{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T01:00:54Z","timestamp":1792803654625,"version":"4.5.0"},"reference-count":166,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2025,2,8]],"date-time":"2025-02-08T00:00:00Z","timestamp":1738972800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Liaoning Province Applied Basic Research Program","award":["2023JH2\/101300072"],"award-info":[{"award-number":["2023JH2\/101300072"]}]},{"name":"Liaoning Province Applied Basic Research Program","award":["22KJCX040"],"award-info":[{"award-number":["22KJCX040"]}]},{"name":"Liaoning Province Applied Basic Research Program","award":["L23ATY003"],"award-info":[{"award-number":["L23ATY003"]}]},{"name":"Science and Technology Innovation Program of the General Administration of Sport of China","award":["2023JH2\/101300072"],"award-info":[{"award-number":["2023JH2\/101300072"]}],"id":[{"id":"https:\/\/ror.org\/021jpad90","id-type":"ROR","asserted-by":"crossref"}]},{"name":"Science and Technology Innovation Program of the General Administration of Sport of China","award":["22KJCX040"],"award-info":[{"award-number":["22KJCX040"]}],"id":[{"id":"https:\/\/ror.org\/021jpad90","id-type":"ROR","asserted-by":"crossref"}]},{"name":"Science and Technology Innovation Program of the General Administration of Sport of China","award":["L23ATY003"],"award-info":[{"award-number":["L23ATY003"]}],"id":[{"id":"https:\/\/ror.org\/021jpad90","id-type":"ROR","asserted-by":"crossref"}]},{"name":"Liaoning Province Social Science Planning Fund for 2023","award":["2023JH2\/101300072"],"award-info":[{"award-number":["2023JH2\/101300072"]}]},{"name":"Liaoning Province Social Science Planning Fund for 2023","award":["22KJCX040"],"award-info":[{"award-number":["22KJCX040"]}]},{"name":"Liaoning Province Social Science Planning Fund for 2023","award":["L23ATY003"],"award-info":[{"award-number":["L23ATY003"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biomolecules"],"abstract":"<jats:p>N6-methyladenosine (m6A) is the most prevalent internal chemical modification in eukaryotic messenger RNA (mRNA), significantly impacting its lifecycle through dynamic and reversible processes involving methyltransferase, demethylase, and binding proteins. These processes regulate mRNA stability, splicing, nuclear export, translation, and degradation. Programmed cell death (PCD), a tightly controlled process encompassing apoptosis, pyroptosis, ferroptosis, autophagy, and necroptosis, plays a crucial role in maintaining cellular homeostasis, tissue development, and function. Recently, m6A modification has emerged as a significant research area due to its role in regulating PCD and its implications in cardiovascular diseases (CVDs). In this review, we delve into the intricate relationship between various PCD types and m6A modification, emphasizing their pivotal roles in the initiation and progression of CVDs such as myocardial ischemia-reperfusion (I\/R), atherosclerosis (AS), pulmonary hypertension (PH), cardiomyopathy, doxorubicin (Dox)-induced cardiotoxicity (DIC), heart failure (HF), and myocardial infarction (MI). Our findings underscore the potential of elucidating the roles of m6A and PCD in CVD to pave new pathways for prevention and treatment strategies.<\/jats:p>","DOI":"10.3390\/biom15020247","type":"journal-article","created":{"date-parts":[[2025,2,10]],"date-time":"2025-02-10T05:53:22Z","timestamp":1739166802000},"page":"247","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["The Emerging Role of m6A and Programmed Cell Death in Cardiovascular Diseases"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9789-997X","authenticated-orcid":false,"given":"Haixia","family":"Wang","sequence":"first","affiliation":[{"name":"College of Exercise and Health, Shenyang Sport University, Shenyang 110102, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juanjuan","family":"Han","sequence":"additional","affiliation":[{"name":"College of Exercise and Health, Shenyang Sport University, Shenyang 110102, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Kong","sequence":"additional","affiliation":[{"name":"College of Exercise and Health, Shenyang Sport University, Shenyang 110102, China"},{"name":"College of Exercise and Health, Shanghai Sport University, Shanghai 200438, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ce","family":"Ma","sequence":"additional","affiliation":[{"name":"Sports Training Teaching and Research Office, Shenyang Sport University, Shenyang 110102, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7854-4134","authenticated-orcid":false,"given":"Xin-an","family":"Zhang","sequence":"additional","affiliation":[{"name":"College of Exercise and Health, Shenyang Sport University, Shenyang 110102, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,2,8]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"D134","DOI":"10.1093\/nar\/gkaa692","article-title":"m6A-Atlas: A comprehensive knowledgebase for unraveling the N6-methyladenosine (m6A) epitranscriptome","volume":"49","author":"Tang","year":"2021","journal-title":"Nucleic Acids Res."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1016\/j.bbagrm.2018.12.002","article-title":"m6A modification of non-coding RNA and the control of mammalian gene expression","volume":"1862","author":"Coker","year":"2019","journal-title":"Biochim. 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