Liu, L., Yao, Y., Zhang, C., Su, H., Lv, Y., Li, R., Sun, L., Zhou, Q., and Zhu, X. (2023). The genetic correlation and causal association between key factors that influence vascular calcification and cardiovascular disease incidence. Front. Cardiovasc. Med., 10.","DOI":"10.3389\/fcvm.2023.1096662"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"4243","DOI":"10.1210\/jc.2004-1324","article-title":"Vascular calcification and osteoporosis--the nature of the nexus","volume":"89","author":"Rubin","year":"2004","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Lian, Y., Li, Y., Liu, A., Ghosh, S., Shi, Y., and Huang, H. (2023). Dietary antioxidants and vascular calcification: From pharmacological mechanisms to challenges. Biomed. Pharmacother., 168.","DOI":"10.1016\/j.biopha.2023.115693"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1088","DOI":"10.1161\/ATVBAHA.119.312509","article-title":"Hypoxia triggers osteochondrogenic differentiation of vascular smooth muscle cells in an HIF-1 (hypoxia-inducible factor 1)-dependent and reactive oxygen species-dependent manner","volume":"39","author":"Balogh","year":"2019","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1093\/ckj\/sfac224","article-title":"Role of prolyl hydroxylase\/HIF-1 signaling in vascular calcification","volume":"16","author":"Negri","year":"2022","journal-title":"Clin. Kidney J."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1186\/1475-2840-13-52","article-title":"The relationship between serum hypoxia-inducible factor 1alpha and coronary artery calcification in asymptomatic type 2 diabetic patients","volume":"13","author":"Li","year":"2014","journal-title":"Cardiovasc. Diabetol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1038\/cdd.2008.12","article-title":"Biology of HIF-1alpha","volume":"15","author":"Weidemann","year":"2008","journal-title":"Cell Death. Differ."},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"Lee, S.H., Golinska, M., and Griffiths, J.R. (2021). HIF-1-independent mechanisms regulating metabolic adaptation in hypoxic cancer cells. Cells, 10.","DOI":"10.3390\/cells10092371"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1016\/S0092-8674(03)00154-5","article-title":"HIF-1alpha is essential for myeloid cell-mediated inflammation","volume":"112","author":"Cramer","year":"2003","journal-title":"Cell"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1080\/25785826.2021.1910187","article-title":"Study on hypoxia-inducible factor and its roles in immune system","volume":"44","author":"Kiani","year":"2021","journal-title":"Immunol. Med."},{"key":"ref_28","first-page":"105","article-title":"Hypoxia-inducible factors as essential regulators of inflammation","volume":"345","author":"Imtiyaz","year":"2010","journal-title":"Curr. Top Microbiol. Immunol."},{"key":"ref_29","doi-asserted-by":"crossref","unstructured":"Csiki, D.M., Ababneh, H., T\u00f3th, A., Lente, G., Sz\u00f6\u0151r, \u00c1., T\u00f3th, A., Fill\u00e9r, C., Juh\u00e1sz, T., Nagy, B., and Balogh, E. (2023). Hypoxia-inducible factor activation promotes osteogenic transition of valve interstitial cells and accelerates aortic valve calcification in a mice model of chronic kidney disease. Front. Cardiovasc. Med., 10.","DOI":"10.3389\/fcvm.2023.1168339"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"581","DOI":"10.3346\/jkms.2002.17.5.581","article-title":"Oxygen-dependent and -independent regulation of HIF-1alpha","volume":"17","author":"Chun","year":"2002","journal-title":"J. Korean Med. Sci."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1186\/1478-811X-11-42","article-title":"Hypoxia-inducible factor (HIF) network: Insights from mathematical models","volume":"11","author":"Cavadas","year":"2013","journal-title":"Cell Commun. Signal."},{"key":"ref_32","doi-asserted-by":"crossref","unstructured":"Bouthelier, A., and Aragon\u00e9s, J. (2020). Role of the HIF oxygen sensing pathway in cell defense and proliferation through the control of amino acid metabolism. Biochim. Biophys. Acta Mol. Cell Res., 1867.","DOI":"10.1016\/j.bbamcr.2020.118733"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"e01718","DOI":"10.1002\/brb3.1718","article-title":"Expression of hypoxia-inducible factor 1alpha, glucose transporter 1, and hexokinase 2 in primary central nervous system lymphoma and the correlation with the biological behaviors","volume":"10","author":"Shen","year":"2020","journal-title":"Brain Behav."},{"key":"ref_34","doi-asserted-by":"crossref","unstructured":"Infantino, V., Santarsiero, A., Convertini, P., Todisco, S., and Iacobazzi, V. (2021). Cancer cell metabolism in hypoxia: Role of HIF-1 as key regulator and therapeutic target. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22115703"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1113\/JP280572","article-title":"Regulation of glycolysis by the hypoxia-inducible factor (HIF): Implications for cellular physiology","volume":"599","author":"Kierans","year":"2021","journal-title":"J. Physiol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/S0896-6273(03)00367-2","article-title":"The regulation of glucose metabolism by HIF-1 mediates a neuroprotective response to amyloid beta peptide","volume":"39","author":"Soucek","year":"2003","journal-title":"Neuron"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"e12909","DOI":"10.1111\/cpr.12909","article-title":"HIF-1alpha ameliorates tubular injury in diabetic nephropathy via HO-1-mediated control of mitochondrial dynamics","volume":"53","author":"Jiang","year":"2020","journal-title":"Cell Prolif."},{"key":"ref_38","doi-asserted-by":"crossref","unstructured":"Carrera, S., Senra, J., Acosta, M.I., Althubiti, M., Hammond, E.M., de Verdier, P.J., and Macip, S. (2014). The role of the HIF-1alpha transcription factor in increased cell division at physiological oxygen tensions. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0097938"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"1764929","DOI":"10.1155\/2021\/1764929","article-title":"HIF-1\u03b1 activation promotes luteolysis by enhancing ROS levels in the corpus luteum of pseudopregnant rats","volume":"2021","author":"Tang","year":"2021","journal-title":"Oxid. Med. Cell. Longev."