{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T19:03:07Z","timestamp":1790017387669,"version":"4.0.1"},"reference-count":129,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2025,1,16]],"date-time":"2025-01-16T00:00:00Z","timestamp":1736985600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Ministry of Research, Innovation, and Digitization, CNCS-UEFISCDI","award":["PN-III-P4-PCE-2021-1692"],"award-info":[{"award-number":["PN-III-P4-PCE-2021-1692"]}]},{"name":"Ministry of Research, Innovation, and Digitization, CNCS-UEFISCDI","award":["PNCDI III"],"award-info":[{"award-number":["PNCDI III"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biomolecules"],"abstract":"<jats:p>Origanum majorana L., also known as sweet marjoram, is a plant with multiple uses, both in the culinary field and traditional medicine, because of its major antioxidant, anti-inflammatory, antimicrobial, and digestive properties. In this research, we focused on the effects of O. majorana essential oil (OmEO, at concentrations of 25, 150, and 300 \u03bcL\/L), evaluating chemical structure as well as its impact on cognitive performance and oxidative stress, in both naive zebrafish (Danio rerio), as well as in a scopolamine-induced amnesic model (SCOP, 100 \u03bcM). The fish behavior was analyzed in a novel tank-diving test (NTT), a Y-maze test, and a novel object recognition (NOR) test. We also investigated acetylcholinesterase (AChE) activity and the brain\u2019s oxidative stress status. In parallel, we performed in silico predictions (research conducted using computational models) of the pharmacokinetic properties of the main compounds identified in OmEO, using platforms such as SwissADME, pKCSM, ADMETlab 2.0, and ProTox-II. The results revealed that the major compounds were trans-sabinene hydrate (36.11%), terpinen-4-ol (17.97%), linalyl acetate (9.18%), caryophyllene oxide (8.25%), and \u03b1-terpineol (6.17%). OmEO can enhance memory through AChE inhibition, reduce SCOP-induced anxiety by increasing the time spent in the top zone in the NTT, and significantly reduce oxidative stress markers. These findings underscore the potential of using O. majorana to improve memory impairment and reduce oxidative stress associated with cognitive disorders, including Alzheimer\u2019s disease (AD).<\/jats:p>","DOI":"10.3390\/biom15010138","type":"journal-article","created":{"date-parts":[[2025,1,16]],"date-time":"2025-01-16T10:44:23Z","timestamp":1737024263000},"page":"138","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Neuroprotective Potential of Origanum majorana L. Essential Oil Against Scopolamine-Induced Memory Deficits and Oxidative Stress in a Zebrafish Model"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3103-9728","authenticated-orcid":false,"given":"Ion","family":"Brinza","sequence":"first","affiliation":[{"name":"Department of Biology, Faculty of Biology, Alexandru Ioan Cuza University of Iasi, 700506 Iasi, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2602-4882","authenticated-orcid":false,"given":"Razvan Stefan","family":"Boiangiu","sequence":"additional","affiliation":[{"name":"Department of Biology, Faculty of Biology, Alexandru Ioan Cuza University of Iasi, 700506 Iasi, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iasmina","family":"Honceriu","sequence":"additional","affiliation":[{"name":"Department of Biology, Faculty of Biology, Alexandru Ioan Cuza University of Iasi, 700506 Iasi, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed M.","family":"Abd-Alkhalek","sequence":"additional","affiliation":[{"name":"Faculty of Medicine (for Boys), Al Azhar University, Cairo 11651, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samir M.","family":"Osman","sequence":"additional","affiliation":[{"name":"Department of Pharmacognosy, Faculty of Pharmacy, October 6 University, Giza 3232031, Giza Governorate, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0972-0560","authenticated-orcid":false,"given":"Omayma A.","family":"Eldahshan","sequence":"additional","affiliation":[{"name":"Department of Pharmacognosy, Faculty of Pharmacy, Ain Shams University, Abbassia, Cairo 11566, Egypt"},{"name":"Center of Drug Discovery Research and Development, Ain Shams University, Cairo 11566, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Todirascu-Ciornea","sequence":"additional","affiliation":[{"name":"Department of Biology, Faculty of Biology, Alexandru Ioan Cuza University of Iasi, 700506 Iasi, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriela","family":"Dumitru","sequence":"additional","affiliation":[{"name":"Department of Biology, Faculty of Biology, Alexandru Ioan Cuza University of Iasi, 700506 Iasi, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6981-4174","authenticated-orcid":false,"given":"Lucian","family":"Hritcu","sequence":"additional","affiliation":[{"name":"Department of Biology, Faculty of Biology, Alexandru Ioan Cuza University of Iasi, 700506 Iasi, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,1,16]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Dey, A., Ghosh, S., Rajendran, R.L., Bhuniya, T., Das, P., Bhattacharjee, B., Das, S., Mahajan, A.A., Samant, A., and Krishnan, A. (2024). Alzheimer\u2019s Disease Pathology and Assistive Nanotheranostic Approaches for Its Therapeutic Interventions. Int. J. Mol. Sci., 25.","DOI":"10.3390\/ijms25179690"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"24","DOI":"10.12703\/r\/12-24","article-title":"Recent Advances in Understanding Alzheimer\u2019s Disease: Diagnosis and Management Strategies","volume":"12","author":"Marin","year":"2023","journal-title":"Fac. Rev."