{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,18]],"date-time":"2026-01-18T01:53:37Z","timestamp":1768701217904,"version":"3.49.0"},"reference-count":23,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2025,1,30]],"date-time":"2025-01-30T00:00:00Z","timestamp":1738195200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"PRIN 2022","award":["20227RT83Z"],"award-info":[{"award-number":["20227RT83Z"]}]},{"name":"PRIN 2022","award":["MFAG 2021 ID 26178"],"award-info":[{"award-number":["MFAG 2021 ID 26178"]}]},{"name":"PRIN 2022","award":["PNRR M4C2-Investimento 1.4-CN00000041-PNRR_CN3RNA_SPOKE2"],"award-info":[{"award-number":["PNRR M4C2-Investimento 1.4-CN00000041-PNRR_CN3RNA_SPOKE2"]}]},{"DOI":"10.13039\/501100007076","name":"Italian Association for Cancer Research","doi-asserted-by":"publisher","award":["20227RT83Z"],"award-info":[{"award-number":["20227RT83Z"]}],"id":[{"id":"10.13039\/501100007076","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007076","name":"Italian Association for Cancer Research","doi-asserted-by":"publisher","award":["MFAG 2021 ID 26178"],"award-info":[{"award-number":["MFAG 2021 ID 26178"]}],"id":[{"id":"10.13039\/501100007076","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007076","name":"Italian Association for Cancer Research","doi-asserted-by":"publisher","award":["PNRR M4C2-Investimento 1.4-CN00000041-PNRR_CN3RNA_SPOKE2"],"award-info":[{"award-number":["PNRR M4C2-Investimento 1.4-CN00000041-PNRR_CN3RNA_SPOKE2"]}],"id":[{"id":"10.13039\/501100007076","id-type":"DOI","asserted-by":"publisher"}]},{"name":"European Union\u2014NextGenerationEU","award":["20227RT83Z"],"award-info":[{"award-number":["20227RT83Z"]}]},{"name":"European Union\u2014NextGenerationEU","award":["MFAG 2021 ID 26178"],"award-info":[{"award-number":["MFAG 2021 ID 26178"]}]},{"name":"European Union\u2014NextGenerationEU","award":["PNRR M4C2-Investimento 1.4-CN00000041-PNRR_CN3RNA_SPOKE2"],"award-info":[{"award-number":["PNRR M4C2-Investimento 1.4-CN00000041-PNRR_CN3RNA_SPOKE2"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biomolecules"],"abstract":"<jats:p>Cancer is one of the major challenges in medicine, necessitating continuous advancements in therapeutic approaches. Autophagy, an intracellular pathway essential for cellular homeostasis and stress response, has emerged as a promising target for cancer treatment. In this context, FAM46C, a novel pan-cancer tumour suppressor, has been shown to induce apoptosis in multiple myeloma cells through indirect inhibition of autophagy. Here, we discuss how FAM46C-induced autophagic dampening could offer new opportunities for global cancer therapy. Specifically, we explore two scenarios in which the expression of a functional FAM46C may either sensitize cancer cells to autophagic inhibition or antagonize their sensitivity. We further comment on how this synergism\/antagonism could be used to refine strategies for cancer treatment, positioning FAM46C as a pivotal factor in future cancer therapy development.<\/jats:p>","DOI":"10.3390\/biom15020196","type":"journal-article","created":{"date-parts":[[2025,1,30]],"date-time":"2025-01-30T11:08:23Z","timestamp":1738235303000},"page":"196","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Modulation of Autophagy by Oncosuppressor FAM46C and Its Implications for Cancer Therapy: An Intriguing Perspective"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1704-0522","authenticated-orcid":false,"given":"Nicola","family":"Manfrini","sequence":"first","affiliation":[{"name":"INGM, Istituto Nazionale Genetica Molecolare Romeo ed Enrica Invernizzi, 20122 Milan, Italy"},{"name":"Department of Biosciences, University of Milan, 20133 Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,1,30]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Lim, S.M., Mohamad Hanif, E.A., and Chin, S.-F. 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