},{"key":"ref_40","doi-asserted-by":"crossref","unstructured":"Tang, Z., Xu, R., Zhang, Z., Shi, C., Zhang, Y., Yang, H., Lin, Q., Liu, Y., Lin, F., and Geng, B. (2021). HIF-1\u03b1 protects granulosa cells from hypoxia-induced apoptosis during follicular development by inducing autophagy. Front. Cell Dev. Biol., 9.","DOI":"10.3389\/fcell.2021.631016"},{"key":"ref_41","doi-asserted-by":"crossref","unstructured":"Tang, Z., Zhang, Z., Lin, Q., Xu, R., Chen, J., Wang, Y., Zhang, Y., Tang, Y., Shi, C., and Liu, Y. (2021). HIF-1\u03b1\/BNIP3-mediated autophagy contributes to the luteinization of granulosa cells during the formation of corpus luteum. Front. Cell Dev. Biol., 8.","DOI":"10.3389\/fcell.2020.619924"},{"key":"ref_42","first-page":"5981","article-title":"Effects of dimethyl carbonate-induced autophagic activation on follicular development in the mouse ovary","volume":"14","author":"Tang","year":"2017","journal-title":"Exp. Ther. Med."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1007\/s10735-015-9609-4","article-title":"Expression and clinical significance of the HIF-1a\/ET-2 signaling pathway during the development and treatment of polycystic ovary syndrome","volume":"46","author":"Wang","year":"2015","journal-title":"J. Mol. Histol."},{"key":"ref_44","first-page":"7153","article-title":"Expression and contribution of the HIF-1\u03b1\/VEGF signaling pathway to luteal development and function in pregnant rats","volume":"12","author":"Wu","year":"2015","journal-title":"Mol. Med. Rep."},{"key":"ref_45","first-page":"51","article-title":"Hypoxia-inducible factor (HIF)-1 regulatory pathway and its potential for therapeutic intervention in malignancy and ischemia","volume":"80","author":"Ziello","year":"2007","journal-title":"Yale J. Biol. Med."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1007\/s10735-023-10153-6","article-title":"The role of HIF-1\u03b1-mediated autophagy in ionizing radiation-induced testicular injury","volume":"54","author":"Xu","year":"2023","journal-title":"J. Mol. Histol."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"6114132","DOI":"10.1155\/2021\/6114132","article-title":"Contribution of oxidative stress to HIF-1-mediated profibrotic changes during the kidney damage","volume":"2021","author":"Zhang","year":"2021","journal-title":"Oxid. Med. Cell. Longev."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1262\/jrd.2012-089","article-title":"Regulatory effect of hypoxia-inducible factor-1\u03b1 on hCG-stimulated endothelin-2 expression in granulosa cells from the PMSG-treated rat ovary","volume":"58","author":"Zhang","year":"2012","journal-title":"J. Reprod. Dev."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1002\/cbin.11090","article-title":"Activation of NF-\u03baB signaling pathway during HCG-induced VEGF expression in luteal cells","volume":"43","author":"Zhang","year":"2019","journal-title":"Cell Biol. Int."},{"key":"ref_50","doi-asserted-by":"crossref","unstructured":"Zhang, Z., Shi, C., and Wang, Z. (2023). Therapeutic effects and molecular mechanism of chlorogenic acid on polycystic ovarian syndrome: Role of HIF-1alpha. Nutrients, 15.","DOI":"10.3390\/nu15132833"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1111\/j.1740-0929.2010.00832.x","article-title":"Contribution of hypoxia-inducible factor-1\u03b1 to transcriptional regulation of vascular endothelial growth factor in bovine developing luteal cells","volume":"82","author":"Zhang","year":"2011","journal-title":"Anim. Sci. J."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1080\/0284186X.2017.1301680","article-title":"HIF-1 in cancer therapy: Two decade long story of a transcription factor","volume":"56","author":"Soni","year":"2017","journal-title":"Acta. Oncol."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/S0006-2952(99)00292-0","article-title":"Expression of hypoxia-inducible factor 1: Mechanisms and consequences","volume":"59","author":"Semenza","year":"2000","journal-title":"Biochem. Pharmacol."},{"key":"ref_54","doi-asserted-by":"crossref","unstructured":"Zimna, A., and Kurpisz, M. (2015). Hypoxia-inducible factor-1 in physiological and pathophysiological angiogenesis: Applications and therapies. Biomed. Res. Int., 2015.","DOI":"10.1155\/2015\/549412"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1038\/s41581-022-00587-8","article-title":"The effect of HIF on metabolism and immunity","volume":"18","author":"Taylor","year":"2022","journal-title":"Nat. Rev. Nephrol."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1186\/s13054-024-04885-4","article-title":"Unraveling the role of HIF-1alpha in sepsis: From pathophysiology to potential therapeutics-a narrative review","volume":"28","author":"Ruan","year":"2024","journal-title":"Crit. Care"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"109","DOI":"10.21037\/atm-21-4222","article-title":"Regulatory mechanism of HIF-1alpha and its role in liver diseases: A narrative review","volume":"10","author":"Chu","year":"2022","journal-title":"Ann. Transl. Med."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1159\/000455166","article-title":"Targeting hypoxia-inducible factors for the treatment of anemia in chronic kidney disease patients","volume":"45","author":"Locatelli","year":"2017","journal-title":"Am. J. Nephrol."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/j.cmet.2006.01.012","article-title":"HIF-1 mediates adaptation to hypoxia by actively downregulating mitochondrial oxygen consumption","volume":"3","author":"Papandreou","year":"2006","journal-title":"Cell Metab."