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1038\/nrneurol.2017.57","article-title":"Neurofilament Light in the Blood Marks Alzheimer Degeneration","volume":"13","author":"Fyfe","year":"2017","journal-title":"Nat. Rev. Neurol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1055\/s-0039-1681041","article-title":"Alzheimer\u2019s Disease Including Focal Presentations","volume":"39","author":"Villain","year":"2019","journal-title":"Semin. Neurol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1","DOI":"10.2174\/0115748855332142240830114503","article-title":"Novel Therapeutic Approaches in Alzheimer\u2019s Disease","volume":"19","author":"Ingle","year":"2024","journal-title":"Curr. Drug Ther."},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Tanvir Kabir, M., Sahab Uddin, M., Al Mamun, A., Jeandet, P., Aleya, L., Mansouri, R.A., Md Ashraf, G., Mathew, B., Bin-Jumah, M.N., and Abdel-Daim, M.M. (2020). Combination Drug Therapy for the Management of Alzheimer\u2019s Disease. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21093272"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1016\/j.biopha.2018.06.147","article-title":"A Molecular Approach in Drug Development for Alzheimer\u2019s Disease","volume":"106","author":"Kettle","year":"2018","journal-title":"Biomed. Pharmacother."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"701","DOI":"10.2174\/0929867329666220803113411","article-title":"da C. Anticholinesterase Agents for Alzheimer\u2019s Disease Treatment: An Updated","volume":"30","author":"Llanes","year":"2022","journal-title":"Curr. Med. Chem."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"927","DOI":"10.2147\/TCRM.S323387","article-title":"Adverse Drug Reactions of Acetylcholinesterase Inhibitors in Older People Living with Dementia: A Comprehensive Literature Review","volume":"17","author":"Ruangritchankul","year":"2021","journal-title":"Ther. Clin. Risk Manag."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/bs.seda.2021.09.012","article-title":"Side Effects of Drugs Used in the Treatment of Alzheimer\u2019s Disease","volume":"43","author":"Hoffman","year":"2021","journal-title":"Side Eff. Drugs Annu."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"4011","DOI":"10.2174\/1381612822666160607065917","article-title":"Essential Oils and Pure Volatile Compounds as Potential Drugs in Alzheimer\u2019s Disease Therapy: An Updated Review of the Literature","volume":"22","author":"Maggio","year":"2016","journal-title":"Curr. Pharm. Des."},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Paudel, P.N., Satyal, P., Satyal, R., Setzer, W.N., and Gyawali, R. (2022). Chemical Composition, Enantiomeric Distribution, Antimicrobial and Antioxidant Activities of Origanum majorana L. Essential Oil from Nepal. Molecules, 27.","DOI":"10.3390\/molecules27186136"},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Wagdy, R., Abdel-Kader, R.M., El-Khatib, A.H., Linscheid, M.W., Handoussa, H., and Hamdi, N. (2023). Origanum majorana L. Protects against Neuroinflammation-Mediated Cognitive Impairment: A Phyto-Pharmacological Study. BMC Complement. Med. Ther., 23.","DOI":"10.1186\/s12906-023-03994-x"},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Postu, P.A., Gorgan, D.L., Cioanca, O., Russ, M., Mikkat, S., Glocker, M.O., and Hritcu, L. (2020). Memory-Enhancing Effects of Origanum majorana Essential Oil in an Alzheimer\u2019s Amyloid Beta1-42 Rat Model: A Molecular and Behavioral Study. Antioxidants, 9.","DOI":"10.3390\/antiox9100919"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.1007\/s11011-022-00933-6","article-title":"A Multi-Parameter Evaluation of the Neuroprotective and Cognitive-Enhancing Effects of Origanum onites L. (Turkish Oregano) Essential Oil on Scopolamine-Induced Amnestic Rats","volume":"37","author":"Aykac","year":"2022","journal-title":"Metab. Brain Dis."},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Zhao, M., Wu, F., Tang, Z., Yang, X., Liu, Y., Wang, F., and Chen, B. (2023). Anti-Inflammatory and Antioxidant Activity of Ursolic Acid: A Systematic Review and Meta-Analysis. Front. Pharmacol., 14.","DOI":"10.3389\/fphar.2023.1256946"},{"key":"ref_17","first-page":"74","article-title":"Anti-Inflammatory Effect of Apigenin-7-Neohesperidoside (Rhoifolin) in Carrageenin-Induced Rat Oedema Model","volume":"2","author":"Eldahshan","year":"2012","journal-title":"J. Appl. Pharm. Sci."