{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T06:22:00Z","timestamp":1792131720347,"version":"4.4.0"},"reference-count":45,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2025,2,24]],"date-time":"2025-02-24T00:00:00Z","timestamp":1740355200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Research Foundation of the Nanhu Laboratory","award":["NSS2021CI05003"],"award-info":[{"award-number":["NSS2021CI05003"]}]},{"name":"Research Foundation of the Nanhu Laboratory","award":["NSS2024CI05004"],"award-info":[{"award-number":["NSS2024CI05004"]}]},{"name":"Research Foundation of the Nanhu Laboratory","award":["82273024"],"award-info":[{"award-number":["82273024"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["NSS2021CI05003"],"award-info":[{"award-number":["NSS2021CI05003"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["NSS2024CI05004"],"award-info":[{"award-number":["NSS2024CI05004"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82273024"],"award-info":[{"award-number":["82273024"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biomolecules"],"abstract":"<jats:p>The recognition of cytosolic nucleic acids is a critical step in the host immune response against danger signals, such as molecular patterns from pathogens or tissue damage. Nonetheless, over-reactivity to self-nucleic acids leads to the sustained production of type I interferon (IFN), mediated either by cGAS or RLR, contributing to the pathogenesis of certain autoimmune diseases, such as Aicardi\u2013Gouti\u00e8res syndrome (AGS). Therefore, inhibiting excessive IFN production represents a potential therapeutic strategy for such autoimmune conditions. In this study, we discovered that petroselinic acid (PA), a natural compound isolated from Apiaceae family plants, effectively suppresses type I IFN production induced by cytosolic nucleic acids. Mechanistic investigations revealed that PA inhibits the phosphorylation of TBK1 and IRF3, which are key nodal proteins within the type I interferon pathway. Notably, molecular docking suggests potential binding between PA and cytosolic nucleic acid sensors, such as cGAS and RIG-I. Moreover, we found that PA effectively attenuates the expression of type I IFN and their downstream interferon-stimulated genes (ISGs) in models of AGS autoimmune disease characterized by excessive nucleic acid accumulation. Thus, our research identifies a natural compound that offers a promising strategy for treating autoimmune diseases resulting from aberrant self-nucleic acid recognition and the hyperactivation of type I interferon.<\/jats:p>","DOI":"10.3390\/biom15030329","type":"journal-article","created":{"date-parts":[[2025,2,24]],"date-time":"2025-02-24T07:46:57Z","timestamp":1740383217000},"page":"329","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Petroselinic Acid from Apiaceae Family Plants Ameliorates Autoimmune Disorders Through Suppressing Cytosolic-Nucleic-Acid-Mediated Type I Interferon Signaling"],"prefix":"10.3390","volume":"15","author":[{"given":"Yue","family":"Guo","sequence":"first","affiliation":[{"name":"Nanhu Laboratory, National Center of Biomedical Analysis, Beijing 100039, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun-Ying","family":"Wang","sequence":"additional","affiliation":[{"name":"Nanhu Laboratory, National Center of Biomedical Analysis, Beijing 100039, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yao","family":"Wang","sequence":"additional","affiliation":[{"name":"Nanhu Laboratory, National Center of Biomedical Analysis, Beijing 100039, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan-Hong","family":"Liu","sequence":"additional","affiliation":[{"name":"Nanhu Laboratory, National Center of Biomedical Analysis, Beijing 100039, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia-Yu","family":"Liu","sequence":"additional","affiliation":[{"name":"Nanhu Laboratory, National Center of Biomedical Analysis, Beijing 100039, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan-Yan","family":"Shen","sequence":"additional","affiliation":[{"name":"Nanhu Laboratory, National Center of Biomedical Analysis, Beijing 100039, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ai-Ping","family":"Cao","sequence":"additional","affiliation":[{"name":"Nanhu Laboratory, National Center of Biomedical Analysis, Beijing 100039, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui-Bo","family":"Wang","sequence":"additional","affiliation":[{"name":"Nanhu Laboratory, National Center of Biomedical Analysis, Beijing 100039, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo-Yang","family":"Xie","sequence":"additional","affiliation":[{"name":"Nanhu Laboratory, National Center of Biomedical Analysis, Beijing 100039, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1982-2261","authenticated-orcid":false,"given":"Xin","family":"Pan","sequence":"additional","affiliation":[{"name":"Nanhu Laboratory, National Center of Biomedical Analysis, Beijing 100039, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ai-Ling","family":"Li","sequence":"additional","affiliation":[{"name":"Nanhu Laboratory, National Center of Biomedical Analysis, Beijing 100039, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6222-2053","authenticated-orcid":false,"given":"Tao","family":"Zhou","sequence":"additional","affiliation":[{"name":"Nanhu Laboratory, National Center of Biomedical Analysis, Beijing 100039, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Na","family":"Wang","sequence":"additional","affiliation":[{"name":"Nanhu Laboratory, National Center of Biomedical Analysis, Beijing 100039, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing","family":"Xia","sequence":"additional","affiliation":[{"name":"Nanhu Laboratory, National Center of Biomedical Analysis, Beijing 100039, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei-Na","family":"Zhang","sequence":"additional","affiliation":[{"name":"Nanhu Laboratory, National Center of Biomedical Analysis, Beijing 100039, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,2,24]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"e112907","DOI":"10.15252\/embj.2022112907","article-title":"Viral recognition and the antiviral interferon response","volume":"42","author":"Dalskov","year":"2023","journal-title":"EMBO J."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1146\/annurev-immunol-032713-120231","article-title":"Interferon-stimulated genes: A complex web of host defenses","volume":"32","author":"Schneider","year":"2014","journal-title":"Annu. 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