},{"key":"ref_60","doi-asserted-by":"crossref","unstructured":"Lin, S., Chai, Y., Zheng, X., and Xu, X. (2023). The role of HIF in angiogenesis, lymphangiogenesis, and tumor microenvironment in urological cancers. Mol. Biol. Rep., 51.","DOI":"10.1007\/s11033-023-08931-2"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"1436","DOI":"10.1182\/blood-2012-08-449181","article-title":"HIF-1alpha is a protective factor in conditional PHD2-deficient mice suffering from severe HIF-2alpha-induced excessive erythropoiesis","volume":"121","author":"Franke","year":"2013","journal-title":"Blood"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"3133","DOI":"10.1182\/blood-2004-05-1695","article-title":"HIF-2alpha regulates murine hematopoietic development in an erythropoietin-dependent manner","volume":"105","author":"Scortegagna","year":"2005","journal-title":"Blood"},{"key":"ref_63","doi-asserted-by":"crossref","unstructured":"Watts, D., Gaete, D., Rodriguez, D., Hoogewijs, D., Rauner, M., Sormendi, S., and Wielockx, B. (2020). Hypoxia pathway proteins are master regulators of erythropoiesis. Int. J. Mol. Sci., 21.","DOI":"10.20944\/preprints202010.0136.v1"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"343","DOI":"10.4143\/crt.2004.36.6.343","article-title":"HIF-1alpha: A valid therapeutic target for tumor therapy","volume":"36","author":"Hong","year":"2004","journal-title":"Cancer Res. Treat."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"2628","DOI":"10.1182\/blood-2008-04-150862","article-title":"The neovasculature homing motif NGR: More than meets the eye","volume":"112","author":"Corti","year":"2008","journal-title":"Blood"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1016\/j.apsb.2015.05.007","article-title":"HIF-1alpha pathway: Role, regulation and intervention for cancer therapy","volume":"5","author":"Masoud","year":"2015","journal-title":"Acta Pharm. Sin. B"},{"key":"ref_67","doi-asserted-by":"crossref","unstructured":"Bui, B.P., Nguyen, P.L., Lee, K., and Cho, J. (2022). Hypoxia-inducible factor-1: A novel therapeutic target for the management of cancer, drug resistance, and cancer-related pain. Cancers, 14.","DOI":"10.3390\/cancers14246054"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"145796","DOI":"10.1016\/j.gene.2021.145796","article-title":"Up-down regulation of HIF-1\u03b1 in cancer progression","volume":"798","author":"Rashid","year":"2021","journal-title":"Gene"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"8547846","DOI":"10.1155\/2019\/8547846","article-title":"Hypoxia-inducible factors as an alternative source of treatment strategy for cancer","volume":"2019","author":"Akanji","year":"2019","journal-title":"Oxid. Med. Cell. Longev."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1186\/s13046-023-02724-y","article-title":"Novel cancer treatment paradigm targeting hypoxia-induced factor in conjunction with current therapies to overcome resistance","volume":"42","author":"Kao","year":"2023","journal-title":"J. Exp. Clin. Cancer Res."},{"key":"ref_71","doi-asserted-by":"crossref","unstructured":"Xiong, A., and Liu, Y. (2017). Targeting hypoxia inducible factors-1\u03b1 as a novel therapy in fibrosis. Front. Pharmacol., 8.","DOI":"10.3389\/fphar.2017.00326"},{"key":"ref_72","doi-asserted-by":"crossref","unstructured":"Xu, R., Wang, F., Yang, H., and Wang, Z. (2022). Action sites and clinical application of HIF-1\u03b1 inhibitors. Molecules, 27.","DOI":"10.3390\/molecules27113426"},{"key":"ref_73","doi-asserted-by":"crossref","unstructured":"Shi, C., Zhang, Z., Xu, R., Zhang, Y., and Wang, Z. (2023). Contribution of HIF-1\u03b1\/BNIP3-mediated autophagy to lipid accumulation during irinotecan-induced liver injury. Sci. Rep., 13.","DOI":"10.1038\/s41598-023-33848-y"},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/j.jvs.2013.02.240","article-title":"Hypoxia-inducible factor pathway and diseases of the vascular wall","volume":"58","author":"Lim","year":"2013","journal-title":"J. Vasc. Surg."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1016\/j.kint.2016.05.020","article-title":"Hypoxia-inducible factor-1 plays a role in phosphate-induced vascular smooth muscle cell calcification","volume":"90","author":"Mokas","year":"2016","journal-title":"Kidney Int."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"C702","DOI":"10.1152\/ajpcell.00419.2009","article-title":"Regulation of vascular smooth muscle cell calcification by extracellular pyrophosphate homeostasis: Synergistic modulation by cyclic AMP and hyperphosphatemia","volume":"298","author":"Prosdocimo","year":"2010","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1186\/s10020-023-00759-7","article-title":"PRMT3 methylates HIF-1alpha to enhance the vascular calcification induced by chronic kidney disease","volume":"30","author":"Zhou","year":"2024","journal-title":"Mol. Med."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1093\/cvr\/cvt146","article-title":"Role of macrophage-derived hypoxia-inducible factor (HIF)-1alpha as a mediator of vascular remodelling","volume":"99","author":"Nakayama","year":"2013","journal-title":"Cardiovasc. Res."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1093\/ije\/31.4.737","article-title":"Vascular calcification and osteoporosis: Inflammatory responses to oxidized lipids","volume":"31","author":"Demer","year":"2002","journal-title":"Int. J. Epidemiol."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.1161\/01.ATV.0000133194.94939.42","article-title":"Vascular calcification: Mechanisms and clinical ramifications","volume":"24","author":"Abedin","year":"2004","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1053\/j.ackd.2006.10.006","article-title":"Clinical assessment of vascular calcification","volume":"14","author":"Raggi","year":"2007","journal-title":"Adv. Chronic Kidney Dis."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1053\/j.jrn.2006.01.006","article-title":"Disordered mineral metabolism and vascular calcification in nondialyzed chronic kidney disease patients","volume":"16","author":"Mehrotra","year":"2006","journal-title":"J. Ren. Nutr."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"2938","DOI":"10.1161\/CIRCULATIONAHA.107.743161","article-title":"Vascular calcification: Pathobiology of a multifaceted disease","volume":"117","author":"Demer","year":"2008","journal-title":"Circulation"},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1007\/s00223-013-9712-z","article-title":"Vascular calcification: An update on mechanisms and challenges in treatment","volume":"93","author":"Wu","year":"2013","journal-title":"Calcif. Tissue Int."