},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Ntalouka, F., and Tsirivakou, A. (2023). Luteolin: A Promising Natural Agent in Management of Pain in Chronic Conditions. Front. Pain Res., 4.","DOI":"10.3389\/fpain.2023.1114428"},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Gregory, J., Vengalasetti, Y.V., Bredesen, D.E., and Rao, R.V. (2021). Neuroprotective Herbs for the Management of Alzheimer\u2019s Disease. Biomolecules, 11.","DOI":"10.3390\/biom11040543"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1016\/j.foodchem.2007.04.015","article-title":"Comparative Chemical Composition, Antioxidant and Hypoglycaemic Activities of Juniperus oxycedrus ssp. Oxycedrus L. Berry and Wood Oils from Lebanon","volume":"105","author":"Loizzo","year":"2007","journal-title":"Food Chem."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1016\/j.pbb.2012.12.010","article-title":"Acute Administration of Dopaminergic Drugs Has Differential Effects on Locomotion in Larval Zebrafish","volume":"103","author":"Irons","year":"2013","journal-title":"Pharmacol. Biochem. Behav."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.tips.2013.12.002","article-title":"Zebrafish as an Emerging Model for Studying Complex Brain Disorders","volume":"35","author":"Kalueff","year":"2014","journal-title":"Trends Pharmacol. Sci."},{"key":"ref_23","unstructured":"McLafferty, F.W., and Stauffer, D.B. (2005). Wiley Registry of Mass Spectral Data, 8th ed, John Wiley & Sons."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"4133","DOI":"10.1080\/14786419.2020.1736064","article-title":"Chemical Composition, Cytotoxicity and Molecular Profiling of Cordia Africana Lam. on Human Breast Cancer Cell Line","volume":"35","author":"Ashmawy","year":"2021","journal-title":"Nat. Prod. Res."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1654","DOI":"10.1080\/13880209.2017.1314512","article-title":"Anti-Inflammatory and Gastroprotective Potential of Leaf Essential Oil of Cinnamomum Glanduliferum in Ethanol-Induced Rat Experimental Gastritis","volume":"55","author":"Azaba","year":"2017","journal-title":"Pharm. Biol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1002\/cbdv.201500139","article-title":"Comparison of the Composition and Antimicrobial Activities of the Essential Oils of Green Branches and Leaves of Egyptian Navel Orange (Citrus sinensis (L.) Osbeck Var. Malesy)","volume":"13","author":"Eldahshan","year":"2016","journal-title":"Chem. Biodivers."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1080\/0972060X.2019.1667877","article-title":"GC\/MS Analysis and Molecular Profiling of Lemon Volatile Oil against Breast Cancer","volume":"22","author":"Ashmawy","year":"2019","journal-title":"J. Essent. Oil Bear. Plants"},{"key":"ref_28","unstructured":"(2023, November 06). PubChem, Available online: https:\/\/pubchem.ncbi.nlm.nih.gov\/."},{"key":"ref_29","unstructured":"(2023, November 06). Way2Drug\u2014Main. Available online: https:\/\/www.way2drug.com\/PASSOnline\/index.php."},{"key":"ref_30","unstructured":"(2023, October 13). SwissADME. Available online: http:\/\/www.swissadme.ch\/."},{"key":"ref_31","unstructured":"(2023, October 13). PkCSM. Available online: https:\/\/biosig.lab.uq.edu.au\/pkcsm\/."},{"key":"ref_32","unstructured":"(2023, November 06). ADMETlab 2.0. Available online: https:\/\/admetmesh.scbdd.com\/service\/screening\/index."},{"key":"ref_33","unstructured":"(2023, November 06). ProTox-II\u2014Prediction of TOXicity of Chemicals. Available online: https:\/\/tox.charite.de\/protox_II\/index.php?site=compound_search_similarity."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1021\/cc9800071","article-title":"A Knowledge-Based Approach in Designing Combinatorial or Medicinal Chemistry Libraries for Drug Discovery. 1. A Qualitative and Quantitative Characterization of Known Drug Databases","volume":"1","author":"Ghose","year":"1999","journal-title":"J. Comb. Chem."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"3867","DOI":"10.1021\/jm000292e","article-title":"Prediction of Drug Absorption Using Multivariate Statistics","volume":"43","author":"Egan","year":"2000","journal-title":"J. Med. Chem."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1289\/ehp.1205784","article-title":"Improving the Human Hazard Characterization of Chemicals: A Tox21 Update","volume":"121","author":"Tice","year":"2013","journal-title":"Environ. Health Perspect."},{"key":"ref_37","doi-asserted-by":"crossref","unstructured":"Daina, A., Michielin, O., and Zoete, V. (2017). SwissADME: A Free Web Tool to Evaluate Pharmacokinetics, Drug-Likeness and Medicinal Chemistry Friendliness of Small Molecules. Sci. Rep., 7.","DOI":"10.1038\/srep42717"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/S0169-409X(96)00423-1","article-title":"Experimental and Computational Approaches to Estimate Solubility and Permeability in Drug Discovery and Development Settings","volume":"23","author":"Lipinski","year":"1997","journal-title":"Adv. Drug Deliv. Rev."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1038\/nchem.1243","article-title":"Quantifying the Chemical Beauty of Drugs","volume":"4","author":"Bickerton","year":"2012","journal-title":"Nat. Chem."},{"key":"ref_40","doi-asserted-by":"crossref","unstructured":"Brinza, I., Boiangiu, R.S., Cioanca, O., Hancianu, M., Dumitru, G., Hritcu, L., Birsan, G.