{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T05:28:31Z","timestamp":1783574911098,"version":"3.55.0"},"reference-count":50,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2024,12,24]],"date-time":"2024-12-24T00:00:00Z","timestamp":1734998400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Italian Ministry of University and Research (MUR)","award":["CUP B53D23013710006"],"award-info":[{"award-number":["CUP B53D23013710006"]}]},{"name":"Italian Ministry of University and Research (MUR)","award":["CUP B53C20040570005"],"award-info":[{"award-number":["CUP B53C20040570005"]}]},{"name":"European Union","award":["CUP B53D23013710006"],"award-info":[{"award-number":["CUP B53D23013710006"]}]},{"name":"European Union","award":["CUP B53C20040570005"],"award-info":[{"award-number":["CUP B53C20040570005"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biomolecules"],"abstract":"<jats:p>Satureja montana essential oil is a natural substance able to inhibit the growth of several pathogens. This antimicrobial effect is often attributed to its ability to penetrate cellular structures and disrupt them. Although these properties are recognized as playing a key role in the mechanism of action of this substance, many unresolved issues still exist, and fundamental studies focused on such aspects are scarce. In this framework, we investigated the interaction of SEO with lipid monolayers, which represent simplified models of cell membranes, using the Langmuir monolayer technique, complemented by fluorescence anisotropy and differential scanning calorimetry on lipid bilayers. By focusing on packing conditions that approximate those of biological membranes and using lipids with different polar heads and structures, such as the ones occurring in bacterial membranes, we aim to clarify the effect of this essential oil on the lipid membrane. Our results show that Satureja montana essential oil consistently manages to insert into the membrane and interfere with the lipid\u2013lipid interactions, thereby altering the lipid packing and significantly increasing the membrane fluidity, depending on the oil concentration and the nature of the lipid.<\/jats:p>","DOI":"10.3390\/biom15010005","type":"journal-article","created":{"date-parts":[[2024,12,24]],"date-time":"2024-12-24T10:58:32Z","timestamp":1735037912000},"page":"5","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Effect of Satureja montana Essential Oil on Model Lipid Membranes"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4793-5359","authenticated-orcid":false,"given":"Simona","family":"Sennato","sequence":"first","affiliation":[{"name":"CNR-Institute for Complex Systems, Piazzale Aldo Moro 5, 00185 Rome, Italy"},{"name":"Department of Physics, Sapienza University of Rome, Piazzale Aldo Moro 5, 00185 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4322-3047","authenticated-orcid":false,"given":"Silvia","family":"Trabalzini","sequence":"additional","affiliation":[{"name":"Drug Chemistry and Technology Department, Sapienza University of Rome, Piazzale Aldo Moro 2, 00185 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-8611-7540","authenticated-orcid":false,"given":"Maria Gioia","family":"Fabiano","sequence":"additional","affiliation":[{"name":"Drug Chemistry and Technology Department, Sapienza University of Rome, Piazzale Aldo Moro 2, 00185 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1841-969X","authenticated-orcid":false,"given":"Domenico","family":"Truzzolillo","sequence":"additional","affiliation":[{"name":"Laboratoire Charles Coulomb, UMR 5221, CNRS\u2013Universit\u00e9 de Montpellier, 34095 Montpellier, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edouard","family":"Chauveau","sequence":"additional","affiliation":[{"name":"Laboratoire Charles Coulomb, UMR 5221, CNRS\u2013Universit\u00e9 de Montpellier, 34095 Montpellier, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0877-0504","authenticated-orcid":false,"given":"Cecilia","family":"Bombelli","sequence":"additional","affiliation":[{"name":"CNR-Institute for Biological Systems, Secondary Office of Rome-Reaction Mechanisms, c\/o Chemistry Department, Sapienza University of Rome, Piazzale Aldo Moro 5, 00185 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3501-4176","authenticated-orcid":false,"given":"Federica","family":"Rinaldi","sequence":"additional","affiliation":[{"name":"Drug Chemistry and Technology Department, Sapienza University of Rome, Piazzale Aldo Moro 2, 00185 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3968-3385","authenticated-orcid":false,"given":"Maria","family":"Carafa","sequence":"additional","affiliation":[{"name":"Drug Chemistry and Technology Department, Sapienza University of Rome, Piazzale Aldo Moro 2, 00185 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,12,24]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Angane, M., Swift, S., Huang, K., Butts, C.A., and Quek, S.Y. 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