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"1044","DOI":"10.1161\/01.RES.0000249379.55535.21","article-title":"Vascular calcification: Pathobiological mechanisms and clinical implications","volume":"99","author":"Johnson","year":"2006","journal-title":"Circ. Res."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1586\/14779072.2014.868305","article-title":"Role of coronary artery calcium in cardiovascular risk assessment","volume":"12","author":"Sunkara","year":"2014","journal-title":"Expert. Rev. Cardiovasc. Ther."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1016\/j.jcmg.2015.02.006","article-title":"Coronary artery calcium scanning: Past, present, and future","volume":"8","author":"Hecht","year":"2015","journal-title":"JACC Cardiovasc. Imaging"},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"1336","DOI":"10.1056\/NEJMoa072100","article-title":"Coronary calcium as a predictor of coronary events in four racial or ethnic groups","volume":"358","author":"Detrano","year":"2008","journal-title":"N. Engl. J. Med."},{"key":"ref_89","doi-asserted-by":"crossref","unstructured":"Wang, C., Liang, Q., He, S., Zhu, J., Lin, X., Lin, G., Wu, D., Zhang, W., and Wang, Z. (2023). Role of inflammation and immunity in vascular calcification: A bibliometric and visual analysis, 2000\u20132022. Front. Cardiovasc. Med., 10.","DOI":"10.3389\/fcvm.2023.1258230"},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"e028358","DOI":"10.1161\/JAHA.122.028358","article-title":"A potential new link between inflammation and vascular calcification","volume":"12","author":"Cai","year":"2023","journal-title":"J. Am. Heart Assoc."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1016\/j.atherosclerosis.2016.05.044","article-title":"Calcification of vascular smooth muscle cells is induced by secondary calciprotein particles and enhanced by tumor necrosis factor-alpha","volume":"251","author":"Aghagolzadeh","year":"2016","journal-title":"Atherosclerosis"},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1159\/000341216","article-title":"RANKL enhances macrophage paracrine pro-calcific activity in high phosphate-treated smooth muscle cells: Dependence on IL-6 and TNF-alpha","volume":"49","author":"Deuell","year":"2012","journal-title":"J. Vasc. Res."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"F744","DOI":"10.1152\/ajprenal.00017.2015","article-title":"Fetuin-A decrease induced by a low-protein diet enhances vascular calcification in uremic rats with hyperphosphatemia","volume":"309","author":"Yamada","year":"2015","journal-title":"Am. J. Physiol. Ren. Physiol."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1093\/ndt\/gfx379","article-title":"New insights into the key role of interleukin 6 in vascular calcification of chronic kidney disease","volume":"33","author":"Massy","year":"2018","journal-title":"Nephrol. Dial. Transplant."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.atherosclerosis.2020.02.016","article-title":"Innate and adaptive immunity in cardiovascular calcification","volume":"306","author":"Passos","year":"2020","journal-title":"Atherosclerosis"},{"key":"ref_96","doi-asserted-by":"crossref","unstructured":"Li, D., Fan, C., Li, X., and Zhao, L. (2024). The role of macrophage polarization in vascular calcification. Biochem. Biophys. Res. Commun., 710.","DOI":"10.1016\/j.bbrc.2024.149863"},{"key":"ref_97","doi-asserted-by":"crossref","unstructured":"T\u00f3th, A., Balogh, E., and Jeney, V. (2020). Regulation of vascular calcification by reactive oxygen species. Antioxidants, 9.","DOI":"10.3390\/antiox9100963"},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"15319","DOI":"10.1074\/jbc.M800021200","article-title":"Oxidative stress induces vascular calcification through modulation of the osteogenic transcription factor Runx2 by AKT signaling","volume":"283","author":"Byon","year":"2008","journal-title":"J. Biol. Chem."},{"key":"ref_99","first-page":"11484","article-title":"Trioxidized cysteine and aging: A molecular binomial that extends far beyond classical proteinopathic paradigms","volume":"16","author":"Mulet","year":"2024","journal-title":"Aging"},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1161\/CIRCRESAHA.110.234914","article-title":"Arterial calcification in chronic kidney disease: Key roles for calcium and phosphate","volume":"109","author":"Shanahan","year":"2011","journal-title":"Circ. Res."},{"key":"ref_101","doi-asserted-by":"crossref","unstructured":"Cozzolino, M., Ciceri, P., Galassi, A., Mangano, M., Carugo, S., Capelli, I., and Cianciolo, G. (2019). The key role of phosphate on vascular calcification. Toxins, 11.","DOI":"10.3390\/toxins11040213"},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"384","DOI":"10.21037\/atm-22-5358","article-title":"Regulatory effects of nutritional and metabolic disorders on vascular calcification in chronic kidney disease: A narrative review","volume":"11","author":"Xiong","year":"2023","journal-title":"Ann. Transl. Med."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"1704","DOI":"10.1093\/ndt\/gfs046","article-title":"Role of vitamin D in vascular calcification: Bad guy or good guy?","volume":"27","author":"Massy","year":"2012","journal-title":"Nephrol. Dial. Transplant."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1038\/ki.2010.432","article-title":"The dualistic role of vitamin D in vascular calcifications","volume":"79","author":"Razzaque","year":"2011","journal-title":"Kidney Int."