-C., and Todirascu-Ciornea, E. (2023). Direct Evidence for Using Coriandrum Sativum Var. Microcarpum Essential Oil to Ameliorate Scopolamine-Induced Memory Impairment and Brain Oxidative Stress in the Zebrafish Model. Antioxidants, 12.","DOI":"10.3390\/antiox12081534"},{"key":"ref_41","doi-asserted-by":"crossref","unstructured":"Brinza, I., Ayoub, I.M., Eldahshan, O.A., and Hritcu, L. (2021). Baicalein 5,6-Dimethyl Ether Prevents Memory Deficits in the Scopolamine Zebrafish Model by Regulating Cholinergic and Antioxidant Systems. Plants, 10.","DOI":"10.3390\/plants10061245"},{"key":"ref_42","doi-asserted-by":"crossref","unstructured":"Bate, S.T., and Clark, R.A. (2014). The Design and Statistical Analysis of Animal Experiments, Cambridge University Press.","DOI":"10.1017\/CBO9781139344319"},{"key":"ref_43","doi-asserted-by":"crossref","unstructured":"Angrand, P.-O., Far\u00edas-Cea, A., Leal, C., H\u00f6dar-Salazar, M., Esparza, E., Mart\u00ednez-Duran, L., Fuentes, I., and Iturriaga-V\u00e1squez, P. (2023). Behavioral Study of 3- and 5-Halocytisine Derivatives in Zebrafish Using the Novel Tank Diving Test (NTT). Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms241310635"},{"key":"ref_44","doi-asserted-by":"crossref","unstructured":"Blaser, R.E., and Rosemberg, D.B. (2012). Measures of Anxiety in Zebrafish (Danio rerio): Dissociation of Black\/White Preference and Novel Tank Test. PLoS ONE, 7.","DOI":"10.1371\/journal.pone.0036931"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.physbeh.2006.08.026","article-title":"Anxiolytic Effects of Nicotine in Zebrafish","volume":"90","author":"Levin","year":"2007","journal-title":"Physiol. Behav."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1007\/s00213-021-05990-w","article-title":"The Zebrafish (Danio rerio) Anxiety Test Battery: Comparison of Behavioral Responses in the Novel Tank Diving and Light\u2013Dark Tasks Following Exposure to Anxiogenic and Anxiolytic Compounds","volume":"239","author":"Fontana","year":"2022","journal-title":"Psychopharmacology"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.bbr.2009.06.022","article-title":"Understanding Behavioral and Physiological Phenotypes of Stress and Anxiety in Zebrafish","volume":"205","author":"Egan","year":"2009","journal-title":"Behav. Brain Res."},{"key":"ref_48","doi-asserted-by":"crossref","unstructured":"Haghani, S., Karia, M., Cheng, R.K., and Mathuru, A.S. (2019). An Automated Assay System to Study Novel Tank Induced Anxiety. Front. Behav. Neurosci., 13.","DOI":"10.3389\/fnbeh.2019.00180"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/978-1-60761-953-6_1","article-title":"Video-Aided Analysis of Zebrafish Locomotion and Anxiety-Related Behavioral Responses","volume":"51","author":"Cachat","year":"2011","journal-title":"Neuromethods"},{"key":"ref_50","first-page":"223","article-title":"A Review of Freely Available, Open-Source Software for the Automated Analysis of the Behavior of Adult Zebrafish","volume":"16","author":"Forero","year":"2019","journal-title":"Zebrafish"},{"key":"ref_51","doi-asserted-by":"crossref","unstructured":"Tan, J.K., Nazar, F.H., Makpol, S., and Teoh, S.L. (2022). Zebrafish: A Pharmacological Model for Learning and Memory Research. Molecules, 27.","DOI":"10.3390\/molecules27217374"},{"key":"ref_52","doi-asserted-by":"crossref","unstructured":"Shenoy, A., Banerjee, M., Upadhya, A., Bagwe-Parab, S., and Kaur, G. (2022). The Brilliance of the Zebrafish Model: Perception on Behavior and Alzheimer\u2019s Disease. Front. Behav. Neurosci., 16.","DOI":"10.3389\/fnbeh.2022.861155"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/j.nlm.2012.09.008","article-title":"Y-Maze Memory Task in Zebrafish (Danio rerio): The Role of Glutamatergic and Cholinergic Systems on the Acquisition and Consolidation Periods","volume":"98","author":"Bortolotto","year":"2012","journal-title":"Neurobiol. Learn. Mem."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/B978-0-12-812012-5.00018-5","article-title":"Immediate-Early Gene Expression in Neural Circuits Related to Object Recognition Memory","volume":"27","author":"Barbosa","year":"2018","journal-title":"Handb. Behav. Neurosci."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1089\/zeb.2018.1703","article-title":"Exploring Object Discrimination in Zebrafish: Behavioral Performance and Scopolamine-Induced Cognitive Deficits at Different Retention Intervals","volume":"16","author":"Stefanello","year":"2019","journal-title":"Zebrafish"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/0006-2952(61)90145-9","article-title":"A New and Rapid Colorimetric Determination of Acetylcholinesterase Activity","volume":"7","author":"Ellman","year":"1961","journal-title":"Biochem. Pharmacol."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/0003-2697(76)90527-3","article-title":"A Rapid and Sensitive Method for the Quantitation of Microgram Quantities of Protein Utilizing the Principle of Protein-Dye Binding","volume":"72","author":"Bradford","year":"1976","journal-title":"Anal. Biochem."},{"key":"ref_58","first-page":"337","article-title":"The Estimation of Red Cell Superoxide Dismutase Activity","volume":"85","author":"Winterbourn","year":"1975","journal-title":"J. Lab. Clin. Med."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1016\/0003-2697(72)90132-7","article-title":"Colorimetric Assay of Catalase","volume":"47","author":"Sinha","year":"1972","journal-title":"Anal. Biochem."