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VaD has been shown to develop when reactive oxygen species (ROS) form from damaged targets at different levels of organization\u2014mitochondria, endothelial cells, or cerebrovasculature. In this review, we highlight how specific ROS molecules may be important in the development of VaD and how they can be targeted as a potential therapeutic for VaD.<\/jats:p>","DOI":"10.3390\/biom15010006","type":"journal-article","created":{"date-parts":[[2024,12,25]],"date-time":"2024-12-25T19:29:52Z","timestamp":1735154992000},"page":"6","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Reactive Oxygen Species, a Potential Therapeutic Target for Vascular Dementia"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4858-0860","authenticated-orcid":false,"given":"Amanda Louise","family":"White","sequence":"first","affiliation":[{"name":"Clinical Neuroscience Research Center, Department of Neurosurgery, Tulane University School of Medicine, New Orleans, LA 70112, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Grant M.","family":"Talkington","sequence":"additional","affiliation":[{"name":"Clinical Neuroscience Research Center, Department of Neurosurgery, Tulane University School of Medicine, New Orleans, LA 70112, USA"},{"name":"Tulane Brain Institute, Tulane University, New Orleans, LA 70112, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Blake","family":"Ouvrier","sequence":"additional","affiliation":[{"name":"Clinical Neuroscience Research Center, Department of Neurosurgery, Tulane University School of Medicine, New Orleans, LA 70112, USA"},{"name":"Tulane Brain Institute, Tulane University, New Orleans, LA 70112, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9976-0939","authenticated-orcid":false,"given":"Saifudeen","family":"Ismael","sequence":"additional","affiliation":[{"name":"Clinical Neuroscience Research Center, Department of Neurosurgery, Tulane University School of Medicine, New Orleans, LA 70112, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5752-9229","authenticated-orcid":false,"given":"Rebecca J.","family":"Solch-Ottaiano","sequence":"additional","affiliation":[{"name":"Clinical Neuroscience Research Center, Department of Neurosurgery, Tulane University School of Medicine, New Orleans, LA 70112, USA"},{"name":"Tulane Brain Institute, Tulane University, New Orleans, LA 70112, USA"},{"name":"Department of Microbiology and Immunology, Tulane University School of Medicine, New Orleans, LA 70112, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8969-9553","authenticated-orcid":false,"given":"Gregory","family":"Bix","sequence":"additional","affiliation":[{"name":"Clinical Neuroscience Research Center, Department of Neurosurgery, Tulane University School of Medicine, New Orleans, LA 70112, USA"},{"name":"Tulane Brain Institute, Tulane University, New Orleans, LA 70112, USA"},{"name":"Department of Microbiology and Immunology, Tulane University School of Medicine, New Orleans, LA 70112, USA"},{"name":"Department of Neurology, Tulane University School of Medicine, New Orleans, LA 70112, USA"},{"name":"School of Public Health and Tropical Medicine, Tulane University, New Orleans, LA 70122, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,12,25]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1186\/1742-4933-6-13","article-title":"Pathophysiology of vascular dementia","volume":"6","author":"Iemolo","year":"2009","journal-title":"Immun. 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