},{"key":"ref_105","doi-asserted-by":"crossref","unstructured":"Hou, Y.C., Liu, W.C., Zheng, C.M., Zheng, J.Q., Yen, T.H., and Lu, K.C. (2017). Role of vitamin D in uremic vascular calcification. Biomed. Res. Int., 2017.","DOI":"10.1155\/2017\/2803579"},{"key":"ref_106","doi-asserted-by":"crossref","unstructured":"Zhu, Y., Ma, W.Q., Han, X.Q., Wang, Y., Wang, X., and Liu, N.F. (2018). Advanced glycation end products accelerate calcification in VSMCs through HIF-1alpha\/PDK4 activation and suppress glucose metabolism. Sci. Rep., 8.","DOI":"10.1038\/s41598-018-31877-6"},{"key":"ref_107","doi-asserted-by":"crossref","unstructured":"Lee, S.Y., Kim, S.J., Park, K.H., Lee, G., Oh, Y., Ryu, J.H., and Huh, Y.H. (2024). Differential but complementary roles of HIF-1alpha and HIF-2alpha in the regulation of bone homeostasis. Commun. Biol., 7.","DOI":"10.1038\/s42003-024-06581-z"},{"key":"ref_108","doi-asserted-by":"crossref","unstructured":"Song, S., Zhang, G., Chen, X., Zheng, J., Liu, X., Wang, Y., Chen, Z., Wang, Y., Song, Y., and Zhou, Q. (2023). HIF-1alpha increases the osteogenic capacity of ADSCs by coupling angiogenesis and osteogenesis via the HIF-1alpha\/VEGF\/AKT\/mTOR signaling pathway. J. Nanobiotechnol., 21.","DOI":"10.1186\/s12951-023-02020-z"},{"key":"ref_109","doi-asserted-by":"crossref","unstructured":"Qi, X., Bie, M., Jiang, R., and Kang, F. (2023). HIF-1alpha regulates osteoclastogenesis and alveolar bone resorption in periodontitis via ANGPTL4. Arch. Oral. Biol., 153.","DOI":"10.1016\/j.archoralbio.2023.105736"},{"key":"ref_110","doi-asserted-by":"crossref","unstructured":"Chen, W., Wu, P., Yu, F., Luo, G., Qing, L., and Tang, J. (2022). HIF-1alpha regulates bone homeostasis and angiogenesis, participating in the occurrence of bone metabolic diseases. Cells, 11.","DOI":"10.3390\/cells11223552"},{"key":"ref_111","first-page":"2405","article-title":"HIF modulation of Wnt signaling regulates skeletal myogenesis in vivo","volume":"142","author":"Majmundar","year":"2015","journal-title":"Development"},{"key":"ref_112","first-page":"3188","article-title":"Hypoxia-inducible factor-1alpha activates transforming growth factor-beta1\/Smad signaling and increases collagen deposition in dermal fibroblasts","volume":"9","author":"Xu","year":"2017","journal-title":"Oncotarget"},{"key":"ref_113","doi-asserted-by":"crossref","unstructured":"Alique, M., S\u00e1nchez-L\u00f3pez, E., Bodega, G., Giannarelli, C., Carracedo, J., and Ram\u00edrez, R. (2020). Hypoxia-inducible factor-1alpha: The master regulator of endothelial cell senescence in vascular aging. Cells, 9.","DOI":"10.3390\/cells9010195"},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1038\/s41392-023-01652-9","article-title":"Hypoxia-induced signaling in the cardiovascular system: Pathogenesis and therapeutic targets","volume":"8","author":"Zhao","year":"2023","journal-title":"Signal. Transduct. Target. Ther."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1093\/cvr\/cvq152","article-title":"HIF-1 inhibition decreases systemic vascular remodelling diseases by promoting apoptosis through a hexokinase 2-dependent mechanism","volume":"88","author":"Lambert","year":"2010","journal-title":"Cardiovasc. Res."},{"key":"ref_116","doi-asserted-by":"crossref","unstructured":"Huang, X., Akg\u00fcn, E.E., Mehmood, K., Zhang, H., Tang, Z., and Li, Y. (2022). Mechanism of hypoxia-mediated smooth muscle cell proliferation leading to vascular remodeling. Biomed. Res. Int., 2022.","DOI":"10.1155\/2022\/3959845"},{"key":"ref_117","doi-asserted-by":"crossref","unstructured":"Mylonis, I., Chachami, G., and Simos, G. (2021). Specific inhibition of HIF activity: Can peptides lead the way?. Cancers, 13.","DOI":"10.3390\/cancers13030410"},{"key":"ref_118","doi-asserted-by":"crossref","unstructured":"Delbrel, E., Soumare, A., Naguez, A., Label, R., Bernard, O., Bruhat, A., Fafournoux, P., Tremblais, G., Marchant, D., and Gille, T. (2018). HIF-1alpha triggers ER stress and CHOP-mediated apoptosis in alveolar epithelial cells, a key event in pulmonary fibrosis. Sci. Rep., 8.","DOI":"10.1038\/s41598-018-36063-2"},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1016\/j.gendis.2023.02.039","article-title":"HIF-1alpha signaling: Essential roles in tumorigenesis and implications in targeted therapies","volume":"11","author":"Zhao","year":"2023","journal-title":"Genes Dis."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"2364","DOI":"10.4161\/cc.10.14.16313","article-title":"Requirement of evading apoptosis for HIF-1alpha-induced malignant progression in mouse cells","volume":"10","author":"Hayashi","year":"2011","journal-title":"Cell Cycle"},{"key":"ref_121","doi-asserted-by":"crossref","unstructured":"Qannita, R.A., Alalami, A.I., Harb, A.A., Aleidi, S.M., Taneera, J., Abu-Gharbieh, E., El-Huneidi, W., Saleh, M.A., Alzoubi, K.H., and Semreen, M.H. (2024). Targeting hypoxia-inducible factor-1 (HIF-1) in cancer: Emerging therapeutic strategies and pathway regulation. Pharmaceuticals, 17.","DOI":"10.3390\/ph17020195"},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1016\/j.cmet.2020.08.002","article-title":"The role of HIF in immunity and inflammation","volume":"32","author":"McGettrick","year":"2020","journal-title":"Cell Metab."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"116247","DOI":"10.1016\/j.bone.2021.116247","article-title":"MIF does only marginally enhance the pro-regenerative capacities of DFO in a mouse-osteotomy-model of compromised bone healing conditions","volume":"154","author":"Lang","year":"2022","journal-title":"Bone"},{"key":"ref_124","doi-asserted-by":"crossref","unstructured":"Vall\u00e9e, A., and Lecarpentier, Y. (2018). Crosstalk between peroxisome proliferator-activated receptor gamma and the canonical WNT\/beta-catenin pathway in chronic inflammation and oxidative stress during carcinogenesis. Front. Immunol., 9.","DOI":"10.3389\/fimmu.2018.00745"},{"key":"ref_125","doi-asserted-by":"crossref","unstructured":"Cartwright, I.M., and Colgan, S.P. (2023). The hypoxic tissue microenvironment as a driver of mucosal inflammatory resolution. Front. Immunol., 14.","DOI":"10.3389\/fimmu.2023.1124774"},{"key":"ref_126","doi-asserted-by":"crossref","unstructured":"Kietzmann, T., Mennerich, D., and Dimova, E.Y. (2016). Hypoxia-inducible factors (HIFs) and phosphorylation: Impact on stability, localization, and transactivity. Front. Cell Dev. Biol., 4.","DOI":"10.3389\/fcell.2016.00011"},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1016\/j.molcel.2010.09.022","article-title":"Hypoxia-inducible factors and the response to hypoxic stress","volume":"40","author":"Majmundar","year":"2010","journal-title":"Mol. Cell"},{"key":"ref_128","doi-asserted-by":"crossref","unstructured":"Yfantis, A., Mylonis, I., Chachami, G., Nikolaidis, M., Amoutzias, G.D., Paraskeva, E., and Simos, G. (2023). Transcriptional response to hypoxia: The role of HIF-1-associated co-regulators. Cells, 12.","DOI":"10.3390\/cells12050798"},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1016\/j.tips.2015.03.003","article-title":"Hypoxia-inducible factors in cancer stem cells and inflammation","volume":"36","author":"Peng","year":"2015","journal-title":"Trends. Pharmacol. Sci."