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"405","DOI":"10.3177\/jnsv.22.405","article-title":"Glutathione Peroxidase Activity in Tissues of Vitamin E-Deficient Mice","volume":"22","author":"Fukuzawa","year":"1976","journal-title":"J. Nutr. Sci. Vitaminol."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1093\/pcp\/pcv015","article-title":"Sulfur Deprivation Results in Oxidative Perturbation in Chlorella Sorokiniana (211\/8k)","volume":"56","author":"Salbitani","year":"2015","journal-title":"Plant Cell Physiol."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"5488","DOI":"10.1016\/S0021-9258(18)45598-6","article-title":"Age-Related Changes in Oxidized Proteins","volume":"262","author":"Oliver","year":"1987","journal-title":"J. Biol. Chem."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/0003-2697(79)90738-3","article-title":"Assay for Lipid Peroxides in Animal Tissues by Thiobarbituric Acid Reaction","volume":"95","author":"Ohkawa","year":"1979","journal-title":"Anal. Biochem."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1007\/978-1-0716-3311-3_16","article-title":"Web Services for the Prediction of ADMET Parameters Relevant to the Design of Neuroprotective Drugs","volume":"203","author":"Perkin","year":"2023","journal-title":"Neuromethods"},{"key":"ref_65","doi-asserted-by":"crossref","unstructured":"Dulsat, J., L\u00f3pez-Nieto, B., Estrada-Tejedor, R., and Borrell, J.I. (2023). Evaluation of Free Online ADMET Tools for Academic or Small Biotech Environments. Molecules, 28.","DOI":"10.3390\/molecules28020776"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"4057","DOI":"10.1021\/acs.jcim.2c00318","article-title":"Predicting Total Drug Clearance and Volumes of Distribution Using the Machine Learning-Mediated Multimodal Method through the Imputation of Various Nonclinical Data","volume":"62","author":"Iwata","year":"2022","journal-title":"J. Chem. Inf. Model."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"6791","DOI":"10.1021\/acsomega.0c05846","article-title":"In Silico Prediction of Fraction Unbound in Human Plasma from Chemical Fingerprint Using Automated Machine Learning","volume":"6","author":"Mulpuru","year":"2021","journal-title":"ACS Omega"},{"key":"ref_68","doi-asserted-by":"crossref","unstructured":"Kumar, R., Sharma, A., Alexiou, A., Bilgrami, A.L., Kamal, M.A., and Ashraf, G.M. (2022). DeePred-BBB: A Blood Brain Barrier Permeability Prediction Model with Improved Accuracy. Front. Neurosci., 16.","DOI":"10.3389\/fnins.2022.858126"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"2184","DOI":"10.2174\/138161209788682479","article-title":"Drug-Like Property Concepts in Pharmaceutical Design","volume":"15","author":"Di","year":"2009","journal-title":"Curr. Pharm. Des."},{"key":"ref_70","doi-asserted-by":"crossref","unstructured":"Kazemeini, S., Nadeem-Tariq, A., Shih, R., Rafanan, J., Ghani, N., and Vida, T.A. (2024). From Plaques to Pathways in Alzheimer\u2019s Disease: The Mitochondrial-Neurovascular-Metabolic Hypothesis. Int. J. Mol. Sci., 25.","DOI":"10.3390\/ijms252111720"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1038\/s41583-019-0132-6","article-title":"Oxidative Stress, Dysfunctional Glucose Metabolism and Alzheimer Disease","volume":"20","author":"Butterfield","year":"2019","journal-title":"Nat. Rev. Neurosci."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.neulet.2018.01.045","article-title":"MiR-34a Deficiency in APP\/PS1 Mice Promotes Cognitive Function by Increasing Synaptic Plasticity via AMPA and NMDA Receptors","volume":"670","author":"Xu","year":"2018","journal-title":"Neurosci. Lett."},{"key":"ref_73","doi-asserted-by":"crossref","unstructured":"Zhang, T., Liu, C., Zhong, N., Wang, Y., Huang, Y., and Zhang, X. (2024). Advances in the Treatment of Cognitive Impairment in Schizophrenia: Targeting NMDA Receptor Pathways. Int. J. Mol. Sci., 25.","DOI":"10.20944\/preprints202408.1626.v1"},{"key":"ref_74","first-page":"367516","article-title":"Cardiovascular Risk Factors Promote Brain Hypoperfusion Leading to Cognitive Decline and Dementia","volume":"2012","year":"2012","journal-title":"Cardiovasc. Psychiatry Neurol."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1007\/s11064-007-9453-3","article-title":"Lipid Peroxidation and Antioxidant Enzyme Activities in Vascular and Alzheimer Dementias","volume":"33","author":"Casado","year":"2008","journal-title":"Neurochem. Res."},{"key":"ref_76","unstructured":"Georgescu, M., Vrinceanu, D., Radulescu, L., Tusaliu, M., Martu, C., Curutiu, C., Dyia Hussien, M., Budu, V., and Tu\u0219aliu, M. (2017). Microbial Biofilms and Implantable Hearing Aids. Rom. Biotechnol. Lett., 22."},{"key":"ref_77","doi-asserted-by":"crossref","unstructured":"Nakajima, M., and Yokoi, T. (2014). MicroRNA: Regulation of P450 and Pharmacogenetics. Handbook of Pharmacogenomics and Stratified Medicine, Academic Press.","DOI":"10.1016\/B978-0-12-386882-4.00019-0"},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"D1003","DOI":"10.1093\/nar\/gkac888","article-title":"Genenames.Org: The HGNC Resources in 2023","volume":"51","author":"Seal","year":"2023","journal-title":"Nucleic Acids Res."