{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T03:18:11Z","timestamp":1790565491977,"version":"4.1.0"},"reference-count":83,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2025,2,4]],"date-time":"2025-02-04T00:00:00Z","timestamp":1738627200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"NIH","award":["GM125082"],"award-info":[{"award-number":["GM125082"]}]},{"name":"NIH","award":["GM149271"],"award-info":[{"award-number":["GM149271"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biomolecules"],"abstract":"<jats:p>Inositol is a vital sugar molecule involved in numerous signaling pathways required for cellular homeostasis and cell survival. Myo-inositol and its phospho-derivatives, inositol phosphates (IPs), are the most prevalent forms of inositol found in living cells. They are involved in regulating ion channels, metabolic flux, stress response, and other key biological processes. While emerging research has highlighted the significant roles of inositol phosphates in immunity, cancer, and metabolic diseases, there is a lack of comprehensive reviews on their roles in psychiatric and neurological disorders. This review aims to fill that gap by analyzing the existing literature on the importance of inositol phosphates in severe psychiatric and neurological conditions such as Parkinson\u2019s disease, Alzheimer\u2019s disease, bipolar disorder, amyotrophic lateral sclerosis, schizophrenia, and Huntington\u2019s disease, underscoring the potential to pave the way for new treatment regimens for these debilitating disorders targeting inositol pathways.<\/jats:p>","DOI":"10.3390\/biom15020225","type":"journal-article","created":{"date-parts":[[2025,2,4]],"date-time":"2025-02-04T05:55:22Z","timestamp":1738648522000},"page":"225","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Inositol Phosphates and Synthesizing Enzymes: Implications in Neurodegenerative Disorders"],"prefix":"10.3390","volume":"15","author":[{"given":"Chisom J.","family":"Onu","sequence":"first","affiliation":[{"name":"Department of Biological Sciences, Wayne State University, Detroit, MI 48202, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Adu","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, Wayne State University, Detroit, MI 48202, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed","family":"Chakkour","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, Wayne State University, Detroit, MI 48202, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-5136-1315","authenticated-orcid":false,"given":"Vikalp","family":"Kumar","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, Wayne State University, Detroit, MI 48202, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miriam L.","family":"Greenberg","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, Wayne State University, Detroit, MI 48202, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,2,4]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1007\/s12038-015-9549-x","article-title":"The emerging roles of inositol pyrophosphates in eukaryotic cell physiology","volume":"40","author":"Thota","year":"2015","journal-title":"J. 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