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"3716","DOI":"10.1172\/JCI84433","article-title":"Hypoxia-dependent regulation of inflammatory pathways in immune cells","volume":"126","author":"Taylor","year":"2016","journal-title":"J. Clin. Investig."},{"key":"ref_131","doi-asserted-by":"crossref","unstructured":"Malkov, M.I., Lee, C.T., and Taylor, C.T. (2021). Regulation of the hypoxia-inducible factor (HIF) by pro-inflammatory cytokines. Cells, 10.","DOI":"10.3390\/cells10092340"},{"key":"ref_132","doi-asserted-by":"crossref","unstructured":"Cui, X., Wei, W., Hu, Y., Zhang, Z., Lu, M., Li, Y., Wu, J., and Li, C. (Crit. Rev. Food. Sci. Nutr., 2024). Dietary inflammation and vascular calcification: A comprehensive review of the associations, underlying mechanisms, and prevention strategies, Crit. Rev. Food. Sci. Nutr., online ahead of print.","DOI":"10.1080\/10408398.2024.2408447"},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1016\/j.fmre.2022.04.020","article-title":"Inflammation-associated ectopic mineralization","volume":"3","author":"Song","year":"2022","journal-title":"Fundam. Res."},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1016\/j.intimp.2004.11.009","article-title":"Cytokines and the regulation of hypoxia-inducible factor (HIF)-1alpha","volume":"5","author":"Haddad","year":"2005","journal-title":"Int. Immunopharmacol."},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/j.smim.2014.05.004","article-title":"Regulation of NF-kappaB by TNF family cytokines","volume":"26","author":"Hayden","year":"2014","journal-title":"Semin. Immunol."},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1038\/cr.2010.177","article-title":"Non-canonical NF-kappaB signaling pathway","volume":"21","author":"Sun","year":"2011","journal-title":"Cell Res."},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1186\/s12964-022-00949-6","article-title":"Exosomes: Mediators regulating the phenotypic transition of vascular smooth muscle cells in atherosclerosis","volume":"20","author":"Yao","year":"2022","journal-title":"Cell Commun. Signal."},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1016\/j.molcel.2008.04.009","article-title":"Oxygen sensing by metazoans: The central role of the HIF hydroxylase pathway","volume":"30","author":"Kaelin","year":"2008","journal-title":"Mol. Cell"},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1016\/j.cell.2012.01.021","article-title":"Hypoxia-inducible factors in physiology and medicine","volume":"14","author":"Semenza","year":"2012","journal-title":"Cell"},{"key":"ref_140","doi-asserted-by":"crossref","unstructured":"Yu, M., Lun, J., Zhang, H., Zhu, L., Zhang, G., and Fang, J. (2021). The non-canonical functions of HIF prolyl hydroxylases and their dual roles in cancer. Int. J. Biochem. Cell Biol., 135.","DOI":"10.1016\/j.biocel.2021.105982"},{"key":"ref_141","doi-asserted-by":"crossref","unstructured":"Bailey, P.S.J., and Nathan, J.A. (2018). Metabolic regulation of hypoxia-inducible transcription factors: The role of small molecule metabolites and iron. Biomedicines, 6.","DOI":"10.3390\/biomedicines6020060"},{"key":"ref_142","doi-asserted-by":"crossref","unstructured":"T\u00f3th, A., Csiki, D.M., Nagy, B., Balogh, E., Lente, G., Ababneh, H., Sz\u00f6\u0151r, \u00c1., and Jeney, V. (2022). Daprodustat accelerates high phosphate-induced calcification through the activation of HIF-1 signaling. Front. Pharmacol., 13.","DOI":"10.3389\/fphar.2022.798053"},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"1263","DOI":"10.1016\/j.bbamcr.2010.08.006","article-title":"Hypoxia-inducible factor 1: Regulator of mitochondrial metabolism and mediator of ischemic preconditioning","volume":"1813","author":"Semenza","year":"2011","journal-title":"Biochim. Biophys. Acta"},{"key":"ref_144","first-page":"e63852","article-title":"Hypoxia-inducible factor 1-alpha (HIF-1alpha): An essential regulator in cellular metabolic control","volume":"16","author":"Basheeruddin","year":"2024","journal-title":"Cureus"},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"1084","DOI":"10.2174\/138955709788922610","article-title":"HIF-1alpha modulates energy metabolism in cancer cells by inducing over-expression of specific glycolytic isoforms","volume":"9","author":"Ralph","year":"2009","journal-title":"Mini Rev. Med. Chem."},{"key":"ref_146","doi-asserted-by":"crossref","unstructured":"Vall\u00e9e, A., Lecarpentier, Y., and Vall\u00e9e, J.N. (2021). The key role of the WNT\/beta-catenin pathway in metabolic reprogramming in cancers under normoxic conditions. Cancers, 13.","DOI":"10.3390\/cancers13215557"},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.ctrv.2016.03.005","article-title":"Metabolic phenotype of bladder cancer","volume":"45","author":"Massari","year":"2016","journal-title":"Cancer Treat. Rev."},{"key":"ref_148","doi-asserted-by":"crossref","unstructured":"Kozlov, A.M., Lone, A., Betts, D.H., and Cumming, R.C. (2020). Lactate preconditioning promotes a HIF-1alpha-mediated metabolic shift from OXPHOS to glycolysis in normal human diploid fibroblasts. Sci. Rep., 10.","DOI":"10.1038\/s41598-020-65193-9"},{"key":"ref_149","doi-asserted-by":"crossref","unstructured":"Carlessi, R., Chen, Y., Rowlands, J., Cruzat, V.F., Keane, K.N., Egan, L., Mamotte, C., Stokes, R., Gunton, J.E., and Bittencourt, P.I.H. (2017). GLP-1 receptor signalling promotes beta-cell glucose metabolism via mTOR-dependent HIF-1alpha activation. Sci. Rep., 7.","DOI":"10.1038\/s41598-017-02838-2"},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"23111","DOI":"10.1074\/jbc.M202487200","article-title":"Hypoxia-inducible factor 1 activation by aerobic glycolysis implicates the Warburg effect in carcinogenesis","volume":"277","author":"Lu","year":"2002","journal-title":"J. Biol. Chem."