},{"key":"ref_79","doi-asserted-by":"crossref","unstructured":"Tambe, V., Sirsat, B., Rajpoot, K., Gadeval, A., and Tekade, R.K. (2021). Pharmacogenomics and Drug Metabolism. Biopharmaceutics and Pharmacokinetics Considerations: Volume 1 in Advances in Pharmaceutical Product. Development and Research, Academic Press.","DOI":"10.1016\/B978-0-12-814425-1.00021-8"},{"key":"ref_80","unstructured":"Panuganti, S.D., and Svensson, C.K. (2023). Drug Clearance. Preclinical Development Handbook: ADME and Biopharmaceutical Properties, John Wiley & Sons, Inc."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"12403","DOI":"10.1021\/acs.jmedchem.2c01075","article-title":"Substrates and Inhibitors of the Organic Cation Transporter 3 and Comparison with OCT1 and OCT2","volume":"65","author":"Gebauer","year":"2022","journal-title":"J. Med. Chem."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1016\/B978-0-12-409547-2.12330-3","article-title":"Label-Free Screening Technologies","volume":"Volumes 2\u20138","author":"Fang","year":"2017","journal-title":"Comprehensive Medicinal Chemistry III"},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/B978-0-323-90909-9.00001-0","article-title":"Evolving Toxicological Measurements for Pharmaceutical Waste-Induced Health Hazards","volume":"Volume 2","author":"Dudhabhate","year":"2023","journal-title":"360-Degree Waste Management, Volume 2: Biomedical, Pharmaceutical, Industrial Waste, and Remediation"},{"key":"ref_84","doi-asserted-by":"crossref","unstructured":"Moukheiber, L., Mangione, W., Moukheiber, M., Maleki, S., Falls, Z., Gao, M., and Samudrala, R. (2022). Identifying Protein Features and Pathways Responsible for Toxicity Using Machine Learning and Tox21: Implications for Predictive Toxicology. Molecules, 27.","DOI":"10.3390\/molecules27093021"},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"W5","DOI":"10.1093\/nar\/gkab255","article-title":"ADMETlab 2.0: An Integrated Online Platform for Accurate and Comprehensive Predictions of ADMET Properties","volume":"49","author":"Xiong","year":"2021","journal-title":"Nucleic Acids Res."},{"key":"ref_86","doi-asserted-by":"crossref","unstructured":"Mare\u015f, C., Udrea, A.M., \u015eu\u0163an, N.A., and Avram, S. (2023). Bioinformatics Tools for the Analysis of Active Compounds Identified in Ranunculaceae Species. Pharmaceuticals, 16.","DOI":"10.3390\/ph16060842"},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1016\/j.jad.2020.11.089","article-title":"A Transdiagnostic Examination of Anxiety and Stress on Executive Function Outcomes in Disorders with Social Impairment","volume":"281","author":"Demetriou","year":"2021","journal-title":"J. Affect. Disord."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1016\/S0091-3057(00)00422-6","article-title":"Drinks like a Fish: Zebra Fish (Danio rerio) as a Behavior Genetic Model to Study Alcohol Effects","volume":"67","author":"Gerlai","year":"2000","journal-title":"Pharmacol. Biochem. Behav."},{"key":"ref_89","doi-asserted-by":"crossref","unstructured":"Hamilton, T.J., Morrill, A., Lucas, K., Gallup, J., Harris, M., Healey, M., Pitman, T., Schalomon, M., Digweed, S., and Tresguerres, M. (2017). Establishing Zebrafish as a Model to Study the Anxiolytic Effects of Scopolamine. Sci. Rep., 7.","DOI":"10.1038\/s41598-017-15374-w"},{"key":"ref_90","doi-asserted-by":"crossref","unstructured":"de Abreu, M.S., Friend, A.J., Amstislavskaya, T.G., and Kalueff, A.V. (2018). Commentary: Establishing Zebrafish as a Model to Study the Anxiolytic Effects of Scopolamine. Front. Pharmacol., 9.","DOI":"10.3389\/fphar.2018.00293"},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1186\/s43088-021-00187-8","article-title":"Long-Term Scopolamine Treatment Altered Locomotor, Exploratory and Anxiety-like Behaviours of Albino Rats","volume":"11","author":"Abdelghany","year":"2022","journal-title":"Beni Suef Univ. J. Basic. Appl. Sci."},{"key":"ref_92","unstructured":"Xu, L.J., Liu, A.L., and Du, G.H. (2023). Scopolamine. Natural Small Molecule Drugs from Plants, Springer."},{"key":"ref_93","first-page":"45","article-title":"Neuroprotective Effect of Ellagic Acid Against Chronically Scopolamine Induced Alzheimer\u2019s Type Memory and Cognitive Dysfunctions: Possible Behavioural and Biochemical Evidences","volume":"1","author":"Ramandeep","year":"2015","journal-title":"Ann. Clin. Transl. Neurol."},{"key":"ref_94","doi-asserted-by":"crossref","unstructured":"Amaghnouje, A., Mechchate, H., Es-Safi, I., Alotaibi, A.A., Noman, O.M., Nasr, F.A., Al-Zharani, M., Cerruti, P., Calarco, A., and El Fatemi, H. (2020). Anxiolytic, Antidepressant-Like Proprieties and Impact on the Memory of the Hydro-Ethanolic Extract of Origanum majorana L. on Mice. Appl. Sci., 10.","DOI":"10.3390\/app10238420"},{"key":"ref_95","first-page":"1717","article-title":"An Updated Review on Traditional Uses, Taxonomy, Phytochemistry, Pharmacology and Toxicology of Origanum majorana","volume":"5","author":"Tripathy","year":"2017","journal-title":"Int. J. Pharma Res. Health Sci."