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Drawing on findings from various branches of \u201comics\u201d, including genomics, epigenomics, transcriptomics, proteomics, lipidomics, metabolomics, and microbiomics, this narrative review aims to (1) discuss mechanistic insights on endometrial receptivity and its implication in infertility; (2) highlight advances in investigations for endometrial receptivity; and (3) discuss novel diagnostic and therapeutic strategies that may improve reproductive outcomes.<\/jats:p>","DOI":"10.3390\/biom15010106","type":"journal-article","created":{"date-parts":[[2025,1,13]],"date-time":"2025-01-13T04:01:52Z","timestamp":1736740912000},"page":"106","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Endometrial Receptivity\u2013Lessons from \u201cOmics\u201d"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5109-6327","authenticated-orcid":false,"given":"Louie","family":"Ye","sequence":"first","affiliation":[{"name":"Reproductive Service Unit, The Royal Women\u2019s Hospital, Melbourne, VIC 3052, Australia"},{"name":"Department of Obstetrics, Gynaecology and Newborn Health, University of Melbourne, Melbourne, VIC 3052, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evdokia","family":"Dimitriadis","sequence":"additional","affiliation":[{"name":"Department of Obstetrics, Gynaecology and Newborn Health, University of Melbourne, Melbourne, VIC 3052, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,1,11]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"101656","DOI":"10.1016\/j.tice.2021.101656","article-title":"Main actors behind the endometrial receptivity and successful implantation","volume":"73","author":"Governini","year":"2021","journal-title":"Tissue Cell"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1400","DOI":"10.1056\/NEJMra000763","article-title":"Implantation and the Survival of Early Pregnancy","volume":"345","author":"Norwitz","year":"2001","journal-title":"N. 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