},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1038\/s41392-022-01151-3","article-title":"Lactate metabolism in human health and disease","volume":"7","author":"Li","year":"2022","journal-title":"Signal. Transduct. Target. Ther."},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.cmet.2006.02.002","article-title":"HIF-1-mediated expression of pyruvate dehydrogenase kinase: A metabolic switch required for cellular adaptation to hypoxia","volume":"3","author":"Kim","year":"2006","journal-title":"Cell Metab."},{"key":"ref_153","doi-asserted-by":"crossref","unstructured":"Wei, X., Hou, Y., Long, M., Jiang, L., and Du, Y. (2022). Molecular mechanisms underlying the role of hypoxia-inducible factor-1 alpha in metabolic reprogramming in renal fibrosis. Front. Endocrinol., 13.","DOI":"10.3389\/fendo.2022.927329"},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"e2208117120","DOI":"10.1073\/pnas.2208117120","article-title":"Hypoxia induces a glycolytic complex in intestinal epithelial cells independent of HIF-1-driven glycolytic gene expression","volume":"120","author":"Kierans","year":"2023","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_155","doi-asserted-by":"crossref","first-page":"9029327","DOI":"10.1155\/2017\/9029327","article-title":"HIF1alpha-induced glycolysis metabolism is essential to the activation of inflammatory macrophages","volume":"2017","author":"Wang","year":"2017","journal-title":"Mediat. Inflamm."},{"key":"ref_156","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1007\/s12185-012-1069-y","article-title":"Hypoxia-inducible factors and their roles in energy metabolism","volume":"95","author":"Goda","year":"2012","journal-title":"Int. J. Hematol."},{"key":"ref_157","doi-asserted-by":"crossref","unstructured":"Liang, B., Deng, L., and Zhou, X. (2022). Targeting hypoxia-related metabolism molecules: How to improve tumour immune and clinical treatment?. Biomed. Pharmacother., 156.","DOI":"10.1016\/j.biopha.2022.113917"},{"key":"ref_158","doi-asserted-by":"crossref","first-page":"e25217","DOI":"10.7554\/eLife.25217","article-title":"HIF-1alpha is required for disturbed flow-induced metabolic reprogramming in human and porcine vascular endothelium","volume":"6","author":"Wu","year":"2017","journal-title":"Elife"},{"key":"ref_159","doi-asserted-by":"crossref","unstructured":"Phadwal, K., Vrahnas, C., Ganley, I.G., and MacRae, V.E. (2021). Mitochondrial dysfunction: Cause or consequence of vascular calcification?. Front. Cell Dev. Biol., 9.","DOI":"10.3389\/fcell.2021.611922"},{"key":"ref_160","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1186\/s13046-021-02188-y","article-title":"HIF-1\u03b1 switches the functionality of TGF-\u03b2 signaling via changing the partners of smads to drive glucose metabolic reprogramming in non-small cell lung cancer","volume":"40","author":"Huang","year":"2021","journal-title":"J. Exp. Clin. Cancer. Res."},{"key":"ref_161","doi-asserted-by":"crossref","unstructured":"He, Q., Ma, Y., Liu, J., Zhang, D., Ren, J., Zhao, R., Chang, J., Guo, Z.N., and Yang, Y. (2021). Biological functions and regulatory mechanisms of hypoxia-inducible factor-1alpha in ischemic stroke. Front. Immunol., 12.","DOI":"10.3389\/fimmu.2021.801985"},{"key":"ref_162","first-page":"5169069","article-title":"Pathophysiological and genetic aspects of vascular calcification","volume":"2020","author":"Lopes","year":"2020","journal-title":"Cardiol. Res. Pract."},{"key":"ref_163","doi-asserted-by":"crossref","first-page":"239","DOI":"10.3892\/mmr.2021.11878","article-title":"The potential role and trend of HIF-1alpha in intervertebral disc degeneration: Friend or foe? (Review)","volume":"23","author":"Li","year":"2021","journal-title":"Mol. Med. Rep."},{"key":"ref_164","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1038\/cdd.2011.95","article-title":"HIF-1alpha is critical for hypoxia-mediated maintenance of glioblastoma stem cells by activating Notch signaling pathway","volume":"1","author":"Qiang","year":"2012","journal-title":"Cell Death Differ."},{"key":"ref_165","doi-asserted-by":"crossref","first-page":"1918","DOI":"10.1002\/stem.518","article-title":"Interaction of hypoxia-inducible factor-1alpha and Notch signaling regulates medulloblastoma precursor proliferation and fate","volume":"28","author":"Pistollato","year":"2010","journal-title":"Stem Cells"},{"key":"ref_166","doi-asserted-by":"crossref","first-page":"3368","DOI":"10.1073\/pnas.0711591105","article-title":"Interaction with factor inhibiting HIF-1 defines an additional mode of cross-coupling between the Notch and hypoxia signaling pathways","volume":"105","author":"Zheng","year":"2008","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_167","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1016\/j.neuroscience.2018.10.037","article-title":"HIF-1alpha is critical for the activation of Notch signaling in neurogenesis during acute epilepsy","volume":"394","author":"Li","year":"2018","journal-title":"Neuroscience"},{"key":"ref_168","doi-asserted-by":"crossref","first-page":"148","DOI":"10.2174\/157340308785160552","article-title":"Notch signaling in cardiovascular disease and calcification","volume":"4","author":"Rusanescu","year":"2008","journal-title":"Curr. Cardiol. Rev."},{"key":"ref_169","doi-asserted-by":"crossref","first-page":"1235","DOI":"10.1152\/physrev.00005.2017","article-title":"Notch signaling in development, tissue homeostasis, and disease","volume":"97","author":"Siebel","year":"2017","journal-title":"Physiol. Rev."},{"key":"ref_170","doi-asserted-by":"crossref","first-page":"45","DOI":"10.4062\/biomolther.2019.119","article-title":"The role of a neurovascular signaling pathway involving hypoxia-inducible factor and Notch in the function of the central nervous system","volume":"28","author":"Kim","year":"2020","journal-title":"Biomol. Ther."