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1016\/B978-0-12-809633-8.90082-7","article-title":"Spatial Memory","volume":"Volume 3","author":"Pritchard","year":"2019","journal-title":"Encyclopedia of Animal Behavior"},{"key":"ref_97","doi-asserted-by":"crossref","unstructured":"Silva, A., and Mart\u00ednez, M.C. (2022). Spatial Memory Deficits in Alzheimer\u2019s Disease and Their Connection to Cognitive Maps\u2019 Formation by Place Cells and Grid Cells. Front. Behav. Neurosci., 16.","DOI":"10.3389\/fnbeh.2022.1082158"},{"key":"ref_98","doi-asserted-by":"crossref","unstructured":"Callahan, P.M., Terry, A.V., Peitsch, M.C., Hoeng, J., and Koshibu, K. (2021). Differential Effects of Alkaloids on Memory in Rodents. Sci. Rep., 11.","DOI":"10.1038\/s41598-021-89245-w"},{"key":"ref_99","first-page":"6372059","article-title":"Scopolamine-Induced Memory Impairment in Mice: Neuroprotective Effects of Carissa Edulis (Forssk.) Valh (Apocynaceae) Aqueous Extract","volume":"2020","author":"Yadang","year":"2020","journal-title":"Int. J. Alzheimer\u2019s Dis."},{"key":"ref_100","first-page":"6666726","article-title":"Effect of Streblus Asper Leaf Extract on Scopolamine-Induced Memory Deficits in Zebrafish: The Model of Alzheimer\u2019s Disease","volume":"2021","author":"Singsai","year":"2021","journal-title":"Adv. Pharmacol. Pharm. Sci."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/B978-0-12-812012-5.00026-4","article-title":"Nicotinic Receptor Ligands and Novel Object Recognition","volume":"27","author":"Callahan","year":"2018","journal-title":"Handb. Behav. Neurosci."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/j.bbr.2015.09.016","article-title":"Object Recognition Memory in Zebrafish","volume":"296","author":"May","year":"2016","journal-title":"Behav. Brain Res."},{"key":"ref_103","doi-asserted-by":"crossref","unstructured":"Oliveira, A.W.C., Pacheco, J.V.N., Costa, C.S., Aquino, J., Maior, R.S., and Barros, M. (2021). Scopolamine and MK-801 Impair Recognition Memory in a New Spontaneous Object Exploration Task in Monkeys. Pharmacol. Biochem. Behav., 211.","DOI":"10.1016\/j.pbb.2021.173300"},{"key":"ref_104","doi-asserted-by":"crossref","unstructured":"Kim, Y.J., Kim, J.H., He, M.T., Lee, A.Y., and Cho, E.J. (2021). Apigenin Ameliorates Scopolamine-Induced Cognitive Dysfunction and Neuronal Damage in Mice. Molecules, 26.","DOI":"10.3390\/molecules26175192"},{"key":"ref_105","first-page":"46","article-title":"Protective Effects of Origanum majorana L. against Neurodegeneration: Fingerprinting, Isolation and In Vivo Glycine Receptors Behavioral Model","volume":"5","author":"Raafat","year":"2013","journal-title":"Int. J. Phytomedicine"},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.brainresbull.2019.01.004","article-title":"Recent Therapeutic Strategies Targeting Beta Amyloid and Tauopathies in Alzheimer\u2019s Disease","volume":"146","author":"Madav","year":"2019","journal-title":"Brain Res. Bull."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"2025","DOI":"10.1016\/S0047-6374(01)00310-4","article-title":"Treatment of Cognitive Dysfunction Associated with Alzheimer\u2019s Disease with Cholinergic Precursors. Ineffective Treatments or Inappropriate Approaches?","volume":"122","author":"Amenta","year":"2001","journal-title":"Mech. Ageing Dev."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"1852","DOI":"10.1212\/01.WNL.0000068336.84399.9E","article-title":"Butyrylcholinesterase and Progression of Cognitive Deficits in Dementia with Lewy Bodies","volume":"60","author":"Perry","year":"2003","journal-title":"Neurology"},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"108352","DOI":"10.1016\/j.neuropharm.2020.108352","article-title":"Efficacy of Acetylcholinesterase Inhibitors in Alzheimer\u2019s Disease","volume":"190","author":"Marucci","year":"2021","journal-title":"Neuropharmacology"},{"key":"ref_110","doi-asserted-by":"crossref","unstructured":"Sharma, C., Kim, S.R., Barone, E., and Trostchansky, A. (2021). Linking Oxidative Stress and Proteinopathy in Alzheimer\u2019s Disease. Antioxidants, 10.","DOI":"10.3390\/antiox10081231"},{"key":"ref_111","doi-asserted-by":"crossref","unstructured":"Huang, W.J., Zhang, X., and Chen, W.W. (2016). Role of Oxidative Stress in Alzheimer\u2019s Disease. Biomed. Rep., 4.","DOI":"10.3892\/br.2016.630"},{"key":"ref_112","first-page":"200","article-title":"Mitochondrial Metabolism of Reactive Oxygen Species","volume":"70","author":"Andreyev","year":"2005","journal-title":"Biochemistry"},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"829","DOI":"10.2174\/0929867013372896","article-title":"Oxidative Stress and Antioxidants in Exercise","volume":"8","author":"Leeuwenburgh","year":"2012","journal-title":"Curr. Med. Chem."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1007\/s11095-014-1447-7","article-title":"Superoxide Dismutase Enzymosomes: Carrier Capacity Optimization, in Vivo Behaviour and Therapeutic Activity","volume":"32","author":"Corvo","year":"2015","journal-title":"Pharm. Res."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"9613090","DOI":"10.1155\/2019\/9613090","article-title":"Role of Catalase in Oxidative Stress- and Age-Associated Degenerative Diseases","volume":"2019","author":"Nandi","year":"2019","journal-title":"Oxid. Med. Cell. Longev."