},{"key":"ref_171","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1016\/j.nbd.2013.10.009","article-title":"Evidence that collaboration between HIF-1alpha and Notch-1 promotes neuronal cell death in ischemic stroke","volume":"62","author":"Cheng","year":"2014","journal-title":"Neurobiol. Dis."},{"key":"ref_172","doi-asserted-by":"crossref","first-page":"114211","DOI":"10.1016\/j.yexcr.2024.114211","article-title":"Vascular smooth muscle cell-derived exosomes promote osteoblast-to-osteocyte transition via beta-catenin signaling","volume":"442","author":"Fernandes","year":"2024","journal-title":"Exp. Cell Res."},{"key":"ref_173","doi-asserted-by":"crossref","unstructured":"Weinstein, N., Mendoza, L., Gitler, I., and Klapp, J. (2017). A network model to explore the effect of the micro-environment on endothelial cell behavior during angiogenesis. Front. Physiol., 8.","DOI":"10.3389\/fphys.2017.00960"},{"key":"ref_174","first-page":"4644","article-title":"AGE\/RAGE promotes thecalcification of human aortic smooth muscle cells via the Wnt\/beta-catenin axis","volume":"8","author":"Liu","year":"2016","journal-title":"Am. J. Transl. Res."},{"key":"ref_175","doi-asserted-by":"crossref","unstructured":"Bundy, K., Boone, J., and Simpson, C.L. (2021). Wnt signaling in vascular calcification. Front. Cardiovasc. Med., 8.","DOI":"10.3389\/fcvm.2021.708470"},{"key":"ref_176","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1186\/s13018-022-03162-w","article-title":"Roxadustat promotes osteoblast differentiation and prevents estrogen deficiency-induced bone loss by stabilizing HIF-1alpha and activating the Wnt\/beta-catenin signaling pathway","volume":"17","author":"Li","year":"2022","journal-title":"J. Orthop. Surg. Res."},{"key":"ref_177","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.yjmcc.2019.05.024","article-title":"Metabolic reprogramming in atherosclerosis: Opposed interplay between the canonical WNT\/beta-catenin pathway and PPARgamma","volume":"133","author":"Lecarpentier","year":"2019","journal-title":"J. Mol. Cell. Cardiol."},{"key":"ref_178","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1038\/s41581-019-0182-z","article-title":"Mechanisms of hypoxia signalling: New implications for nephrology","volume":"15","author":"Ratcliffe","year":"2019","journal-title":"Nat. Rev. Nephrol."},{"key":"ref_179","doi-asserted-by":"crossref","first-page":"906","DOI":"10.1161\/HYPERTENSIONAHA.121.18778","article-title":"Capsaicin attenuates arterial calcification through promoting SIRT6-mediated deacetylation and degradation of Hif1alpha (hypoxic-inducible factor-1 alpha)","volume":"79","author":"Luo","year":"2022","journal-title":"Hypertension"},{"key":"ref_180","doi-asserted-by":"crossref","first-page":"6346115","DOI":"10.1155\/2024\/6346115","article-title":"Hypoxia-inducible factor-1alpha regulates high phosphate-induced vascular calcification via type III sodium-dependent phosphate cotransporter 1","volume":"2024","author":"Guo","year":"2024","journal-title":"Cardiol. Res. Pract."},{"key":"ref_181","doi-asserted-by":"crossref","unstructured":"T\u00f3th, A., Lente, G., Csiki, D.M., Balogh, E., Sz\u00f6\u0151r, \u00c1., Nagy, B., and Jeney, V. (2024). Activation of PERK\/eIF2\u03b1\/ATF4\/CHOP branch of endoplasmic reticulum stress response and cooperation between HIF-1\u03b1 and ATF4 promotes Daprodustat-induced vascular calcification. Front. Pharmacol., 15.","DOI":"10.3389\/fphar.2024.1399248"},{"key":"ref_182","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1007\/s00018-024-05152-z","article-title":"ALKBH1 promotes HIF-1alpha-mediated glycolysis by inhibiting N-glycosylation of LAMP2A","volume":"81","author":"Liu","year":"2024","journal-title":"Cell. Mol. Life. Sci."},{"key":"ref_183","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s12276-019-0299-y","article-title":"Hypoxia signaling in human diseases and therapeutic targets","volume":"51","author":"Lee","year":"2019","journal-title":"Exp. Mol. Med."},{"key":"ref_184","doi-asserted-by":"crossref","unstructured":"Adhikari, R., Jung, J., Shiwakoti, S., Park, E.Y., Kim, H.J., Ko, J.Y., You, J., Lee, M., and Oak, M.H. (2023). Capsaicin inhibits aortic valvular interstitial cell calcification via the redox-sensitive NFkappaB\/AKT\/ERK1\/2 pathway. Biochem. Pharmacol., 212.","DOI":"10.1016\/j.bcp.2023.115530"},{"key":"ref_185","doi-asserted-by":"crossref","first-page":"894","DOI":"10.1002\/dvdy.24127","article-title":"A Notch-dependent transcriptional hierarchy promotes mesenchymal transdifferentiation in the cardiac cushion","volume":"243","author":"Chang","year":"2014","journal-title":"Dev. Dyn."},{"key":"ref_186","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.yexcr.2017.04.030","article-title":"The interplay between the cellular hypoxic response and Notch signaling","volume":"356","author":"Landor","year":"2017","journal-title":"Exp. Cell Res."},{"key":"ref_187","doi-asserted-by":"crossref","first-page":"3365","DOI":"10.3892\/mmr.2015.3812","article-title":"Hypoxia-inducible factor-1alpha and Wnt\/beta-catenin signaling pathways promote the invasion of hypoxic gastric cancer cells","volume":"12","author":"Liu","year":"2015","journal-title":"Mol. Med. Rep."},{"key":"ref_188","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1007\/s00223-021-00833-4","article-title":"RTEF-1 inhibits vascular smooth muscle cell calcification through regulating Wnt\/beta-catenin signaling pathway","volume":"109","author":"Cong","year":"2021","journal-title":"Calcif. Tissue Int."}],"container-title":["Biomolecules"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2218-273X\/14\/12\/1592\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T16:53:55Z","timestamp":1760115235000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2218-273X\/14\/12\/1592"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12,12]]},"references-count":188,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["biom14121592"],"URL":"https:\/\/doi.org\/10.3390\/biom14121592","relation":{},"ISSN":["2218-273X"],"issn-type":[{"value":"2218-273X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,12,12]]}}}