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"2773","DOI":"10.1021\/acs.jafc.0c07798","article-title":"Characterization and Exploration of Potential Neuroprotective Peptides in Walnut (Juglans Regia) Protein Hydrolysate against Cholinergic System Damage and Oxidative Stress in Scopolamine-Induced Cognitive and Memory Impairment Mice and Zebrafish","volume":"69","author":"Wang","year":"2021","journal-title":"J. Agric. Food Chem."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"1240","DOI":"10.1016\/j.bbadis.2013.10.015","article-title":"Oxidative Stress and Mitochondrial Dysfunction in Alzheimer\u2019s Disease","volume":"1842","author":"Wang","year":"2014","journal-title":"Biochim. Biophys. Acta (BBA)-Mol. Basis Dis."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1016\/S0306-4522(00)00580-7","article-title":"Protein Oxidation in the Brain in Alzheimer\u2019s Disease","volume":"103","author":"Aksenov","year":"2001","journal-title":"Neuroscience"},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"2061","DOI":"10.1046\/j.1471-4159.1997.68052061.x","article-title":"An Assessment of Oxidative Damage to Proteins, Lipids, and DNA in Brain from Patients with Alzheimer\u2019s Disease","volume":"68","author":"Lyras","year":"1997","journal-title":"J. Neurochem."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"2146","DOI":"10.1046\/j.1471-4159.1995.65052146.x","article-title":"Brain Regional Correspondence Between Alzheimer\u2019s Disease Histopathology and Biomarkers of Protein Oxidation","volume":"65","author":"Hensley","year":"1995","journal-title":"J. Neurochem."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1186\/s13195-022-00961-5","article-title":"Altered Central and Blood Glutathione in Alzheimer\u2019s Disease and Mild Cognitive Impairment: A Meta-Analysis","volume":"14","author":"Chen","year":"2022","journal-title":"Alzheimer\u2019s Res. Ther."},{"key":"ref_122","doi-asserted-by":"crossref","unstructured":"Espinoza, S.E., Guo, H., Fedarko, N., DeZern, A., Fried, L.P., Xue, Q.L., Leng, S., Beamer, B., and Walston, J.D. (2008). Glutathione Peroxidase Enzyme Activity in Aging. J. Gerontol. A Biol. Sci. Med. Sci., 63.","DOI":"10.1093\/gerona\/63.5.505"},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"1185","DOI":"10.1080\/1071576021000016454","article-title":"Oxidation of Cu, Zn-Superoxide Dismutase by the Myeloperoxidase\/Hydrogen Peroxide\/Chloride System: Functional and Structural Effects","volume":"36","year":"2002","journal-title":"Free Radic. Res."},{"key":"ref_124","doi-asserted-by":"crossref","unstructured":"Braidy, N., Zarka, M., Jugder, B.E., Welch, J., Jayasena, T., Chan, D.K.Y., Sachdev, P., and Bridge, W. (2019). The Precursor to Glutathione (GSH), \u03b3-Glutamylcysteine (GGC), Can Ameliorate Oxidative Damage and Neuroinflammation Induced by A\u03b240 Oligomers in Human Astrocytes. Front. Aging Neurosci., 11.","DOI":"10.3389\/fnagi.2019.00177"},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"116826","DOI":"10.1016\/j.jep.2023.116826","article-title":"Phytochemical Analysis of Origanum majorana L. Extract and Investigation of Its Antioxidant, Anti-Inflammatory and Immunomodulatory Effects against Experimentally Induced Colitis Downregulating Th17 Cells","volume":"317","author":"Taha","year":"2023","journal-title":"J. Ethnopharmacol."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1186\/s42269-023-01012-1","article-title":"Origanum majorana L. Extract Alleviates Dexamethasone-Induced Hepatotoxicity, Oxidative Stress and Pathological Alterations in Vivo","volume":"47","author":"Hozayen","year":"2023","journal-title":"Bull. Natl. Res. Cent."},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"1150","DOI":"10.1126\/science.2964084","article-title":"The Fos Complex and Fos-Related Antigens Recognize Sequence Elements That Contain AP-1 Binding Sites","volume":"239","author":"Franza","year":"1988","journal-title":"Science"},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1638\/2017-0161.1","article-title":"Comparison of the efficacy and safety of medetomidine-ketamine versus medetomidine-azaperone-alfaxalone combination in free-ranging rocky mountain bighorn sheep (Ovis canadensis)","volume":"49","author":"Williams","year":"2018","journal-title":"J. Zoo. Wildl. Med."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1638\/2017-0182.1","article-title":"Inhalant anesthetic recovery following intramuscular epinephrine in the loggerhead sea turtle (Caretta caretta)","volume":"49","author":"Balko","year":"2018","journal-title":"J. Zoo. Wildl. Med."}],"container-title":["Biomolecules"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2218-273X\/15\/1\/138\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T10:30:09Z","timestamp":1759919409000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2218-273X\/15\/1\/138"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1,16]]},"references-count":129,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,1]]}},"alternative-id":["biom15010138"],"URL":"https:\/\/doi.org\/10.3390\/biom15010138","relation":{},"ISSN":["2218-273X"],"issn-type":[{"value":"2218-273X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1,16]]}}}